检索结果-南通市图书馆

NCAD v1.0: a database for non-coding variant annotation and interpretation

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 230-242页

作者： Xiaoshu Feng Sihan Liu ke Li Fengxiao Bu Huijun Yuan Institute of Rare Diseases West China HospitalSichuan UniversityChengduSichuan 610044China

The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools. Hence, we develop the non-coding variant annotation database (NCAD, http://***/), encompassing comprehensive insights into 665,679,194 variants, regulatory elements, and element interaction details. Integrating data from 96 sources, spanning both GRCh37 and GRCh38 versions, NCAD v1.0 provides vital information to support the genetic diagnosis of non-coding variants, including allele frequencies of 12 diverse populations, with a particular focus on the population frequency information for 230,235,698 variants in 20,964 Chinese individuals. Moreover, it offers prediction scores for variant functionality, five categories of regulatory elements, and four types of non-coding RNAs. With its rich data and comprehensive coverage, NCAD serves as a valuable platform, empowering researchers and clinicians with profound insights into non-coding regulatory mechanisms while facilitating the interpretation of non-coding variants.

关键词： Non-coding variants Annotation Variant interpretation Database

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining ke En Huang key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Effects of the inlet particle spatial distribution on the performance of a gas-solid cyclone separator

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第2期85卷 133-145页

作者： Yuge Yao Manxia Shang Xiwei ke Zhong Huang Tuo Zhou Junfu Lyu key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing100084China

The present study was aimed at the inlet particle spatial distribution of a gas-solid separator with high solid loading and investigated its effects on cyclone performance and the inner flow *** flow fields of a cyclone with different rectangular particle flow areas on the inlet surface were numerically simulated using a four-way coupling *** simulated results indicate that reducing the inlet particle flow area and lowing the inlet particle position can effectively reduce the scattered particles inside the cyclone separator and enhance the separation *** gathering the particles to the centerline can also weaken the particle *** particles near the roof account for the swirling particle ceiling *** inlet particle spatial distribution affects the pressure drop mainly by affecting the gas tangential velocity in the cylinder ***,compared to the hori-zontal particle distribution on the inlet surface,the vertical particle distribution has greater effects on cyclone performance.

关键词： Gas-solid cyclone Inlet particle spatial distribution Four-way coupling Separation efficiency Scattered particle

Open-vessel Synthesis of Poly-N-methoxyethylglycine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第1期40卷 153-158页

作者： LIU Guojan MA ke CHEN Qi ZHANG Donghui LIU Runhui State key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237P.R.China key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237P.R.China School of Biotechnology East China University of Science and TechnologyShanghai200237P.R.China

Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic *** type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial ***,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to *** this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel *** adding BnNH_(2) as an initiator at 80℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.

关键词： Open-vessel Polypeptoid synthesis Poly-N-methoxyethylglycine Stable monomer Narrow dispersity

Combining graph neural network with deep reinforcement learning for resource allocation in computing force networks

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Information Technology & Electronic Engineering 2024年第5期25卷 701-712页

作者： Xueying HAN Mingxi XIE ke YU Xiaohong HUANG Zongpeng DU Huijuan YAO School of Computer Science Beijing University of Posts and TelecommunicationsBeijing 100876China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China Department of Infrastructure Network Technology Research China Mobile Research InstituteBeijing 100032China

Fueled by the explosive growth of ultra-low-latency and real-time applications with specific computing and network performance requirements,the computing force network(CFN)has become a hot research *** primary CFN challenge is to leverage network resources and computing *** recent advances in deep reinforcement learning(DRL)have brought significant improvement in network optimization,these methods still suffer from topology changes and fail to generalize for those topologies not seen in *** paper proposes a graph neural network(GNN)based DRL framework to accommodate network trafic and computing resources jointly and *** taking advantage of the generalization capability in GNN,the proposed method can operate over variable topologies and obtain higher performance than the other DRL methods.

关键词： Computing force network Routing optimization Deep learning Graph neural network Resource allocation

Exercise-induced adaptation of neurons in the vertebrate locomotor system

在线全文

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： Yue Dai Yi Cheng Renkai Ge ke Chen Liming Yang key Lab of Adolescent Health Assessment and Exercise Intervention of Ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai key Laboratory of Multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health Care East China Jiaotong UniversityNanchang 330013China key Laboratory of High Confidence Software Technologies of Ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein *** hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise Ion channel modulation Neuron adaptation

High-responsivity on-chip waveguide coupled germanium photodetector for 2 μm waveband

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2024年第1期12卷 115-122页

作者： JIANING WANG XI WANG YIHANG LI YANFU YANG QINGHAI SONG ke XU Guangdong Provincial key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems Harbin Institute of TechnologyShenzhen 518055China Department of Electronic&Information Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Science Harbin Institute of TechnologyShenzhen 518055China

Recently,the emerging 2μm waveband has gained increasing interest due to its great potential for a wide scope of *** with the existing optical communication windows at shorter wavelengths,it also offers distinct advantages of lower nonlinear absorption,better fabrication tolerance,and larger free carrier plasma effects for silicon photonics,which has been a proven device *** much progress has been witnessed for silicon photonics at the 2μm waveband,the primary challenge still exists for on-chip *** the maturity and compatibility of the waveguide coupled photodetectors made of germanium,the 2μm regime is far beyond its cutoff *** this work,we demonstrate an efficient and high-speed on-chip waveguidecoupled germanium photodetector operating at the 2μm *** weak sub-bandgap absorption of epitaxial germanium is greatly enhanced by a lateral separation absorption charge multiplication *** detector is fabricated by the standard process offered by a commercial *** device has a benchmark performance with responsivity of 1.05 A/W and 3 dB bandwidth of 7.12 GHz,which is able to receive high-speed signals with up to 20 Gbit/s data *** availability of such an efficient and fast on-chip detector circumvents the barriers between silicon photonic integrated circuits and the potential applications at the 2μm waveband.

关键词： waveguide responsivity wave

Projecting Wintertime Newly Formed Arctic Sea Ice through Weighting CMIP6 Model Performance and Independence

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第8期41卷 1465-1482页

作者： Jiazhen ZHAO Shengping HE ke FAN Huijun WANG Fei LI key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway School of Atmospheric Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Bergen 5007Norway Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

Precipitous Arctic sea-ice decline and the corresponding increase in Arctic open-water areas in summer months give more space for sea-ice growth in the subsequent cold seasons. Compared to the decline of the entire Arctic multiyear sea ice,changes in newly formed sea ice indicate more thermodynamic and dynamic information on Arctic atmosphere–ocean–ice interaction and northern mid–high latitude atmospheric teleconnections. Here, we use a large multimodel ensemble from phase 6 of the Coupled Model Intercomparison Project(CMIP6) to investigate future changes in wintertime newly formed Arctic sea ice. The commonly used model-democracy approach that gives equal weight to each model essentially assumes that all models are independent and equally plausible, which contradicts with the fact that there are large interdependencies in the ensemble and discrepancies in models' performances in reproducing observations. Therefore, instead of using the arithmetic mean of well-performing models or all available models for projections like in previous studies, we employ a newly developed model weighting scheme that weights all models in the ensemble with consideration of their performance and independence to provide more reliable projections. Model democracy leads to evident bias and large intermodel spread in CMIP6 projections of newly formed Arctic sea ice. However, we show that both the bias and the intermodel spread can be effectively reduced by the weighting scheme. Projections from the weighted models indicate that wintertime newly formed Arctic sea ice is likely to increase dramatically until the middle of this century regardless of the emissions ***, it may decrease(or remain stable) if the Arctic warming crosses a threshold(or is extensively constrained).

关键词： wintertime newly formed Arctic sea ice model democracy model weighting scheme model performance model independence

Adaptive Trajectory Tracking Control for Nonholonomic Wheeled Mobile Robots:A Barrier Function Sliding Mode Approach

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1007-1021页

作者： Yunjun Zheng Jinchuan Zheng ke Shao Han Zhao Hao Xie Hai Wang the School of Mechanical Engineering Hefei University of TechnologyHefei 230009China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyHawthorn VIC 3122Australia the School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072China the Shanghai Aerospace Control Technology Institute Shanghai 201109 the School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China the College of Science HealthEngineering and EducationMurdoch UniversityPerth WA6150Australia

The trajectory tracking control performance of nonholonomic wheeled mobile robots(NWMRs)is subject to nonholonomic constraints,system uncertainties,and external *** paper proposes a barrier function-based adaptive sliding mode control(BFASMC)method to provide high-precision,fast-response performance and robustness for *** with the conventional adaptive sliding mode control,the proposed control strategy can guarantee that the sliding mode variables converge to a predefined neighborhood of origin with a predefined reaching time independent of the prior knowledge of the uncertainties and disturbances *** advantage of the proposed algorithm is that the control gains can be adaptively adjusted to follow the disturbances amplitudes thanks to the barrier *** benefit is that the overestimation of control gain can be eliminated,resulting in chattering ***,a modified barrier function-like control gain is employed to prevent the input saturation problem due to the physical limit of the *** stability analysis and comparative experiments demonstrate that the proposed BFASMC can ensure the prespecified convergence performance of the NWMR system output variables and strong robustness against uncertainties/disturbances.

关键词： Adaptive sliding mode barrier function nonholonomic wheeled mobile robot(NWMR) trajectory tracking control