检索结果-南通市图书馆

Regulation of the pore structure of carbon nanosheets based electrocatalyst for efficient polysulfides phase conversions

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第4期171卷 37-46页

作者： Xiaoyang Liu Jingbo zhang Kangli Liu Shijie zhang Rouhan Hou Xiaoyi Hu Peng zhang Guosheng shao State Center for International Cooperation on Designer Low-Carbon&Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Zhengzhou Materials Genome Institute(ZMGI) Xingyang 450100China

The practical applications of lithium-sulfur(Li-S)batteries are hampered by the sluggish redox kinetics and polysulfides shuttle in the cyclic process,which leads to a series of problems including the loss of active materials and poor cycling *** this paper,the pore structures of carbon nanosheets based electrocatalysts were precisely controlled by regulating the content of water-soluble KCl *** relationship between pore structures and Li-S electrochemical behavior was studied,which demonstrates a key influence of pore structure in polysulfides phase *** the liquid-sloid redox reaction of polysulfides,the micropores and small mesopores(d20 nm)and macropores played a decisive *** a typical exhibition,the nickel-embedded carbon nanosheets(Ni-CNS)with a high content of large mesopores and macropores can aid Li-S batteries in exhibiting stable cycling performance(760.1 mAh g^(-1)at 1 C after 300 cycles)and superior rate capac-ity(847.8 mAh g^(-1)at 2 C).Furthermore,even with high sulfur loading(8 mg cm^(−2))and low electrolyte(E/S is around 6μL mg^(-1)),the high area capacity of 7.7 mAh cm^(−2)at 0.05 C could be *** work can provide a guideline for the design of the pore structure of carbon-based electrocatalysts toward high-efficiency sulfur species redox reactions,and afford a general,controllable,and simple approach to constructing high performance Li-S batteries.

关键词： Hierarchical porous carbon network Electrocatalyst Molten salt templating method Modified separators Li-S batteries

Lime pretreatment of maize stover and solubilization of pretreated solids by enzymatic hydrolysis and Clostridium thermocellum fermentation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2024年第4期17卷 288-296页

作者： Guanying Wang Gang zhang Xiongjun shao State Key Laboratory of Biocatalysis and Enzyme Engineering/Hubei Key Laboratory of Industrial Biotechnology School of Life SciencesHubei UniversityWuhan 430062China

Lime pretreatment on maize stover was conducted with various pretreatment conditions selected by central composite *** and lignin contents in pretreated maize stover were relatively *** of glucose monomer and oligomers decreased while concentration of xylooligomers increased in the pretreatment hydrolysate with increasing pretreatment *** overall carbohydrate recovery was at least 85%for the conditions *** removal during pretreatment was found to have a linear correlation with lignin *** had a higher effect in enhancing carbohydrate solubilization for enzymatic hydrolysis than that for *** *** all the pretreated solids,Clostridium thermocellum fermentation was found to result in much higher carbohydrate solubilization than enzymatic hydrolysis with a cellulase loading of 8 mg/g solids and a xylanase loading of 2 mg/g *** solubilization was found to have a linear correlation with lignin removal during lime pretreatment for both enzymatic hydrolysis and *** *** the current challenges,this research provides a new idea for the industrial application of lignocellulosic biorefinery.

关键词： central composite design lime pretreatment enzymatic hydrolysis clostridium thermocellum carbohydrate solubilization

Body-force modeling considering induced upstream effects for a transonic compressor with total temperature distortion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第6期37卷 7-19页

作者： Jiahui QIU Chen YANG Wenqiang zhang min zhang Juan DU Digital Twin Research Center Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China School of Engineering and Science University of Chinese Academy of SciencesBeijing 100190China National Key Laboratory of Science and Technology on Advanced Light-duty Gas-turbine Chinese Academy of SciencesBeijing 100190China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

To numerically study the impact of total temperature distortion on a transonic compressor with reduced computational costs,a Body-Force Model(BFM)is ***,the interactions between the distorted flow and the compressor are analyzed using full-annulus Unsteady Reynolds-Averaged Navier-Stokes(URANS)results and the orbit *** is found that the induced swirl distortion and the mass flux nonuniformity are intensified in the compressor upstream flow field.A correction factor is thus added to the BFM to account for the effect of the induced swirl,which is crucial for the accurate representation of distortion transfer in the ***,steady simulations with large-amplitude 180circumferential total temperature distortion are performed using the developed *** is shown that the distorted compressor map simulated with the BFM matches well with URANS *** circumferential phase shift of total temperature and the generation of the additional total pressure distortion across the rotor are in line with the time-averaged URANS flow *** compressor upstream effects on the distorted inflow can also be exactly *** above-mentioned results demonstrate the BFM developed in this paper can effectively capture the distorted flow features inside the compressor,and significantly reduce the computational costs by five orders of magnitude compared with URANS.

关键词： Upstream effect Orbit method Induced swirl distortion Body force model Correction factor Time-averaged URANS

Oral delivery of ferroptosis inducers for effective treatment of hepatic fibrosis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7621-7630页

作者： Yinglan Yu Shunlong zhang Yongfeng Xu Hao shao Lei Luo College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix(ECM),which is primarily produced by activated hepatic stellate cells(HSCs).However,effective therapies for hepatic fibrosis are currently *** is a promising anti-fibrotic drug candidate,but its clinical application is hindered by limited ***,we present a novel oral delivery platform that enhances the HSCs uptake of artesunate and induces potent *** platform is vitamin Adecorated nanoparticles encapsulated with *** multifunctional ligand vitamin A interacts with retinol-binding proteins that are highly expressed on the intestinal epithelium to promote transcytosis,highly expressed on the surface of HSCs but lowly expressed in normal *** oral administration,this oral delivery platform enhances transepithelial transport in the intestine,improves drug accumulation in the liver,and continuously increases HSCs uptake of *** drug release in HSCs,artesunate depletes glutathione peroxidase 4 and glutathione,effectively initiating *** vivo experiments demonstrate that this strategy induces pronounced ferroptosis,efficiently relieving liver *** work provides a proof-ofconcept demonstration that an oral delivery strategy for ferroptosis inducers may be beneficial for liver fibrosis treatment.

关键词： liver fibrosis hepatic stellate cells oral delivery intestinal epithelium ferroptosis

Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 952-963页

作者： Zhenhao zhang Doudou Jing Baijun Xuan Zhicai zhang Wei Wu Zengwu shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Orthopedics The Second Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Osteosarcoma is the most common primary malignancy of bones and primarily occurs in adolescents and young ***,a second smaller peak of osteosarcoma incidence was reported in the elderly aged more than *** patients with osteosarcoma exhibit different characteristics compared to young patients,which usually results in a poor *** mechanism underlying osteosarcoma development in elderly patients is intriguing and of significant value in clinical *** cells can accelerate tumor progression by metabolic *** research has shown that methylmalonic acid(MMA)was significantly up-regulated in the serum of older individuals and played a central role in the development of aggressive *** found that the significant accumulation of MMA in elderly patients imparted proliferative potential to osteosarcoma *** expression of MAFB was excessively up-regulated in osteosarcoma specimens and was further enhanced in response to MMA accumulation as the patient ***,we first confirmed a novel molecular mechanism between cellular senescence and cancer,in which the MMA-driven transcriptional reprogramming of the MAFB-NOTCH3 axis accelerated osteosarcoma progression via the activation of PI3K-AKT ***,the down-regulation of the MAFB-NOTCH3 axis increased the sensitivity and effect of AKT inhibitors in osteosarcoma through significant inhibition of AKT *** conclusion,we confirmed that MAFB is a novel age-dependent biomarker for osteosarcoma,and targeting the MAFB-NOTCH3 axis in combination with AKT inhibition can serve as a novel therapeutic strategy for elderly patients with osteosarcoma in experimental and clinical trials.

关键词： Cellular senescence Elderly patients MAFB-NOTCH3axis Methylmalonic acid Osteosarcoma PI3K-AKTpathway

Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第4期21卷 312-330页

作者： Qian zhang mingran Yang Peng zhang Bowen Wu Xiaosen Wei shao Li Institute for TCM-X MOE Key Laboratory of BioinformaticsBioinformatics DivisionBNRISTDepartment of AutomationTsinghua UniversityBeijing 100084China

Gastric cancer(GC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in GC development;therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investigating GC development. Of note, we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early GC warning biomarkers and precise treatment strategies. This review offers integrative insights for GC research, with the goal of paving the way to novel paradigms for GC precision oncology and prevention.

关键词： Gastric cancer inflammation-induced tumorigenesis multi-omics artificial intelligence network-based methods

Crystalline-amorphous M@MN_x(M=Co,Fe,Ni)encapsulated in nitrogen-doped carbon for enhanced efficient and durable hydrogen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1547-1556页

作者： Yang Yang Xiao-Chuan Duan shao-Hui Guo Xian-ming zhang College of Materials Science and Engineering College of ChemistryKey Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyYuci030600China

Developing earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is important for the sustainable energy ***,efficient and stable heterocatalysts consisting of crystalline-amorphous M@MN_(x)(M=Co,Fe,Ni)encapsulated in N-doped carbon layers supported with N-doped graphene sheets(denoted as M@MN_(x)@NC-NG)are synthesized by facile hydrothermal reaction and nitridation *** the nitriding process,metal ions in M(tzbc)_2(H_(2)O)_4(tzbc=4-(1H-1,2,4-triazol-1-yl)benzoic acid)complexes are reduced to crystalline M cores,accompanied by the formation of amorphous MN_(x)shells;the tzbc ligands are insitu carbonized to form outermost N-doped carbon(NC)layers that connect with inner MN_(x)via M-N-C motifs inherited from the complex precursors and inhibit the transition of MN_(x)from amorphous to crystalline *** Co@CoN_(x)@NC-NG catalyst exhibits excellent HER activity with small overpotentials of 45 and 64 mV at a cathode current density of 10 mA·cm^(-2)and low Tafel slopes of 40 and 85 mV·dec^(-1)in 0.5 mol·L^(-1)H_(2)SO_4 and1.0 mol·L^(-1)KOH electrolytes,*** Co@CoN_(x)@NC-NG retains 97%of the initial overpotential after 100,000 s in both acidic and alkaline *** outstanding HER performance originates from the crystalline-amorphous Co@CoN_(x)that redistributes electrons around the heterointerfaces,facilitating the conversion process of H^(+)/H_(2)O to hydrogen and thereby promoting HER *** outermost NC layers serve as the armor of Co@CoN_(x),and graphene nanosheets act as carriers of egg-like Co@CoN_(x)@NC and conduction paths for electron shuttles,ensuring stable and continuous electrocatalytic hydrogen production.

关键词： Hydrogen evolution reaction Electrocatalysts Iron group metals Heterojunction Crystalline-amorphous structure

Bone block from lateral window-correcting vertical and horizontal bone deficiency in maxilla posterior site:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第12期12卷 2109-2115页

作者： Yu-Lan Wang Wen-Jun shao min Wang State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079Hubei ProvinceChina Department of Oral Implantology School and Hospital of StomatologyWuhan UniversityWuhan 430079Hubei ProvinceChina

BACKGROUND Lateral window approach for sinus floor lift is commonly used for vertical bone augmentation in cases when the residual bone height is less than 5 ***,managing cases becomes more challenging when a maxillary sinus pseudocyst is present or when there is insufficient bone *** this case,we utilized the bone window prepared during the lateral window sinus lift as a shell for horizontal bone *** allowed for simultaneous horizontal and vertical bone augmentation immediately after the removal of the maxillary sinus *** SUMMARY A 28-year-old female presented to our clinic with the chief complaint of missing upper left posterior *** examination showed a horizontal deficiency of the alveolar ridge *** height of the alveolar bone was approximately 3.6 mm on cone beam computed tomography(CBCT).And a typical well-defined'dome-shaped'lesion in maxillary sinus was observed on CBCT *** lateral bony window was prepared using a piezo-ultrasonic device,then the bony window was fixed to the buccal side of the 26 alveolar ridge using a titanium screw with a length of 10 mm and a diameter of 1.5 *** space between the bony window and the alveolar ridge was filled with Bio-Oss,covered with a Bio-Gide collagen membrane,and subsequently *** months later,the patient’s bone width increased from 4.8 to 10.5 mm,and the bone height increased from 3.6 to 15.6 ***,a Straumann^(■)4.1 mm×10 mm implant was *** final all-ceramic crown restoration was completed four months later,and both clinical and radiographic examinations showed that the implant was successful,and the patient was satisfied with the *** The bone block harvested from the lateral window sinus lift can be used for simultaneous horizontal bone augmentation acting as a shell for good two-dimensional bone augmentation.

关键词： Sinus lift Lateral window Dental implant Horizontal bone augmentation Case report

Fifty-five cases of hepatic alveolar echinococcosis combined with lymph node metastasis:A retrospective study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第23期30卷 2981-2990页

作者： Yilizhati Aimaitijiang Tie-min Jiang Ying-Mei shao Tuerganaili Aji State Key Laboratory on Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaThe First Clinical CollegeXinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina The First Ward of Hepatobiliary and Pancreatic Surgery Tumor Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina Department of Hepatobiliary&Hydatid Diseases Digestive&Vascular Surgery CenterThe First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Echinococcosis and Hepatobiliary Diseases The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina

BACKGROUND Lymph node metastasis is a specific type of metastasis in hepatic alveolar echinococcosis(AE).Currently,there is a scarcity of describing the clinical characteristics and lymph node metastasis rules of patients with hepatic AE combined with lymph node metastasis and its mechanism and management are still *** hepatectomy combined with regional lymph node dissection is a better *** To analyse the clinical features of hepatic AE combined with lymph node metastasis to explore its treatment and *** A total of 623 patients with hepatic AE admitted to the First Affiliated Hospital of Xinjiang Medical University from 1 January 2012 to 1 January 2022 were retrospectively ***-five patients with combined lymph node metastasis were analysed for their clinical data,diagnosis and treatment methods,follow-up efficacy,and characteristics of lymph node ***,we comparatively analysed the lymph node metastasis rates at different *** variables are expressed as frequencies and percentages,and the analysis of difference was performed using theχ2 *** Bonferroni method was used for pairwise comparisons when statistical differences existed between multiple categorical *** A lymph node metastasis rate of 8.8%(55/623)was reported in patients with hepatic AE,with a female predilection(69.1%)and a statistically significant sex difference(χ2=8.018,P=0.005).Of the 55 patients with lymph node metastasis,72.7%had a parasite lesion,neighbouring organ invasion,and metastasis stage of P3N1M0 and above,of which 67.3%,78.2%,and 34.5%of hepatic AE lesions invaded the bile ducts,blood vessels,and distant metastases,*** rates of lymph node metastasis of 16.4%,21.7%,and 34.2%were reported for a preoperative abdominal ultrasound,magnetic resonance imaging,and computed tomography *** patients were intraoperatively suspected with enlarged lymph nodes and underwent radica

关键词： Echinococcosis Radical hepatectomy Lymph node metastasis Lymph node dissection Alveolar echinococcosis Hepatic