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World Journal of Gastroenterology 2018年第33期24卷 3806-3812页

作者： Rui Xie Kuang-I Fu shao-min chen Bi-Guang Tuo Hui-ChaoWu Department of Gastroenterology Affiliated Hospital to Zunyi Medical College Department of Endoscopy Kanma Memorial Hospital

Neurofibromatosis type 1(NF-1) is commonly associated with benign or malignant tumors in both the central and peripheral nervous systems. However, rare cases of NF-1-associated multiplerectal neuroendocrine tumors have been reported. This report describes a case of a 39 year old female with NF-1 and intermittent hematochezia as a primary symptom. Physical examination showed multiple subcutaneous nodules and café au lait spots with obvious scoliosis of the back. Imaging examinations and colonoscopy found malformation of the left external iliac vein and multiple gray-yellow nodules with varying sizes and shapes in the rectal submucosal layer. Histological and immunohistochemical results suggested multiple rectal neuroendocrine tumors, a rare disease with few appreciable symptoms and a particularly poor prognosis. The patient with NF-1 presented here had not only multiple rectal neuroendocrine neoplasms but also vascular malformations, scoliosis and other multiple system lesions. This case therefore contributes to improving clinical understanding, diagnosis and treatment of related complications for patients with NF-1 who present with associated medical conditions.

关键词： Neurofibromatosis type 1 Multiple rectal neuroendocrine tumors Vascular malformations Scoliosis

Two case of preoperative bridging therapy for patients undergoing non- cardiac surgery after coronary stent implantation

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Journal of Geriatric Cardiology 2017年第7期14卷 488-490页

作者： Le-Qun ZHOU shao-min chen Yong-Zhen ZHANG Li-Yun HE Wei GAO Department of Cardiology Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and RegulatoryPeptidesMinistry of HealthBeijingChina

It has been reported that up to 12% of patients underwent non-cardiac surgery or invasive procedures within the first year after the coronary stent implantation. Premature dis- continuation of antiplatelet therapy is associated with a sig- nificant increase in mortality and major adverse cardiac events, in particular, stent thrombosis. Thus, postpone- ment of elective surgery is advocated during the first year after the coronary stent implantation.

关键词： Coronary stent implantation Non-cardiac surgery Preoperative bridging therapy Tirofiban

Higher serum angiopoietin 2 levels are independently associated with coronary microvascular dysfunction in patients with angina in the absence of obstructive coronary artery disease

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Chinese Medical Journal 2020年第14期133卷 1662-1668页

作者： shao-min chen Dan Li Xing Xing Zhao-Ping Li Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Cardiovascular Medicine Beijing First Hospital of Integrated Chinese and Western MedicineBeijing 100039China.

Background:Angiopoietin-2(Ang-2)is a type of endothelial growth factor involved in angiogenesis and vascular *** Ang-2 levels are elevated in patients with obstructive coronary artery disease(CAD).This study aimed to evaluate the association between serum Ang-2 levels and coronary microvascular dysfunction in patients without obstructive ***:A total of 125 patients with angina in the absence of obstructive CAD were included in this cross-sectional *** flow reserve(CFR)was measured in the distal left anterior descending coronary artery by trans-thoracic Doppler *** patients were divided into the following two sub-groups according to CFR:the impaired CFR group with CFR valuesmined using enzyme-linked immunosorbent *** predictors for impaired CFR were identified by binary logistic regression *** receiveroperating characteristic curve was determined to evaluate the ability of serum Ang-2 in predicting impaired ***:We found that age,percentage of female sex,N-terminal pro-B-type natriuretic peptide levels,Ang-2 levels(763.3±264.9 vs.579.7±169.3 pg/mL,P<0.001),and the left atrial volume index were significantly higher in patients with impaired CFR than in patients with preserved *** Ang-2 levels were negatively correlated with CFR(r=0.386,P<0.001).Binary logistic regression analysis showed that Ang-2(odds ratio:1.004,95%confidence interval[CI]:1.001–1.006,P=0.003)and age(odds ratio:1.088,95%CI:1.023–1.156,P=0.007)were independently associated with impaired ***,Ang-2 was a significant predictor of impaired CFR on the receiver-operating characteristic curve(P<0.001).The area under the curve was 0.712(95%CI:0.612–0.813).Conclusions:High serum Ang-2 levels are independently associated with impaired CFR in patients with angina in the absence of obstructive CAD.

关键词： Coronary microvascular dysfunction Angiopoietin 2 Coronary flow reserve

Extracorporeal membrane oxygenation successfully treated massive right ventricular myocardial infaction with aneurysm

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Journal of Geriatric Cardiology 2022年第8期19卷 618-621页

作者： cheng-Duo ZHANG Li-Jie SUN Bao-Xia chen Jiang-Li HAN shao-min chen Xin-Yu WANG Yuan-Yuan FAN Dan LI Xin-Ye XU Department of Cardiology Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijingChina

Acute obstruction of the right coronary ar-tery(RCA)can lead to right ventricular myocardial infarction(MI),which rarely lead to cardiogenic shock(CS).Hemodynamic sta-bility could be restored through fluid resuscitation and vasoactive drugs in most ***,we present a highly representative case of refractory CS caused by massive right ventricular MI with api-cal aneurysm formation,who was successfully treated with extracorporeal membrane oxygenation(ECMO)post severe complication of acute right coronal dis-section.

关键词： ventricular aneurysm drugs

Precise Asymptotics of Error Variance Estimator in Partially Linear Models

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Acta Mathematicae Applicatae Sinica 2008年第1期24卷 59-74页

作者： shao-jun Guo, min chen, Feng Liu Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100080, China Department of Statistics, Chongqing Institute of Technology, Chongqing 630000, China Academy of Mathematics Systems Science Chinese Academy of Sciences Beijing 100080 China Department of Statistics Chongqing Institute of Technology Chongqing 630000 China

In this paper, we focus our attention on the precise asymptotics of error variance estimator in partially linear regression models, yi = xiτβ+ g(ti) +εi, 1≤i≤n, {εi,i = 1,…, n} are i.i.d random errors with mean 0 and positive finite varianceσ2. Following the ideas of Allan Gut and Aurel Spatarut and Zhang, on precise asymptotics in the Baum-Katz and Davis laws of large numbers and precise rate in laws of the iterated logarithm, respectively, and subject to some regular conditions, we obtain the corresponding results in partially linear regression models.

关键词： Precise asymptotics partially linear models error variance estimator

Relationship between exercise induced elevation of left ventricular filling pressure and exercise intolerance in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第6期13卷 546-551页

作者： shao-min chen Rong HE Wei-Hong LI Zhao-Ping LI Bao-Xia chen Xin-Heng FENG Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides Ministry of Health Beijing China Department of Cardiology Beijing Tsinghua Changgung Hospital Medical Center Tsinghua University Beijing China

Background Elevated left ventricular filling pressure （LVFP） is an important cause of exercise intolerance in patients with atrial fib- dilation （AF）. Exercise stress echocardiography could assess LVFP during exercise. The objective of this study was to investigate the relationship between exercise induced elevation of LVFP and exercise capacity in patients with AF. Methods This study included 145 con- secutive patients （81 men and 64 women; mean age 65.5 ± 8.0 years） with persistent non-valvular AF and normal left ventricular systolic function （left ventdcular ejection fraction 〉 50%）. All patients underwent a symptom-limited cardiopulmonary exercise test （CPET）. Doppler echocardiography was performed both at rest and immediately after exercise. Five consecutive measurements of early diastolic mitral inflow velocity （E） and early diastolic mitral annular velocity （e＇） were taken and averaged. E/e＇ ratio was calculated. Elevated LVFP was defined as E/e＇〉 9, and patients with elevated LVFP at rest were excluded. Results Patients were classified into two groups according to LVFP estimated by E/e＇ ratio after exercise： 39 （26.9%） with elevated LVFP after exercise and 106 （73.1%） with normal LVFP. As compared with patients with normal LVFP, the ones with elevated LVFP after exercise had significantly lower peak oxygen uptake （VO2 peak）（21.7 ± 2.3 vs. 26.4 ± 3.8 mL/min per kilogram, P 〈 0.001）, lower anaerobic threshold （19.9 ± 2.5 vs. 26.0± 4.0 mL/min per kilogram, P 〈 0.001）, and shorter exercise time duration （6.2± 0.8 vs. 7.0 ±1.3 min, P 〈 0.001）. Multivariate analysis showed that age, gender and E/e＇ after exercise were significantly correlated with VO2peak. Conclusion Elevated LVFP estimated by E/e＇ ratio after exercise is independently associated with reduced exercise capacity in AF patients.

关键词： Atrial fibrillation Diastolic dysfunction Exercise capacity, Exercise stress echocardiography

Left atrial area index predicts adverse cardiovascular events in patients with unstable angina pectoris

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Journal of Geriatric Cardiology 2016年第8期13卷 652-657页

作者： Yi-Fan LI Wei-Hong LI Zhao-Ping LI Xin-Heng FENG Wei-Xian XU shao-min chen Wei GAO Department of Cardiology Peking University Third Hospital Beijing China Department of Pediatric Cardiology Guangdong Cardiovascular institute Guangdong General Hospital GuangzhouChina.

Background The left atrial size has been considered as a useful marker of adverse cardiovascular outcomes. However, it is not well known whether left atrial area index （LAAI） has predictive value for prognosis in patients with unstable angina pectoris （UAP）. This study was aimed to assess the association between LAAI and outcomes in UAP patients. Methods We enrolled a total of 391 in-hospital patients diag- nosed as UAP. Clinical and echocardiographic data at baseline were collected. The patients were followed for the development of ad- verse cardiovascular （CV） events, including hospital readmission for angina pectoris, acute myocardial infarction （AMI）, congestive heart failure （CHF）, stroke and all-cause mortality. Results During a mean follow-up time of 26.3±8.6 months, 98 adverse CV events occurred （84 hospital readmission for angina pectoris, four AMI, four CHF, one stroke and five all-cause mortality）. In a multivariate Cox model, LAAI [OR： 1.140, 95% CI： 1.01±1.279, P = 0.026], diastolic blood pressure （OR： 0.976, 95% CI： 0.956-0.996, P = 0.020） and pulse pressure （OR 1.020, 95% CI： 1.007-1.034, P = 0.004） were independent predictors for adverse CV events in UAP patients. Conclusions LAAI is a predictor of adverse CV events independent of clinical and other echocardiographic parameters in UAP patients.

关键词： Adverse cardiovascular events Left atrial area index Prognostic factor Unstable angina pectoris

Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxelmirrored homotopic connectivity:a resting state fMRI study

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 297-307页

作者： Xue-Lin Wang Yu chen Jin-Yu Hu Hong Wei Qian Ling Liang-Qi He cheng chen Yi-Xin Wang Yan-Mei Zeng Xiao-Yu Wang Qian-min Ge Xu chen Yi shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeShangrao Center HospitalEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Department of Traditional Chinese Medicine the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To analyze whether alterations of voxel mirror homology connectivity(VMHC)values,as determined by resting-state functional magnetic resonance imaging(rsfMRI),occur in cerebral regions of patients with hypertensive retinopathy(HR)and to determine the relationship between VMHC values and clinical characteristics in patients with ***:Twenty-one patients with HR and 21 agematched healthy controls(HCs)were assessed by rsfMRI *** functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC,with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic(ROC)curve *** in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample *** relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation ***:Mean VMHC values of the bilateral cuneus gyrus(BA19),bilateral middle orbitofrontal gyrus(BA47),bilateral middle temporal gyrus(BA39)and bilateral superior medial frontal gyrus(BA9)were lower in the HR than in the HC ***:VMHC values can predict the development of early HR,prevent the transformation of hypertensive microangiopathy,and provide useful information explaining the changes in neural mechanism associated with HR.

关键词： hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional MRI resting state

Multiphoton photoredox catalysis enables selective hydrodefluorinations

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Chinese Chemical Letters 2025年第2期36卷 366-372页

作者： Jiaqi Jia Kathiravan Murugesan chen Zhu Huifeng Yue shao-Chi Lee Magnus Rueping KAUST Catalysis Center KCC King Abdullah University of Science and Technology

Late-stage modification of complex molecules via site-selective hydrodefluorination is a challenging endeavor. The selective activation of carbon-fluorine(C–F) bonds in the presence of multiple C–F bonds is of importance in organic synthesis and drug discovery. Herein, we describe the activation of C-F bonds via multiphoton photoredox catalysis to selectively produces a series of hydrodefluorinated compounds by simply tuning the reaction conditions. Moreover, this protocol was successfully applied to the late-stage functionalization of different drug-derivatives and the corresponding mono-, di-, and tri-defluorinated products were obtained in good to excellent yields. A detailed mechanistic investigation provides insight into the unprecedented hydrodefluorination pathway.

关键词： C-F bond activation Multiphoton Photoredox catalysis Site-selectivity Trifluoroacetamide

Effect of dopamine and metaraminol on the renal function of patients with septic shock

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Chinese Medical Journal 2007年第8期120卷 680-683页

作者： HOU Li-chao LI Shu-zhi XIONG Li-ze chen shao-yang chen min ZHANG Xi-jing HUO Ting-ting WANG Qiang WANG Ya-li HU Wen-neng Department of Anaesthesiology Xijing Hospital Fourth Military Medical University Xi＇an 710032 China

Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial blood pressure, but also on the blood flow perfusion of internal organs. The effects of dopamine and metaraminol on the renal function of the patients with septic shock were investigated retrospectively in this study. Methods Ninety-eight patients with septic shock were divided into three groups according to the highest infusing rate of metaraminol, with the lightest infusing rate of （0.1-0.5, 0.6-1.0, 〉1.0） pg · kg^-1 · min^-1 in group A, B and C respectively. Urine output, mean arterial blood pressure （MAP）, heart rate （HR）, urine output, blood urea nitrogen （BUN）, creatinine （CRE）, urine albumin （U-ALB）, urine β2-microglubulin （Uβ2-MG） and Apache Ⅲ scores were recorded. Results Before antishock therapy, hypotension, tachycardia and oliguria occurred to all the 98 patients with septic shock and CRE, BUN, U-ALB, Uβ2-MG and Apache Ⅲ scoring were abnormal in most cases. With the antishock therapy, MAP, HR, urine output, BUN and CRE in all patients returned gradually to normal （P〈0.05 or 〈0.01 compared to those before antishock therapy）. U-ALB, Uβ2-MG output and Apache Ⅲ scoring also reverted but remained abnormal （P〈0.01 compared to those before antishock therapy）. No statistically significant differences in the changes of these indices with the time existed among the three groups （P〉0.05）.Conclusion Dopamine and metaraminol when applied to the patients with septic shock could effectively maintain the circulatory stability and promote restoration of renal function.

关键词： dopamine metaraminol septic shock renal function