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Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma

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Current Medical Science 2022年第4期42卷 832-840页

作者： Liang GE shao-feng LIU Department of Otorhinolaryngology Head and Neck Surgery the Yijishan Hospital of Wannan Medical CollegeWuhu 241001China

Objective:Follistatin(FST)inhibits the action of activin by interfering with the binding of activin to its *** the prognostic value of FST in various cancers has been investigated previously,studies rarely focused on hypopharyngeal carcinoma(HPC).In our study,the effect of FST expression on HPC tissues and cell lines was ***:A total of 60 patients with HPC were recruited for this *** of FST mRNA and protein were measured by quantitative polymerase chain reaction(PCR)and immunohistochemistry in HPC tissue samples and by qPCR in the HPC FaDu cells,as well as immortal nasopharyngeal epithelial cell line NP-69 *** silencing the FST expression in FaDu cells using lentivirus-mediated siRNA that was specific for FST mRNA,cell proliferation was determined by a Celigo *** growth was monitored in nude mice and viability was determined by a methylthiazoletetrazolium *** ratio of cell cycle arrest and apoptosis was evaluated by flow *** colony formation ability was performed using Giemsa *** addition,wound healing and Transwell migration and invasion assays were performed for the analysis of cell ***:FST expression was significantly higher in human HPC tissue and FaDu cells than in normal tissue and NP-69 cells.A higher expression of FST in HPC samples was positively correlated with advanced ***,FST knockdown by shRNA significantly decreased cell growth,colony formation,migration and ***,FST silencing increased the cell apoptosis percentage,and arrested cell cycle in the S phase in FaDu *** addition,FST silencing suppressed tumor growth in ***:Our results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC.

关键词： follistatin hypopharyngeal carcinoma migration invasion proliferation apoptosis

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Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy

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Genes & Diseases 2018年第4期5卷 358-366页

作者： Yuchao Li Xiaoqing Zhang Jianbo Chen Chengya feng Yifan He Yong shao min Ding Key Laboratory of Clinical Laboratory Diagnostics Ministry of EducationSchool of Laboratory MedicineChongqing Medical UniversityChongqing400016PR China Guangzhou Kingmed Center for Clinical Laboratory Guangzhou510005PR China Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China

Intrahepatic cholestasis of pregnancy(ICP)is related to cholestatic disorder in *** urinary sulfated bile acids(SBAs)were found increased in *** distinguished the metabolic profiling of urinary SBAs in ICP to find potential biomarkers for the diagnosis and grading of *** targeted metabolomics based on high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)was used to analyze urinary SBAs profiling in mild and severe ICP cases,as well as healthy controls.16 kinds of urinary SBAs were determined by HPLC-MS/*** dihydroxy glycine bile acid(di-GBA-S),glycine cholic acid 3-sulfate(GCA-3S),sulfated dihydroxy taurine bile acid(di-TBA-S)and taurine cholic acid 3-sulfate(TCA-3S)increased significantly in ICP group compared with the control *** kinds of SBAs were significantly different(pminant analysis(OPLS-DA).GCA-3S was well-suited to be used as the biomarker for the diagnosis of ICP with the sensitivity of 100%and specificity of 95.5%.A multi-variable logistic regression containing GCA-3S and di-GBA-S-1 was constructed to distinguish severe ICP from mild ICP,with the sensitivity of 94.4%and specificity of 100%.The developed HPLC-MS/MS method is suitable for the measurement of urinary SBAs ***,the urinary SBAs in the metabolomic profiling have the potential to be used as non-intrusive biomarkers for the diagnosis and grading of ICP.

关键词： Biomarker HPLC-MS/MS Intrahepatic cholestasis of pregnancy Sulfated bile acids Targeted metabolomics Urine

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The role of velocity derivative skewness in understanding non-equilibrium turbulence

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Chinese Physics B 2020年第11期29卷 99-105页

作者： feng Liu Le Fang Liang shao School of Energy and Power Engineering North University of ChinaTaiyuan 030051China Laboratory of Mathematics and Physics Ecole Centrale de PékinBeihang UniversityBeijing 100191China Laboratoire de Mécaniques des Fluides et d’Acoustique Ecole Centrale de Lyon-Université de LyonEcully 69134France

The turbulence governed by the Navier-Stokes equation is paramount in many physical ***,it has been considered as a challenging problem due to its inherent nonlinearity,non-equilibrium,and ***,we review the connections between the velocity derivative skewness Sk and the non-equilibrium properties of ***,a reasonable candidate for describing the non-equilibrium turbulence,which varies during the non-equilibrium procedure.A lot of experimental or numerical evidences have shown that the perturbation of energy spectrum,which associated with the excitation of large scales,results in an obvious variation of Sk,and Sk is a negative value in this rapid energy decay *** variation of positive Sk is closely related to the perturbation of transfer spectrum,and this corresponds to the backward energy transfer *** addition,the skewness characterizes the production(or reduction)rate of enstrophy due to vortex stretching(or compression).Using the transport equation of turbulent energy dissipation rate and enstrophy,it is possible to establish a theoretical connection between skewness and the non-equilibrium *** is expected that this work could trigger the rapid advancement of the future studies of non-equilibrium turbulence,and also the improvement of turbulence models.

关键词： velocity derivative skewness non-equilibrium turbulence turbulence model

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Transfer active learning by querying committee

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第2期15卷 107-118页

作者： Hao shao feng TAO Rui XU School of WTO Research & Education Shanghai University of International Business and Economics School of Business East China University of Science and Technology School of Computer Science and Technology University of Science and Technology of China

In real applications of inductive learning for classifi cation, labeled instances are often defi cient, and labeling them by an oracle is often expensive and time-consuming. Active learning on a single task aims to select only informative unlabeled instances for querying to improve the classifi cation accuracy while decreasing the querying cost. However, an inevitable problem in active learning is that the informative measures for selecting queries are commonly based on the initial hypotheses sampled from only a few labeled instances. In such a circumstance, the initial hypotheses are not reliable and may deviate from the true distribution underlying the target task. Consequently, the informative measures will possibly select irrelevant instances. A promising way to compensate this problem is to borrow useful knowledge from other sources with abundant labeled information, which is called transfer learning. However, a signifi cant challenge in transfer learning is how to measure the similarity between the source and the target tasks. One needs to be aware of different distributions or label assignments from unrelated source tasks;otherwise, they will lead to degenerated performance while transferring. Also, how to design an effective strategy to avoid selecting irrelevant samples to query is still an open question. To tackle these issues, we propose a hybrid algorithm for active learning with the help of transfer learning by adopting a divergence measure to alleviate the negative transfer caused by distribution differences. To avoid querying irrelevant instances, we also present an adaptive strategy which could eliminate unnecessary instances in the input space and models in the model space. Extensive experiments on both the synthetic and the real data sets show that the proposed algorithm is able to query fewer instances with a higher accuracy and that it converges faster than the state-of-the-art methods.

关键词： Active learning Transfer learning Classification

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RHEOLOGICAL PROPERTIES OF WHEAT GLIADINS IN AQUEOUS PROPANOL

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Chinese Journal of Polymer Science 2013年第5期31卷 809-814页

作者： shao-min Sun 宋义虎 Qiang Zheng MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

Rheological properties of wheat gliadins in 50% （V/F） aqueous propanol were carried out as a function of gliadin concentration c and temperature. The solutions at 20 g L-1 to 200 g L-1 behave as Newtonian fluids with an flow activation energy of 23.5-27.3 kJ mol-1. Intrinsic viscosity [η] and Huggins constant kH are determined according to Huggins plot at c 〈 120 g L-1. The results reveal that gliadins are not spherical shaped and the molecular size tends to increase with temperature due to improved solvation.

关键词： Gliadin Solution Rheological properties Intrinsic viscosity.

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Layered double hydroxide-based core-shell nanoarrays for efficient electrochemical water splitting

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 537-554页

作者： Wenfu Xie Zhenhua Li mingfei shao min Wei State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China

Electrochemical water splitting is an efficient and clean strategy to produce sustainable energy produc- tions （especially hydrogen） from earth-abundant water. Recently, layered double hydroxide （LDH）-based materi- als have gained increasing attentions as promising electrocatalysts for water splitting. Designing LDHs into hierarchical architectures （e.g., core-shell nanoarrays） is one of the most promising strategies to improve their electrocatalytic performances, owing to the abundant exposure of active sites. This review mainly focuses on recent progress on the synthesis of hierarchical LDH-based core-shell nanoarrays as high performance electrocatalysts for electrochemical water splitting. By classifying different nanostructured materials combined with LDHs, a number of LDH-based core-shell nanoarrays have been developed and their synthesis strategies, structural characters and electrochemical performances are rationally described. Moreover, further developments and challenges in devel- oping promising electrocatalysts based on hierarchical nanostructured LDHs are covered from the viewpoint of fundamental research and practical applications.

关键词： layered double hydroxides (LDHs) core-shell nanoarrays oxygen evolution reaction (OER) hydrogen evolution reaction (HER) photoelectrochemical water splitting (PEC)

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Extraction of a target in sea clutter via signal decomposition

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Science China(Information Sciences) 2020年第2期63卷 230-232页

作者： Zhiyu shao Jiangheng HE Shunshan feng School of Mechatronical Engineering Beijing Institute of Technology State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

Dear editor,Target detection at the sea surface is crucial for the ensuring the security of drilling platforms, ships,ports, etc. However, the presence of sea clutter poses a challenge to radar detection. Since the sea surface is a dynamic surface, its scattering properties are extremely complex. For a highresolution radar working at a low grazing angle,

关键词： Doppler Extraction of a target in sea clutter via signal decomposition

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Differential Fault Attack on GIFT

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Chinese Journal of Electronics 2021年第4期30卷 669-675页

作者： XIE min TIAN feng LI Jiaqi State Key Laboratory of Integrated Services Networks Xidian University Shaanxi Key Laboratory of Blockchain and Secure Computing

GIFT, a lightweight block cipher proposed at CHES2017, has been widely cryptanalyzed this *** paper studies the differential diffusion characteristics of round function of GIFT at first, and proposes a random nibble-based differential fault attack. The key recovery scheme is developed on the statistical properties we found for the differential distribution table of the S-box. A lot of experiments had been done and experimental results show that one round key can be retrieved with an average of20.24 and 44.96 fault injections for GIFT-64 and GIFT-128 respectively. Further analysis shows that a certain number of fault injections recover most key bits. So we demonstrate an improved fault attack combined with the method of exhaustive search, which shows that the master key can be recovered by performing 2;and 2;computations and injecting 31 and 32 faults on an average for GIFT-64 and GIFT-128 respectively.

关键词： GIFT Lightweight block cipher Differential fault attack Key recovery

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Lyapunov-Based Output Containment Control of Heterogeneous Multi-Agent Systems With Markovian Switching Topologies and Distributed Delays

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IEEE/CAA Journal of Automatica Sinica 2023年第6期10卷 1421-1433页

作者： Haihua Guo min Meng Gang feng the Department of Biomedical Engineering City University of Hong KongHong KongChina the Department of Control Science and Engineering College of Electronics and Information Engineeringand Shanghai Research Institute of Intelligent Autonomous SystemsTongji UniversityShanghai 200092China

This paper considers the mean square output containment control problem for heterogeneous multi-agent systems(MASs)with randomly switching topologies and nonuniform distributed *** modeling the switching topologies as a continuous-time Markov process and taking the distributed delays into consideration,a novel distributed containment observer is proposed to estimate the convex hull spanned by the leaders'states.A novel distributed output feedback containment controller is then designed without using the prior knowledge of distributed *** constructing a novel switching Lyapunov functional,the output containment control problem is then solved in the sense of mean square under an easily-verifiable sufficient ***,two numerical examples are given to show the effectiveness of the proposed controller.

关键词： Heterogeneous multi-agent systems Lyapunov method Markovian switching topologies output containment control time delays

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Quantum gradient descent algorithms for nonequilibrium steady states and linear algebraic systems

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Science China(Physics,Mechanics & Astronomy) 2022年第5期65卷 21-33页

作者： Jin-min Liang Shi-Jie Wei shao-ming Fei School of Mathematical Sciences Capital Normal UniversityBeijing J00048China Beijing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China

The gradient descent approach is the key ingredient in variational quantum algorithms and machine learning tasks,which is an optimization algorithm for finding a local minimum of an objective *** quantum versions of gradient descent have been investigated and implemented in calculating molecular ground states and optimizing polynomial *** on the quantum gradient descent algorithm and Choi-Jamiolkowski isomorphism,we present approaches to simulate efficiently the nonequilibrium steady states of Markovian open quantum many-body *** strategies are developed to evaluate the expectation values of physical observables on the nonequilibrium steady ***,we adapt the quantum gradient descent algorithm to solve linear algebra problems including linear systems of equations and matrix-vector multiplications,by converting these algebraic problems into the simulations of closed quantum systems with well-defined *** examples are given to test numerically the effectiveness of the proposed algorithms for the dissipative quantum transverse Ising models and matrix-vector multiplications.

关键词： quantum simulation quantum gradient descent algorithm nonequilibrium steady state quantum open system

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