检索结果-南通市图书馆

RON in hepatobiliary and pancreatic cancers:Pathogenesis and potential therapeutic targets

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第20期27卷 2507-2520页

作者： shao-long chen Guo-Ping Wang Dan-Rong Shi Shu-Hao Yao Ke-Da chen Hang-Ping Yao Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina Department of Surgical Oncology The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Stomatology Wenzhou Medical University Renji CollegeWenzhou 325035Zhejiang ProvinceChina

The receptor protein tyrosine kinase RON belongs to the c-MET proto-oncogene *** has shown that RON has a role in cancer pathogenesis,which places RON on the frontline of the development of novel cancer therapeutic *** and pancreatic(HBP)cancers have a poor prognosis,being reported as having higher rates of cancer-related ***,to combat these malignant diseases,the mechanism underlying the aberrant expression and signaling of RON in HBP cancer pathogenesis,and the development of RON as a drug target for therapeutic intervention should be *** RON expression and signaling have been identified in HBP cancers,and also act as tumorigenic determinants for HBP cancer malignant *** addition,RON is emerging as an important mediator of the clinical prognosis of HBP ***,not only is RON significant in HBP cancers,but also RON-targeted therapeutics could be developed to treat these cancers,for example,therapeutic monoclonal antibodies and small-molecule *** them,antibody-drug conjugates have become increasingly popular in current research and their potential as novel anti-cancer biotherapeutics will be determined in future clinical trials.

关键词： RON Signal transduction Hepatobiliary Pancreatic neoplasms Molecular targeted therapy

Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第32期21卷 9598-9606页

作者： Jia-Li Wang Xin-Fang Du shao-long chen Yi-Qi Yu Jing Wang Xi-Qi Hu Ling-Yun shao Jia-Zhen chen Xin-Hua Weng Wen-Hong Zhang Department of Infectious Diseases Huashan Hospital Fudan University Department of Infectious Diseases Beilun People’s Hospital Department of Pathology Shanghai Medical College Fudan University Key Laboratory of Medical Molecular Virology Ministry of Education and Health Shanghai Medical College and Institutes of Biomedical Science Fudan University

AIM: To compare the histological outcome of chronic hepatitis B(CHB) patients treated with entecavir(ETV) or lamivudine(LAM)-based ***: We conducted a retrospective analysis of data from 42 CHB patients with advanced fibrosis(baseline Ishak score ≥ 2) or cirrhosis who were treated with ETV or LAM-based therapy in Beilun People's Hospital, Ningbo between January 2005 and May 2012. The patients enrolled were more than 16 years of age and underwent a minimum of 12 mo of antiviral therapy. We collected data on the baselinecharacteristics of each patient and obtained paired liver biopsies pre- and post-treatment. The Knodell scoring system and Ishak fibrosis scores were used to evaluate each example. An improvement or worsening of necroinflammation was defined as ≥ 2-point change in the Knodell inflammatory score. The progression or regression of fibrosis was defined as ≥ 1-point change in the Ishak fibrosis score. The continuous variables were compared using t-test or Mann-Whitney test, and the binary variables were compared using χ2 test or Fisher's exact test. The results of paired liver biopsies were compared with a Wilcoxon signed rank ***: Nineteen patients were treated with ETV and 23 patients were treated with LAM therapy for a mean duration of 39 and 42 mo, respectively. After long-term antiviral treatment, 94.74%(18/19) of the patients in the ETV arm and 95.65%(22/23) in the LAM arm achieved an HBV DNA level less than 1000 IU/m L. The majority of the patients(94.74% in the ETV arm and 73.91% in the LAM arm) had normalized ALT levels. The median Knodell necroinflammatory score decreased from 11 to 0 in the patients receiving ETV, and the median Knodell score decreased from 9 to 3 in the patients receiving LAM(P = 0.0002 and < 0.0001, respectively). The median Ishak fibrosis score showed a 1-point reduction in ETV-treated patients and a 2-point reduction in LAM-treated patients(P = 0.0019 and 0.0205, respectively). The patients receiving ETV

关键词： Advanced fibrosis Chronic hepatitis B Cirrhosis En

Quantitative evaluation of space charge effects of laser-cooled three-dimensional ion system on a secular motion period scale

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2018年第4期27卷 292-298页

作者： Li-Jun Du Hong-Fang Song shao-long chen Yao Huang Xin Tong Hua Guan Ke-Lin Gao China Academy of Space Technology (Xi'an) Xi'an 710100 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Key Laboratory of Atomic Frequency Standards Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Center for Cold Atom Physics Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China

In this paper,we introduce a method of quantitatively evaluating and controlling the space charge effect of a lasercooled three-dimensional（3 D） ion system in a linear Paul *** relationship among cooling efficiency,ion quantity,and trapping strength is analyzed quantitatively,and the dynamic space distribution and temporal evolution of the 3 D ion system on a secular motion period time scale in the cooling process are *** ion number influences the eigen-micromotion feature of the ion *** trapping parameter q is ～ 0.3,relatively ideal cooling efficiency and equilibrium temperature can be *** decrease of axial electrostatic potential is helpful in reducing the micromotion heating effect and the degradation in the total *** a single secular motion period under different cooling conditions,ions transform from the cloud state（each ion disperses throughout the envelope of the ion system） to the liquid state（each ion is concentrated at a specific location in the ion system） and then to the crystal state（each ion is subjected to a fixed motion track）.These results are conducive to long-term storage and precise control,motion effect suppression,high-efficiency cooling,and increasing the precision of spectroscopy for a 3 D ion system.

关键词： space charge effects cooling dynamics ion trajectory ion energy

Deceleration of Metastable Li^+ Beam by Combining Electrostatic Lens and Ion Trap Technique

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2020年第7期37卷 15-18页

作者： shao-long chen Peng-Peng Zhou Shi-Yong Liang Wei Sun Huan-Yao Sun Yao Huang Hua Guan Ke-Lin Gao State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

Ion deceleration has played a critical role in ion-related research when the ions are produced in the form of a high-energy *** present a deceleration method combining electrostatic lens and ion trap technique,which can effectively decelerate ions to energy below the trapping potential of a typical ion *** experiments were performed on metastable 1s2s3S1Li+ions,and demonstrated that the kinetic energy could easily be reduced from^450 e V to a few e V,with the latter being confirmed using the Doppler-shifted fluorescence spectra.

关键词： spectra. beam. latter

Significantly Improving the Escape Time of a Single 40Ca+Ion in a Linear Paul Trap by Fast Switching of the Endcap Voltage

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2020年第9期37卷 21-25页

作者： Peng-Peng Zhou shao-long chen Shi-Yong Liang Wei Sun Huan-Yao Sun Yao Huang Hua Guan Ke-Lin Gao State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

Sympathetic cooling is a method used to lower the kinetic energy of ions with complicated energy-level structures,via Coulomb interactions with laser-cooled ions in an ion *** ion to be sympathetically cooled is sometimes prepared outside of the trap,and it is critical to introduce this ion into the trap by temporarily lowering the potential of one endcap without allowing the coolant ion to *** study the time required for a laser-cooled ion to escape from a linear Paul trap when the voltage of one endcap is *** escape time is on the order of a few microseconds,and varies significantly when the low-level voltage changes.A re-cooling time of a maximum of 13 s was measured,which can be reduced to approximately one hundred of milliseconds by decreasing the duration of the low-level *** measurement of these critical values lays the foundation for the smooth injection and cooling of the ion to be sympathetically cooled.

关键词： outside Paul critical

Mirror Asymmetric Dark Matter and Direct Detection

在线全文

学校读者我要写书评

暂无评论

Mirror Asymmetric Dark Matter and Direct Detection

LPS pretreatment ameliorates D-aminegalactose/lipopolysaccharideinduced liver injury in Rat

2010粒子物理宇宙学研讨会

作者： shao-long chen University of Maryland Haipeng An, R. Mohapatra, Yue Zhang

＜正＞～～

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

LPS pretreatment ameliorates D-aminegalactose/lipopolysaccha...

MoS_(2)Lubricate‑Toughened MXene/ANF Composites for Multifunctional Electromagnetic Interference Shielding

中华医学会第十三次全国感染病学术会议

作者： jinzhong dong li-ping wang sai-nan zhang ke-qin shi shao-long chen chun-wei shi yu-qun wang su-ting cao zhuo lin yong-ping chen ming-qin lu Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical University

Acute liver failure(ALF)remains an extremely poor prognosis and high mortality;with no effective *** endotoxin tolerance(ET)phenotype is characterized with decreased inflammation,has been reported to exhibit protective activities in several sepsis *** now investigated the effects and underlying mechanisms of ET on D-galactosamine(D-GaIN)/lipopolysaccharide(LPS)-induced ALF in *** model was induced by daily intraperitoneal injection of 0.1 mg/kg of LPS for five consecutive days before D-Galn/LPS injec-

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei Ming longfu chen Tianliang Song Moxi Yele Hao Zhang long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EMI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** MXene/ANF(aramid nanofibers)–MoS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of MoS_(2)into binary MXene/ANF composite *** introduction of MoS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 MPa and to 25.8±0.7%and 167.3±9.1 MPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 MJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of MXene/ANF(mass ratio of 50:50)decreases~10.8%.EMI shielding effectiveness(EMI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of MoS_(2)into binary MXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EMI SE is 43.9 *** MoS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,MXene/ANF–MoS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high MXene content,electric heating performance,and photothermal conversion performance,EMI shielding ternary MXene/ANF–MoS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： MXene-MoS_(2) Lubrication toughening EMI shielding Photothermal conversion Electric heating performance

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing chen Yong-Qi Li Yu-long Wang Mei-chen Liu Yun-Bo Ruan Yang Zhang Shu-Juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation Medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric