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Transformation of sulfamethazine during the chlorination disinfection process: Transformation,kinetics, and toxicology assessment

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Journal of Environmental Sciences 2019年第2期31卷 48-56页

作者： Yunjia Yang Jiachen Shi Yi Yang jie Yin Jing zhang Bing shao Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and Control Beijing Research Center for Preventive Medicine

Various disinfection byproducts(DBPs) form during the process of chlorination disinfection,posing potential threats to drinking water safety and human health. Sulfamethazine(SMT),the most commonly used and frequently detected veterinary antibiotic, was investigated in detail with regard to its transformation and kinetics in reactions with free available chlorine(FAC). Using liquid chromatography coupled to quadrupole time-of-flight tandem mass spectrometry, several DBPs were identified based on different confidence levels, and a variety of reaction types, including desulfonation, S–N cleavage, hydroxylation, and chlorine substitution, were proposed. The kinetic experiments indicated that the reaction rate was FAC-and pH-dependent, and SMT exhibits low reactivity toward FAC in alkaline conditions. The DBPs exhibited a much higher acute toxicity than SMT, as estimated by quantitative structure activity relationship models. More importantly, we observed that the FAC-treated SMT reaction solution might increase the genotoxic potential due to the generation of DBPs. This investigation provides substantial new details related to the transformation of SMT in the chlorination disinfection process.

关键词： LC-QTOF Sulfamethazine Transformation products Chlorination Toxicity

丙泊酚复合阿片类药物在无痛结肠镜检查中的应用

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潍坊医学院学报 2016年第5期38卷 327-329页

作者：赵亚娟刘采采张少杰张志梅王伟芝潍坊医学院麻醉学教研室山东潍坊261053 潍坊市人民医院麻醉科

目的探讨丙泊酚复合阿片类药物与单纯应用丙泊酚维持用于结肠镜检查的临床效果。方法选取行无痛结肠镜检查的患者215例,年龄18~55岁,ASAⅠ或Ⅱ级,随机分为3组：芬太尼复合丙泊酚组（F组,n=72）、地佐辛复合丙泊酚组（D组,n=71例）和单... 详细信息

目的探讨丙泊酚复合阿片类药物与单纯应用丙泊酚维持用于结肠镜检查的临床效果。方法选取行无痛结肠镜检查的患者215例,年龄18~55岁,ASAⅠ或Ⅱ级,随机分为3组：芬太尼复合丙泊酚组（F组,n=72）、地佐辛复合丙泊酚组（D组,n=71例）和单纯丙泊酚组（C组,n=72例）。F组静脉注射芬太尼50μg,丙泊酚1~2mg/kg;D组静脉注射地佐辛5mg,丙泊酚1~2mg/kg;C组注射与F组、D组相同容量的生理盐水,丙泊酚1~2mg/kg。3组均静注丙泊酚2~4mg·kg-1·h-1维持一定的麻醉深度。记录3组患者麻醉诱导前（T0）、诱导后2min（T1）、结肠镜过肝曲时（T2）、镜检结束时（T3）的心率（HR）、收缩压（SBP）、脉搏氧饱和度（SpO_2）,记录3组患者的意识消失时间、结肠镜检查时间、苏醒时间、丙泊酚总量及不良反应发生情况。结果与T_0相比,T_1,T_2时3组HR明显减弱,SBP,SpO_2明显降低（P〈0.05）;T1时D组SpO_2明显高于F组、C组（P〈0.05）,且F组高于C组（P〈0.05）。3组意识消失时间、结肠镜检查时间差异无统计学意义。C组术毕苏醒时间、丙泊酚用量均多于F组、D组（P〈0.05）,而F组、D组差异无统计学意义。C组不良反应例数明显多于F组、D组（P〈0.05）,其中D组最少。结论丙泊酚复合阿片类药物行无痛肠镜检查有助于减轻单独应用引起的不良反应,安全有效,与丙泊酚复合芬太尼比较,地佐辛的呼吸抑制作用明显弱于芬太尼,在麻醉安全和麻醉管理方面更具优势。

关键词：丙泊酚芬太尼地佐辛无痛肠镜

Research on Channelization Techniques of Radio Astronomical Wideband Signal with Oversampled Polyphase Filter Banks

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Research in Astronomy and Astrophysics 2023年第8期23卷 188-205页

作者： Meng zhang Hai-Long zhang Ya-Zhou zhang jie Wang shao-Cong Guo Qiao Meng Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China School of Information Science and Engineering Southeast UniversityNanjing 211100China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

Digital channelization decomposes a wideband signal into multiple adjacent sub-bands using Parallel *** can effectively reduce the pressure on the radio astronomy digital backends system and make wideband signal processing *** at the problems of signal attenuation at sub-band edge,spectral leakage and aliasing encountered in wideband signal channelization,algorithms to reduce the problems are *** design a Critically Sampled Polyphase Filter Bank(CS-PFB)based on the Finite Impulse Response digital filter with a Hamming Window and systematically analyze the frequency response characteristics of the *** on the channelized structure of the CS-PFB,an Over Sampled Polyphase Filter Bank(OS-PFB)is designed by data reuse,and the filtering frequency response characteristics of CS-PFB and OS-PFB are compared and *** the wideband baseband data generated by the CASPSR(Collaboration for Astronomy Signal processing and electronics research Parkes Swinburne Recorder),we implement sub-band division and 16-band output of these data based on the 2×oversampling OS-PFB,and the problem of spectrum inversion in the sub-bands is *** removing 25%of redundant data in the head and tail of each sub-band,we recombine the sub-bands into a *** wideband signal is almost identical to the original observed ***,the experimental results show that the OS-PFB can improve the channel *** the 400 MHz baseband data of J0437-4715,we compare the pulse profile obtained from the original baseband data with the pulse profile obtained after the channelization and *** phase and amplitude information of the pulse profiles are consistent,which verifies the correctness of our channelization algorithm.

关键词： (stars:)pulsars general-methods analytical-miscellaneous-methods data analysis

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Influence of the Earth's rotation on measurement of gravitational constant G with the time-of-swing method

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Chinese Physics B 2020年第2期29卷 137-141页

作者： jie Luo Tao Dong Cheng-Gang shao Yu-jie Tan Hui-jie zhang School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China MOE Key Laboratory of Fundamental Physical Quantities Measurement&Hubei Key Laboratory of Gravitation and Quantum Physics PGMF and School of PhysicsHuazhong University of Science and TechnologyWuhan 430074China

In the measurement of the Newtonian gravitational constant G with the time-of-swing method,the influence of the Earth's rotation has been roughly estimated before,which is far beyond the current experimental ***,we present a more complete theoretical modeling and assessment *** figure out this effect,we use the relativistic Lagrangian expression to derive the motion equations of the torsion *** the correlation method and typical parameters,we estimate that the influence of the Earth's rotation on G measurement is far less than 1 ppm,which may need to be considered in the future high-accuracy experiments of determining the gravitational constant G.

关键词： the Earth's rotation relativistic Lagrangian G measurement time-of-swing method

Early child development: a challenge in China

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World Journal of Pediatrics 2019年第1期15卷 1-3页

作者： jie shao Children's Hospital Zhejiang University School of MedicineHangzhouChina

Early childhood development has been linked with adult health and *** is a necessary component of the sustainable development goals (SDGs) [1,2],which are conceptualized from a lifespan *** researches in the past two decades have elucidated that the period from conception through early childhood (i.e.,at least the first 3 years) is foundational for brain development [3].Children acquire an orderly progression of skills that form the blueprint for subsequent ***,immunological,physiological,and psychological adaptations to the environment occur during this period,and these adaptations affect development throughout the life course [4].Risks including poverty,stunting,and nutritional deficiencies contribute to inequities in children's development [5],resulting in over 200 million children under 5 years of age in low-and middle-income countries not reaching their developmental potential,leading to an average deficit of 19.8% in adult annual income [3].Quality interventions in the early years of children have long-term beneficial effects with cost efficiency,including reductions in violence [6],depression and social inhibition,improving adult health,competence (e.g.,learning and academic attainment),and subsequently economic productivity [7,8].

关键词： Early child development challenge

Chemical Quenching of Positronium in CuO/Al2O3 Catalysts

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Chinese Physics Letters 2011年第1期28卷 193-196页

作者： zhang Hong-Jun LIU Zhe-Wen CHEN Zhi-Quan WANG shao-jie Hubei Nuclear Solid Physics Key Laboratory Department of Physics Wuhan University Wuhan 430072

CuO/Al2O3 catalysts were prepared by mixing CuO and environment of the catalysts are characterized by positron v-AI203 nanopowders. Microstrueture and chemical annihilation spectroscopy. The positron annihilation lifetime measurements reveal two long lifetime components 73 and τ4, which correspond to ortho-positronium （o- Ps） annihilating in mierovoids and large pores, respectively. With increasing CuO content from 0 to 40 wt%, both 3-4 and its intensity I4 show significant decrease, which indicates quenching effect of o-Ps. The para-positronium （p-Ps） intensities derived from multi-Gaussian fitting of the coincidence Doppler broadening spectra also decreases gradually with increasing CuO content. This excludes the possibility of spin-conversion of positronium. Therefore, the chemicM quenching by CuO is probably responsible for the decrease of o-Ps lifetime. Variation in the o-Ps annihilation rate A4 （1/T4） as a function of CuO content can be well fitted by a straight line, and the slope of the fitting line is （1.83 ± 0.05） × 10^7 s-1.

关键词： Condensed matter: electrical magnetic and optical Surfaces interfaces and thin films Condensed matter: structural mechanical & thermal Chemical physics and physical chemistry

Correlation method estimation of the modulation signal in the weak equivalence principle test

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Chinese Physics B 2018年第8期27卷 136-142页

作者： jie Luo Liang-Cheng Shen Cheng-Gang shao Qi Liu Hui-jie zhang School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China MOE Key Laboratory of Fundamental Physical Quantities Measurements Hubei Key Laboratory of Gravitation and Quantum PhysicsSchool of PhysicsHuazhong University of Science and TechnologyWuhan 430074China TIANQIN Research Center for Gravitational Physics School of Physics and AstronomySun Yat-sen UniversityZhuhai 519082China

In a test of the weak equivalence principle （WEP） with a rotating torsion pendulum, it is important to estimate the amplitude of the modulation signal with high precision. We use a torsional filter to remove the free oscillation signal and employ the correlation method to estimate the amplitude of the modulation signal. The data analysis of an experiment shows that the uncertainties of amplitude components of the modulation signal obtained by the correlation method are in agreement with those due to white noise. The power spectral density of the modulation signal obtained by the correlation method is about one order higher than the thermal noise limit. It indicates that the correlation method is an effective way to estimate the amplitude of the modulation signal and it is instructive to conduct a high-accuracy WEP test.

关键词： weak equivalence principle test correlation method amplitude estimation thermal noise limit

Mechanical properties and enhancement mechanisms of titanium-graphene nanocomposites

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Acta Mechanica Sinica 2020年第4期36卷 855-865页

作者： Wanhong Tang jie zhang Jianyang Wu Jinyou shao Peng Ding Guozhen Hou Xiaoming Chen Micro-and Nanotechnology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi'an Jiaotong UniversityXi'an 710049China Electronic Materials Research Lab Key Lab of the Ministry of EducationXi’an Jiaotong UniversityXi’an 710049China Department of Physics Jiujiang Research Institute and Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China

Molecular dynamics(MD)simulations of the titanium-graphene nanocomposites(TiGNCs)under uniaxial tension are carried out to investigate the mechanical properties and reinforcement mechanism of graphene in *** is found that introduction of mechanically robust graphene limits the strain-induced dislocation and araorphization and thereby highly improves the mechanical properties of metallic titanium that are greatly affected by the crystal stacking orientation of graphene and titanium *** thickness of titanium layers,interface interaction and working temperature play an important role in the mechanical strength and elastic moduli of *** results show the mechanical properties of TiGNCs are monotonically enhanced with reduction of the titanium layer thickness and working temperature,and the Young5s modulus obtained by MD simulation are higher than that predicted by the rule of mixture(ROM)due to consideration of interfacial interaction in computational *** addition,once the critical thickness of titanium layer is reached,graphene wrinkles are induced in composites because of Poisson's effect induced large lateral compression stress in the interface *** study provides helpful insights into fundamental understanding reinforcing mechanism of graphene and ultimately contribute to the optimal design and performance of mechanically robust graphene-based metallic composites.

关键词： Mechanical properties Enhancement mechanisms Titanium-graphene composites Wrinkling Molecular dynamics