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Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1006-1018页

作者： jun-jun lin Ye-Cai Lu Department of Gastrointestinal Surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one very usual tumor together with higher death ***-specific protease 21(USP21)has been confirmed to take part into the regulation of CRC progression through serving as a ***,the promotive function of USP21 has also discovered in the progression of ***1 has illustrated to be modulated by USP7,USP22 and USP51 in ***,the regulatory functions of USP21 on ZEB1 in CRC progression need more *** To investigate the relationship between USP21 and ZEB1 in CRC *** The mRNA and protein expressions were assessed through RT-qPCR,western blot and IHC *** interaction between USP21 and ZEB1 was evaluated through Co-IP and GST pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,USP21 and ZEB1 exhibited higher expression in CRC,and resulted into poor ***,the interaction between USP21 and ZEB1 was further *** was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,USP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that USP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing *** discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of CRC.

关键词： Ubiquitin-specific protease 21 ZEB1 Stemness Colorectal cancer

Investigation on the influence of vortex generator on particle resuspension

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Particuology 2024年第3期86卷 126-136页

作者： Dongchi Yu jun-Li lin Jin-Han Xie ASML 80W Tasman DrSan Jose95134CaliforniaUSA Department of Mechanics and Engineering Science at College of Engineering and State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100081China

The vortex generator(VG)and its well-known effect in flow optimization are widely studied and employed across different engineering ***,while the same working principles of VG may be well suited for the applications on surface-cleaning technologies,such promising potential is hardly,if any,explored in the published ***,in the present study,the influence on flow-induced particle resuspension brought by a rectangular vG in a channel flow is investigated with the help of highfidelity computational fluid dynamics *** increases of particle removal forces and resuspension rates are discovered in long,strip-like regions with reduced boundary-layer thickness resulted from the vG-induced vortices,and the enhancement effect is especially significant for configurations with the VG installed at a greater angle of *** is also shown that while the resuspension enhancements on the lower and the upper surfaces of the channel exhibit distinct statistical characteristics,having a VG in the channel improves the overall particle-removing capability of the channel flow by introducing higher surface-averaged removal forces and particle resuspension *** but not least,the increase of resuspension rate is especially significant for the smaller,micron-scale particles which are otherwise hardly disturbed by a VG-less channel flow,and such resuspension-enhancement effectgenerally subsides with increasing particle size.

关键词： Particle resuspension Vortexgenerator CFD Surface cleaning

CFD-DEM simulation of high density particles fluidization behaviors in 3D conical spouted beds

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Particuology 2024年第5期88卷 266-281页

作者： lin Jiang Mofan Qiu Rongzheng Liu Bing Liu Youlin shao Malin Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy TechnologyTsinghua UniversityBeijing 100084China

The spouted bed has been used in the coating process of high-density nuclear fuel *** particle fluidization behaviors in pseudo-2D and 3D spouted beds were simulated and *** effects of four independent variables(cone angle,particle density,inlet gas velocity,and particle loading)on particle fluidization behaviors in the 3D spouted bed were investigated *** cone angle effect on fluidization mechanism was studied quantitatively first time.A new fluidization quality index was proposed based on the particle entrainment principle,and an extreme value was obtained when the cone angle was 60°,considered to be the optimum value for the 3D conical spouted *** was indicated the gas–solid contact efficiency can be kept up if the gas velocity was proportional to ρ_(p)^(0.65) and N_(p)^(0.78) when the particle density or loading was *** results will be useful for geometry and operation parameters design of the 3D conical spouted bed and helpful for developing the fluidization mechanism of high-density particles.

关键词： Spouted bed High-density particle CFD-DEM Fluidization quality index Particle loading

Magnetic behaviors and magnetocaloric effects in rare earth high-entropy amorphous/nanocrystalline alloys

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Journal of Rare Earths 2024年第1期42卷 129-136,I0005页

作者： lin Xue Liliang shao Baosen Zhang Zongzhen Li Jiangbo Cheng Baolong Shen College of Mechanics and Materials Hohai UniversityNanjing211106China School of Materials Science and Engineering Jiangsu Key Laboratory of Advanced Metallic MaterialsSoutheast UniversityNanjing211189China School of Materials Science and Engineering Nanjing Institute of TechnologyNanjing211167China Jiangsu JITRI Advanced Energy Materials Research Institute Co. Ltd.Changzhou213000China

Rare earth high-entropy alloys(RE-HEAs)exhibit great potential to be applied as refrigerants due to their good comprehensive magnetocaloric *** this work,octary GdTbDyHoErTmCoAl and GdTbDyHoErTmCoNi RE-HEAs with amorphous/nanocrystalline structure exhibiting comparable magnetocaloric effect were *** RE-HEAs show a second-order magnetic phase transition in the temperature range of hydrogen *** to the complex magnetic interactions,a spin glasslike behavior at low temperatures is observed in the RE-HEAs.A superior magnetocaloric effect is obtained in the nanocrystalline GdTbDyHoErTmCoNi high-entropy alloy that is multiphase attributed to a stronger magnetic exchange interaction when compared with the other that exhibits single amorphous *** heterogeneous microstructure,homogeneous chemical distributions are observed in the partially crystallized high-entropy *** addition,the magnetocaloric effect and magnetic transition behavior of rare earth medium-and high-entropy alloys,including the RE-HEAs in this study,are summarized and *** results in this work provide a helpful guide for the design of RE-HEAs for hydrogen liquefaction applications with excellent magnetocaloric effects.

关键词： Rare earths High-entropy alloy Metallic glass Magnetocaloric effect

Role of adaptation measures in addressing heatwave exposure in China

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Advances in Climate Change Research 2024年第1期15卷 148-157页

作者： Qin-Mei HAN Qing-Chen CHAO shao SUN Pei-jun SHI National Climate Centre China Meteorological AdministrationBeijing 100081China State Key Laboratoryof Severe Weather Chinese Academy of Meteorological Sciences Beijing 0o08lChina Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Heatwave exposure has increased dramatically because of climate warming and population growth,along with their interactive ***,effective adaptation measures can reduce these ***,the dynamic changes,regional inequality in adaptive capacity and their potential contributions to reducing exposure in the future remain *** study quantifies the impact of adaptive capacity and underscores regional variations in heatwave magnitudes,population exposure and adaptation levels in *** projected the future adaptive capacity using air-conditioner penetration,factoring in climate cooling requirements and individuals'purchasing *** population and gross domestic product(GDP)data from four Shared Socioeconomic Pathways(SSP1,SSP2,SSP3 and SSP5)and daily temperature data from four SSP-based emission scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5),we estimated heatwave duration,population exposure and avoided impacts through adaptation across China and its *** show a substantial increase in heatwave duration in Southwest and Southern China,especially under the SSP5-8.5 scenario,with a projection of 163.2±36.7 d during *** the SSP3|SSP3-7.0 scenario,total exposure reaches 156.4±76.8 billion person d per year,which is the highest among all scenarios and 23 times greater than that in 1986-2005 without *** considering adaptation measures,a noteworthy reduction in population exposure is observed,especially in the SSP3|SSP3-7.0 and SSP5JSSP5-8.5 scenarios,with reductions of(62.6±3.9)%and(65.8±5.1)%,respectively,compared with the scenario without adaptation during *** regional disparities in avoided impacts are also evident,with variations of up to 50%across different *** implementation of effective and environmentally friendly adaptation measures can notably address climate change,thereby alleviating the profound threats posed to human well-being.

关键词： Heatwaves Population exposure Adaptation Future projection China

Macroscopic model and statistical model to characterize electromagnetic information of a digital coding metasurface

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National Science Review 2024年第3期11卷 159-171页

作者： Rui Wen shao jun Wei Wu Zheng Xing Wang Hui Xu Han Qing Yang Qiang Cheng Tie jun Cui Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University Peng Cheng Laboratory Pazhou Laboratory(Huangpu)

A digital coding metasurface is a platform connecting the digital space and electromagnetic wave space, and has therefore gained much attention due to its intriguing value in reshaping wireless channels and realizing new communication architectures. Correspondingly, there is an urgent need for electromagnetic information theory that reveals the upper limit of communication capacity and supports the accurate design of metasurface-based communication systems. To this end, we propose a macroscopic model and a statistical model of the digital coding metasurface. The macroscopic model uniformly accommodates both digital and electromagnetic aspects of the meta-atoms and predicts all possible scattered fields of the digital coding metasurface based on a small number of simulations or measurements. Full-wave simulations and experimental results show that the macroscopic model is feasible and accurate. A statistical model is further proposed to correlate the mutual coupling between meta-atoms with covariance and to calculate the entropy of the equivalent currents of digital coding metasurface. These two models can help reconfigurable intelligent surfaces achieve more accurate beamforming and channel estimation, and thus improve signal power and coverage. Moreover, the models will encourage the creation of a precoding codebook in metasurface-based direct digital modulation systems, with the aim of approaching the upper limit of channel capacity. With these two models, the concepts of current space and current entropy, as well as the analysis of information loss from the coding space to wave space, is established for the first time, helping to bridge the gap between the digital world and the physical world, and advancing developments of electromagnetic information theory and new-architecture wireless systems.

关键词： electromagnetic information theory current entropy current space digital coding metasurface macroscopic model statistical model

Selective photosynthesis of imines from biomass-derived aldehydes over Ni/TiO_(2)

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Rare Metals 2024年第3期43卷 1116-1124页

作者： Wu-lin Li Qing-Qing Zhang lin Dong Wen-jun Zhang Li-Li lin Zu-Peng Chen Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Chemical EngineeringNanjing Forestry UniversityNanjing210037China Institute of Industrial Catalysis State Key Laboratory of Green Chemistry Synthesis TechnologyCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou310014China

Photocatalytic reductive amination of biomass-derived aldehydes is a desirable way to selectively upgrade biomass into value-added nitrogen-containing chemicals under mild ***,it is challenging to produce imines in high selectivity because of the undesirable side reactions caused by the activity of functional ***,we demonstrate the highly reactive and selective production of imines from biomass derived aldehydes via the photocatalytic reductive amination,using a defective TiO_(2)supported nickel *** employment of methanol as the hydrogen donor and ammonia solution as the nitrogen source avoids the use of high-pressure H_(2)and expensive amines,rendering the current catalytic process safe,economical,and environmentally *** depth investigations attribute the improved separation and transfer of photogenerated charge carriers to the presence of oxygen vacancies and decorated Ni nanoparticles,thereby accelerating the production of imines from benzaldehyde amination(conversion,95.8%;seleetivity,95.2%).Furthermore,the developed system could be easily translated to the photocatalytic conversions of various biomass derived aldehydes,which provided an example of a cost-effective and sustainable approach for the valorization of biomass derived feedstocks.

关键词： Photocatalysis Biomass derivatives Imines Reduction amination Heterogeneous catalyst

Distribution of oxide inclusions in H13 castings under super-gravity field with multi-stage rotation speeds

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Journal of Iron and Steel Research International 2024年第1期31卷 121-133页

作者： shao-ying Li Xiao-jun Xi Xing-ming Zhao Han-jie Guo Jing Guo School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Beijing Beiye Functional Materials Corporation Beijing100192China Shandong Tianwu Forming Technology Co. Ltd.Liaocheng252024ShandongChina

The 42 kg industrial H13 castings were prepared by different super-gravity fields with multi-rotation speeds,and the distribution of oxide inclusions in the castings was *** addition,the inward movement Reynolds number and inward movement time of oxide inclusions as well as the solidification time of molten steel at different positions in the castings were calculated to clarify the removal mechanism of oxide inclusions in super-gravity *** results show that the large size(i.e.,greater than 10μm)oxide inclusions are mainly concentrated in the inner and outer parts of the super-gravity castings with constant rotation speed(500 r min^(-1))and five-stage rotation speeds(500,600,750,850,and 950 r min^(-1)),respectively,while there are no large oxide inclusions in the super-gravity castings with three-stage rotation speeds(500,600,and 750 r min^(-1)).Although an increase in the particle size of inclusion and the rotation speed in super-gravity field is conducive to the increase in the inward movement Reynolds number of oxide inclusions and reduction in the inward movement time of oxide inclusions,it will reduce the local solidification time of molten *** the range of the rotation speed studied,the super-gravity field with three-stage rotation speeds has the best effect on the removal of inclusions in H13 molten steel.

关键词： Distribution Oxide inclusion H13 casting Super-gravity field Rotation speed

Realizing the excellent oxidation resistance of an environmental barrier coating through aluminum surface modification

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Journal of Advanced Ceramics 2024年第7期13卷 976-986页

作者： lin Dong Wen-Qi Yang lin Chen Guan-jun Yang Chang-Jiu Li State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Aerospace Engine Company Limited in China Aerospace Science and Technology Corporation Xi’an 710065China

The lifetime of Si-based environmental barrier coatings(EBCs)is constrained by thermally grown SiO_(2)oxidelayer(SiO_(2)-TGO),which can cause premature cracking and *** address this issue,a new approach for surfacemodification using aluminum is *** oxidation performance was examined in a 50 vol%H_(2)O-50 vol%O_(2)environment at 1350℃for up to 300 *** results indicate that a dense ytterbium aluminum garnet(YbAG)layer wasformed after modification,decreasing the porosity by 80%.Due to the elimination of fast diffusion channels and the lowoxygen permeability of YbAG,aluminum modification significantly reduced the growth rate of SiO_(2)-TGO by nearly twoorders of ***,its thickness decreased by more than 70%after 300 h of exposure.A diffusioncontrolled oxidation mechanism indicates that the modified dense surface is equivalent to an initial SiO_(2)layer with a specificthickness,causing a shift in the oxidation time and increasing the oxidation *** research provides valuableinsights for designing Si-based EBC with improved lifetimes.

关键词： environmental barrier coating(EBC) oxidation modification diffusion cracking