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World Journal of Clinical Cases 2022年第7期10卷 2315-2321页

作者： Yuan Li Yu-De Xie shao-Jie He Jia-Mei Hu Zhi-Sheng Li shao-hua qu Department of Breast Surgery The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Granulocytic sarcoma(GS)is a rare malignant tumor,and relapse is even rarer in the breast and dorsal spine following allogeneic hematopoietic stem cell ***,a standard treatment regimen is not *** SUMMARY A rare case of GS of the right breast and dorsal spine after complete remission of acute myelogenous leukemia is reported here.A 55-year-old female patient presented with a palpable,growing,painless lump as well as worsening dorsal compressive *** had a history of acute myelomonocytic leukemia(AML M4)and achieved complete remission after chemotherapy following allogeneic hematopoietic stem cell *** examinations showed the breast lump and C7-T1 epidural masses suspected of *** results were compatible with GS in both the right breast and dorsal spine,which were considered extramedullary relapse of the AML treated 4 years *** A rare case of GS relapse following allogeneic hematopoietic stem cell transplantation and guidelines for treatment are discussed.

关键词： Granulocytic sarcoma Breast Dorsal spine Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation Case report

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铣削功率信号低通滤波特性的仿真与试验分析

上海交通大学学报 1998年第5期32卷 49-52页

作者：邵华瞿澄然翁世修林益耀上海交通大学机械工程学院

通过仿真和试验分析了铣削功率信号波形，解释了切削点至功率信号测量点之间中间环节对负载变化的滤波作用．仿真和试验揭示，当铣削负载发生突变时，在电动机输入功率信号的波形中会产生阶跃响应波动；由功率负载突变引起的阶跃响应波... 详细信息

通过仿真和试验分析了铣削功率信号波形，解释了切削点至功率信号测量点之间中间环节对负载变化的滤波作用．仿真和试验揭示，当铣削负载发生突变时，在电动机输入功率信号的波形中会产生阶跃响应波动；由功率负载突变引起的阶跃响应波动，其周期对一定的主电动机功率测量系统（包括主传动系统和功率变送器）为常数τ（本试验系统的τ≈０．０８ｓ）；当齿切削周期（等于铣削频率的倒数）小于阶跃响应波动周期的１／２时，铣削功率信号时域波形中的主峰值会发生粘连现象，表现为对负载波动频率的低通滤波效应（低通滤波截止频率为２／τ），从而造成功率信号中的负载波动特征减弱甚至消失．

关键词：功率信号低通滤波铣削仿真试验故障诊断

考虑ESG行为类别的碳减排与经济增长均衡机制研究

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经济问题 2025年第1期 15-26页

作者：曲卫华孙娜曲国华山西大学经济与管理学院山西太原030006 山西大学管理与决策研究所山西太原030006 山西财经大学管理科学与工程学院山西太原030006

“双碳”目标视域下,探究企业ESG(Environmental、Social and Governance)行为对碳排放的作用机理具有重要意义。考虑ESG行为存在表面上顺应迎合而实质上“言行不一”,构建了划分ESG行为类别的动态随机一般均衡(DSGE)模型,研究实质性ES... 详细信息

“双碳”目标视域下,探究企业ESG(Environmental、Social and Governance)行为对碳排放的作用机理具有重要意义。考虑ESG行为存在表面上顺应迎合而实质上“言行不一”,构建了划分ESG行为类别的动态随机一般均衡(DSGE)模型,研究实质性ESG行为与策略性ESG行为对碳排放等宏观经济因素的动态传导机制。研究发现:相比难以实现碳减排的策略性ESG行为,企业采取实质性ESG行为能够显著降低碳排放量且对宏观经济有正向影响,推动经济向低碳绿色转型,实现减排与经济发展的“共赢”。企业实质性ESG行为对碳减排与经济增长的影响机制为:(1)内部资本投入机制:企业采取实质性ESG行为对碳减排技术研发投入形成溢出效应,且实质性ESG行为激励企业将生产要素投入由高碳产品转移到低碳产品,以实现“增低碳降高碳”,达到碳减排与经济增长的协调统一;(2)外部政策激励机制:企业采取实质性ESG行为可获得更多的政府碳减排补贴,促使企业增加低碳产出投入,实现外部政策激励与内部低碳转型的协同效应;(3)金融机构信贷优惠机制:企业采取实质性ESG行为能够激发金融机构对其实行差异化信贷优惠利率,增加企业碳减排技术的研发投入,推动绿色金融与绿色技术的协同发展。研究为辨识ESG行为类别推动企业低碳转型发展提供理论依据与政策启示。

关键词：实质性ESG行为策略性ESG行为绿色金融碳排放动态随机一般均衡模型

小儿豉翘清热颗粒联合利巴韦林治疗小儿疱疹性咽峡炎临床效果观察

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罕少疾病杂志 2025年第1期32卷 47-48,51页

作者：邵华郑州大学附属儿童医院河南省儿童医院郑州儿童医院药学部河南郑州450000

目的分析对小儿疱疹性咽峡炎患儿实施利巴韦林、小儿豉翘清热颗粒联合治疗的效果和价值。方法收集本院在2021年6月至2023年3月期间就诊的75例小儿疱疹性咽峡炎患儿的临床资料,使用电脑随机分组原则对75例患儿进行分组,其中参照组(37例... 详细信息

目的分析对小儿疱疹性咽峡炎患儿实施利巴韦林、小儿豉翘清热颗粒联合治疗的效果和价值。方法收集本院在2021年6月至2023年3月期间就诊的75例小儿疱疹性咽峡炎患儿的临床资料,使用电脑随机分组原则对75例患儿进行分组,其中参照组(37例)患儿实施利巴韦林治疗,治疗组(38例)患儿加用小儿豉翘清热颗粒干预,对比两组小儿的治疗效果。结果治疗组患儿治疗后的症状缓解时间短于参照组患儿(P<0.05),差异具有统计学意义;治疗组干预后的白细胞计数、C反应蛋白、降钙素原低于参照组(P<0.05),差异具有统计学意义;治疗组患儿的IgG、IgA、治疗优良率高于参照组患儿(P<0.05),差异具有统计学意义。结论儿科治疗小儿疱疹性咽峡炎中使用小儿豉翘清热颗粒联合利巴韦林治疗的效果十分显著,不仅能在短时间内缓解患儿的症状,还能纠正机体炎症状态,缩短患儿的病程时间,改善患儿预后。

关键词：小儿疱疹性咽峡炎利巴韦林小儿豉翘清热颗粒治疗优良率

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不同宿主来源产气荚膜梭菌生物被膜形成前后药物敏感性分析

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动物医学进展 2025年第1期46卷 38-42页

作者：吴莹邵长军刘文华青岛农业大学动物医学院山东青岛266109 烟台市农科院山东烟台264200

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测... 详细信息

为了检测5株不同宿主来源产气荚膜梭菌形成生物被膜能力及其对抗菌药物的敏感性差异,首先用纸片扩散法药敏试验测定5株不同来源的产气荚膜梭菌对7种抗菌药物的敏感性;筛选高敏药物测定各菌株的最小抑菌浓度(MIC);利用结晶紫染色法检测不同来源产气荚膜梭菌生物被膜形成能力和高敏药物对生物被膜的抑制和清除能力。药敏结果显示,5株不同宿主来源产气荚膜梭菌均对氨苄西林高度敏感,对其余6种抗菌药物有不同程度耐药;氨苄西林对不同菌株的MIC值在0.031~2.000μg/mL之间;所有菌株均能生成生物被膜,但生物被膜生成能力有差异;不同菌株在各自4、2、1 MIC下生物被膜的生成受到不同程度抑制,而亚抑菌浓度的氨苄西林能刺激生物被膜的生成,氨苄西林对已经生成的生物被膜不能完全清除。结果表明,不同来源产气荚膜梭菌形成生物被膜前后对药物敏感性不同,可为产气荚膜梭菌的临床用药选择及使用剂量提供一定的参考依据。

关键词：产气荚膜梭菌生物被膜最小抑菌浓度耐药性

MicroRNA-324-3p Plays A Protective Role Against Coxsackievirus B3-Induced Viral Myocarditis

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Virologica Sinica 2021年第6期36卷 1585-1599页

作者： Tingjun Liu Jing Tong Chen shao Junyan qu hua Wang Yi Shi Yajing Lin Yun Liu Shihe shao Hongxing Shen School of Medicine College Jiangsu UniversityZhenjiang212013China Xuzhou Municipal Center for Disease Control and Prevention Xuzhou221006China Department of Cardiology Affiliated Hospital of Jiangsu UniversityZhenjiang212000China Center of Infectious Disease West China Hospital Sichuan UniversityChengdu610041China

Viral myocarditis(VM) is an inflammatory disease of the myocardium associated with heart failure, which is caused by common viral infections. A majority of the infections are initiated by coxsackievirus B3(CVB3). Micro RNAs(mi RNAs)have a major role in various biological processes, including gene expression, cell growth, proliferation, and apoptosis, as well as viral infection and antiviral immune responses. Although, mi RNAs have been found to regulate viral infections,their role in CVB3 infection remains poorly understood. In the previous study, mi RNA microarray results showed that mi R-324-3 p expression levels were significantly increased when cells and mice were infected with CVB3. It was also found that miR-324-3p downregulated TRIM27 and decreased CVB3 replication in vitro and in vivo. In vitro, analysis of downstream signaling of TRIM27 revealed that, miR-324-3p inhibited CVB3 infection, and reduced cytopathic effect and viral plaque formation by reducing the expression of TRIM27. In vivo, miR-324-3p decreased the expression of TRIM27,reduced cardiac viral replication and load, thereby strongly attenuating cardiac injury and inflammation. Taken together,this study suggests that miR-324-3p targets TRIM27 to inhibit CVB3 replication and viral load, thereby reducing the cardiac injury associated with VM.

关键词： Coxsackievirus B3(CVB3) Viral myocarditis(VM) miR-324-3p TRIM27

Factors influencing particle agglomeration during solid-state sintering

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Acta Mechanica Sinica 2012年第3期28卷 711-719页

作者： Chao Wang shao-hua Chen State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences100190 BeijingChina

Discrete element method （DEM） is used to study the factors affecting agglomeration in three-dimensional copper particle systems during solid-state sintering. A new parameter is proposed to characterize agglomeration. The effects of a series of factors are studied, including particle size, size distribution, inter-particle tangential viscosity, tem- perature, initial density and initial distribution of particles on agglomeration. We find that the systems with smaller particles, broader particle size distribution, smaller viscos- ity, higher sintering temperature and smaller initial density have stronger particle agglomeration and different distribu- tions of particles induce different agglomerations. This study should be very useful for understanding the phenomenon of agglomeration and the micro-structural evolution during sin- tering and guiding sintering routes to avoid detrimental ag- glomeration.

关键词： Solid-state sintering Discrete element simula-tion. Agglomeration. Densification

The effect of agglomerate on micro-structural evolution in solid-state sintering

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Acta Mechanica Sinica 2012年第5期28卷 1323-1330页

作者： Chao Wang shao-hua Chen State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of Sciences

Discrete element method （DEM） is used in the present paper to simulate the microstructural evolution of a planar layer of copper particles during sintering. Formation of agglomerates and the effect of their rearrangement on densification are mainly focused on. Comparing to the existing experimental observations, we find that agglomerate can form spontaneously in sintering and its rearrangement could accelerate the densification of compacts. Snapshots of numerical simulations agree qualitatively well with experimental observations. The method could be readily extended to investigate the effect of agglomerate on sintering in a three- dimensional model, which should be very useful for understanding the evolution of microstructure of sintering systems.

关键词： Solid-state sintering Discrete element method Agglomerate Densification Micro-structural evolution

Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats

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Current Medical Science 2024年第2期44卷 355-368页

作者： shao-ze JING Shu-han YANG Yun-kun qu Hai-hu HAO hua WU Department of Orthopedics Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Osteoarthritis(OA)is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local *** study aimed to investigate the anti-OA effect of scutellarein(SCU),a single-unit flavonoid compound obtained from Scutellaria barbata ***,in ***:The extracted rat chondrocytes were treated with SCU and IL-1β.The chondrocytes were divided into control group,IL-1βgroup,IL-1β+SCU 50µmol/L group,and IL-1β+SCU 100µmol/L *** of rat chondrocytes was observed by toluidine blue and safranin O ***-8 method was used to detect the cytotoxicity of ***,qRT-PCR,Western blotting,immunofluorescence,SAβ-gal staining,flow cytometry,and bioinformatics analysis were applied to evaluate the effect of SCU on rat chondrocytes under IL-1β***,anterior cruciate ligament transection(ACL-T)was used to establish a rat OA *** changes were detected by safranin O/fast green,hematoxylin-eosin(HE)staining,and ***:SCU protected cartilage and exhibited anti-inflammatory effects via multiple ***,it could enhance the synthesis of extracellular matrix in cartilage cells and inhibit its *** addition,SCU partially inhibited the nuclear factor kappa-B/mitogen-activated protein kinase(NF-κB/MAPK)pathway,thereby reducing inflammatory cytokine production in the joint ***,SCU significantly reduced IL-1β-induced apoptosis and senescence in rat chondrocytes,further highlighting its potential role in OA *** vivo experiments revealed that SCU(at a dose of 50 mg/kg)administered for 2 months could significantly delay the progression of cartilage damage,which was reflected in a lower Osteoarthritis Research Society International(OARSI)score,and reduced expression of matrix metalloproteinase 13(MMP13)in ***:SCU is effective in the therapeutic management of OA and could serve as a potential candidate f

关键词： scutellarein osteoarthritis apoptosis mitogen-activated protein kinase(MAPK) nuclear factor kappa-B(NF-κB)

Interface characteristics between TiN and matrix and their effect on solidification structure

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Journal of Iron and Steel Research International 2021年第9期28卷 1149-1158页

作者： Tian-peng qu De-yong Wang Hui-hua Wang Dong Hou Jun Tian shao-yan Hu Li-juan Su Shagang School of Iron and Steel Soochow UniversitySuzhou215021JiangsuChina

Heterogeneous nucleation is an effective way to promote the dispersion and precipitation of second-phase particles in steel and refine the grain size of the solidification *** only refining as-cast structure grain size,but TiN in ferritic stainless steel can also pin grain boundaries and restrain the overgrowth of grains during *** interface characteristics between TiN and heterogeneous phases(high-melting inclusions and ferrite phase)were studied based on the wetting angles between molten steel with different compositions and TiN substrate,and on the matching degree between TiN and ferrite *** was found that,for the molten steel with the same composition,the wetting angle with the TiN substrate was significantly smaller than the contact angles with the other three substrates,while the wetting angle between ferrite phase and TiN was the *** lattice matching was compared among MgAl_(2)O_(4),TiN andδmatrix by means of a high-resolution transmission electron microscope,which revealed that a coherent or semi-coherent interface was formed between the crystal plane(400)of MgAl_(2)O_(4)and the crystal plane(200)of TiN,as well as between the crystal plane(200)of TiN and the crystal plane(110)ofδmatrix,with a lattice misfit of 5.1%and 3.4%,***,these two characteristics between TiN and ferrite phase were both explained from the perspective of interfacial *** microstructure refinement mechanism from high temperature to room temperature can be better reflected by the proposed wetting–lattice misfit theory.

关键词： TiN Heterogeneous nucleation Interfacial wetting Lattice matching Grain refinement