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Global Transmission of Human Immunodeficiency Virus 1 Subtype C and Its Impact on the Circulation of B/C Recombination Strains in China

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Infectious Microbes & Diseases 2022年第4期4卷 157-160页

作者： Zhanmou Liu Yanling Liang Yi Feng Kang Li yiming shao Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease School of Public HealthGuangxi Medical UniversityNanningChina Division of Research on Virology and Immunology National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

This study aimed to reconstruct the origin and worldwide epidemic history of human immunodeficiency virus(HIV)1 subtype C and comprehend how HIV-1 subtype C was introduced into and spread throughout China in the formof B/C recombinant *** sequences ofHIV-1 subtype C and some other subtypes deposited before December 31,2020 were downloaded from the Los Alamos HIV Database and the Chinese National Center for AIDS/STD Control and Prevention *** available sequences were screened for quality,and Bayesian analysis was used to build the maximum clade credibility evolutionary tree to analyze and judge the origin and spread of HIV-1 subtype ***-1 subtype C originated in central Africa around 1952,then spread to southern Africa around 1969 and to eastern Africa around ***-1 subtype C fromsouthern Africa was introduced into India in ***-1 subtype C of eastern Africa was introduced into Brazil in *** HIV-1 subtype C was exported to China in three migration events during the period from 1986 to *** two predominant recombinants in China(CRF07_BC and CRF08_BC)emerged in 1988 and 1990,*** B/C recombinants,namely,CRF64_BC,CRF61_BC and CRF62_BC,originated in 1993,2002 and 2000,*** study has reconstructed the global origin and evolutionary history of HIV-1 subtype *** addition,our study demonstrated that the Chinese HIV-1 subtype C originated from three related Indian lineages around the mid to late 1980s and,since then,has formed some B/C recombinants with subtype B that caused a widespread epidemic in China.

关键词： HIV-1 subtype C origin B/C recombination strains China global

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The YDA-MKK4/MKK5-MPK3/MPK6 Cascade Functions Downstream of the RGF1-RGI Ligand-Receptor Pair in Regulating Mitotic Activity in Root Apical Meristem

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Molecular Plant 2020年第11期13卷 1608-1623页

作者： yiming shao Xinxing Yu Xuwen Xu Yong Li Wenxin Yuan Yan Xu Chuanzao Mao Shuqun Zhang Juan Xu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China Division of Biochemistry University of MissouriColumbiaMO 65211USA Department of Molecular Cellular and Developmental BiologyYale UniversityNew HavenCT 06511USA

The mitotic activity of root apical meristem(RAM)is critical to primary root growth and *** studies have identified the roles of ROOT GROWTH FACTOR 1(RGF1),a peptide ligand,and its receptors,RGF1 INSENSITIVEs(RGIs),a clade of five leucine-rich-repeat receptor-like kinases,in promoting cell division in the RAM,which determines the primary root ***,the downstream signaling components remain *** this study,we identify a complete mitogen-activated protein kinase(MAPK or MPK)cascade,composed of YDA,MKK4/MKK5,and MPK3/MPK6,that functions downstream of the RGF1-RGI ligand-receptor *** to the rgi1/2/3/4/5 quintuple mutant,loss-of-function mutants of MPK3 and MPK6,MKK4 and MKK5,or YDA show a short-root phenotype,which is associated with reduced mitotic activity and lower expression of PLETHORA 1(PLT1)/PLT2 in the ***,MPK3/MPK6 activation in response to exogenous RGF1 treatment is impaired in the rgi1/2/3/4/5 quintuple,yda single,and mkk4 m kk5 double *** analyses demonstrated that the expression of constitutively active MKK4,MKK5,or YDA driven by the RGI2 promoter can rescue the short-root phenotype of the rgi1/2/3/4/5 *** together,these results suggest that the YDA-MKK4/MKK5-MPK3/MPK6 cascade functions downstream of the RGF1-RGI ligand-receptor pair and upstream of PLT1/PLT2 to modulate the stem cell population and primary root growth in Arabidopsis.

关键词： root meristem MPK3/MPK6 RGF1-RGIs PLT1/PLT2 signaling pathway Arabidopsis

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Spray characteristics and controlling mechanism of fuel containing CO2

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Frontiers in Energy 2012年第1期6卷 80-88页

作者： Zhen HUANG Jin XIAO Xinqi QIAO Gaozhi JIANG yiming shao Seiichi SHIGA Yasuhiro DAISHO Key Laboratory for Power Machinery and Engineering of Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240China Faculty of Engineering Depamnent of Mechanical System EngineeringGunma UniversityGunma 376-8515Japan Faculty of Transportation Engineering Chongqing Jiaotong UniversityChongqing 400074China Faculty of Science and Engineering Waseda UniversityTokyo169-8555Japan

This paper presents studies of spray characteristics and controlling mechanism of fuel containing CO2. Using diesel fuel containing CO2 gas, experiments were conducted on diesel hole-type nozzles and simple nozzles. The steady spray and transient spray characteristics were observed and measured by instantaneous shadowgraphy, high-speed photography, phase Doppler anemometry （PDA） and LDSA respectively. The effects of CO2 concentration in the fuel, the injection pressure, the nozzle L/D ratio, surrounding gas pressure and temperature on the atomization behavior and spray pattern were evaluated. The results show that the injection of fuel containing CO2 can greatly improve the atomization and produce a parabolic-shaped spray; and the CO2 gas concentration, surrounding gas pressure, temperature and nozzle config- uration have dominant influences on spray characteristics of the fuel containing CO2. New insight into the controlling mechanism of atomization of the fuel containing CO2 was provided.

关键词： spray characteristics fuel atomization fuelcontaining CO2

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Internet search data could Be used as novel indicator for assessing COVID-19 epidemic

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Infectious Disease Modelling 2020年第1期5卷 848-854页

作者： Kang Li Yanling Liang Jianjun Li Meiliang Liu Yi Feng yiming shao Key Laboratory of Molecular Microbiology and Technology Ministry of EducationCollege of Life SciencesNankai UniversityTianjinChina State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Guangxi Center for Disease Prevention and Control NanningGuangxiChina School of Public Health Guangxi Medical UniversityNanningGuangxiChina

The pandemic of the coronavirus disease(COVID-19)poses a huge challenge all countries,since no one is well prepared for *** be better prepared for future pandemics,we evaluated association between the internet search data with reported COVID-19 cases to verify whether it could become an early indicator for emerging *** the keyword filtering and Index composition,we found that there were close correlations between Composite Index and suspected cases for COVID-19(r?0.921,P<0.05).The Search Index was applied for the Autoregressive Integrated Moving Average with Exogenous Variables(ARIMAX)model to quantify the *** with the model based on surveillance data only,the ARIMAX model had smaller Akaike Information Criterion(AIC?403.51)and the most accurate predictive ***,the Internet search data could serve as a convenient indicator for predicting the epidemic and to monitor its trends.

关键词： COVID-19 Internet data ARIMAX Predict

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A new pattern-based method for identifying recent HIV-1 infections from the viral env sequence

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Science China(Life Sciences) 2012年第4期55卷 328-335页

作者： YANG Jing XIA XiaYu HE Xiang YANG SenLin RUAN YuHua ZHAO QuanBi WANG ZhiXin shao yiming PAN XianMing Key Laboratory of Bioinformatics Ministry of Education School of Life Sciences Tsinghua University Beijing 100084 China State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

The long asymptomatic stage of HIV infection poses a great challenge in identifying recent HIV infections. This is a bottleneck for monitoring HIV epidemic trends and evaluating the effectiveness of national AIDS control programs. Several serological methods were used to address this issue with some success. Because of high false-positive rates in patients with advanced infection or in ART treatment, UNAIDS still hesitates to recommend their use in routine surveillance. We developed a new pattern-based method for measuring intra-patient viral genetic diversity for determination of recent infections and estimation of population incidence. This method is verified by using several datasets (424 subtype B and 77 CRF07_BC samples) with clearly identified HIV-1 infection times. Pattern-based diversities of recent infections are significantly lower than that of chronic ones. With larger window periods varying from 200 to 350 days, a higher accuracy (90% 95%) not affected by advanced disease nor ART treatment could be obtained. The pattern-based genetic method is supplementary to the existing serology-based assays, both of which could be suitable for use in low and high epidemic regions, respectively.

关键词： determination of HIV recent infections estimation of population incidence viral genetic diversity pattern-based distance

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基于HIV-1的pol基因区序列分析我国CRF07_BC毒株的跨地区传播特征

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中国艾滋病性病 2024年第3期30卷 232-239页

作者：王栋冯毅郝静静胡红萍李方园李佳璐廖玲洁阮玉华邵一鸣邢辉中国疾病预防控制中心性病艾滋病预防控制中心北京102206

目的通过构建我国HIV-1的CRF07_BC毒株pol基因区序列的分子网络,分析CRF07_BC毒株在我国的跨地区传播特征,为促进我国HIV精准防控提供数据支持。方法使用FastTree与中国艾滋病病毒基因序列数据平台(https://***/hiv/)的亚型判别工具进... 详细信息

目的通过构建我国HIV-1的CRF07_BC毒株pol基因区序列的分子网络,分析CRF07_BC毒株在我国的跨地区传播特征,为促进我国HIV精准防控提供数据支持。方法使用FastTree与中国艾滋病病毒基因序列数据平台(https://***/hiv/)的亚型判别工具进行亚型判别,筛选出我国CRF07_BC毒株的pol基因序列构建分子网络,使用单因素与多因素Logistic回归分析入网率与跨地区连接影响因素,计算跨地区聚类系数等分子网络分析指标描述不同省份之间的传播连接和强度特征。结果共收集到我国HIV-1毒株pol基因区序列81612条,其中CRF07_BC毒株26181条序列,在0.5%基因距离阈值下构建分子网络,形成2028个分子网络,最大的分子网络含有6262个节点,命名为07-1-1,节点来自全国31个省(自治区、直辖市),以男男性行为传播途径为主(32.0%,2005/6262)。跨地区分析指标显示07-1-1分子网络中68.9%为跨地区连接边,80.6%为跨地区节点;跨地区聚类系数显示分子网络07-1-1的跨地区传播以广东省(66.6%,79114/118819)与北京市(27.9%,33159/118819)为中心,发生在我国华东地区、西南地区、华南地区和华中地区等地区间。结论我国HIV跨地区传播中CRF07_BC毒株起很强的主导作用,广东省与北京市处于跨地区传播的中心位置,有效控制HIV毒株在我国的跨地区传播,将成为我国艾滋病防控高质量发展的重要举措之一。

关键词： 1型艾滋病病毒跨地区传播分子网络聚类系数

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IDM editorial statement on the 2019-nCoV

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Infectious Disease Modelling 2020年第1期5卷 233-234页

作者： yiming shao Jianhong Wu State Key Laboratory of Infectious Disease Prevention and Control Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina Laboratory for Industrial and Applied Mathematics Centre for Disease ModellingDepartment of Mathematics and StatisticsYork UniversityTorontoONM3J 1P3Canada

In December of 2019,27 patients with viral pneumonia including 7 severe cases were reported inWuhan,the capital city of Hubei province and one of the largest cities of *** the morning of January 23,2020,the infected cases have increased to 571 including 17 deaths,and spread to 25 of 31 mainland provinces and municipals and Hong Kong,Macao and Taiwan as well as to 7 other countries,including South Korea,Japan,Thailand,Singapore,Philippines,Mexico and the United States of America.

关键词： 2019-nCoV Wuhan Novel coronavirus World Health Organization(WHO) SARS SARI Severe Acute Respiratory Syndrome

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Comparison of different strategies for controlling HIV/AIDS spreading in MSM

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Infectious Disease Modelling 2018年第1期3卷 293-300页

作者： Jie Lou Jinjin Cheng Yan Li Chen Zhang Hui Xing Yuhua Ruan yiming shao Department of Mathematics Shanghai University99 Shangda RoadShanghaiChina Henan Cable TV Network Group Co. LtdZhengzhou BranchZhengzhouChina School of Nursing University of Rochester Medical Center255 Crittenden BlvdRm 2w218RochesterNY14642USA State Key Laboratory of Infectious Disease Prevention and Control(SKLID) Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina Guangxi Center for Disease Control and Prevention NanningChina

As proposed in the UNAIDSs 2014 report,to end global AIDS epidemic by 2030,90%of people living with HIV need to be diagnosed,90%of the diagnosed need to receive antiretroviral therapy(ART),and 90%of those on treatment need to achieve viral suppression(90-90-90 strategy).The strategies focus on the *** controls HIV spreading by reducing infectiousness of HIV infected individuals via diagnosis and *** this manuscript,we compared the effects of HIV/AIDS interventions that focus on different individuals in MSM population through a dynamics *** results showed that,the success or not of the”90-90-90”strategies depends on a very important factor:the infectious strength among individuals taking *** highly effective HIV treatment,the”90-90-90”strategies are likely to ***,we call for the combination of both primary prevention among the susceptible with the 90-90-90 strategy among the infected to curb the HIV epidemic in Chinese MSM.

关键词： HIV/AIDS Dynamics model Prevention and treatment strategies

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Comparison between sepsis-induced coagulopathy and sepsis-associated coagulopathy criteria in identifying sepsis-associated disseminated intravascular coagulation

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World Journal of Emergency Medicine 2024年第3期15卷 190-196页

作者： Huixin Zhao yiming Dong Sijia Wang Jiayuan Shen Zhenju Song Mingming Xue Mian shao Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND:Disseminated intravascular coagulation(DIC)is associated with increased mortality in sepsis *** this study,we aimed to assess the clinical ability of sepsis-induced coagulopathy(SIC)and sepsis-associated coagulopathy(SAC)criteria in identifying overt-DIC and preDIC status in sepsis ***:Data from 419 sepsis patients were retrospectively collected from July 2018 to December *** performances of the SIC and SAC were assessed to identify overt-DIC on days 1,3,7,or *** SIC status or SIC score on day 1,the SAC status or SAC score on day 1,and the sum of the SIC or SAC scores on days 1 and 3 were compared in terms of their ability to identify *** SIC or SAC status on day 1 was evaluated as a pre-DIC indicator for anticoagulant ***:On day 1,the incidences of coagulopathy according to overt-DIC,SIC and SAC criteria were 11.7%,22.0%and 31.5%,*** specificity of SIC for identifying overt-DIC was significantly higher than that of the SAC criteria from day 1 to day 14(P3 had a significantly higher sensitivity(72.00%)and area under the curve(AUC)(0.69)in identifying pre-DIC than did the SIC or SAC status(sensitivity:SIC status 44.00%,SAC status 52.00%;AUC:SIC status 0.62,SAC status 0.61).The sum of the SIC scores on days 1 and 3 had a higher AUC value for identifying the pre-DIC state than that of SAC(0.79 vs.0.69,P<0.001).Favorable effects of anticoagulant therapy were observed in SIC(adjusted hazard ratio[HR]=0.216,95%confidence interval[95%CI]:0.060–0.783,P=0.018)and SAC(adjusted HR=0.146,95%CI:0.041–0.513,P=0.003).CONCLUSION:The SIC and SAC seem to be valuable for predicting *** sum of SIC scores on days 1 and 3 has the potential to help identify pre-DIC.

关键词： Sepsis Disseminated intravascular coagulation Sepsis-induced coagulopathy Sepsis-associated coagulopathy

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Impact of HIV Pretreatment Drug Resistance on Virological Failure After One-Year Antiretroviral Therapy--China,2018-2019

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China CDC weekly 2022年第25期4卷 535-540页

作者： Miaomiao Li Chang Song Aobo Dong Jing Hu Ruihua Kang Hui Xing Yuhua Ruan yiming shao Kunxue Hong Lingjie Liao State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?While antiretroviral therapy(ART)has been rapidly scaled-up among the population living with human immunodeficiency virus or acquired immune deficiency syndrome(HIV/AIDS)... 详细信息

关键词： Therapy Impact patients

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