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China CDC weekly 2021年第14期3卷 291-297页

作者： Tianhao Zhang Lingjie Liao yiming shao Yi Feng Yuhua Ruan Hui Xing State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

Summary What is already known about this topic?With increasing coverage of antiretroviral therapy(ART)for HIV-infected patients,more and more attention has been paid to the impact of HIV drug resistance on death in those patients in *** is added by this report?Among HIV-infected patients receiving ART,the risk of death is higher in patients with HIV drug resistance[adjusted odds ratio(AOR)=4.25.

关键词： death patients Infect

MODELING PRIMARY AND SECONDARY DRUG RESISTANCES UNDER CHINA^S ＂FOUR-FREE-ONE-CARE POLICY＂

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International Journal of Biomathematics 2012年第5期5卷 1-19页

作者： JIE LOU LINGCHEN BU ESTHER HAN YUHUA RUAN HUI XING yiming shao Department of Mathematics Shanghai University99 Shangda Road Shanghai 200~ P. R. China Texas College of Osteopathic MedicineUniversity of North Texas Health Science Center Fort Worth TX USA State Key Laboratory for Infectious Disease Control and Prevention andNational Center for AIDS//STD Control and Prevention Chinese Center for Disease Control and Prevention 155 Changbai Road Changping District Beijing 102206 P. R. China

We propose a mathematical model to evaluate the effect of China＇s ＂Four-Free-One-Care Policy＂ in MSM population in Beijing. We divided the drug resistant H[V patients into two sub-populations： primary drug resistance and secondary drug resistance. Uncertainty and sensitivity analysis based on Latin Hypercube Sampling （LHS） were used for these thresholds of our model. We find that drug-resistant HIV will spread fast in MSM population under China＇s current treatment policy. Especially＇, primary-resistant strain is very likely to dominate the HIV positive MSM individuals after 10 years. The conclusions hint that, China＇s outlook on HIV infections is not optimistic if sufficient kinds free second-line drugs in China cannot be put into use in the near future.

关键词： HIV Latin Hypercube Sampling primary drug resistance secondary drugresistance.

Potent T cell Responses Induced by Single DNA Vaccine Boosted with Recombinant Vaccinia Vaccine

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Virologica Sinica 2013年第2期28卷 109-115页

作者： Lianxing Liu Chao Qiu Yang Huang Jianqing Xu yiming shao State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Science Research Department Shanghai Public Health Clinical Center Public Health Clinical Center affiliated to Fudan University

Plasmid DNA, an effective vaccine vector, can induce both cellular and humoral immune responses. However, plasmid DNA raises issues concerning potential genomic integration after injection. This issue should be considered in preclinical studies. Tiantan vaccinia virus (TV) has been most widely utilized in eradicating smallpox in China. This virus has also been considered as a successful vaccine vector against a few infectious diseases. Potent T cell responses through T-cell receptor (TCR) could be induced by three injections of the DNA prime vaccine followed by a single injection of recombinant vaccinia vaccine. To develop a safer immunization strategy, a single DNA prime followed by a single recombinant Tiantan vaccinia (rTV) AIDS vaccine was used to immunize mice. Our data demonstrated that one DNA prime/rTV boost regimen induced mature TCR activation with high functional avidity, preferential T cell Vβ receptor usage and high sensitivity to anti-CD3 antibody stimulation. No differences in T cell responses were observed among one, two or three DNA prime/rTV boost regimens. This study shows that one DNA prime/rTV boost regimen is sufficient to induce potent T cell responses against HIV.

关键词： HIV Vaccine T cell responses Prime-boost regimen

Higher levels of circulating monocyte-platelet aggregates are correlated with viremia and increased sCD 163 levels in HIV- 1 infection

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Cellular & Molecular Immunology 2015年第4期12卷 435-443页

作者： Hua Liang Zhaojun Duan Dan Li Dongliang Li ZhengWang Li Ren Tao Shen yiming shao State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and Prevention China CDC CollaborativeInnovation Center for Diagnosis and Treatment of Infectious Diseases Beijing China Department of Microbiology School of Basic Medical SciencesPekin8 University Beijing China and 3Beijing Chaoyang District Center for Disease Control and Prevention Beijing China Correspondence: Dr T Shen Department of Microbiology Peking University Health Science Center Beijing 100191 China.

Increased levels of monocyte-platelet aggregates （MPAs） are reported to be highly correlated with cardiovascular events. In this study, the MPA levels in different monocyte subsets and the associations between MPA levels, HIV-1 viremia and monocyte activation were evaluated during HIV-1 infection. The results showed that the percentages of MPAs in all three monocyte subsets were higher in HIV-l-infected subjects than in healthy controls, and were associated with the plasma viral load in the non-classical and intermediate monocyte subsets. The plasma levels of sCD14 and sCD163 were upregulated in HIV-1 infection and were positively associated with viral loads and negatively associated with CD4 counts. P-selectin glycoprotein ligand-1 （PSGL-1） was shown to be expressed at significantly lower levels on all three monocyte subsets and was negatively correlated with the sCD163 level. The MPA level was correlated with the levels of plasma sCD163 but negatively correlated with CD163 and PSGL-1 on all three monocyte subsets. An elevated immune activation status was correlated with increased MPA formation, underlying the potential interaction between monocyte activation and MPA formation. This interaction may be related to a higher thromboembolic risk in patients infected with HIV-I.

关键词： HIV-1 immune activation monocytes platelets sCD163

艾滋病病毒流行重组毒株CRF01_AE及其影响

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中国艾滋病性病 2024年第1期30卷 79-83页

作者：李斯斯李康 Abdur Rashid 贺江珊王沛葭刘茂顺冯毅邵一鸣广西艾滋病防治研究重点实验室公共卫生学院广西医科大学南宁530021 中国疾病预防控制中心性病艾滋病预防控制中心北京102206 南开大学天津300071 北京师范大学北京100875

CRF01_AE作为HIV最主要的流行重组毒株,在全球范围长时序演变,形成区域间的流行特征,构成特色且独立的流行与传播模式,本文从其起源、遗传多样性、流行特征及其对诊断和治疗延迟、疾病进程、治疗效果影响等方面进行综述,阐释CRF01_AE及... 详细信息

CRF01_AE作为HIV最主要的流行重组毒株,在全球范围长时序演变,形成区域间的流行特征,构成特色且独立的流行与传播模式,本文从其起源、遗传多样性、流行特征及其对诊断和治疗延迟、疾病进程、治疗效果影响等方面进行综述,阐释CRF01_AE及时监测对遏制HIV区域间和全球蔓延的作用。

关键词：艾滋病亚型重组流行病学

A conserved structural motif shared by EIAV gp90 and HIV gp120

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Chinese Science Bulletin 2005年第20期50卷 2393-2394页

作者： LI Huiguang TONG Xiao SHEN Tao SHEN Rongxian ZHANG Xiaoyan shao yiming Department of Research on Virology and Immunology National Center for AIDS/STD Control and Prevention CDC Beijing 100052 China Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Department of Research on EIAV Harbin Veterinary Research Institute Harbin 150001 China

Both HIV and EIAV belong to the retroviridae family and lentivirus genus. They share considerable simi- larity at gene structural and component level. Hotzel pro- posed that two variable regions and surrounding amino acids of EIAV gp90 might adopt the same topology as V1, V2 and bridging sheet of HIV gp120. These regions map to V3, V4 and surrounding amino acids of EIAV gp90. Based on this proposal, we further analyzed the distribution profile of N-glycosylation site and linear epitope for EIAV gp90 and HIV gp120 at these regions. Our results demonstrated that EIAV gp90 and HIV gp120 are highly similar at these two aspects. Most likely, V3, V4 and surrounding amino acids of EIAV gp90 adopt the same topology structure as V1, V2 and bridging sheet of HIV gp120.

关键词： HIV 爱滋病病毒传染病传播途径基因结构

Narrow bandgap molecular dyads incorporating Y-series acceptor backbones for efficient single-molecular organic solar cells

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Science China Chemistry 2023年第11期66卷 3205-3212页

作者： Yuan Gao Bo Xiao Shanshan Wang Mingxia Chen Wei Wang Xinrong Yang yiming shao Rui Sun Jie Min The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

The performance of organic solar cells(OSCs)is mainly related to the bulk heterojunction(BHJ)microstructure of specific active layer systems,which is often in a metastable state.A promising strategy to address the abovementioned shortcomings of BHJs is to develop single-component active layer *** to the single-component small molecule materials with defined chemical structures generally exhibit poor absorption spectra,herein we first introduced narrow bandgap Y-series acceptors into the molecular skeleton of single-component materials,and designed two molecular dyads,SM-Et-1Y and *** optical bandgaps(E_g~(opt)s)of the two dyads are 1.364 and 1.361 eV,respectively,which are much smaller than those of previously reported single-component ***,the SM-Et-2Y-based single-component OSCs(SCOSCs)showed a power conversion efficiency(PCE)of 5.07%,superior to SM-Et-1Y(2.53%),which is one of the highest PCEs reported for SCOSCs to ***,both SM-Et-1Y-and SM-Et-2Y-based devices exhibited excellent photo-stability,retaining over 90%of their initial performance after 250 h of continuous *** results provide a deeper understanding of the molecular backbone and a guiding principle for the rational design or selection of non-fullerene single-component materials with suitable donor/acceptor ratios.

关键词： donor-acceptor dyads single-material organic solar cells Y-series acceptors operational stability optical bandgap

右美托咪定对脓毒症急性肾损伤患者的肾功能影响的队列研究

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实用医学杂志 2024年第10期40卷 1423-1428页

作者：郑因碧邵义明黎焯基黎诗婷陈鸣娣曾文驰董宏裕广东医科大学附属第二医院广东湛江524000 广东医科大学附属东莞第一医院广东东莞523710

目的探讨右美托咪定对脓毒症急性肾损伤(AKI)患者的肾功能影响。方法采取前瞻性队列研究,选取2021年10月至2023年4月广东医科大学附属第二医院180例入住ICU治疗的脓毒症患者为研究对象。按照随机对照原则进行分组,将60例非AKI患者分为S-... 详细信息

目的探讨右美托咪定对脓毒症急性肾损伤(AKI)患者的肾功能影响。方法采取前瞻性队列研究,选取2021年10月至2023年4月广东医科大学附属第二医院180例入住ICU治疗的脓毒症患者为研究对象。按照随机对照原则进行分组,将60例非AKI患者分为S-D组(n=30,右美托咪定+常规治疗)和S组(n=30,常规治疗),比较两组治疗后AKI的发生和病情评分。将120例AKI患者分为SA-D-RT组(n=30,右美托咪定+血液净化+常规治疗)、SA-D组(n=30,右美托咪定+常规治疗)、SA-RT组(n=30,血液净化+常规治疗)和SA组(n=30,常规治疗),比较四组患者治疗后的肾功能、炎症因子水平和病情变化。结果经治疗,S-D组患者的AKI发生率低于S组,S-D组患者治疗后第7天的APACHEⅡ评分、SOFA评分均低于S组(P<0.05)。治疗第7天后,四组患者的Scr、BUN和Cys C水平较第1、3天均明显降低,且SA-D-RT组低于SA-D组、SA-RT组和SA组(P<0.05)。治疗第7天后,四组患者的CRP、PCT、TNF-α、IL-6和IL-1β水平较第1、3天均明显降低,且SA-D-RT组低于SA-D组、SA-RT组和SA组(P<0.05)。治疗第7天后,四组患者的APACHEⅡ评分、SOFA评分较第1、3天均明显降低,且SA-D-RT组低于SA-D组、SA-RT组和SA组(P<0.05)。结论右美托咪定应用于脓毒症的治疗中,可有效降低AKI的发生率,影响SAKI患者肾功能、炎症因子各项指标在血清中的表达水平,改善患者的病情。

关键词：右美托咪定脓毒症急性肾损伤肾功能炎症因子队列研究

基于双碳目标下居住区风环境及能耗模拟研究--以洛阳市河南科技大学家属院居住区为例

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工业建筑 2024年第3期54卷 90-96页

作者：王江丽王璐晗陈淼王飞邵一鸣河南科技大学土木建筑学院河南洛阳471003 建筑安全与环境国家重点实验室北京100013 河南科技大学建筑能源与热科学技术研究所河南洛阳471003 河南省建筑环境控制与安全工程研究中心河南洛阳471003 中铁十五局集团第三工程有限公司成都611756 洛阳市住房和城乡建设局河南洛阳430074 建科环能科技有限公司北京100013 西南交通大学利兹学院成都611756

为了研究老旧小区中出现的风环境问题,以河南洛阳市河南科技大学家属院为研究对象,以原始气象数据作为数据源,将其作为边界条件利用CFD软件Phoenics对其进行风环境模拟,并结合绿色建筑相关技术标准对院区七月份主导风向下风速和风压进... 详细信息

为了研究老旧小区中出现的风环境问题,以河南洛阳市河南科技大学家属院为研究对象,以原始气象数据作为数据源,将其作为边界条件利用CFD软件Phoenics对其进行风环境模拟,并结合绿色建筑相关技术标准对院区七月份主导风向下风速和风压进行分析,对院区现有风环境存在的问题提供改进措施并对改进后的方案再次进行风环境模拟。结果表明:通过对第一排迎风建筑的底层进行架空、适当的加大风向角使室外平均风速增加0.7 m/s,对院区风环境及建筑能耗均有较好的改善,同时也验证了CFD模拟在建筑规划设计中的可行性和重要性。

关键词：风环境老旧小区 CFD模拟平均风速改善潜力

Prospects for the Implementation of HIV Molecular Transmission Network–Informed AIDS Prevention and Control in China

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Infectious Microbes & Diseases 2022年第3期4卷 111-115页

作者： Yi Feng Hui Xing Yuhua Ruan Lingjie Liao yiming shao State Key Laboratory for Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina

The human immunodeficiency virus(HIV)-infected population with a transmission link has a strong genetic similarity in viral gene sequences that tend to *** recent years,a strategy for guiding HIV/acquired immunodeficiency syndrome(AIDS)prevention using sequence-based transmission networks has been *** execution of this strategy provides an opportunity to effectively control the spread of the AIDS epidemic in *** molecular transmission network research has been actively pursued by a number of Chinese research ***-and long-term strategies were created with the goal of using HIV molecular transmission networks to guide targeted prevention and control in *** guidelines for HIV transmission network monitoring and intervention have been written and *** studies are continuing in the *** the fact that this strategy has a bright future,there are still many challenges to overcome to achieve the intended AIDS prevention and control goals.

关键词： human immunodeficiency virus(HIV) acquired immunodeficiency syndrome(AIDS) HIV molecular transmission network