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Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling

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Cellular & Molecular Immunology 2020年第2期17卷 143-152页

作者： Zurong wan Xingxing shao Xingyu Ji Lihui Dong Jiacheng Wei Zhuqing Xiong wanli Liu Hai Qi Tsinghua-Peking Center for Life Sciences Tsinghua University100084 BeijingChina Laboratory of Dynamic Immunobiology Institute for Immunology100084 BeijingChina Department of Basic Medical Sciences School of Medicine100084 BeijingChina School of Life Sciences 100084 BeijingChina Beijing Key Lab for Immunological Research on Chronic Diseases 100084 BeijingChina MOE Key Laboratory of Protein Sciences Tsinghua University100084 BeijingChina

The B7-family inducible costimulator(ICOS)activates phosphoinositide-3 kinase(PI3K)and augments calcium mobilization triggered by the T-cell receptor(TCR).We surprisingly found that the entire cytoplasmic domain of ICOS is dispensable for its costimulation of calcium *** costimulatory function relies on the unique transmembrane domain(TMD)of ICOS,which promotes association with the tyrosine kinase ***-enabled Lck association is also required for p85 recruitment to ICOS and subsequent PI3K activation,and Lck underlies both the bystander and costimulatory signaling activity of ***-replaced ICOS,even with an intact cytoplasmic domain,fails to support T FH development or GC formation in *** transplanted onto a chimeric antigen receptor(CAR),the ICOS TMD enhances interactions between T cells and antigen-presenting target ***,by revealing an unexpected function of the ICOS TMD,our study offers a new perspective for the understanding and potential application of costimulation biology.

关键词： ICOS stimulation stimulator

Graphitic carbon nitride/La,Rh co-doped SrTiO_(3)S-scheme heterojunction for photocatalytic CO_(2)reduction

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Rare Metals 2024年第11期43卷 5880-5890页

作者： Si-Jie wan Yan-Ting Hou wang wang Guo-Qiang Luo Chuan-Bin wang Rong Tu shao-Wen Cao Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Technology Innovation Center for Advanced Composites Wuhan University of TechnologyWuhan 430070China

Photocatalytic reduction of CO_(2)has attracted considerable interest owing to its potential to resolve the energy and environmental ***,the lack of proficient photocatalysts has restricted the application of solar-driven photocatalytic CO_(2)***,we reported an S-scheme heterojunction by combining g-C_(3)N_(4)with La^(3+)and Rh^(3+)co-doped SrTiO_(3)through the electrostatic self-assembly method for the efficient photocatalytic CO_(2)*** comparison with g-C_(3)N_(4),the asprepared CN/LRSTO-30 wt%S-scheme heterojunction not only possesses a broadened visible-light response due to the defect states in La,Rh co-doped SrTiO_(3)induced by codoped La^(3+)and Rh^(3+)but also has more adsorption sites for the capture and activation of CO_(2)***,separation and transfer efficiency of the photoinduced charge carriers is much enhanced in the CN/LRSTO-30wt%S-scheme heterojunction via its robust internal electric field,which is firmly demonstrated by in situ irradiation X-ray photoelectron spectroscopy ***,the prepared S-scheme heterojunction achieves impressive photocatalytic CO_(2)reduction performance with an average CO and CH4 evolution rate of4.1-1.8μmol·g^(-1)·h^(-1),respectively,which are~1.9 and~22.5-fold higher than those of pure g-C_(3)N_(4).This study provides innovative perspectives on the design of creative S-scheme heterojunctions for applications in photocatalytic CO_(2)reduction.

关键词： g-C_(3)N_(4) La Rh co-doped SrTiO_(3) S-scheme heterojunction Separation of photogenerated charge carriers Photocatalytic CO_(2)reduction

Performance variability of Ba0.5Sr0.5Co0.8Fe0.2O3-δ cathode on proton-conducting electrolyte SOFCs with Ag and Au current collectors

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Rare Metals 2018年第8期37卷 633-641页

作者： Ting-Ting wan An-Kang Zhu Hai-Bo Li Chun-Chang wang You-Min Guo Zong-Ping shao Oumarou Savadogo School of Physics and Materials Science Anhui UniversityHefei 230601China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical EngineeringNanjing University of TechnologyNanjing 210009China Department of Chemical Engineering Curtin UniversityPerth W A 6845.Australia Laboratory of New Materials for Electrochemistry and Energy Polytechnique MontrealC.P.6079Succursale Centre-VilleMontr6alQC H3C 3A7Canada

Ba0.5Sr0.5Co0.8Fe0.2O3-δ （BSCF） is one of the most active cathode materials and shows significant hydration effect suggesting possible proton conductivity. In this study, the performance of BSCF cathode on a protonconducting BaZr0.1Ce0.7Y0.2O3-δ（BZCY） electrolyte with silver and gold current collectors was determined. The electrochemical characteristics of the symmetrical and anode-supported cell with diluted silver electrode, silver current collector or gold current collector on BSCF electrode were compared. The significant result is that, although the diluted silver electrode itself shows poor operation stability, the silver current collector has strong electrocatalytic contribution to the BSCF cathode performance on the proton-conducting electrolyte, leading to higher cell performance than that with the gold current collector.

关键词： Solid oxide fuel cell Proton conductor Agcurrent collector Operation stability

Super-resolution quantification of nanoscale damage to mitochondria in live cells

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Nano Research 2020年第8期13卷 2149-2155页

作者： Xintian shao Qixin Chen Lianting Hu Zhiqi Tian Liuyi Liu Fei Liu Fengshan wang Peixue Ling Zong-wan Mao Jiajie Diao Shandong Academy of Pharmaceutical Sciences Key Laboratory of BiopharmaceuticalsEngineering Laboratory of Polysaccharide DrugsNational-Local Joint Engineering Laboratory of Polysaccharide DrugsJinan250101China Department of Cancer Biology University of Cincinnati College of MedicineCincinnatiOH45267USA School of Pharmaceutical Sciences Cheeloo College of MedicineShandong UniversityJinan250012China Xintian shao Qixin Chenand Lianting Hu contributed equally to this work.Shandong First Medical University&Shandong Academy of Medical SciencesJinan250062China Xintian shao Qixin Chenand Lianting Hu contributed equally to this work.School of Information ManagementWuhan UniversityWuhan430072China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou510275China

Mitochondrial damage,characterized by altered morphological distribution and the damage of cristae,is closely associated with mitochondrial ***,imaging methods for capturing mitochondrial morphology at the nanoscale level in live samples remain unavailable,which seriously hinders the accurate evaluation and diagnosis of mitochondrial-related *** response,we propose a super-resolution quantification strategy based on structured illumination microscopy(SIM)for the rapid,accurate evaluation of mitochondrial *** the strategy,we accurately captured the morphological distribution of mitochondria at the nanoscale level in a way generally applicable to checking various cell processes and identifying patients with mitochondrial disease who exhibit the SLC25A46 *** also used algorithm-assisted super-resolution imaging to quantitatively analyze damage to mitochondrial cristae,which supports a novel drug screening strategy—high-resolution drug screening—for investigating drugs’pharmacodynamics on organelles in living *** short,our strategy improves the accurate examination of changes in mitochondrial morphology in living cells and indicates new ways in which SIM-imaging can assist in diagnosing mitochondrial disease at the single-cell level.

关键词： mitochondria structured illumination microscopy quantification analyze morphology cristae

Scalable synthesis of N-doped Si/G@voids@C with porous structures for high-performance anode of lithium-ion batteries

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Rare Metals 2023年第12期42卷 4091-4102页

作者： Lei wang Yan Jiang shao-Yuan Li Xiu-Hua Chen Feng-Shuo Xi Xiao-Han wan Wen-Hui Ma Rong Deng Faculty of Metallurgical and Energy Engineering State Key Laboratory of Complex Nonferrous Metal Resources Clean UtilizationKunming University of Science and TechnologyKunming 650093China School of Materials Science and Engineering Yunnan UniversityKunming 650091China School of Science and Technology Pu'erUniversityPu'er 665000China School of Photovoltaic and Renewable Energy Engineering(SPREE) University of New South WalesSydney 2052Australia

The co-utilization of silicon(Si) and graphite(G) has been considered as the preferred strategy to achieve high energy density anode materials,but the effective synergistic integration of Si and graphite is still a challenge and it is necessary to find a scheme to accommodate the large-scale production of Si/graphite *** this work,silicon cutting waste from the photovoltaic industry was used as raw material,mixed with graphite,pitch,and polyvinylpyrrolidone,and subjected to high-energy ball *** mixture was then heated in an Ar atmosphere for the carbon coating,and the resulting Si/graphite/carbon(Si/G/C) composite was etched to remove the thicker SiOx layer formed on the Si surface to allow the pores between the Si and the carbon matrix to obtain Si@voids/G@*** from the integrated structural design and the significantly enhanced electronic conductivity,the Si/G@voids@C composite exhibited the first dischargespecific capacity of 2530 mAh·g^(-1) with an initial coulombic efficiency(ICE) of 86.7%,and the remaining capacity exceeded 1000 mAh·g^(-1) after 550 cycles at 1.5A·g^(-1).Notably,full lithium-ion batteries with a Si/G@voids@C anode and LiFePO_4 cathode delivered a stable capacity of 140 mAh·g^(-1).The synthesis method is facile and cost-effective,providing an integration strategy for Si and G with a potential scheme for large-scale commercial applications.

关键词： Silicon/graphite anodes Surface coating Integration strategy Silicon cutting waste High-energy ball milling Lithium-ion battery(LIB)

Clinical characteristics and corticosteroid therapy in patients with autoimmune-hepatitis-induced liver failure

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World Journal of Gastroenterology 2014年第23期20卷 7473-7479页

作者： Bing Zhu shao-Li You Zhi-Hong wan Hong-Ling Liu Yi-Hui Rong Hong Zang shao-Jie Xin Liver Failure Treatment and Research Center 302~(nd) Military Hospital

AIM: To investigate the clinical features, response to corticosteroids, and prognosis of autoimmune hepatitis (AIH)-induced liver failure in China.

关键词： Autoimmune hepatitis Liver failure Autoantibody Prognosis Corticosteroid therapy

An efficient method for mapping the 12C+12C molecular resonances at low energies

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Nuclear Science and Techniques 2019年第8期30卷 77-83页

作者： Xiao-Dong Tang shao-Bo Ma Xiao Fang Brian Bucher Adam Alongi Craig Cahillane wan-Peng Tan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Idaho National Laboratory Idaho FallsID 83415USA Institute for Structure and Nuclear Astrophysics University of Notre DameNotre DameIN 46556USA 123

The 12C+12C fusion reaction is famous because of its complication of molecular resonances,and it plays an important role in both nuclear structural research and astrophysics. It is extremely difficult to measure the cross sections of 12C+12C fusions at energies of astrophysical relevance because of the very low reaction yields. To measure the complicated resonant structure that exists in this important reaction, an efficient thick target method has been developed and applied for the first time at energies Ec.m.<5.3 MeV. A scan of the cross sections over a relatively wide range of energies can be carried out using only a single beam energy. The result of measurement at Ec.m.=4.1 MeV is compared with results from previous *** method will be useful for searching for potentially existing resonances of 12C+12C in the energy range 1 MeV

关键词： 12C+12C Molecular resonance Thick targetmethod 12C(12C, p)^23Na

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

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Neural Regeneration Research 2021年第1期16卷 6-11页

作者： wan Zhang Tian Tian shao-Xin Gong Wen-Qian Huang Qin-Yi Zhou Ai-Ping wang Ying Tian Institute of Clinical Research Affiliated Nanhua HospitalUniversity of South ChinaHengyangHunan ProvinceChina Department of Clinical Laboratory the First Hospital of ChangshaChangshaHunan ProvinceChina Department of Pathology the First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina

Microglia-associated neuroinflammation plays an important role in the pathophysiology of ischemic *** activation and polarization,and the inflammatory response mediated by these cells play important roles in the development,progression and outcome of brain injury after ischemic ***,there is no effective strategy for treating ischemic stroke in clinical ***,it is clinically important to study the role and regulation of microglia in *** this review,we discuss the involvement of microglia in the neuroinflammatory process in ischemic stroke,with the aim of providing a better understanding of the relationship between ischemic stroke and microglia.

关键词： brain cells central nervous system inflammation injury macrophages repair review stroke

Effects of Pb on microstructure, mechanical properties and corrosion resistance of as-cast Mg97Zn1Y2 alloys

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China Foundry 2018年第6期15卷 443-448页

作者： Di-qing wan Ying-lin Hu Shu-ting Ye Hou-bin wang shao-min Wei School of Material Science and Engineering East China Jiaotong University

In this present work, Pb was applied in the Mg97Zn1Y2 alloy to improve its microstructure and properties, using conventional casting methods. The microstructure and properties of the Mg97 Zn1 Y2 alloy and Mg97Zn1Y2-x Pb(x=0.6 wt.%, 1.2 wt.% and 1.8 wt.%) alloys were observed by optical microscopy, scanning electron microscopy method and analyzed by X-ray diffraction, hardness and strength measurement and electrochemical testing. After adding Pb to the Mg97Zn1Y2 alloy, a new particle phase Mg_2 Pb was identified along the grain boundaries, and dendrites were refined. In addtion, the hardness of Mg97Zn1Y2-xPb(x=0.6 wt.%, 1.2 wt.% and 1.8 wt.%) alloys was higher than that of the Mg97 Zn1Y2 alloy; with the increase of Pb content, the hardness of the alloy increased first and then decreased, followed by a final slight increase, and reached a maximum of 89.1 HV when the Pb content was 0.6 wt.%. The strength of the alloy increased first and then decreased as the Pb content increased. Moreover, adding a small amount of Pb to the alloy can effectively inhibit corrosion, and Mg97Zn1Y2-0.6 wt.%Pb exhibits the best corrosion resistance ability.

关键词： Mg-Zn-Y-Pb alloy microstructure LPSO phase mechanical properties corrosion resistance