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IMAGGS: a radiogenomic framework for identifying multi-way associations in breast cancer subtypes

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Journal of Genetics and Genomics 2024年第4期51卷 443-453页

作者： Shuyu Liang Sicheng Xu Shichong Zhou cai Chang Zhiming shao Yuanyuan Wang Sheng Chen Yunxia Huang Yi Guo Department of Electronic Engineering School of Information Science and TechnologyFudan UniversityShanghai 200433China The Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention(MICcai)of Shanghai Shanghai 200032China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200433China Department of Ultrasound Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Breast Surgery Fudan University Shanghai Cancer CenterDepartment of OncologyShanghai Medical CollegeFudan UniversityShanghai 200032China

Investigating correlations between radiomic and genomic profiling in breast cancer(BC)molecular subtypes is crucial for understanding disease mechanisms and providing personalized *** present a well-designed radiogenomic framework image–gene–gene set(IMAGGS),which detects multi-way associations in BC subtypes by integrating radiomic and genomic *** dataset consists of 721 patients,each of whom has 12 ultrasound(US)images captured from different angles and gene mutation *** better characterize tumor traits,12 multi-angle US images are fused using two distinct ***,we analyze complex many-to-many associations between phenotypic and genotypic features using a machine learning algorithm,deviating from the prevalent one-to-one relationship pattern observed in previous *** radiomic and genomic features are screened using these *** addition,gene set enrichment analysis is performed to investigate the joint effects of gene sets and delve deeper into the biological functions of BC *** further validate the feasibility of IMAGGS in a glioblastoma multiforme dataset to demonstrate the scalability of IMAGGS across different modalities and *** together,IMAGGS provides a comprehensive characterization for diseases by associating imaging,genes,and gene sets,paving the way for biological interpretation of radiomics and development of targeted therapy.

关键词： IMAGGS Radiogenomic framework "lmage-gene-geneset"associations Molecular subtypes Breast cancer

Research on the flow stability and noise reduction characteristics of quasi-periodic elastic support skin

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Defence Technology（防务技术） 2024年第3期33卷 222-236页

作者： Lu Chen shao-gang Liu Dan Zhao Li-qiang Dong Kai Li Shuai Tang Jin Cui hong Guo Department of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin150001China

To enhance flow stability and reduce hydrodynamic noise caused by fluctuating pressure,a quasiperiodic elastic support skin composed of flexible walls and elastic support elements is proposed for fluid noise *** arrangement of the elastic support element is determined by the equivalent periodic distance and quasi-periodic *** this paper,a dynamic model of skin in a fluid environment is *** influence of equivalent periodic distance and quasi-periodic coefficient on flow stability is *** results suggest that arranging the elastic support elements in accordance with the quasi-periodic law can effectively enhance flow ***,the hydrodynamic noise calculation results demonstrate that the skin exhibits excellent noise reduction performance,with reductions of 10 dB in the streamwise direction,11 dB in the spanwise direction,and 10 dB in the normal *** results also demonstrate that the stability analysis method can serve as a diagnostic tool for flow fields and guide the design of noise reduction structures.

关键词： Flow stability Quasi-period Flexible wall Elastic support element Hydrodynamic noise

Ileal collision tumor associated with gastrointestinal bleeding: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 628-634页

作者： Yu-Qi Wu hong-Yan Wang Mu-Min shao Lin Xu Xiao-Yan Jiang shao-Ju Guo Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Pathology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND Collision tumors involving the small intestine,specifically the combination of a hamartomatous tumor and a lipoma,are extremely *** our knowledge,no previous case report has described a collision tumor composed of two benign tumors of different origins in the small *** SUMMARY Here,we present the case of an 82-year-old woman who presented with hemorrhagic shock and was found to have a mass measuring approximately 50 mm×32 mm×30 mm in the terminal *** on computed tomography scan findings,the mass was initially suspected to be a lipoma.A subsequent colonoscopy revealed a pedunculated submucosal elevation consisting of two distinct parts with a visible demarcation line.A biopsy of the upper portion suggested a juvenile polyp(JP).Owing to the patient’s advanced age,multiple comorbidities,and poor surgical tolerance,a modified endoscopic submucosal dissection was *** examination of the excised mucosal mass revealed a lipoma at the base and a JP at the top,demonstrating evidence of rupture and associated *** patient’s overall health remained satisfactory,with no recurrence of hematochezia during the six-month follow-up *** This case report provides new evidence for the understanding of gastrointestinal collision tumors,emphasizing their diverse clinical presentations and histopathological *** also offers diagnostic and therapeutic insights as well as an approach for managing benign collision tumors.

关键词： Collision tumor Gastrointestinal bleeding Hamartomatous tumor Lipoma Modified endoscopic submucosal dissection Case report

Optimizing theπ-Bridge of Non-fullerene Acceptors to Suppress Dark Current in NIR Organic Photodetectors

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Chemical Research in Chinese Universities 2024年第4期40卷 712-721页

作者： shao Lin HUANG Yijun hong Ling XU Zishuo YANG Xiye LIU Chunchen HUANG Fei CAO Yong State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSchool of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510640P.R.China Lumidar Technology Co. Ltd.Guangzhou510530P.R.China

Recently,the rapid development of non-fullerene acceptors(NFAs)has laid the foundation for performance improvements in near-infrared(NIR)organic photodetectors(OPDs).However,reducing the bandgap of NFAs to achieve strong absorption in the shorter-wave region usually leads to increased dark current density(J_(d))and decreased responsivity(R),severely limiting the detectivity(D*)of *** date,it remains challenging to manipulate the J_(d) of NIR-OPDs through rational structure engineering of ***,three NIR-NFAs,namely bis(2-decyltetradecyl)4,4′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(6-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(TSIC-4F),bis(2-decyltetradecyl)6,6′-(2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(4-(((Z)-1-(dicyanomethylene)-5,6-difluoro-3-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)thieno[3,4-b]thiophene-2-carboxylate)(STIC-4F),and 2,2′-((2Z,2′Z)-(((2′,7′-di-tert-butylspiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene]-2,6-diyl)bis(2,3-bis(5-(2-butyloctyl)thiophen-2-yl)thieno[3,4-b]pyrazine-7,5-diyl))bis(metha-neylylidene))bis(5,6-difluoro-3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile(TPIC-4F),were designed using the thieno[3,4-b]thiophene(TT)and thieno[3,4-b]pyrazine(TPy)derivatives as theπ-*** to the intramolecular S-S and S-N interactions,STIC-4F and TPIC-4F exhibited smaller backbone distortions than TSIC-4F.A significantly red-shifted absorption with a peak at 1015 nm was observed in TPIC-4F film,larger than that(ca.960 nm)for TSIC-4F and STIC-4F ***,OPDs operating in a photovoltaic mode were successfully fabricated,and TPIC-4F-based OPDs achieved the lowest J_(d) of 3.18×10^(-8) A/cm^(2) at-0.1 ***,although TPIC-4F-based OPDs exhibited the lowest R,higher shot-noise-limited specific detectivity(D_(sh)*)in 1000-1200 nm co

关键词： π-Bridge Near-infrared Non-fullerene acceptor Dark current Organic photodetector

Beyond surgery:Overcoming postoperative depression in cancer patients

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World Journal of Psychiatry 2024年第7期14卷 1140-1142页

作者： shao-Ming Song Xiao Wang hong-Mei Yue Rong Liu The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Faculty of Hepato-pancreato-biliary Surgery The First Medical Center of PLA General HospitalBeijing 100853China

Depression is a common occurrence among cancer patients,and it significantly impacts their clinical outcomes and quality of life,with a high incidence during anti-tumor treatment or after *** association between surgery and depression is the result of the interaction of various factors,including physio-logical,psychological,and social factors,all of which are intertwined and make patients susceptible to depression after surgical *** depression has a significant negative impact on many aspects of cancer patients,and it requires timely identification and intervention to improve the overall outcome.

关键词： Depression Surgery Tumor Anti-tumor therapy

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产业组织三重结构与经济增长

云南财经大学学报 2010年第3期26卷 28-34页

作者：向秋兰蔡绍洪贵州财经学院贵州省经济系统仿真重点实验室贵阳550004

有效的产业组织结构不仅能提升产业竞争力,而且能优化产业结构、促进经济发展。传统的产业组织优化只注重产业市场结构优化,而忽略了产业内企业间的生产组织关系及以组织、协调为特征的管理组织关系。从市场组织结构、生产组织结构和管... 详细信息

有效的产业组织结构不仅能提升产业竞争力,而且能优化产业结构、促进经济发展。传统的产业组织优化只注重产业市场结构优化,而忽略了产业内企业间的生产组织关系及以组织、协调为特征的管理组织关系。从市场组织结构、生产组织结构和管理组织结构的角度出发,重新剖析了产业组织优化的内涵。在循环经济基础上发展产业集群,是三种组织结构整合的结果,是促进中国产业组织合理化,从而推动区域经济发展的必然趋势和可靠选择。

关键词：产业生产组织循环经济产业市场组织产业管理组织产业集群产业组织优化

奥斯特罗姆自主治理理论的主要思想及实践意义

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贵州财经学院学报 2010年第5期 18-24页

作者：蔡绍洪向秋兰贵州财经学院贵州贵阳55004

埃莉诺.奥斯特罗姆提出的公共资源自主治理思想,从理论上探讨了市场和政府之外自主治理公共资源的可能性,拓宽了制度分析的视野,对公共事务治理理论发展做出了巨大贡献。不仅如此,建立在自主治理思想基础上的公共资源管理模式,在提高资... 详细信息

埃莉诺.奥斯特罗姆提出的公共资源自主治理思想,从理论上探讨了市场和政府之外自主治理公共资源的可能性,拓宽了制度分析的视野,对公共事务治理理论发展做出了巨大贡献。不仅如此,建立在自主治理思想基础上的公共资源管理模式,在提高资源利用率、缓解生态环境压力、激发公民意识以及发展民主政治等方面均具有突出的实践指导意义。

关键词：奥斯特罗姆公共资源自主治理制度

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低碳经济约束与西部地区资源型产业发展

商业研究 2012年第5期 140-145页

作者：蔡绍洪陈胜男贵州财经学院欠发达地区发展研究中心贵阳550004

我国西部具有资源优势,然而资源型产业的生产效率却很低下,"三高一低"的发展模式不仅造成了资源的大量浪费,也带来了严重的生态环境问题。在低碳经济约束下,西部地区面临着跨越式快速发展和可持续绿色发展的双重任务,单纯的产业集群和... 详细信息

我国西部具有资源优势,然而资源型产业的生产效率却很低下,"三高一低"的发展模式不仅造成了资源的大量浪费,也带来了严重的生态环境问题。在低碳经济约束下,西部地区面临着跨越式快速发展和可持续绿色发展的双重任务,单纯的产业集群和单纯的循环经济都不能很好地解决这一问题,只有采用循环产业集群模式,资源型产业才能避免以牺牲环境为代价发展的恶性循环,并形成经济效益与生态效益双赢的统一,实现可持续的快速发展。

关键词：低碳经济西部地区资源型产业可持续发展循环产业集群

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双气囊小肠镜在儿科患者中的应用

中华儿科杂志 2010年第8期48卷 599-602页

作者：黄瑛邵彩虹梁英杰复旦大学附属儿科医院消化科上海201102

目的探讨双气囊小肠镜在儿童中的使用方法、安全性,评价其临床价值,及其在儿科应用的困难.方法本组22例,为2006年12月至2009年10月在我院消化科住院,因为胃肠道出血、再发性腹痛、低蛋白血症等原因接受双气囊小肠镜检查患儿,年龄4～16... 详细信息

目的探讨双气囊小肠镜在儿童中的使用方法、安全性,评价其临床价值,及其在儿科应用的困难.方法本组22例,为2006年12月至2009年10月在我院消化科住院,因为胃肠道出血、再发性腹痛、低蛋白血症等原因接受双气囊小肠镜检查患儿,年龄4～16岁,所有操作均在麻醉下进行,患儿均取仰卧位,利用双气囊小肠独有的外套管、肠镜前端的双气囊交替充气、放气,经幽门或回盲瓣进入小肠,小肠镜和外套管不断地前进和退镜,将小肠缩短到内窥镜可以检查的范围.在检查过程中记录检查范围、病变,患儿耐受性等.结果本组共接受25例次双气囊小肠镜检查,其中3例次顺行进镜,22例次逆行进镜;3例同时经口和经肛门检查.18例发现病灶,病变检出率为81.82%.所有操作均在麻醉下进行,包括麻醉和术后恢复,一般需要90～120 min.本组均未发生吸入性肺炎、肠道穿孔、出血等严重并发症.通过双气囊小肠镜,诊断克罗恩病7例,Meckel憩室并溃疡3例,空肠、横结肠息肉1例,小肠淋巴管扩张症1例、阿米巴肠炎1例、小肠炎出血3例,非特异性回肠炎2例.本组均耐受检查,未发现严重不良反应和并发症.结论双气囊小肠镜对小肠疾病有良好的检出率,儿童患者能耐受检查,在儿科患者中应用是有效和可行的.但双气囊小肠镜在儿科的推广应用仍受到一些因素的制约.

关键词：内窥镜检查,消化系统小肠儿童美克尔憩室