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Significant effect of ordered micro-domain on cell boundary phase distribution and demagnetization curve squareness of Sm_(2)Co_(17)-type magnet

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Rare Metals 2024年第4期43卷 1724-1735页

作者： Zhuang Liu Hai-Chen Wu Chao-Yue Zhang Chao-qun Zhu Guo-Xin Chen Huan-Ming Lu Ren-Jie Chen Aru yan CISRI&NIMTE Joint Innovation Center for Rare Earth Permanent Magnets Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China Analytical Center Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China

Cu-rich cell boundary phase is difficult to precipitate evenly,resulting in a generally poor demagnetization curve squareness for Fe-rich Sm_(2)Co_(17)-type magnet,which is a key factor limiting the further improvement of magnetic energy *** this study,we report that nanoscale strip-like ordered micro-domains distributed in1:7H disordered matrix phase of the solid solution precursor is a new factor significantly affecting the precipitation and distribution of the cell boundary *** strip-like and continuous micro-twin structure with twin boundaries neatly perpendicular to the C-axis is observed after sintering *** solution treatment,sequential and long strip-like micro-twins gradually transform into disordered state along the basal plane,forming narrow disordered 1:7H(TbCu_(7)-type structure)phase between the separated strip-like ordered *** disordering transformation takes place via broken down of the long strip-like ordered micro-domains,which is accomplished by narrowing along the width direction followed by reduction of the ***,a new model revealing the effect of the ordered micro-domains on the formation of the cell boundary phase is *** boundaries enriched in Cu have already existed in the precursor with long strip-like ordered ***,the Cu-rich cell boundary phase acting as strong pinning centers cannot be precipitated homogeneously and distributed continuously after aging,resulting in a poor demagnetization curve squareness of Sm_(2)Co_(17)-type *** results indicate that significant broken down of the nanoscale ordered micro-domains in solution precursor is the key factor improving the distribution of cell boundary phase in Sm_(2)Co_(17)-type magnets.

关键词： Sm_(2)Co_(17) magnets Solution precursor Ordered micro-domains Disordering transformation Cellular structure

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Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： Xing-yang Wu Hui-Hui Fang yan-Wu Xu yan-Ling Zhang shao-Chong Zhang Wei-Hua yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

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Recent Advances of Bioactive Marine Natural Products in Drug Discovery

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Journal of Ocean University of China 2024年第5期23卷 1297-1318页

作者： ZHANG qun LV Liuxia WANG Wenhui WEI Meiyan GU Yucheng shao Changlun Key Laboratory of Marine Drugs Ministry of Education of China School of Medicine and Pharmacy Ocean University of China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education College of Chemistry and Chemical Engineering Hainan Normal University Syngenta Jealott's Hill International Research Centre

Marine natural products(MNPs) are valuable resources for drug development. To date, 17 drugs from marine sources are in clinical use, and 33 pharmaceutical compounds are in clinical trials. Presently the success of drug development from the marine resources is higher than the industry average. It is a feasible strategy to conduct the discovery of drug-lead compounds based on marine chemical ecology by fully exploiting the pharmacological potential of marine chemical defense matters. In the search for bioactive MNPs, our group has constructed a biological resources library including more than 1500 strains of fungi. Focusing on the strategy of Blue Drug Library, we have discovered a series of novel MNPs with abundant biological functions. Highly efficient and scalable total synthesis of(+)-aniduquinolone A(44) and pesimquinolone I(48) have been completed, which will facilitate access to sufficient quantities of candidates for in vivo pharmacological and toxicological studies. As a nucleoprotein(NP) inhibitor, QLA(75) possesses significant anti-influenza A virus(IAV) activities both in vitro and in vivo. CHNQD-00803(76) is a potent and selective AMPactivated kinase(AMPK) activator that can effectively inhibit metabolic disorders and metabolic dysfunction-associated steatohepatitis(MASH) progression. Moreover, we identified two new candidate molecules with potent anti-hepatocellular carcinoma effects. Particularly, as a natural guanine-nucleotide exchange factors for ADP-ribosylation factor GTPases(Arf-GEFs) inhibitor prodrug, CHNQD-01255(78) is qualified to be developed as a targeted candidate anticancer drug, which may be promising to apply for cancer immunotherapy. Hence, it is evident that MNPs play an important role in drug development.

关键词： discovery and optimization drug development marine drug marine medicinal organisms natural products

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Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei Sun Xu Zhang Shu-Ping Song Ya-qun Yao yan Zhang Cheng-Liang Wang Jing-Jiang Sun Qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

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Circ_0004592:An auxiliary diagnostic biomarker for gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2757-2768页

作者： Shan Kong yan-Hua Xu Ming Zheng shao-Qing Ju Heng-Chuan Shi Department of Laboratory Medicine Jiangsu Province Official HospitalNanjing 210000Jiangsu ProvinceChina Department of Laboratory Medicine Northern Jiangsu People’s HospitalYangzhou 225000Jiangsu ProvinceChina Department of Laboratory Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate,and robust diagnostic biomarkers are currently ***,the clinical relevance of circular RNAs(circRNAs)as GC biomarkers remains largely *** To evaluate the potential of novel circRNA circ_0004592 in the early screening and prognosis of *** High-throughput sequencing of circRNAs was performed to screen for potential target ***_0004592 expression was examined in GC tissues,cells,and *** samples were collected from healthy subjects’patients,as well as from patients with benign lesions,precancerous lesions,and GC,whereafter the diagnostic accuracy of circ_0004592 was *** correlation between circ_0004592 levels in plasma and clinicopathological data of patients with GC was further *** Circ_0004592 was upregulated in both the tissue and plasma of patients with ***,circ_0004592 expression was higher in patients with precancerous lesions than in healthy controls while being highest in patients with *** the same patient,the postoperative plasma level of circ_0004592 was lower than that in the preoperative ***,circ_0004592 level was significantly correlated with tumor differentiation,tumor depth,and lymph node *** area under the curve(AUC)of plasma circ_0004592 exhibited high sensitivity and specificity for differentiating patients with GC from healthy *** based on circ_0004592,carcinoembryonic antigen,and cancer antigen 199 achieved a superior AUC and was highly *** Plasma circ_0004592 may represent a potential non-invasive auxiliary diagnostic biomarker for patients with GC.

关键词： Biomarker Circular RNA Diagnosis Gastric cancer Plasma

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Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

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Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan JIANG Dong-yan CUI Ai ZHANG Xiong WANG Ai-guo LIU qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

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Inertinite in coal and its geoenvironmental significance:Insights from AI and big data analysis

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Science China Earth Sciences 2024年第6期67卷 1779-1801页

作者： Longyi shao Jiamin ZHOU Timothy PJONES Fanghui HUA Xiaotao XU Zhiming yan Haihai HOU Dongdong WANG Jing LU State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources and College of Geoscience and Surveying Engineering China University of Miningand Technology(Beijing)Beijing 100083China School of Earth and Environmental Sciences Cardiff UniversityCardiff CF103YEWalesEngland General Prospecting Institute of China National Administration of Coal Geology Beijing 100039China Institute of Architectural Engineering Weifang UniversityWeifang 261061China College of Mining Liaoning Technical UniversityFuxin 123000China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Inertinite,as an important and abundant maceral group in coal,is critical for the study of palaeowildfires and their roles in the Earth’s ***,there has been a significant amount of research on the relationship between palaeowildfire,palaeoclimate change and palaeovegetation evolution based on inertinite *** reflectance of fusinite and semifusinite has been used to estimate the combustion temperature and type of palaeowildfires,and then to evaluate the combustion characteristics of different types of *** relative abundance of inertinite can be used to estimate the atmospheric oxygen *** rapid development of artificial intelligence(AI)and online tools to search scientific databases has presented an opportunity for us to find,collect,arrange,and analyse data from the earliest to latest publications on *** data extraction tool Deep Shovel is used to collect and analyse global inertinite data from the Silurian to the *** software programs such as Gplates,ArcGIS pro and Tableau are then applied to model the relative abundance of inertinite over geological time,which can be correlated with other parameters such as atmospheric oxygen contents,plant evolution and palaeoclimate *** distribution of inertinite in coals varied over different geological periods,being typified by the“high inertinite content-high atmospheric oxygen level”period in the Permian and the“low inertinite content-low atmospheric oxygen level”period in the *** study has proposed a possible model of the positive and negative feedbacks between inertinite characteristics and palaeoenvironmental factors,and has revealed the exceptional role of inertinite in palaeoenvironmental *** research on inertinite will be focused on the integrated study of organic petrology and organic geochemistry of inertinite,the big data-driven research on the temporal and spatial distribution of the global inertinite,the exploration of the

关键词： Inertinite Palaeowildfires Atmospheric oxygen Palaeoclimates Palaeoecosystems

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退火温度对Ti/IrO_2-Ta_2O_5电极的结构和电容性能的影响

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材料热处理学报 2017年第4期38卷 25-31页

作者：罗彦兰于文泰李彦泽邵艳群唐电福州大学材料科学与工程学院福建福州350108

采用热分解法在Ti基体上制备了Ti/IrO_2-Ta_2O_5氧化物电极涂层。采用X射线衍射、循环伏安、恒流充放电、交流阻抗等方法对其组织结构和电化学性能之间的关系进行了详细研究。结果表明:温度低于350℃的电极以非晶态的形式存在,当温度为... 详细信息

采用热分解法在Ti基体上制备了Ti/IrO_2-Ta_2O_5氧化物电极涂层。采用X射线衍射、循环伏安、恒流充放电、交流阻抗等方法对其组织结构和电化学性能之间的关系进行了详细研究。结果表明:温度低于350℃的电极以非晶态的形式存在,当温度为370℃时,金红石衍射峰出现,说明在350~370℃范围为电极的临界结晶温度区间。370℃下制备的电极具有最大的积分电量,电量损失率最小,比电容达到最大值,为239.2 F/g。随温度升高,电荷转移电阻R_(ct)总体呈下降趋势。

关键词：组织结构超级电容器电容性能 IrO2-Ta2O5二元氧化物热分解

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Anomalous thermal expansion and enhanced magnetocaloric effect in<001>-textured Mn_(x)Fe_(5-x)Si_(3) alloys

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Rare Metals 2024年第5期43卷 2263-2274页

作者： Yong Gong Xue-Fei Miao Tapas Samanta Chris Taake Jun Liu Feng-Jiao Qian yan-yan shao Yu-Jing Zhang Qing-Yong Ren Luana Caron Feng Xu MIIT Key Laboratory of Advanced Metallic and Intermetallic Materials Technology School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing210094China Department of Physics Bielefeld University33501BielefeldGermany College of Physics Nanjing University of Aeronautics and AstronauticsNanjing210016China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Spallation Neutron Source Science Center Dongguan523803China Guangdong-Hong Kong-Macao Joint Laboratory for Neutron Scattering Science and Technology Dongguan523803China Department of Physics Bielefeld University33501BielefeldGermany Helmholtz-Zentrum Berlin für Materialien und Energie12489BerlinGermany

The development of zero and negative therma expansion(i.e.,ZTE and NTE)materials is of crucial importance to the control of undesirable thermal expansion for high-precision *** the present work,ZTE and NTE were obtained in directionally-solidified Mn_(x)Fe_(5-x)Si_(3)alloys with a strongtexture,in striking contrast to positive thermal expansion in their isotropic counterparts Magnetometry and in-situ X-ray diffraction(XRD)measurements were performed to uncover the origin of the anomalous thermal *** measurements indicate a strong easy-plane magnetocrystalline anisotropy in the textured samples,where the magnetic moments are aligned within the ab plane of the hexagonal structure Temperature-dependent XRD on the x=1 sample reveals a ZTE character in the ab plane that is coupled to a ferromagnetic *** a result,the macroscopic ZTE(~0.22×10^(-6)K^(-1))in the x=1 sample can be attributed to the microscopic magneto volume effect within the ab plane,which is realized by the introduction of the-textured ***,the competition between antiferromagnetic and ferromagnetic exchange coupling leads to NTE in textured x=1.5 and 2 ***,textured x=1 sample displays enhanced magnetocaloric properties as compared to the conventional counterparts with randomly-oriented *** this work demonstrates a new strategy toward the exploration of anomalous thermal expansion properties as well as the enhancement of magnetocaloric properties for materials with a strong magnetocrystalline anisotropy.

关键词： MnFeySis Magnetocaloric effect Magnetic phase transition Negative thermal expansion

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Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-Nian Wu Kai He Yi-Bei Yu Bo Zheng shao-Jun Zhu Xiang-Qian Hong Wen-qun Xi Zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

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