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Total knee arthroplasty using computer assisted navigation in patients with severe valgus deformity of the knee

Chinese Medical Journal 2010年第19期123卷 2666-2670页

作者： shao jun-jie zhang xian-long wang qi chen yun-su shen hao jiang yao Department of Joint surgery Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China

Background Severe valgus deformity often has bone defect and laxity of the medial ligamentous, and total knee arthroplasty in severe valgus knee is, in most cases, more challenging for surgeons. The usefulness of a computer assisted navigation system in reestablishing the mechanical axis has been well established. Hence, the interest for surgeons is how the navigation system makes the procedure of total knee arthroplasty with severe valgus knee easier. Methods From june 2006 to March 2008 in Department of Joint surgery, Shanghai Sixth People＇s Hospital, 6 patients （7 knees） with severe valgus knee underwent total knee arthroplasty using the Stryker Navigation system, which is an active wireless and imageless system. All the patients were followed up for 12 to 18 months after surgery. The X-ray radiographs for whole limbs were obtained on all patients to determine preoperative and postoperative alignments. Results A primary, posterior stabilized prosthesis was utilized in all cases. The average preoperative overall mechanical axis of the seven knees was 19.6°±4.6° of valgus （range 16°to 29°）, and the average postoperative mechanical axis was 0.4°±0.7° （range 0.8° varus to 1.4° valgus ）. Conclusions The navigation system is a very effective and useful tool for accurate intraoperative restoration of alignment in the face of significant deformity with valgus knee. To prevent component malposition, we did not reduce the knee before solidification of bone cement but controlled alignment using the navigation system up to implantation of the final component.

关键词： arthroplasty knee replacement computer assisted surgery

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Anatomical references for tibial sagittal alignment in total knee arthroplasty： A comparison of three anatomical axes based on 3D reconstructed CT images

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Chinese Medical Journal 2013年第20期126卷 3840-3844页

作者： shao jun-jie Vail, Thomas Parker wang qiao-jie shen hao chen yun-su wang, qi jiang yao zhang xian-long Shanghai Jiao Tong Univ Shanghai Peoples Hosp 6 Dept Joint Surg Shanghai 200233 Peoples R China Univ Calif San Francisco Dept Orthopaed Surg San Francisco CA 94143 USA

Background This study was designed to analyze three tibial axis reference lines including the anterior tibial cortex （ATC） line, the fibular line （FL）, and the anatomical axis of tibia （AAT） line, to determine which line most closely parallels the mechanical axis （MA） of the tibia in the sagittal plane. The clinical relevance of the study is that through finding a reliable landmark on the leg, a surgeon may minimize posterior tibial slope measurement errors thereby and improving the technique for assuring proper alignment of total knee arthroplasty.

关键词： knee arthroplasty fibula tibia," axis," computer-assisted image reconstruction

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辐照深冻异体骨打压植骨在髋臼翻修中的应用

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中华外科杂志 2010年第14期48卷 1045-1049页

作者：王琦张先龙蒋垚陈云苏沈灏邵俊杰上海交通大学附属第六人民医院骨科 200233

目的研究辐照深冻异体骨用于髋臼翻修中严重骨缺损的打压植骨重建的临床效果.方法 2006年2月至2009年1月髋关节翻修术中共有20例21髋应用打压植骨技术结合金属网重建严重髋臼侧骨缺损,18例19髋获得随访.患者翻修时平均年龄为64.4岁（43... 详细信息

目的研究辐照深冻异体骨用于髋臼翻修中严重骨缺损的打压植骨重建的临床效果.方法 2006年2月至2009年1月髋关节翻修术中共有20例21髋应用打压植骨技术结合金属网重建严重髋臼侧骨缺损,18例19髋获得随访.患者翻修时平均年龄为64.4岁（43～81岁）.采用Paprosky分型,本组患者均有髋臼骨缺损,其中PaproskyⅡB型4髋,PaproskyⅡC型8髋,PaproskyⅢA型5髋,PaproskyⅢB型2髋.手术用金属网修复髋臼节段性缺损,采用辐照深冻同种异体颗粒骨打压植骨结合骨水泥臼杯完成髋臼翻修.患者术后定期进行影像学和临床评估,观察手术前后髋关节Harris评分变化,假体移位松动及异体骨骨整合情况,及术中、术后并发症等.术前Harris评分平均42.5分（31～56分）.术前疼痛评分平均14.4分（10～20分）.结果患者平均随访时间22.4个月（12～48个月）.术后Harris评分提高到88.6分（82～96分）.术后疼痛评分提高至平均42.3分（40～44分）.并发症：术后感染1例,经清创愈合.股神经损伤1例,术后1年随访时已恢复正常.1例患者术后出现股骨近端外侧皮质吸收,大粗隆骨折.有1例Paprosky ⅢB型患者出现金属网及髋臼杯明显移位等影像学松动表现,其余18髋的髋臼假体稳定,未发现臼杯在垂直和水平方向大于1 mm的移位,也未发现髋臼假体外展角的改变;植骨层和宿主骨床可见连续骨小梁通过、移植骨与周围骨床骨密度趋向一致等骨整合表现.结论金属网与打压植骨及骨水泥髋臼技术联合应用能有效地完成髋臼的生物学翻修.辐照深冻异体骨用于打压植骨能与周围骨床很好的整合.

关键词：关节成形术置换髋治疗失败髋关节翻修骨缺损打压植骨

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髋关节表面置换术治疗先天性髋关节发育不良

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中华外科杂志 2008年第17期46卷 1293-1296页

作者：王琦张先龙蒋垚陈云苏沈灏邵俊杰上海交通大学附属第六人民医院骨科 200233

目的探讨髋关节表面置换术治疗先天性髋关节发育不良的临床疗效。方法2005年3月至2006年12月对34例（37髋）先天性髋关节发育不良患者行髋关节表面置换术，其中CroweⅠ型28例（31髋）、CroweⅡ型6例（6髋）。其中女性29例（32髋），男性... 详细信息

目的探讨髋关节表面置换术治疗先天性髋关节发育不良的临床疗效。方法2005年3月至2006年12月对34例（37髋）先天性髋关节发育不良患者行髋关节表面置换术，其中CroweⅠ型28例（31髋）、CroweⅡ型6例（6髋）。其中女性29例（32髋），男性5例（5髋），患者平均年龄45岁（26～57岁）。患者在术后6周、3个月、1年，及此后每年1次进行随访，接受放射学及临床评价。术前患者Harris评分平均35分，髋关节屈曲101°，外展24°，内收15°，术前12例患者双下肢等长。结果34例患者中，3例（3髋）患者术中改行全髋关节置换术。31例（34髋）行表面置换。31例表面置换患者平均随访时间21．4个月（12～33个月）。患者术后最后一次随访平均为94分（82～100分），与术前比较差异具有统计学意义（P〈0.01）。术后髋关节屈曲改善至133°，外展48°，内收26°。术后23例患者双下肢等长。患者股骨及髋臼假体周围均未见透亮线，髋臼假体的平均外展角为43°（40°～53°），股骨假体柄干角平均为139°（130°～145°）。结论本组患者短期随访结果令人满意，良好的手术技术和手术适应证的严格掌握是先天性髋关节发育不良患者手术成功的关键。

关键词：髋脱位先天性关节成形术置换髋髋关节表面置换

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晚期髋关节结核的非骨水泥全髋关节置换

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中华医学杂志 2012年第35期92卷 2456-2459页

作者：沈灏王俏杰张先龙蒋垚王琦陈云苏邵俊杰上海交通大学附属第六人民医院关节外科 200233

目的评估非骨水泥全髋关节置换治疗晚期髋关节结核的临床效果。方法上海交通大学附属第六人民医院关节外科2004年7月至2008年9月，共晚期髋关节结核病例行全髋置换术14例，男8例，女6例。术前有1例存在开放性窦道，3例存在陈旧性已闭合... 详细信息

目的评估非骨水泥全髋关节置换治疗晚期髋关节结核的临床效果。方法上海交通大学附属第六人民医院关节外科2004年7月至2008年9月，共晚期髋关节结核病例行全髋置换术14例，男8例，女6例。术前有1例存在开放性窦道，3例存在陈旧性已闭合窦道瘢痕。术前C反应蛋白（CRP）和红细胞沉降率（ESR）正常者未行术前抗结核治疗；CRP升高、ESR升高者给予术前抗结核治疗2周后再手术。14例中有12例采用一期彻底清创，非骨水泥假体全髋置换，其中1例髋关节高脱位，行粗隆下截骨。另2例术中发现结核，而术前未行抗结核治疗或病灶范围较广泛对彻底清创没有把握，采用间隔物植入，6～8个月后二期置换非骨水泥假体。所有病例术后均采用抗结核药物治疗6个月。结果术后随访平均49（27～77）个月，HSS评分从术前平均36分到术后最后一次随访平均87分。1例患者术后7个月出现结核复发，行清创术并去除假体做关节成形，其余13例没有发现结核复发、感染、脱位、骨折和神经血管损伤等并发症。终末随访没有发现进展性的透亮线或腔隙等假体松动的迹象。结论非骨水泥人工全髋关节置换是治疗晚期髋关节结核的有效方法。

关键词：关节成形术置换髋结核骨关节

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非骨水泥假体二期翻修治疗慢性人工全髋关节置换术后感染

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中华外科杂志 2012年第5期50卷 402-406页

作者：沈灏王俏杰张先龙蒋垚王琦陈云苏邵俊杰上海交通大学医学院附属第六人民医院关节外科 200233

目的探讨非骨水泥假体二期翻修治疗慢性髋关节假体周围感染的临床疗效。方法回顾性分析自2002年1月至2009年12月因髋关节假体周围慢性深部感染而采用非骨水泥股骨组件行二期翻修的23例患者资料，其中男性9例，女性14例；年龄52-78岁，... 详细信息

目的探讨非骨水泥假体二期翻修治疗慢性髋关节假体周围感染的临床疗效。方法回顾性分析自2002年1月至2009年12月因髋关节假体周围慢性深部感染而采用非骨水泥股骨组件行二期翻修的23例患者资料，其中男性9例，女性14例；年龄52-78岁，平均（64±8）岁。所有患者一期手术彻底清创并插入含抗生素骨水泥间隔物，术后静脉使用敏感抗生素2周后改口服抗生素4周。一期取出假体术后平均6．7个月（3-28个月）采用非骨水泥股骨假体进行二期翻修术，术后静脉使用抗生素2周后改口服抗生素4周，然后停药。观察统计手术相关并发症，评估关节功能及治疗效果。结果术后平均随访（4．3±3．5）年，所有病例中2例再次发生感染，有3例发生术中骨折，1例在两次手术中间发生间隔物脱位，二期翻修手术后共2例发生脱位。所有病例中1例患者出现股骨柄轻度下沉，所有感染未复发病例均没有发生股骨组件和非骨水泥髋臼组件的松动。Harris评分从术前（36±13）分上升到术后12个月（85±13）分。结论采用非骨水泥假体二期翻修治疗髋关节假体周围慢性感染可以获得良好的感染控制率和假体稳定性，但对耐药菌感染的治疗采用非骨水泥假体时需要慎重。

关键词：关节成形术,置换,髋髋假体假体相关感染再手术

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Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2522-2532页

作者： Nawal Al Kaabi yun Kai Yang Jing zhang Ke Xu Yu Liang yun Kang Ji Guo su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai shao Sen Sen Yang Wenwen Lei Xue jun Gao Zhiwei jiang Hui wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue zhang Chang Qu Dan Ying Liu Jing zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian wang Jin Liang Yin Xiao Yan Mao Jin zhang Ning Liu Fu jie shen Liang Qu yun Tao zhang Xiao Ming Yang Guizhen Wu qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUnited Arab Emirates China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUnited Arab Emirates G42 Healthcare Abu DhabiUnited Arab Emirates

The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster *** conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as *** groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV *** assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control *** Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous *** results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and *** heterologous and homologous boosters have a good safety *** and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster *** findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron.

关键词： phase neutral GMT

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股骨近端粗隆间后侧纵形截骨法在全髋关节翻修术中的应用

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中华外科杂志 2010年第14期48卷 1065-1068页

作者：蒋垚张立智王琦陈云苏沈灏邵俊杰张先龙上海交通大学附属第六人民医院骨科 200233

目的探讨股骨近端粗隆间后侧纵形截骨在全髋翻修术中应用的初步经验.方法 2005年9月至2009年12月对35例患者应用股骨近端粗隆间后侧纵形截骨法取出股骨侧假体,截骨长度约11～14 cm,宽约1 cm.翻修假体为生物固定型组合式翻修假体,腔隙... 详细信息

目的探讨股骨近端粗隆间后侧纵形截骨在全髋翻修术中应用的初步经验.方法 2005年9月至2009年12月对35例患者应用股骨近端粗隆间后侧纵形截骨法取出股骨侧假体,截骨长度约11～14 cm,宽约1 cm.翻修假体为生物固定型组合式翻修假体,腔隙性骨缺损采用了颗粒异体骨植骨,钢丝环扎固定复位截骨块.对手术前、后Harris评分、肢体长度以及影像学改变进行评估.术前Harris评分平均30分（19～40分）,其中疼痛评分平均12分（10～20分）.结果 35例患者术后平均随访15个月（5～55个月）.术后Harris评分平均85分（80～92分）,其中疼痛评分平均40分（30～44分）.股骨截骨处及植骨均愈合,平均愈合时间约20周（10～32周）.未发生钢丝滑脱、感染、脱位、假体松动等并发症.结论短期随访表明,股骨近端粗隆间后侧纵形截骨法有利于股骨假体的显露和取出,便于髓腔清理以及股骨侧重建,在全髋翻修术中是一种操作相对容易、有效町靠的方法.

关键词：关节成形术,置换,髋治疗失败髋关节翻修后侧纵形截骨

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Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants:a randomized phase 2 trial

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Signal Transduction and Targeted Therapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi yun Kai Yang Yu Liang Ke Xu Xue Feng zhang yun Kang Yu qin Jin jun Wei Hou Jing zhang Tian Yang Salah Hussein Mohamed Saif ElDein Ze Hua Lei hao zhang Shuai shao Zhao Ming Liu Ning Liu xiang Zheng Ji Guo su Sen Sen Yang xiangfeng Cong yao Tan Wenwen Lei Xue jun Gao Zhiwei jiang Hui wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue zhang Chang Qu Dan Ying Liu Jing zhang Mengjie Yang Islam Eltantawy Peng Xiao Fu jie shen Jin Juan Wu Zi Bo Han Li Fang Du Fang Tang Shi chen Zhi Jing Ma Fan Zheng Ya Nan Hou Xin Yu Li Xin Li Zhao Nian wang Jin Liang Yin Xiao Yan Mao Jin zhang Liang Qu yun Tao zhang Xiao Ming Yang Guizhen Wu qi Ming Li Sheikh Khalifa Medical City SEHAAbu DhabiUAE College of Medicine and Health Sciences Khalifa UniversityAbu DhabiUAE China National Biotec Group Company Limited BeijingChina The Sixth Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzhou Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 Healthcare Abu DhabiUAE

An ongoing randomized,double-blind,controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from the United Arab Emirates(UAE),who had administered two or three doses of inactivated vaccine BBIBP-CorV at least 6 months prior to *** participants were randomly assigned with 1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and the exploratory outcome was cross-immunogenicity against other circulating *** May 25 and 30,2022,516 adults received booster vaccination with 260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results showed a similar safety profile between two booster groups,with low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,the fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably higher than those by BBIBP-CorV against the prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,the neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold higher than those by *** findings indicated that a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： phase neutral spectrum

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi su sun-Bin Ling qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia Li Zhuang Tian shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo sun Guang-Ming Li Tai-Shi Fang Nan jiang Kun zhang Zhao-jie su Zhi-Hai Peng Ren Lang Tao jiang qiang He Lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi Guo Liu-Gen Lan Xu-Yong sun Dong chen Zhi-Shui chen Da-Wei Zhou shao-jun Ye qi-Fa Ye Min Tian Jian-Hua Shi Bo wang jiang Liu qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen wang Lin Zhong Jing-sheng Ma qi-Gen Li sheng-Dong Wu Chang-jiang Lu Cai-De Lu Dong-Hua zhang Xuan wang Zi-qiang Li Mu-Jian Teng jun-jie Li Wen-Tao jiang Jian-Hua Li Quan-Bao zhang Ning-qi Zhu Zheng-Xin wang Kang He qiang Xia shao-Hua Song Zhi-Ren Fu Wei qiu Guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang Jian Zhou Gang chen Ying-Peng Zhao Li Li Ze-Min Hu qi-jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong Guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

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