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Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study

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International Journal of Dermatology and Venereology 2024年第2期7卷 78-83页

作者： Jin Zhang Xiao-Yu Zhu Jing-Wei Liu Yue-Ping Yin shao-Chun Chen Reference Laboratory for STD Control Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences&Peking Union Medical CollegeNanjingJiangsu 210042China National Center for STD Control Chinese Center for Disease Control and PreventionNanjingJiangsu 210042China

Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015.and *** multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant *** results are described as ***:Seventy-four(3.6%)cephalosporin-resistant isolates were ***_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365.(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)***-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5.8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported *** CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are *** the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关键词： gonorrhea resistance cephalosporin cefixime ceftriaxone

超高效液相色谱-串联质谱法测定调节三高类保健食品中5.种非法添加药物

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食品科学 2024年第9期45卷 232-242页

作者：邵瑞婷丁学妍姜洁北京市食品检验研究院(北京市食品安全监控和风险评估中心) 国家市场监管重点实验室(食品安全重大综合保障关键技术)北京100041

本实验建立了调节三高类保健食品中5.种非法添加药物的超高效液相色谱-串联质谱检测方法。样品经甲醇提取,QuEChERS净化,氮吹至近干,1 mL 40%甲醇溶液(体积分数)复溶,以乙腈和0.1%甲酸溶液(5.mmol/L乙酸铵)为流动相,经ACQUITY UPLC HSS... 详细信息

本实验建立了调节三高类保健食品中5.种非法添加药物的超高效液相色谱-串联质谱检测方法。样品经甲醇提取,QuEChERS净化,氮吹至近干,1 mL 40%甲醇溶液(体积分数)复溶,以乙腈和0.1%甲酸溶液(5.mmol/L乙酸铵)为流动相,经ACQUITY UPLC HSS T3反相柱梯度分离,超高效液相色谱-串联质谱在正、负离子模式下多反应监测,采用基质外标法定量。结果表明:5.种非法添加药物在线性范围内,决定系数(R^(2))均大于0.980,回收率在60.2%~119.5.之间,相对标准偏差在1.2%~15.0%之间。该方法具有前处理较简单、分析时间较短、灵敏度好、准确度高、杂质干扰小等特点,可以用于调节三高类保健食品中多种非法添加药物的检测。

关键词：调节三高类保健食品 QuEChERS净化超高效液相色谱-串联质谱非法添加药物

Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality

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Precision Chemistry 2024年第5期2卷 208-220页

作者： Shuang Yang Jia-Bo Huang Da-Hua Wang Ning-Yi Wang Yu-Yu Chen Xin-Yan Ke Hao Chen shao-Fei Ni Yu-Chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China Department of Chemistry Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Otolaryngology Xuzhou First People’s HospitalAffiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221002China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China

The catalytic asymmetric diastereodivergent synthesis of axially chiral 2-alkenylindoles was established via chiral phosphoric acid-catalyzed addition reactions of C3-unsubstituted 2-alkenylindoles with o-hydroxybenzyl alcohols under different reaction *** this strategy,two series of 2-alkenylindoles bearing both axial and central chirality were synthesized in a diastereodivergent fashion with moderate to high yields and good stereoselectivities(up to 99%yield,95.5.er,>95.5.dr).Moreover,theoretical calculations were performed on the key transition states leading to different stereoisomers,which provided an in-depth understanding of the origin of the observed stereoselectivity and diastereodivergence of the products under different reaction *** importantly,these 2-alkenylindoles were utilized in asymmetric catalysis as chiral organocatalysts and in medicinal chemistry for evaluation of their cytotoxicity,which demonstrated their potential *** study has not only established the catalytic atroposelective synthesis of axially chiral 2-alkenylindoles,but also provided an efficient strategy for catalytic asymmetric diastereodivergent construction of indole-based scaffolds bearing both axial and central chirality.

关键词： 2-Alkenylindole Axial chirality Central chirality Diastereodivergent synthesis Chiral phosphoric acid

节段拼装变截面波形钢腹板连续组合箱梁的剪切性能试验研究

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湖南大学学报（自然科学版） 2024年第3期51卷 170-181页

作者：赵品邵旭东荣学亮刘鑫道路与铁道工程安全保障省部共建教育部重点实验室(石家庄铁道大学) 河北石家庄050043 石家庄铁道大学土木工程学院河北石家庄050043 湖南大学土木工程学院湖南长沙410082 河北自贸区汉曹铁路有限公司河北唐山063200

为了研究节段预制拼装波形钢腹板连续组合箱梁的抗剪性能,制作两片缩尺试验梁,包括节段拼装变截面波形钢腹板连续箱梁和相同尺寸的整体浇筑变截面波形钢腹板连续箱梁.通过静力试验和数值分析,得到了节段拼装梁的剪应力分布规律、波形钢... 详细信息

为了研究节段预制拼装波形钢腹板连续组合箱梁的抗剪性能,制作两片缩尺试验梁,包括节段拼装变截面波形钢腹板连续箱梁和相同尺寸的整体浇筑变截面波形钢腹板连续箱梁.通过静力试验和数值分析,得到了节段拼装梁的剪应力分布规律、波形钢腹板承剪比例等.结果表明:在中跨对称加载作用下,中跨1/4位置处节段拼装梁与整体梁波形钢腹板的剪应力沿梁高方向均匀分布,节段拼装梁的剪应力值要大于整体梁的相应值.推导出节段拼装变截面波形钢腹板组合箱梁的剪应力计算公式,并考虑施工工艺对剪应力的影响,通过与实测值对比验证公式的准确性.两片试验梁的波形钢腹板的承剪比受荷载影响较小,保持一个恒定的比例;两片试验梁在中支座位置处的钢腹板承剪比均为5.%,并沿着试验梁纵向方向向两侧不断增大;在中跨1/4位置,节段拼装梁钢腹板的承剪比达到85.以上,整体梁的钢腹板在该位置的承剪比在75.左右,两片试验梁在边跨相应位置承剪比相差不大.将适用于节段拼装混凝土箱梁的AASHTO接缝抗剪强度计算公式乘0.9可用于接缝截面抗剪承载力计算;上述公式值与试验值、有限元结果的误差在5.左右,可以较好地预测钢混组合结构胶接缝的抗剪强度.

关键词：桥梁工程节段拼装剪切性能室内试验变截面波形钢腹板抗剪承载力

Changes in blood lipid levels and influencing factors among treatment-naïve adult male HlV/AlDS patients following BlC/FTC/TAF vs.3TC+EFV+TDF

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Chinese Medical Journal 2024年第12期137卷 1447-1452页

作者： Xi Wang An Liu Zaicun Li Hongwei Zhang Ruojun Esther Wu Ying shao Jianwei Li Jiangzhu Ye Wei Liu Lijun Sun Clinic of Center for Infection Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Harvard School of Dental Medicine BostonMAUSA Department of Pharmacy Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Chinese Association of STD and AIDS Prevention and Control Beijing 100050China

Background:Antiretroviral therapy(ART)was often associated with dyslipidemia among human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)*** study aimed to assess treatment-naïve adult male patients with HIV/AIDS who initiated ART with either co-formulated bictegravir,emtricitabine,and tenofovir alafenamide(BIC/FTC/TAF)or lamivudine,efavirenz,and tenofovir disoproxil fumarate(3TC+EFV+TDF),monitoring at weeks 4,12,24,and ***:A case-control retrospective study was *** newly diagnosed HIV-infected individuals attending the sexual transmission disease(STD)/AIDS clinic of Beijing Youan Hospital,Capital Medical University,from January to December *** patients were divided into BIC/FTC/TAF group or 3TC+EFV+TDF ***-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglyceride(TG),and total cholesterol(TC)at different time points over 48 weeks between two groups were compared.A multivariate Cox regression model was used to identify relevant influencing factors for the population at high risk of increased ***:A total of 870 participants,with 5.0 in BIC/FTC/TAF group and 360 in 3TC+EFV+TDF *** were no statistically significant differences in median age,baseline CD4/CD8 ratio,median body mass index(BMI)between the two *** both two groups,levels of TG,TC,and LDL-C were higher at 4 weeks,12 weeks,and 24 weeks of treatment(all P5.,and there were no statistically significant differences at 48 weeks compared to those at baseline(all P>0.05..In addition,the differences in average changes of the level of TG,TC,HDL-C,and LDL-C from weeks 4,12,24,and 48 to baseline between two groups were not statistically significant(all P>0.05..Multivariate Cox proportional risk model analysis showed that initiating ART with HIV RNA≥10^(5.copies/mL(compared with5.copies/mL)was associated with an increased risk of elevated LDL-C(hazard ratio=1.26,95.confidence interval:1.07-1.48,

关键词： Antiretroviral therapy Blood lipids Bictegravir/emtricitabine/tenofovir alafenamide Lamivudine,efavirenz,and tenofovir disoproxil fumarate BIC/FTC/TAF 3TC+EFV+TDF HIV AIDS

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度

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Journal of Plant Ecology 2024年第1期17卷 135-147页

作者： Lei Huang Zi-Cheng shao Ling-Ling Dai Ai-Qin Zheng Qing-Ling Zhang Xiao-Lei Wang Sheng Qiang Xiao-Ling Song Weed Research Laboratory College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度转基因作物的抗性基因能否成功渗入野生或近缘杂草取决于携带转基因回交后代的适合度。为深入了解转基因油菜(Brassica napus)向野芥菜(wild ***)基因流动的生... 详细信息

抗草甘膦转基因油菜和野芥菜回交1代子2代-子6代在无除草剂选择压下的适合度转基因作物的抗性基因能否成功渗入野生或近缘杂草取决于携带转基因回交后代的适合度。为深入了解转基因油菜(Brassica napus)向野芥菜(wild ***)基因流动的生态风险,本文研究了在低密度(5./m^(2))和高密度(10株/m^(2))下,以及单种和混合种植(野芥菜:BC1F2R-BC1F6R=1:1)下抗草甘膦转基因油菜与野芥菜回交1代子2代到子6代(BC1F2R-BC1F6R)的适合度;并分析回交后代的适合度成分、种植密度和种植方式之间的相关性。研究结果表明:在单种低密度下,与野芥菜相比,回交1代子2代(BC1F2R)和子3代(BC1F3R)具有较低的适合度,而回交1代子4代-子6代(BC1F4R-BC1F6R)具有较高的适合度;无论是单种还是混种,高密度下所有回交后代的适合度均低于野芥菜。相关性分析结果显示,种植密度和种植方式对回交后代(BC1F2R-BC1F6R)的适合度成分有显著影响。这些结果表明,转基因从栽培油菜渗入到野芥菜很大程度上取决于回交后代的特定生长环境。

关键词：野芥菜抗草甘膦转基因油菜回交后代适合度基因漂移

Clinicopathological Features and Long-Term Prognostic Role of Human Epidermal Growth Factor Receptor-2 Low Expression in Chinese Patients with Early Breast Cancer:A Single-Institution Study

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Biomedical and Environmental Sciences 2024年第5期37卷 457-470页

作者： KONG Zi Qing LIU Li Qun HUANG De Qin WANG Yu Tong LI Jing Jie ZHANG Zheng WANG Xi Xi LIU Chuan Ling ZHANG Ya Di shao Jia Kang ZHU Yi Min CHEN Yi Meng LIU Mei ZHAO Wei Hong Medical School of Chinese PLA Beijing 100853China Department of Medical Oncology the First Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100853China Nankai University School of Medicine Tianjin 300071China Department of Medical Oncology the Fifth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100039China Department of Medical Oncology Xi'an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Pathology the Sixth Medical CenterGeneral Hospital of the Chinese People’s Liberation ArmyBeijing 100037China

Objective This study aimed to comprehensively analyze and compare the clinicopathological features and prognosis of Chinese patients with human epidermal growth factor receptor 2(HER2)-low early breast cancer(BC)and HER2-IHC0 *** Patients diagnosed with HER2-negative BC(N=999)at our institution between January2011 and December 2015.formed our study *** characteristics,association between estrogen receptor(ER)expression and HER2-low,and evolution of HER2 immunohistochemical(IHC)score were ***-Meier method and log-rank test were used to compare the long-term survival outcomes(5.year follow-up)between the HER2-IHC0 and HER2-low *** HER2-low BC group tended to demonstrate high expression of ER and more progesterone receptor(PgR)positivity than HER2-IHC0 BC group(P5.,P<0.001).Survival analysis revealed a significantly longer overall survival(OS)in HER2-low BC group than in HER2-IHC0 group(P=0.007)in the whole cohort and the hormone receptor(HR)-negative *** were no significant differences between the two groups in terms of disease-free survival(DFS).The discordance rate of HER2 IHC scores between primary and metastatic sites was 36.84%.Conclusion HER2-low BC may not be regarded as a unique BC group in this population-based study due to similar clinicopathological features and prognostic roles.

关键词： HER2 HER2-low Breast cancer Estrogen receptor Trastuzumab deruxtecan

Cation effects in electrocatalytic reduction reactions:Recent advances

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Chinese Journal of Catalysis 2024年第8期63卷 16-32页

作者： Qinghui Ren Liang Xu Mengyu Lv Zhiyuan Zhang Zhenhua Li Mingfei shao Xue Duan State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China College of Chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000ZhejiangChina

Electrocatalytic reduction reactions,powered by clean energy sources such as solar energy and wind,offer a sustainable method for converting inexpensive feedstocks(e.g.,CO_(2),N2/NOx,organics,and O_(2))into high-value-added chemicals or *** design and modification of electrocatalysts have been widely implemented to improve their performance in these ***,bottle-necks are encountered,making it challenging to further improve performance through catalyst development ***,cations in the electrolyte have emerged as critical factors for tuning both the activity and product selectivity of reduction *** review summarizes recent advances in understanding the role of cation effects in electrocatalytic reduction ***,we introduce the mechanisms underlying cation *** then provide a comprehensive overview of their application in electroreduction *** techniques and theoretical calcula-tion methods for studying cation effects are also ***,we address remaining challeng-es and future perspectives in this *** hope that this review offers fundamental insights and design guidance for utilizing cation effects,thereby advancing their development.

关键词： Electrocatalysis Reduction reaction Cation effect Mechanism Application

CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma

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Oncology Research 2024年第2期32卷 261-272页

作者： SHUANGSHUANG ZENG XI CHEN QIAOLI YI ABHIMANYU THAKUR HUI YANG YUANLIANG YAN shao LIU Department of Pharmacy Xiangya HospitalCentral South UniversityChangsha410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha410008China Pritzker School of Molecular Engineering Ben May Department for Cancer ResearchUniversity of ChicagoChicagoILUSA Department of Pathology The Second Affiliated Hospital of Shandong First Medical UniversityTaian271000China

Finding biomarkers for immunotherapy is an urgent issue in cancer *** retinoic acid-binding protein 2(CRABP2)is a controversial factor in the occurrence and development of human ***,there is limited research on the relationship between CRABP2 and immunotherapy *** study found that negative correlations of CRABP2 and immune checkpoint markers(PD-1,PD-L1,and CTLA-4)were observed in breast invasive carcinoma(BRCA),skin cutaneous melanoma(SKCM),stomach adenocarcinoma(STAD)and testicular germ cell tumors(TGCT).In particular,in SKCM patients who were treated with PD-1 inhibitors,high levels of CRABP2 predicted poor ***,CRABP2 expression was elevated in cancer-associated fibroblasts(CAFs)at the single-cell *** expression of CRABP2 was positively correlated with markers of CAFs,such as MFAP5.PDPN,ITGA11,PDGFRα/βand THY1 in *** validate the tumor-promoting effect of CRABP2 in vivo,SKCM xenograft mice models with CRABP2 overexpression have been *** models showed an increase in tumor weight and *** analysis indicated that CRABP2 may be involved in immunerelated pathways of SKCM,such as extracellular matrix(ECM)receptor interaction and epithelial-mesenchymal transition(EMT).The study suggests that CRABP2 may regulate immunotherapy in SKCM patients by influencing infiltration of *** conclusion,this study provides new insights into the role of CRABP2 in immunotherapy *** findings suggest that CRABP2 may be a promising biomarker for PD-1 inhibitors in SKCM *** research is needed to confirm these findings and to explore the clinical implications of CRABP2 in immunotherapy.

关键词： CRABP2 Melanoma PD-1 Cancer-associated fibroblasts Immune infiltration