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Drug-target networks for Tanshinone IIA identified by data mining

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Chinese Journal of Natural Medicines 2015年第10期13卷 751-759页

作者： CHEN shao-Jun Department of Traditional Chinese Medicine Zhejiang Pharmaceutical College

Tanshinone IIA is a pharmacologically active compound isolated from Danshen(Salvia miltiorrhiza), a traditional Chinese herbal medicine for the management of cardiac diseases and other disorders. But its underlying molecular mechanisms of action are still unclear. The present investigation utilized a data mining approach based on network pharmacology to uncover the potential protein targets of Tanshinone IIA. Network pharmacology, an integrated multidisciplinary study, incorporates systems biology, network analysis, connectivity, redundancy, and pleiotropy, providing powerful new tools and insights into elucidating the fine details of drug-target interactions. In the present study, two separate drug-target networks for Tanshinone IIA were constructed using the Agilent Literature Search(ALS) and STITCH(search tool for interactions of chemicals) methods. Analysis of the ALS-constructed network revealed a target network with a scale-free topology and five top nodes(protein targets) corresponding to Fos, Jun, Src, phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha(PIK3CA), and mitogen-activated protein kinase kinase 1(MAP2K1), whereas analysis of the STITCH-constructed network revealed three top nodes corresponding to cytochrome P450 3A4(CYP3A4), cytochrome P450 A1(CYP1A1), and nuclear factor kappa B1(NFκB1). The discrepancies were probably due to the differences in the divergent computer mining tools and databases employed by the two methods. However, it is conceivable that all eight proteins mediate important biological functions of Tanshinone IIA, contributing to its overall drug-target network. In conclusion, the current results may assist in developing a comprehensive understanding of the molecular mechanisms and signaling pathways of in a simple, compact, and visual manner.

关键词： Data mining Network analysis Network pharmacology Tanshinone IIA

A Homomorphism between Circuit Cobordism Groups and Pseudohomology Groups over Configuration Space B

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Acta Mathematica Sinica,English Series 2016年第12期32卷 1415-1429页

作者： shao Feng WANG School of Mathematical Sciences Peking University

We develop a new method to perturb singular circuits in configuration space B with trivial isotropy groups, and construct a homomorphism Ф. between its circuit cobordism groups and pseudo- homology groups. This work ... 详细信息

关键词： Homomorphism circuit cobordism pseudohomology

Harnack and HWI Inequalities on Infinite-Dimensional Spaces

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Acta Mathematica Sinica,English Series 2011年第6期27卷 1195-1204页

作者： Jing Hai shao School of Mathematical Sciences Beijing Normal University Beijing 100875 P. R. China

In this paper, the dimensional-free Harnack inequalities are established on infinite-dimen- sional spaces. More precisely, we establish Harnack inequalities for heat semigroup on based loop group and for Ornstein-Uhlenbeck semigroup on the abstract Wiener space. As an application, we establish the HWI inequality on the abstract Wiener space, which contains three important quantities in one inequality, the relative entropy ＂H＂, Wasserstein distance ＂W＂, and Fisher information ＂T＂.

关键词： Harnack inequality loop groups HWI inequality abstract Wiener space Ornstein- Uhlenbeck semigroup

Adolescent social isolation influences cognitive function in adult rats

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Neural Regeneration Research 2013年第11期8卷 1025-1030页

作者： Feng shao Xiao Han Shuang shao Weiwen Wang Department of Psychology Peking University Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation （isolated housing, 38-51 days of age） and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.

关键词： neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophicfactor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmentaldisorders grants-supported paper neuroregeneration

Roles of histamine and its receptors in allergic and inflammatory bowel diseases

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World Journal of Gastroenterology 2005年第19期11卷 2851-2857页

作者： HuaXie shao-HengHe AllergyandInflammationResearchInstitute ShantouUniversityMedicalCollegeShantou515031GuangdongProvinceChina

Mast cell has a long history of being recognized as an important mediator-secreting cell in allergic diseases, and has been discovered to be involved in IBD in last two decades. Histamine is a major mediator in allergic diseases, and has multiple effects that are mediated by specific surface receptors on target cells. Four types of histamine receptors have now been recognized pharmacologically and the first three are located in the gut. The ability of histamine receptor antagonists to inhibit mast cell degranulation suggests that they might be developed as a group of mast cell stabilizers. Recently, a series of experiments with dispersed colon mast cells suggested that there should be at least two pathways in man for mast cells to amplify their own activation-degranulation signals in an autocrine or paracrine manner. In a word, histamine is an important mediator in allergic diseases and IBD, its antagonists may be developed as a group of mast cell stabilizers to treat these diseases.

关键词： Allergic diseases Immunoglobulin

Blow-up Solutions for Mixed Nonlinear Schrodinger Equations

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Acta Mathematica Sinica,English Series 2004年第1期20卷 115-124页

作者： shao Bin TAN Department of Mathematics Xiamen UniversityXiamen 361005P.R.China

This paper is concerned with the initial boundary-value problem for the following nonlinear evolution equation:

关键词： Existence Nonexistence Blow-up Nonlinear Schrodinger equation

Estimates for Vector-valued Commutators on Weighted Morrey Space and Applications

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Acta Mathematica Sinica,English Series 2013年第5期29卷 883-896页

作者： shao Guang SHI School of Science Linyi University School of Mathematical Sciences Beijing Normal University

In this paper, we introduce weighted vector-valued Morrey spaces and obtain some estimates for vector-valued commutators on these spaces. Applications to CalderSn-Zygmund singular integral operators, oscillatory singu... 详细信息

关键词： Weighted Morrey space vector-valued commutator Ap weights

Numerical Simulation and Analysis of Electromagnetic Fields Induced by a Moving Ship Based on a Three-Layer Geoelectric Model

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Journal of Ocean University of China 2020年第6期19卷 1299-1306页

作者： shao Guihang LI Yuguo College of Marine Geoscience and Key Laboratory of Submarine Geosciences and Prospecting TechniquesMinistry of EducationOcean University of ChinaQingdao 266100China Evaluation and Detection Technology Laboratory of Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

In this paper,we present a numerical simulation method of electromagnetic(EM)fields induced by a moving ship(EMFMS),which consist of both the shaft-rate EM field and the static EM *** shaft-rate EM fields in the frequency domain are first obtained by solving the partial differential equations together with suitable boundary conditions,and then they are transformed into the time domain by using the inverse Fourier ***,the static fields are added to obtain the EM fields of a moving *** effects of the source current intensity and the source position on the EM fields of a moving ship are discussed in detail.A field example of EM response of a moving ship is presented and its characteristics are analyzed.

关键词： moving ship shaft-rate EM field static EM field numerical simulation

Manifolds with pinched 2-positive curvature operator

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Frontiers of Mathematics in China 2012年第5期7卷 873-882页

作者： Gang PENG Hongliang shao Department of Mathematics Capital Normal UniversityBeijing 100048China

In this paper, we show that any complete Riemannian manifold of dimension great than 2 must be compact if it has positive complex sectional curvature and δ-pinched 2-positive curvature operator, namely, the sum of the two smallest eigenvalues of curvature operator are bounded below by δ.scal 〉 O. If we relax the restriction of positivity of complex sectional curvature to non- negativity, we can also show that the manifold is compact under the additional condition of positive asymptotic volume ratio.

关键词： δ-pinched 2-positive curvature operator complex sectional curvature asymptotic volume ratio