检索结果-南通市图书馆

Study on Activated Bentonite Applied to tert-Butylation of Toluene

在线全文

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2011年第1期13卷 38-44页

作者： Chen Linbo Shi Li (Department of Petroleum Processing,East China University of Science and Technology,shanghai 200237) Department of Petroleum Processing East China University of Science and Technology Shanghai 200237 China

tert-Butylation of toluene with tert-butanol used as the alkylating agent was investigated over the activated bentonite and HY zeolite used as the *** influences of various butylation reaction parameters,including the toluene/tert-butanol ratio,the reaction temperature,and the space velocity were *** optimal results were obtained at a reaction temperature of 180 ℃,a space velocity of 4 h-1,and a mole ratio of toluene to tert-butanol equating to *** structure and acidic properties of catalyst were characterized by the BET method and the Fourier transform infrared (FTIR) *** with the HY zeolite,the activated bentonite possessed high activity for toluene conversion and high para-selectivity because it had larger pore diameter,smaller micropore surface area and higher ratio of total Lewis acids to total Br nsted acids.

关键词： t-butylation activated bentonite p-tert-butyltoluene pore diameter Lewis acid

Fusion Protein of Interleukin 4 and Diphtherial Toxin with High Cytotoxicity to Cancer Cells

在线全文

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2004年第6期36卷 437-442页

作者： Yu-Jian ZHANG, Xiao-BoHU, Su-Xia LI1, Li-Ping TIAN, Sheng-Li YANG, and Yi GONG* Research Center of Biotechnology, shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, shanghai 200233, China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, shanghai 200237, China Research Center of Biotechnology Shanghai Institutes for Biological SciencesChinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200233 China State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237 China

Receptor of human interleukin 4 (hIL4R) has been found to be present on many types of cancer, so it may be a good target for cancer therapy. Here, fusion toxin gene DT4H has been constructed by fusing DNA sequence encoding the first 389 amino acids of diphtherial toxin (DT), which can not bind its own receptor, to human interleukin 4 (hIL4) gene. In order to improve the affinity of fusion toxin for hIL4R, a circularly permuted form of hIL4 (cpIL4) was used. The fusion gene was expressed in Escherichia coli where the fusion toxin DT4H was highly expressed. Purified DT4H was very cytotoxic to cancer cell line U251 cells, and moderate cytotoxic to HepG2 and MCF-7 cells. SGC-7901 cells were insensitive to it. The cytotoxic action of DT4H was specific because it was blocked by excess hIL4. These results suggest that DT4H may be a useful agent in the treatment of certain malignancies.

关键词： fusion toxin diphtherial toxin cancer therapy interleukin 4 IL-4 receptor

Removal of Trace Olefins from Aromatics by Catalytic Alkylation Using 1-Alkyl-3-methylimidazolium Bromochloroaluminate Catalyst

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2011年第2期13卷 14-18页

作者： Sun Yu Shi Li(State Key Laboratory of Chemical Engineering,East China University of Science and Technology,shanghai 200237) State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China

Removal of trace olefins from aromatic liquids had been investigated in the presence of various ionic liquids like 1-ethyl-3-methylimidazoliurn bromochloroaluminate （EMIMBr-AlCl3）, 1-butyl-3-methylimidazolium bromochloroaluminate （BMIMBr-AlCl3）, l-hexyl-3-methylimidazolium bromochloroaluminate （HMIMBr-AlCl3）, and 1-octyl-3-methylimidazolium bromochloroaluminate （OMIMBr-A1C13）. It was found that the longer the alkyl chain of ionic liquid cations was, the higher the olefins conversion would be. OMIMBr-AlCl3 （with 0.67 molar fraction of AlCl3） had an obvious performance on olefins removal. The influences of various reaction parameters such as the dosage of catalyst, the reaction temperature, and the reaction time on the reaction catalyzed by OMIMBr-AlCl3 were investigated. Under optimum reaction conditions, a higher than 99% conversion of olefins was achieved. The preliminary results revealed that the process could save time, consume less energy, separate products easier, and cause less pollution to the environment.

关键词： ionic liquids olefins removal 1-alkyl-3-methylimidazolium bromochloroaluminate aromatic

The Preparation and Application of two New Types of Oxazaborolidines

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2000年第5期11卷 381-382页

作者： Guo Bin RONG Xing Ming LI Yong ZHANG (Department of Chemistry East China University of Science and Technology. shanghai 200237) Department of Chemistry E. China Univ. of Sci. and Technol. Shanghai 200237 China

Two new type of 1,3,2-oxazaborolidines were prepared from (Is,2s)-2-amino-1-(4-nitrophenyl)-propane-1-3-diol and were used as catalyst in the asymmetric reduction of acetophenone. The influence of the reaction temperature as well as the effect of the structure of catalyst on the enantioselectivity was investigated. The origin of the products' configuration was discussed.

关键词： oxazaborolidine asymmetric catalytic reduction prochiral ketone

COMPLEX REACTIONS OF ETHYL-GLUCOSIDES SYNTHESIS OVER ION EXCHANGE RESIN

在线全文

学校读者我要写书评

暂无评论

化工学报 2000年第S1期51卷 163-167页

作者： Tu Maobing and Wei Dongzhi (The State Key Laboratory of Bioreactor Engineering ECUST, shanghai 200237)

The glycosidation reactions of D-glucose with ethanol have been carried out over a reusable and separable heterogeneous catalyst, namely, ion exchange resin. Detailed kinetic data for these reactions are reported. A complex reaction model has been developed for interpreting the data. The reactions were found to be global second-order reactions and first -order with respect to each component. Meanwhile, a new regression method is applied to determine the rate constant from time-dependent profiles.

关键词： Ethyl-glucoside solid catalyst kinetic complex reactions

Quantum dots enhance Cu^(2+)-induced hepatic L02 cells toxicity

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2010年第12期22卷 1987-1992页

作者： Yuxia Zhao,Kuangfei Lin,Wei Zhang,Lili Liu State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process,shanghai 200237,China State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process Shanghai 200237 China. E-mail: maryzyx@***

As a new class of xenogenous nanoparticle, quantum dots （QDs） possess the potential to co-exist with Cu^2＋ in human liver. The combined toxicity is thus concerned. Considering QDs and Cu^2＋ are known ROS （reactive oxygen species） inducer, we investigated the combined oxidative stress and corresponding protective strategy using human hepatic L02 cells. The results demonstrated that the presence of a small amount of MPA-CdTe QDs （2 μg/mL） in a Cu^2＋ solution （2.5-20 μg/mL） resulted in a higher toxicity with up to 8-fold cell viability decrease, which was accompanied by cell morphology changes. The combined toxicity was then confirmed as ROS associated oxidative stress with up to 300% and 35% increase of the intracellular ROS level and glutathione S-transferase （GST） activity, respectively. N-acetylcysteine （NAC） can also provide almost complete protection against the induced toxicity. Therefore, the ROS associated oxidant injury might be responsible for the QDs-Cu^2＋/Cu^2＋ induced toxicity and could be balanced through cytoprotective antioxidant enzyme GST.

关键词： quantum dots hepatic L02 cell reactive oxygen species glutathione S-transferase

Disposable amperometric biosensors based on xanthine oxidase immobilized in the Prussian blue modified screen-printed three-electrode system

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2010年第12期53卷 2581-2586页

作者： TENG YuanJie,CHEN Chen,ZHOU ChangXiang,ZHAO HongLi & LAN MinBo shanghai key Laboratory of Functional Materials Chemistry Research Center of Analysis Test,East China University of Science and Technology,shanghai 200237,China shanghai key Laboratory of Functional Materials Chemistry Research Center of Analysis Test East China University of Science and Technology Shanghai China

The screen-printed three-electrode system was applied to fabricate a new type of disposable amperometric xanthine oxidase ***-working,carbon-counter and Ag/AgCl reference electrodes were all manually printed on the polyethylene terephthalate substrate forming the screen-printed three-electrode system by the conventional screen-printing *** a mediator,Prussian blue could not only catalyze the electrochemical reduction of hydrogen peroxide produced from the enzyme reaction,but also keep the favorable potential around 0 *** optimum operational conditions,including pH,potential and temperature,were *** sensitivities of xanthine and hypoxanthine detections were 13.83 mA/M and 25.56 mA/M,respectively.A linear relationship was obtained in the concentration range between 0.10μM and 4.98μM for xanthine and between 0.50μM and 3.98μM for *** small Michaelis-menten constant value of the xanthine oxidase biosensor was calculated to be 3.90 μ*** results indicate that the fabricated xanthine oxidase biosensor is effective and sensitive for the detection of xanthine and hypoxanthine.

关键词： xanthine oxidase xanthine hypoxanthine screen-printed three-electrode system Prussian blue

Ni-loaded Catalyst Containing Activated Clay for Maleic Anhydride Hydrogenation to Succinic Anhydride

在线全文

学校读者我要写书评

暂无评论

China Petroleum Processing & Petrochemical Technology 2011年第4期13卷 35-40页

作者： Tian Weiping Guo Shaofei Shi Li (The State Key Laboratory of Chemical Engineering, East China University of Science and Technology, shanghai 200237) State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai 200237 China

In this work, the hydrogenation of maleic anhydride to succinic anhydride in the presence of 5 m%Ni/clay catalysts was investigated. These catalysts were characterized by X-ray diffraction （XRD）, H2 temperature programmed reduction （TPR） and thermogravimetric analysis （TGA） techniques. The XRD and TPR studies showed that Ni was present as Ni2＋ on the support, which indicated that there were no elemental nickel （Ni^0） and Ni203 species in the unreduced samples. Increasing of calcination temperature to 650 ℃ leads to destruction of the support structure observed in TGA, while the catalyst sample calcined at 550 ℃ exhibits better performances than other samples. The ideal conversion of maleic anhydride （97.14%） and selectivity of succinic anhydride （99.55%） were realized at a reaction temperature of 180 ℃ and a weight hourly space velocity of 4 h^-1 under a reaction pressure of 1 MPa.

关键词： maleic anhydride hydrogenation succinic anhydride nickel

OPIOID　δ　RECEPTOR　IRREVERSIBLE　INHIBITORS　***　OF　ISOTHIOCYANATE　DERIVATIVES　OF　CARFENTANIL　AND　4-METHOXYMETHYLFENTANYL

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1995年第9期6卷 763-764页

作者： Zhi Xian WANG Jing YANG , You Cheng ZHU and Ru Yun JI(shanghai Institute of Materia Medica, Chinese Academy of Sciences, shanghai 20003)(East China University of Science and Techology, shanghai 200237) Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China E China Univ Sci & Technol Shanghai 200237 Peoples R China

Abstract: The synthesis of isothiocyanate derivatives of carfentanil and 4-methoxymethyl-fentanyl was described.

关键词：