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Prognostic value of preoperative weight loss-adjusted body mass index on survival after esophagectomy for esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2020年第8期26卷 839-849页

作者： Han-Lu Zhang yu-shang yang Jia-Nan Duan Qi-Xin shang Song-Lin He Yi-Min Gu Wei-Peng Hu Wen-Ping Wang yang Hu yun Wang Yong yuan Long-Qi Chen Department of Thoracic Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Thoracic and Cardiovascular Surgery the Second People's Hospital of ChengduChengdu 610017Sichuan ProvinceChina

BACKGROUND The impact of body mass index(BMI)on survival in patients with esophageal squamous cell carcinoma(ESCC)undergoing surgery remains ***,a definition of clinically significant BMI in patients with ESCC is *** To explore the impact of preoperative weight loss(PWL)-adjusted BMI on overall survival(OS)in patients undergoing surgery for *** This retrospective study consisted of 1545 patients who underwent curative resection for ESCC at West China Hospital of Sichuan University between August 2005 and December *** relationship between PWL-adjusted BMI and OS was examined,and a multivariate analysis was performed and adjusted for age,sex,TNM stage and adjuvant *** Trends of poor survival were observed for patients with increasing PWL and decreasing *** with BMI≥20.0 kg/m2 and PWL<8.8%were classified into Group 1 with the longest median OS(45.3 mo).Patients with BMI<20.0 kg/m2 and PWL<8.8%were classified into Group 2 with a median OS of 29.5 *** with BMI≥20.0 kg/m2 and PWL≥8.8%(HR=1.9,95%CI:1.5-2.5),were combined into Group 3 with a median OS of 20.1 *** in the three groups were associated with significantly different OS(P<0.05).In multivariate analysis,PWL-adjusted BMI,TNM stage and adjuvant therapy were identified as independent prognostic *** PWL-adjusted BMI has an independent prognostic impact on OS in patients with ESCC undergoing *** might be an indicator for patients with PWL<8.8%rather than≥8.8%.

关键词： Esophageal neoplasms Body mass index Body weight change Survival Surgery Nutrition status

Timing of surgery after neoadjuvant chemoradiotherapy affects oncologic outcomes in patients with esophageal cancer

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World Journal of Gastrointestinal Oncology 2020年第6期12卷 687-698页

作者： Qi-Xin shang yu-shang yang Yi-Min Gu Xiao-Xi Zeng Han-Lu Zhang Wei-Peng Hu Wen-Ping Wang Long-Qi Chen Yong yuan Department of Thoracic Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina West China Biomedical Big Data Center West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The optimal time interval between neoadjuvant chemoradiotherapy(nCRT)and esophagectomy in esophageal cancer has not been *** To evaluate whether a prolonged time interval between the end of nCRT and surgery has an effect on survival outcome in esophageal cancer *** We searched PubMed,Embase,Web of Science,the Cochrane Library,Wanfang and China National Knowledge Infrastructure databases for relevant articles published before November 16,2019,to identify potential studies that evaluated the prognostic role of different time intervals between nCRT and surgery in esophageal *** hazard ratios and 95%confidence intervals(95%CI)were merged to estimate the correlation between the time intervals and survival outcomes in esophageal cancer,esophageal squamous cell carcinoma and adenocarcinoma using fixed-and random-effect *** This meta-analysis included 12621 patients from 16 *** results demonstrated that esophageal cancer patients with a prolonged time interval between the end of nCRT and surgery had significantly worse overall survival(OS)[hazard ratio(HR):1.107,95%CI:1.014-1.208,P=0.023]than those with a shorter time *** analysis showed that poor OS with a prolonged interval was observed based on both the sample size and *** was also significant association between a prolonged time interval and decreased OS in Asian,but not Caucasian *** addition,a longer wait time indicated worse OS(HR:1.385,95%CI:1.186-1.616,P<0.001)in patients with *** A prolonged time interval from the completion of nCRT to surgery is associated with a significant decrease in ***,esophagectomy should be performed within 7-8 wk after nCRT.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Esophagectomy Time interval Survival outcome Meta-Analysis

Research on the solid particle erosion wear of pipe steel for hydraulic fracturing based on experiments and numerical simulations

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Petroleum Science 2024年第4期21卷 2779-2792页

作者： Si-Qi yang Jian-Chun Fan Ming-Tao Liu De-Ning Li Jun-Liang Li Li-Hong Han Jian-Jun Wang shang-yu yang Si-Wei Dai Lai-Bin Zhang State Key Laboratory of Oil and Gas Equipment CNPC Tubular Goods Research InstituteXi'an710077ShaanxiChina Key Laboratory of Oil and Gas Safety and Emergency Technology China University of PetroleumBeijing102249China Oil Production Technology Research Institute of Liaohe Oilfield Company Panjin124010LiaoningChina Tianjin Gas Storage Branch PetroChina Dagang Oilfield CompanyTianjin300280China Petroleum Production Engineering Research Institute Daqing Oilfield CompanyDaqing163712HeilongjiangChina

Erosion wear is a common failure mode in the oil and gas *** the hydraulic fracturing,the fracturing pipes are not only in high-pressure working environment,but also suffer from the impact of the high-speed solid particles in the fracturing *** such complex conditions,the vulnerable components of the pipe system are prone to perforation or even burst accidents,which has become one of the most serious risks at the fracturing ***,it is not yet fully understood the erosion mechanism of pipe steel for hydraulic ***,this article provides a detailed analysis of the erosion behavior of fracturing pipes under complex working conditions based on experiments and numerical ***,we conducted erosion experiments on AISI 4135 steel for fracturing pipes to investigate the erosion characteristics of the *** effects of impact angle,flow velocity and applied stress on erosion wear were comprehensively *** a particle impact dynamic model of erosion wear was developed based on the experimental parameters,and the evolution process of particle erosion under different impact angles,impact velocities and applied stress was *** combining the erosion characteristics,the micro-structure of the eroded area,and the micro-mechanics of erosion damage,the erosion mechanism of pipe steel under fracturing conditions was studied in detail for the first *** high-pressure operating conditions,it was demonstrated through experiments and numerical simulations that the size of the micro-defects in the eroded area increased as the applied stress increased,resulting in more severe erosion wear of fracturing pipes.

关键词： Erosion wear Applied stress Particle impact dynamics Erosion mechanism

Effects of neutrophil elastase inhibitor in patients undergoing esophagectomy:A systematic review and meta-analysis

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World Journal of Gastroenterology 2015年第12期21卷 3720-3730页

作者： Zhi-Qiang Wang Long-Qi Chen Yong yuan Wen-Ping Wang Zhong-Xi Niu yu-shang yang Jie Cai Department of Thoracic Surgery West China Hospital Sichuan University

AIM: To evaluate the benefit and safety of sivelestat(a neutrophil elastase inhibitor) administration in patients undergoing esophagectomy. METHODS: Online databases including Pub Med, EMBASE, the Cochrane Library, Web of Knowledge, and Chinese databases(Wanfang database, VIP and CNKI) were searched systematically up to November 2013. Randomized controlled trials and high-qualitycomparative studies were considered eligible for inclusion. Three reviewers evaluated the methodological quality of the included studies, and Stata 12.0 software was used to analyze the extracted data. The risk ratio(RR) was used to express the effect size of dichotomous outcomes, and mean difference(MD) or standardized mean difference was used to express the effect size of continuous ***: Thirteen studies were included in this systematic review and nine studies were included in the meta-analysis. The duration of mechanical ventilation was significantly decreased in the sivelestat group on postoperative day 5 [I2 = 76.3%, SMD =-1.41, 95%CI:-2.63-(-0.19)]. Sivelestat greatly lowered the incidence of acute lung injury in patients after surgery(I2 = 0%, RR = 0.27, 95%CI: 0.08-0.93). However, it did not decrease the incidence of pneumonia, intensive care unit stay or postoperative hospital stay, and did not increase the incidence of complications such as anastomotic leakage, recurrent nerve palsy, wound infection, sepsis and catheter-related fever. CONCLUSION: A neutrophil elastase inhibitor is beneficial in patients undergoing esophagectomy. More high quality, large sample, multi-center and randomized controlled trials are needed to validate this effect.

关键词： Neutrophil elastase inhibitor Esophageal cancer Es

Unraveling the significance of cobalt on transformation kinetics,crystallography and impact toughness in high-strength steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： Yishuang yu Jingxiao Zhao Xuelin Wang Hui Guo Zhenjia Xie Chengjia shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao Shuling Liao Quanhong yang Nianjun yang Siyu yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Polymer membrane electrodes

Precise gradient separation of nanoparticles using reduced graphene oxide-polyoxomolybdate membranes

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Science China Chemistry 2025年第1期68卷 209-216页

作者： Yixin yang Wanlei Zhao Ruoxuan Zheng Hongqiang Li Wei Chen yu-Fei Song State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Quzhou Institute for Innovation in Resource Chemical Engineering

The purification and size sieving of nanoparticles （NPs） represents a significant scientific ***,the r GO-polyoxometalates (POMs=PMo12,Mo132and Mo368) membranes were fabricated successfully via a simple and scalable POMsassisted in-situ photoreduction *** the mass ratio of r GO to PMo12was 1:30,the resultant r GO-PMo12membranes with highly ordered and uniform nanochannels of 1.0 nm can be obtained,which showed an accurate carbon quantum dots（CQDs） separation with a cut-off size approximately 1.0 *** increase of the size of the interlayered POMs from PMo12（1.0 nm）,{Mo132}（2.9 nm） to{Mo368}（3.8 nm）,the resultant r GO-PMo12,r GO-Mo132and r GO-Mo368exhibited precise gradient separation of CQDs and Au nanoparticles by size exclusion *** results pave a promising way to construct new twodimensional （2D） membranes for highly efficient size-selective separation.

关键词： reduced graphene oxide polyoxometalates membranes gradient separation nanoparticles

Ideal Bi‑Based Hybrid Anode Material for Ultrafast Charging of Sodium‑Ion Batteries at Extremely Low Temperatures

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Nano-Micro Letters 2025年第3期17卷 152-167页

作者： Jie Bai Jian Hui Jia yu Wang Chun Cheng yang Qing Jiang Key Laboratory of Automobile Materials(Jilin University) Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at−20°C or ***,the key capability of ultrafast charging at ultralow temperature for SIBs is rarely ***,a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue,which is synthesized via a high temperature shock *** a hybrid shows an unprecedented rate performance(237.9 mAh g^(−1)at 2 A g^(−1))at−60℃,outperforming all reported SIB anode *** with a Na_(3)V_(2)(PO_(4))_(3)cathode,the energy density of the full cell can reach to 181.9 Wh kg^(−1)at−40°*** on this work,a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries