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Mitophagy in neurodegenerative disease pathogenesis

Neural Regeneration Research 2024年第5期19卷 998-1005页

作者： Kan yang Yuqing Yan Anni Yu ru Zhang Yuefang Zhang Zilong Qiu Zhengyi Li Qianlong Zhang Shihao Wu Fei Li Department of Developmental and Behavioural Pediatric&Child Primary Care Brain and Behavioural Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghaiChina College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtanHunan ProvinceChina School of Medicine Yunnan UniversityKunmingYunnan ProvinceChina Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Neurosurgery Department Kunming Yenan HospitalKunmingYunnan ProvinceChina

Mitochondria are critical cellular energy resources and are central to the life of the *** selectively clears damaged or dysfunctional mitochondria through autophagic machinery to maintain mitochondrial quality control and *** neurons are postmitotic and consume substantial energy,thus require highly efficient mitophagy pathways to turn over damaged or dysfunctional *** evidence indicates that mitophagy is pivotal to the pathogenesis of neurological ***,more work is needed to study mitophagy pathway components as potential therapeutic *** this review,we briefly discuss the characteristics of nonselective autophagy and selective autophagy,including ERphagy,aggrephagy,and *** then introduce the mechanisms of Parkin-dependent and Parkin-independent mitophagy pathways under physiological ***,we summarize the diverse repertoire of mitochondrial membrane receptors and phospholipids that mediate ***,we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***,we discuss recent studies considering mitophagy as a potential therapeutic target for treating neurodegenerative ***,our review may provide novel views to better understand the roles of mitophagy in neurodegenerative disease pathogenesis.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis autophagy mitochondria mitophagy mitophagy receptor Parkin Parkinson’s disease PINK1

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XOR spin logic operated by unipolar current based on field-free spin-orbit torque switching induced by a lateral interface

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Rare Metals 2024年第8期43卷 3868-3875页

作者： Yan-ru Li Mei-Yin yang Guo-Qiang Yu Bao-Shan Cui Jin-Biao Liu Yong-Liang Li Qi-Ming Shao Jun Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences(IMECAS)Beijing 100029China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Spin logics have emerged as a promising avenue for the development of logic-in-memory *** particular,the realization of XOR spin logic gates using a single spin-orbit torque device shows great potential for low-power stateful logic circuits in the next *** this study,we successfully obtained the XOR logic gate by utilizing a spin-orbit torque device with a lateral interface,which was created by local ion implantation in the Ta/Pt/Co/Ta Hall device exhibiting perpendicular magnetic *** angle of the lateral interface is set at 45°relative to the current direction,leading to the competition between symmetry breaking and current-driven Néel-type domain wall ***,the field-free magnetic switching reversed is realized by the same sign of current amplitude at this *** on this field-free magnetic switching behavior,we successfully proposed an XOR logic gate that could be implemented using only a single spin-orbit torque Hall *** study provides a potentially viable approach toward efficient spin logics and in-memory computing architectures.

关键词： Filed-free magnetic switching Spin-orbit torque XOR logic gate Lateral interface

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Copper isotope constraints on the origins of basaltic and andesitic magmas in the Tengchong volcanic field,SE Tibet

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Geoscience Frontiers 2024年第4期15卷 290-303页

作者： Yuan-ru Qu Sheng-Ao Liu State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China

The Tengchong volcano field(TVF),situated at the southeastern margin of the Tibetan Plateau,holds crucial information regarding Cenozoic volcanic activities and geotectonic evolution of the SE *** provide new constraints on petrogenesis and evolution of the Tengchong volcanism,here we conducted copper(Cu)elemental and isotopic analyses on a suite of samples that document the evolution from basalts to andesites in the *** basalts are Cu-depleted(29.7-36.9 ppm)and have higherδ65Cu val-ues(0.19‰-0.40‰,mean=0.31‰±0.05‰;n=11)than those of mid-ocean ridge basalts(MORBs,~0.09‰)and the mantle(~0.06‰)as well as the majority of island arc *** with the low Cu/Zr ratios,these characteristics are interpreted to reflect the fractionation of isotopically light sulfides in the S-saturated systems during magma ascent,rather than source heterogeneity induced by recycled materials and redox *** with the basalts,the andesites have slightly lower Cu contents(14.4-29.4 ppm)and lighter Cu isotopic compositions(mean=-0.14‰±0.06‰;n=13).These differences cannot be attributed to progressive sulfide fractionation of basaltic magmas but require the assimilation of lower crustal materials with lowδ65Cu values during evolution of the andesitic *** results collectively suggest that Cu isotopes can provide valuable insights into magma origin and evolution.

关键词： Copper isotopes Sulfide segregation Magmatic differentiation Tengchong volcanic field

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Energy harvesting technology for AC overhead insulated transmission line based on electric field induction

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High Voltage 2024年第4期9卷 816-825页

作者： Le Zhou Hongwei Liu Kun Zuo Kuo shang School of Electrical and Electronic Engineering North China Electric Power UniversityBeijingChina Electric Power Company of Sichuan Province Tianfu Power Supply Company ChengduSichuanChina Changde Power Supply Branch State Grid Hunan Electric Power Company LimitedChangdeHunanChina

To solve the problem of the energy harvesting(EEH)effect of the condition monitoring devices power supply on the transmission line is not *** authors designed three kinds of EEH schemes based on AC electric field induction,which can effectively improve the output power of load power *** EEH principle of each scheme was analysed in detail,and the influence factors such as the shape of outer energy harvester,capacitance compensation and impedance matching characteristics were ***,the experiment showed that 140.9 mW of power was obtained in direct-mode field EEH when the line voltage level was 10 *** high-potential field EEH mode obtained 4.1 mW of *** harvesting effect of the inner energy harvester with the same potential as the aluminium wire was obviously better,and 30.7 mW of power was ***,based on the third mode,when the load resistance was 2200Ω,the rectifier received 23.7 mW DC *** experimental results are in agreement with the theoretical analysis,which verifies the effectiveness of the electric field induction power supply technology.

关键词： field harvesting mode

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Vibration suppression for rotating space slender flexible structures based on novel deformation description and NNSMC controller with hyperbolic tangent function

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Chinese Journal of Aeronautics 2024年第10期37卷 339-364页

作者： Dongyang shang Xiaopeng LI Men YIN Sainan ZHOU School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

Rotating Space Slender Flexible Structures(RSSFS)are extensively utilized in space operations because of their light weight,mobility,and low energy *** realize the accurate space operation of the RSSFS,it is necessary to establish a precise mechanical model and develop a control algorithm with high ***,with the application of traditional control strategies,the RSSFS often suffers from the chattering phenomenon,which will aggravate structure *** this paper,novel deformation description is put forward to balance modeling accuracy and computational efficiency of the RSSFS,which is better appropriate for real-time ***,the Neural Network Sliding Mode Control(NNSMC)strategy modified by the hyperbolic tangent(tanh)function is put forward to compensate for modeling errors and reduce the chattering phenomenon,thereby improving the trajectory tracking accuracy of the ***,a mathematical model for the RSSFS is developed according to the novel deformation description and the vibration theory of flexible *** of the deformation accuracy between different models proves that the novel modeling method proposed has high modeling ***,the universal approximation property of the Radial Basis Function(RBF)neural network is put forward to determine and compensate for modeling errors,which consist of higher-order modes and the uncertainties of external *** addition,the tanh function is proposed as the reaching law in the conventional NNSMC strategy to suppress driving torque *** control law of modified NNSMC strategy and the adaptive law of weight coefficients are developed according to the Lyapunov theorem to guarantee the RSSFS ***,the simulation and physical experimental tests of the RSSFS with different control strategies are *** results show that the control law according to the novel deformation description and the modified NNSMC strategy can obta

关键词： Space slender flexible structure Novel deformation description RBF neural network Vibration suppression Hyperbolic tangent function

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Energy-Function Based Pilot Protection Scheme for Hybrid UHVDC Transmission Applying Improved Hausdorff Distance

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 891-902页

作者： Zijiang Wang Youping Fan Ben shang Yinbiao Shu School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Institute of Next Generation Power Systems&International Standards Wuhan UniversityWuhan 430072China CSEE IEEE

A hybrid UHVDC transmission system applying LCC as the rectifier and MMC as the inverter combines the advantages of both converter types,which makes this protection scheme more complicated.A new pilot protection scheme for a three-terminal hybrid DC transmission system applying energy functions is *** energy function for LCC is applied to MMC to derive the energy level of the hybrid ***,an improved Hausdorff distance(IHD)algorithm is proposed to detect the difference in energy levels between the normal and fault *** abrupt change in energy level is characterized by IHD change *** points at which the IHD change rate exceeds the threshold at converter stations are applied to determine the fault line and to estimate the fault *** proposed protection scheme is then verified by a simulation model of the Wudongde±800 kV three-terminal hybrid UHVDC transmission *** appropriate sampling frequency is selected for a real-time calculation,and the threshold is selected considering the effect of *** show the proposed scheme can identify and trip fault lines quickly and effectively,even for a 600Ωgrounding *** waveshape similarity algorithms are compared and *** with existing protection schemes,the proposed scheme transmits less data to improve communication speed and reliability.

关键词： Energy function Hausdorff distance pilot protection UHVDC transmission

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Screening of low-friction two-dimensional materials from highthroughput calculations using lubricating figure of merit

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Friction 2024年第8期12卷 1897-1908页

作者： Kewei TANG Weihong QI Guoliang ru Weimin LIU State Key Laboratory of Solidification Processing and Center of Advanced Lubrication and Seal Materials Northwestern Polytechnical UniversityXi’an 710072China Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Two-dimensional materials are excellent lubricants with inherent ***,superlubricity has been reported for only a few of these ***,other promising two-dimentional(2D)materials with different physical properties cannot be discovered or applied in production;thus,energy consumption can be greatly ***,we carry out high-throughput calculations for 1,4752D materials and screen for low-friction *** set a standard,we propose,for the first time,a geometry-independent lubricating figure of merit based on the conditions for stick-slip transition and our theory of Moiré*** the efficient calculation of this figure of merit,an innovative approach was developed based on an improved registry index *** calculations,340 materials were found to have a figure of merit lower than 10−***,a small set of 21 materials with a figure of merit lower than 10−4 were screened *** materials can provide diverse choices for various *** addition,the efficient computational approach demonstrated in this work can be used to study other stacking-dependent properties.

关键词： two-dimensional materials high-throughput calculation tribology low-friction materials Moirépatterns

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Research progress and prospect of low-carbon biological technology for nitrate removal in wastewater treatment

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 1-21页

作者： ru Zheng Kuo Zhang Lingrui Kong Sitong Liu College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China Key Laboratory of Water and Sediment Sciences Ministry of Education of ChinaBeijing 100871China Eco-Environment and Resource Efficiency Research Laboratory School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Wastewater treatment plants are the major energy consumers and significant sources of greenhouse gas emissions,among which biological nitrogen removal of wastewater is an important contributor to carbon ***,traditional heterotrophic denitrification still has the problems of excessive residual sludge and the requirement of external carbon ***,the development of innovative low-carbon nitrate removal technologies is *** review outlines the key roles of sulfur autotrophic denitrification and hydrogen autotrophic denitrification in low-carbon wastewater *** discovered nitrate/nitrite dependent anaerobic methane oxidation enables sustainable methane emission reduction and nitrogen removal by utilizing available methane in *** microorganisms exhibited a promising potential to achieve carbon-negative nitrate ***,the algal-bacterial symbiosis system and photogranules offer effective and prospective low-carbon options for nitrogen ***,the emerging nitrate removal technology of photoelectrotrophic denitrification and the underlying,photoelectron transfer mechanisms are ***,we summarize and prospect these technologies,highlighting that solar-driven biological nitrogen removal technology is a promising area for future sustainable wastewater *** review has important guiding significance for the design of low-carbon wastewater treatment systems.

关键词： Carbon emissions Low-carbon Biological nitrogen removal Denitrification

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Moxibustion of Zusanli(ST36)and Shenshu(BL23)alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling

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Journal of Traditional Chinese Medicine 2024年第2期44卷 353-361页

作者： ZHANG Linlin ZHONG Yumei LU Wenting shang Yanan GUO Yanding LUO Xiaochao CHEN yang LUO Kun HU Danhui YU Huiling ZHOU Haiyan Acupuncture and Moxibustion College Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Painology First People's Hospital of ChengduChengdu 610095China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu 610044China Traditional Chinese Medicine College Chongqing Medical UniversityChongqing 400016China External treatment center First People's Hospital of ChengduChengdu 610095China

OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fifty male Sprague-Dawley rats were randomly divided into five groups(n=10 each):blank Control(CON)group,RA Model(RA)group,Moxibustion(MOX)group,MIF inhibitor(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)group,and Moxibustion+MIF inhibitor ISO-1(MOX+ISO-1)*** in the ISO-1 group and ISO-1+MOX group were intraperitoneally injected with the inhibitor *** rats in the RA group,ISO-1 group,MOX group,and ISO-1+MOX group were injected with Freund's complete adjuvant(FCA)in the right hind footpad to establish an experimental RA rat *** the MOX group and MOX+ISO-1 group,rats were treated with *** thickness of the footpads of the rats in each group was measured at three-time points before,after modeling and after moxibustion *** contents of serum MIF,corticosterone(CORT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were detected by enzyme-linked immunosorbent assay;and the contents of synovial MIF were detected by Western ***-eosin(HE)staining method was used to observe the pathological changes of synovial tissue under a section light microscope,and pathological scoring was performed according to the grading standard of the degree of synovial tissue ***:Moxibustion was found to reduce the level of MIF and alleviate inflammation in RA rats in this *** addition,after inhibiting the expression of MIF,the level of CORT increased,and the level of TNF-α *** RA rats with inhibited MIF by moxibustion,the level of CORT was almost unchanged,but the level of TNF-α further *** correlation analysis data suggested that MIF was positively related to the expression of TNF-α and negatively correlated with the expression of ***:Reducing MIF to

关键词： rheumatoid arthritis macrophage migration inhibitory factor moxibustion corticosterone glucocorticoids

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Atorvastatin, etanercept and the nephrogenic cardiac sympathetic remodeling in chronic renal failure rats

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Journal of Geriatric Cardiology 2024年第4期21卷 443-457页

作者： Jing-Yue XU Zheng-Kai XUE Ya-ru ZHANG Xing LIU Xue ZHANG Xi yang Tong LIU Kang-Yin CHEN Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardiologythe Second Hospital of Tianjin Medical UniversityTianjinChina

BACKGROUND Chronic renal failure(CRF) patients are predisposed to arrhythmias, while the detailed mechanisms are unclear. We hypothesized the chronic inflammatory state of CRF patients may lead to cardiac sympathetic remodeling, increasing the incidence of ventricular arrhythmia(VA) and sudden cardiac death. And explored the role of atorvastatin and etanercept in this *** A total of 48 rats were randomly divided into sham operation group(Sham group), CRF group, CRF + atorvastatin group(CRF + statin group), and CRF + etanercept group(CRF + rhTNFR-Fcgroup). Sympathetic nerve remodeling was assessed by immunofluorescence of growth-associated protein 43(GAP-43) and tyrosine hydroxylase positive area fraction. Electrophysiological testing was performed to assess the incidence of VA by assessing the ventricular effective refractory period and ventricular fibrillation threshold. The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1beta were determined by Western blotting and enzyme-linked immunosorbent *** Echocardiogram showed that compared with the Sham group, left ventricular end-systolic diameter and ventricular weight/body weight ratio were significantly higher in the CRF group. Hematoxylin-eosin and Masson staining indicated that myocardial fibers were broken, disordered, and fibrotic in the CRF group. Western blotting, enzyme-linked immunosorbent assay,immunofluorescence and electrophysiological examination suggested that compared with the Sham group, GAP-43 and TNF-α proteins were significantly upregulated, GAP-43 and tyrosine hydroxylase positive nerve fiber area was increased, and ventricular fibrillation threshold was significantly decreased in the CRF group. The above effects were inhibited in the CRF + statin group and the CRF + *** In CRF rats, TNF-α was upregulated, cardiac sympathetic remodeling was more severe, and the nephrogenic cardiac sympathetic remodeling existed. Atorvastatin and etanercept c

关键词： remodeling cardiac inhibited

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