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非手术疗法治疗腰椎间盘突出症的循证实践指南

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中国循证医学杂志 2024年第2期24卷 125-148页

作者：葛龙李镜尚文茹邢新牛军强闵凯莉惠旭何升华姜宏焦锋姚嫄董敬石徐倩郝国雄冷向阳李刚林定坤刘军马维虎莫文史晓林宋敏王拥军王勇平姚啸生于杰詹红生朱立国谢兴文邢丹杜亮卢卫忠郭珂李紫珺李秀霞李美萱李艳飞张立存赵继荣杨克虎兰州大学公共卫生学院卫生政策与管理学系兰州730000 世界卫生组织指南实施与知识转化合作中心/甘肃省医学指南行业技术中心兰州730000 兰州大学基础医学院循证医学中心兰州730000 兰州大学第一医院兰州730000 兰州大学第二临床医学院兰州730000 深圳市中医院广东深圳518033 南京中医药大学苏州附属医院江苏苏州215000 广州市中西医结合医院广州510000 兰州大学第一临床医学院兰州730000 甘肃中医药大学兰州730000 长春中医药大学长春130000 山东中医药大学附属医院济南250000 广州中医药大学广州510000 广东省第二中医院广州510000 宁波市第六医院浙江宁波315000 上海中医药大学附属龙华医院上海200000 浙江中医药大学附属第二医院杭州310000 上海中医药大学上海200000 辽宁中医药大学附属医院沈阳110000 中国中医科学院望京医院北京100000 上海中医药大学附属曙光医院上海200000 甘肃中医药大学附属医院兰州730000 北京大学人民医院北京100000 四川大学华西医院成都610041 重庆市中医院重庆404100

腰椎间盘突出症(LDH)是导致腰腿痛最常见原因之一,严重影响患者的生活质量。非手术疗法作为LDH的一线治疗方案,可缓解80%~90%LDH患者的临床症状。本指南遵循《中国制订/修订临床诊疗指南的指导原则(2022版)》和《世界卫生组织指南制定手... 详细信息

腰椎间盘突出症(LDH)是导致腰腿痛最常见原因之一,严重影响患者的生活质量。非手术疗法作为LDH的一线治疗方案,可缓解80%~90%LDH患者的临床症状。本指南遵循《中国制订/修订临床诊疗指南的指导原则(2022版)》和《世界卫生组织指南制定手册(2014版)》,成立指南工作组。结合文献回顾和专家调研,确定14个临床问题。通过系统的证据检索、评价与分级,形成推荐意见决策表;采用德尔菲法对初步形成的推荐意见进行专家共识,最终形成19条非手术疗法治疗LDH的推荐意见。本指南可供中西医骨科相关从业人员参考和使用。

关键词：腰椎间盘突出症非手术疗法循证实践指南

A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

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Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao guo Cheng Zhou Ting Gao Jing-Jing Wu Victor Han Steven Cao hong-jiang Wei Yu-Yao Zhang Min Xuan Quan-Quan Gu Pei-Yu huang Chun-Lei liu Jia-li Pu Bao-Rong Zhang Feng Cui Xiao-Jun Xu Min-Ming Zhang Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain ***,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous *** this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August *** to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation *** extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training *** informative features so identified were then used to construct a diagnostic model for *** constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training *** the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,*** accuracies for predicting tremor-dominant and non-tremor-dominant PD w

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

基于氢化物发生技术的CdSe量子点水相制备新方法研究及其用于银的高灵敏传感分析

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发光学报 2017年第5期38卷 574-579页

作者：黄科李玲黄国英江雪罗虹熊小莉袁欣四川师范大学化学与材料科学学院四川成都610068 成都中医药大学药学院四川成都611137

报道了一种新型的利用氢化物发生技术水相合成高质量硒化镉量子点(CdSe QDs)的方法。通过将硼氢化钾与亚硒酸混合产生H_2Se气体,并将其可调控地引入到含镉溶液中,从而制备出化学性质稳定、荧光性能良好的CdSe量子点。所合成的量子点被... 详细信息

报道了一种新型的利用氢化物发生技术水相合成高质量硒化镉量子点(CdSe QDs)的方法。通过将硼氢化钾与亚硒酸混合产生H_2Se气体,并将其可调控地引入到含镉溶液中,从而制备出化学性质稳定、荧光性能良好的CdSe量子点。所合成的量子点被成功应用于环境水样及细胞样品中痕量银的分析,分析检出限为0.005μg·mL^(-1),相对标准偏差小于2.7%(n=7),分析结果令人满意。该方法具有操作简单、稳定性好、灵敏度高、绿色环保等优点。

关键词： CdSe量子点氢化物发生银离子

Clinical Control Study of Endoscopic Full-thickness Resection and Laparoscopic Surgery in the Treatment of Gastric Tumors Arising from the Muscularis Propria

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Chinese Medical Journal 2015年第11期128卷 1455-1459页

作者： Cheng-Rong Wu liu-Ye huang Juan guo Bo Zhang Jun Cgi Cheng-Ming Sun li-Xin jiang Zhi-Hua Wang Ai-hong Ju Department of Gastroenterology Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Clinical Laboratory Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China Department of Abdominal Surgery Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University Yantai Shandong 264000 China

Background： Gastric stromal tumors arising from the muscularis propria are located in deeper layers. Endoscopic resection may be contraindicated due to the possibility of perforation. These tumors are therefore usually removed by surgical or laparoscopic procedures. This study evaluated the curative effects, safety and feasibility of endoscopic full-thickness resection （EFR） of gastric stromal tumors originating from the muscularis propria. Methods： This study enrolled 92 patients with gastric stromal tumors 〉2.5 cm originating from the muscularis propria. Fifty patients underwent EFR, and 42 underwent laparoscopic intragastric surgery. Operation time, complete resection rate, length of hospital stay, incidence of complications, and recurrence rates were compared in these two groups. Results： EFR resulted in complete resection of all 50 gastric stromal tumors, with a mean procedure time of 85± 20 min, a mean hospitalization time of 7.0± 1.5 days and no complications. Laparoscopic intragastric surgery also resulted in a 100% complete resection rate, with a mean operation time of 88 ± 12 min and a mean hospitalization period of 7.5 ± 1.6 days. The two groups did not differ significantly in operation time, complete resection rates, hospital stay or incidence of complications （P 〉 0.05）. No patient in either group experienced tumor recurrence. Conclusions： EFR technique is effective and safe for the resection of gastric stromal tumors arising from the muscularis propria.

关键词： Endoscopy Full-thickness Excision Gastric Stromal Tumor Muscularis Propria Treatment

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1585-1600页

作者： Yiyue Ge Tingzhong Tian Suling huang Fangping Wan Jingxin li Shuya li Xiaoting Wang Hui Yang lixiang hong Nian Wu Enming Yuan Yunan Luo lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan jiang Yunfu Wu Ying Chi Xiling guo Lunbiao Cui liang Xiao Zeng li Chunhao Yang Zehong Miao ligong Chen Haitao li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng Institute for Interdisciplinary Information Sciences Tsinghua UniversityBeijingChina NHC Key laboratory of Emeric Pathogenic Microbiology Jiangsu Provincial Center for Diseases Control and PreventionNanjingJiangsu ProvinceChina shanghai Institute of Materia Medica Chinese Academy of SciencesShanghaiChina Silexon Al Technology Co. Ltd.NanjingJiangsu ProvinceChina Department of Computer Science University of Illinois at Urbana-ChampaignIllinoisILUSA School of Pharmaceutical Sciences Tsinghua UniversityBeijingChina School of Electronic Information and Communications Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Automation Tsinghua UniversityBeijingChina Inner Mongolia Alashan League Organization Establishment Committee Office Electronic Support Center AlashanInner MongoliaChina Convalife(shanghai)Co. Ltd.ShanghaiChina Advanced Innovation Center for Human Brain Protection Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Beijing Advanced Innovation Center for Structural Biology Tsinghua-Peking Joint Center for Life SciencesDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijingChina Center for Global Health Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against *** in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat *** in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic *** addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection.

关键词： prevention respiratory acute

3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration

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Bioactive Materials 2021年第10期6卷 3620-3633页

作者： Weimin guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang li Yufeng Zheng Xu li Jingxiang huang Wei Niu Shuangpeng jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu libo Hao Xifu Zheng Shuyun liu Quanyi guo Department of Orthopaedic Surgery First Affiliated HospitalSun Yat-sen UniversityNo.58 Zhongshan Second RoadYuexiu DistrictGuangzhouGuangdong510080People’s Republic of China Institute of Orthopedics The First Medical CenterChinese PLA General HospitalBeijing Key Lab of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLA.No.28 Fuxing RoadHaidian DistrictBeijing 100853People’s Republic of China Department of Orthopedic Surgery Beijing Jishuitan HospitalFourth Clinical College of Peking UniversityNo.31 Xinjiekou East StreetXicheng DistrictBeijing100035People’s Republic of China Department of Orthodontics Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityNo.56 Linyuan Xi RoadYuexiu DistrictGuangzhouGuangdong 510055People’s Republic of China Center for Biomaterial and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871People’s Republic of China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing 100871People’s Republic of China Musculoskeletal Research Laboratory Department of Orthopaedics and TraumatologyInnovative Orthopaedic Biomaterial and Drug Translational Research LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongPeople’s Republic of China Institute of Anesthesiology The First Medical CenterChinese PLA General HospitalNo.28 Fuxing RoadHaidian DistrictBeijing 100853People’s Republic of China Department of Orthopedic Surgery First Affiliated HospitalDalian Medical UniversityNo.222 Zhongshan RoadXigang DistrictDalian 116011China

Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in *** this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem ***,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in ***,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native *** these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was *** cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native ***,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep *** staining confirmed neo-menisci showed meniscus-like heterogeneous *** scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same *** magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold *** conclusion,PCL-MECM scaffold appears to optimize meniscus *** could represent a promising approach worthy of further investigation in preclinical applications.

关键词： 3D printing Cell-free Decellularization Biomimetic scaffold Meniscus regeneration

Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition)

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World Journal of Pediatrics 2018年第5期14卷 437-447页

作者： Xing-Wang li Xin Ni Su-Yun Qian Quan Wang Rong-Meng jiang Wen-Bo Xu Yu-Cai Zhang Guang-Jun Yu Qiang Chen Yun-Xiao shang Cheng-Song Zhao Hui Yu Ting Zhang Gang liu Hui-ling Deng Jie Gao Xian-Gui Ran Qiao-Zhi Yang Bian-li Xu Xue-Yong huang Xing-Dong Wu Yi-Xiao Bao Yi-Ping Chen Zhi-Hai Chen Qing-Quan liu guo-Ping Lu Chun-Feng liu Rong-Bing Wang guo-liang Zhang Fang Gu hong-Mei Xu Ying li Tao Yang Infectious Disease Diagnosis and Treatment Center Beijing Ditan Hospital Capital Medical UniversityBeijingChina Otorhinolaryngology Head andN eck Surgery Beijing Children’s HospitalCapital Medical UniversityBeijingChina Prediatric Intensive Care Unit Beijing Children’s Hospital of Capit al Medical UniversityBeijingChina National Institute For Viral Disease Control and Prevention Chinese Center for Disease Control and Pre ventionBeijingChina Children’s Hospital ofshanghai Jiaotong University ShanghaiChina Pneumology department Jiangxi Provincial Children’s HospitalNanchangChina Department of P ediatric Pneumology Shengjing Hospital of China Medical UniversityShenyangChina Department of Inf ectious Diseases Beijing Children’s HospitalCapital Medical UniversityBeijingChina Department of Inf ectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Digestive Department Children’s Hospital of Shanghai Jiaotong UniversityShanghaiChina Department of Inf ectious Diseases The Children’s Hospital of Xi'anXi’anChina Infection Control Offi ce Children’s Hospital ofShanghai Jiaotong UniversityShanghaiChina Department ofR espiratory Medicine People’s Hospital ofFuy ang CityFuyangChina Department of P ediatrics People’s Hospital of Liaoc heng CityLiaochengChina

Background Hand, foot, and mouth disease (HFMD) is a common infectious disease in childhood caused by an enterovirus (EV), and which is principally seen in children under 5 years of age. To promote diagnostic awareness and effective treat-ments, to further standardize and strengthen the clinical management and to reduce the mortality of HFMD, the guidelines for diagnosis and treatment have been developed. Methods National Health Commission of China assembled an expert committee for a revision of the guidelines. The com-mittee included 33 members who are specialized in diagnosis and treatment of HFMD. Results Early recognition of severe cases is utmost important in diagnosis and treatment of patients with HFMD. The key to diagnosis and treatment of severe cases lies in the timely and accurate recognition of stages 2 and 3 of HFMD, in order to stop progression to stage 4. Clinicians should particularly pay attention to those EV-A71 cases in children aged less than 3 years, and those with disease duration less than 3 days. The following indicators should alert the clinician of possible deterioration and impending critical disease: (1) persistent hyperthermia;(2) involvement of nervous system;(3) worsening respiratory rate and rhythm;(4) circulatory dysfunction;(5) elevated peripheral WBC count;(6) elevated blood glucose and (7) elevated blood lactic acid. For treatment, most mild cases can be treated as outpatients. Patients should be isolated to avoid cross-infection. Intense treatment modalities should be given for those severe cases. Conclusion The guidelines can provide systematic guidance on the diagnosis and management of HFMD.

关键词： Diagnosis Guidelines HFMD Treatment

MiR-515-5p通过调控硫酸软骨素蛋白聚糖4表达对卵巢癌A2780细胞增殖和转移的影响及其机制

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解剖学报 2022年第1期53卷 42-49页

作者：江红黄艳丽邢辉汪黎明郭红湖北文理学院附属医院襄阳市中心医院妇产科湖北襄阳441021 华中科技大学同济医学院湖北省妇幼保健院妇产科武汉430070

目的探讨miR-515-5p对硫酸软骨素蛋白聚糖4(CSPG4)的靶向调控作用,以及对卵巢癌细胞系A2780细胞增殖和转移的影响。方法通过生物信息学工具预测miR-515-5p的靶基因。Real-time PCR和Western blotting法检测65例卵巢癌组织和与其对应的... 详细信息

目的探讨miR-515-5p对硫酸软骨素蛋白聚糖4(CSPG4)的靶向调控作用,以及对卵巢癌细胞系A2780细胞增殖和转移的影响。方法通过生物信息学工具预测miR-515-5p的靶基因。Real-time PCR和Western blotting法检测65例卵巢癌组织和与其对应的癌旁组织中miR-515-5p和CSPG4的表达。将A2780细胞分为miR-NC组、miR-515-5p组、si-NC组、si-CSPG4组、miR-515-5p+pcDNA组和miR-515-5p+pcDNA-CSPG4组。MTT法检测细胞增殖活力,Transwell检测细胞迁移和侵袭数,Western blotting检测细胞周期蛋白D1(cyclinD1)、P21、基质金属蛋白酶(MMP)-2和MMP-9蛋白的表达。双荧光素酶报告基因实验和Western blotting验证miR-515-5p对CSPG4基因的调控作用。结果生物信息学分析显示,CSPG4是miR-515-5p的潜在靶基因之一。与癌旁组织相比,卵巢癌组织miR-515-5p的表达较低,CSPG4的表达较高(PlinD1、MMP-2和MMP-9蛋白的表达较低,P21蛋白的表达较高,细胞活力较低,细胞迁移和侵袭数较少(PlinD1、MMP-2和MMP-9蛋白的表达较低,P21蛋白的表达较高,细胞活力较低,细胞迁移和侵袭数较少(PlinD1、MMP-2和MMP-9蛋白的表达较高,P21蛋白的表达较低,细胞活力较高,细胞迁移和侵袭数较多(P<0.05)。MiR-515-5p靶向并负性调控CSPG4表达。结论MiR-515-5p通过靶向CSPG4可抑制卵巢癌细胞A2780增殖和转移。

关键词：卵巢癌微小RAN-515-5p 硫酸软骨素蛋白聚糖4 细胞增殖转移 Transwell实验人

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非时间参考的类车机器人定点跟踪控制

中国机械工程 2015年第13期26卷 1705-1711页

作者：李红郭孔辉宋晓琳黄江湖南大学汽车车身先进设计制造国家重点实验室长沙410082 清华大学汽车安全与节能国家重点实验室北京100084 吉林大学汽车仿真与控制国家重点实验室长春130022

针对移动机器人控制研究中的小车速度与加速度饱和限制现象,提出了非时间参考的定点跟踪控制方法。选择随时间单调递增的非时间变量为转向控制律变量,摆脱了移动机器人速度与加速度对控制律的时域限制。在Simulink中建立控制逻辑并进行... 详细信息

针对移动机器人控制研究中的小车速度与加速度饱和限制现象,提出了非时间参考的定点跟踪控制方法。选择随时间单调递增的非时间变量为转向控制律变量,摆脱了移动机器人速度与加速度对控制律的时域限制。在Simulink中建立控制逻辑并进行了单目标点与多目标点连续跟踪仿真。单目标点跟踪仿真结果表明,对于任意初始状态机器人,提出的定点跟踪控制方法均能使小车到达目标状态。多目标点连续跟踪结果表明,可将定点跟踪控制策略应用于类车机器人的路径跟踪控制。

关键词：定点跟踪非完整约束非时间参考非线性反馈类车机器人