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Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia

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Journal of Pharmaceutical Analysis 2021年第2期11卷 155-162页

作者： Ming-Rui Shen Yi He shang-mei Shi Chinese Pharmacopoeia Commission No.11 Fahua NanliBeijing100061China

As an important branch of medicine, Traditional Chinese Medicine(TCM) has been applied for the treatment of diseases for thousands of years in China and other countries in East Asia. The Chinese Pharmacopoeia(ChP) is a drug code formulated by the Chinese government, and it includes a special volume for the monographs of TCM, which plays an important role in ensuring the quality of drugs. The use of quality control technology has always been a complex and important factor in TCM. Owing to the chemical diversity of TCM, chromatography technology has been proven to be a comprehensive strategy for the assessment of the overall quality of TCM and has become the main analytical method in the *** article provides an overview of the classical and modern chromatographic technologies applied in the ChP, and summarizes the advantages and disadvantages of each technique in the TCM *** 2020, the new edition of the Ch P(the 2020 edition) has been implemented at the end of 2020. This paper also contains a brief introduction about the application of chromatographic technologies in the new edition of the ChP.

关键词： Traditional Chinese medicine Chinese pharmacopoeia Chromatographic technology Quality control

Fusobacterium nucleatum and colorectal cancer:A review

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World Journal of Gastrointestinal Oncology 2018年第3期10卷 71-81页

作者： Fu-mei shang Hong-Li Liu Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Fusobacterium nucleatum (***) is a Gramnegative obligate anaerobe bacterium in the oral cavity and plays a role in several oral diseases, including periodontitis and gingivitis. Recently, several studies have reported that the level of *** is significantly elevated in human colorectal adenomas and carcinomas compared to that in adjacent normal tissue. Several researchers have also demonstrated that *** is obviously associated with colorectal cancer and promotes the development of colorectal neoplasms. In this review, we have summarized the recent reports on *** and its role in colorectal cancer and have highlighted the methods of detecting *** in colorectal cancer, the underlying mechanisms of pathogenesis, immunity status, and colorectal cancer prevention strategies that target ***.

关键词： Fusobacterium nucleatum Carcinoma Colon and rectal carcinoma Host immunity Gut microbiome

Esterification and Chemoselective Synthesis of R-Tetrahydrothiazo-2-thione-4-carboxylic Esters Catalyzed by TiCl_4

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Chemical Research in Chinese Universities 2007年第4期23卷 430-432页

作者： shang Yan-mei LI Jing SONG Zhi-guang LI Ye-zhi HUANG Hua-min College of Chemistry School of Public Health Key Laboratory for Supermolecular Structure and Materials of Ministry of Education Jilin University Changchun 130021 P. R. China

A series of esters of R-tetrahydrothiazo-2-thione-4-carboxylic acid [ R-TTCA ] was synthesized by direct esterifica- tion of R-TTCA with alcohols（CH3OH, C2H5OH, n-C3HTOH, i-C3HTOH, n-C4H9OH, sec-C4H9OH） in the presence of TiCl4 as the catalyst at room temperature without using any other solvent or dehydrant in high yields, 91.6%-99.1% for primary alcohols and 55%- 80% for secondary alcohols. The catalyst has a strong chemoselec-tive activity for the esterification of primary alcohols with R-TTCA in the presence of secondary alcohols. Owing to high yield, high chemoselectivity, and mild conditions used, this is an efficient method for the esterification of prima-ry alcohols with R-TTCA.

关键词： R-Tetrahydrothiazo-2-thione-4-carboxylic acid TICl4 Chemoselectivity Esterification

Esterification and Selective Esterification in the Presence of TiCl_4

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Chemical Research in Chinese Universities 2007年第6期23卷 669-673页

作者： shang Yan-mei LI Jing ZHANG Ping SONG Zhi-guang LI Ye-zhi HUANG Hua-min College of Chemistry Jilin University Changchun 130021 P. R. China School of Public Health Jilin University Changchun 130021 P. R. China Key Laboratory for Supermolecular Structure and Materials of Ministry of Education Jilin University Changchun 130012 P. R. China

A series of carboxylic acids was esterified to the corresponding esters with TICl4 as catalyst at room temperature, in high yields. This catalyst was highly effective for the selective esterification of primary alcohols with carboxylic acids, in the presence of secondary alcohols, and for the selective esterification of saturated acid with alcohol in the presence of conjugated acid or aromatic acid. On account of the high yield, high chemoselectivity, mild condition, and being free of other dehydrants, this is an efficient method.

关键词： Esterification Chemoselectivity TiCl4

Synthesis and Crystal Structure of (R)-4-Hydroxymethyl-2-thioxo Thiazolidine and Its Asymmetric Catalysis

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Chemical Research in Chinese Universities 2009年第1期25卷 43-46页

作者： LI Jing shang Yan-mei XIAO Chuan SONG Zhi-guang LI Ye-zhi HUANG Hua-min College of Chemistry Jilin University School of Public Health Jilin University Changchun 130021 P. R. China Key Laboratory for Supramoleeular Structure and Materials of Ministry of Education Jilin University Changehun 130012 P. R. China

（R）-4-Hydroxymethyl-2-thioxo thiazolidine as a new chiral catalyst in the asymmetric addition of diethylzinc to benzaldehyde was synthesized from （R）-4-hydroxymethyl-2-thioxo thiazolidine carboxylic acid and its crystal structure was determined by X-ray diffraction method. The compound was crystallized in the orthorhombic system, space group P212121 with unit cell dimensions a=0.67253（12） nm; b=0.89164（17） nm; c=1.06146（19） nm, volume 0.6365（2） nm^3; Z=4, calculated denisity 1.557 Mg/m^3; absorption coefficient 0.733 mm^-1; F（000）=312. The X-ray crystal structure analysis reveals that the compound has a thione group.

关键词： Crystal structure Asymmetric (R)-4-Hydroxymethyl-2-thioxothiazolidine

A new member of the calix[4]crown family:Facile synthesis and characterization of a calix[4]crown-9 cone conformer

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Chinese Chemical Letters 2009年第2期20卷 143-146页

作者： Hao Hui Zhou Xian mei shang Zhi Luo Yu Xiang Xia Jun Luo Guang Ya Xiang Tongji School of Pharmacy Huazhong University of Science and Technology Wuhan 430030 China

25,27-Dipropoxy-p-tert-butylcalix[4]crown-9 cone conformer 5 was readily synthesized via an intramolecular cyclization strategy in good yields. The structures of all the new compounds involved were confirmed by NMR, E... 详细信息

关键词： Calixcrown-9 Cone conformation Synthesis Intramolecular cyclization

一阶Lagrange系统的Lie对称性与守恒量

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物理学报 2000年第10期49卷 1901-1903页

作者：梅凤翔尚玫北京理工大学应用力学系北京100081

将一阶微分方程组化成一阶Lagrange方程 .利用常微分方程在无限小变换下的不变性 ,建立Lie对称性的确定方程 .给出Lie对称性导致守恒量的条件以及守恒量的形式 .

关键词：一阶LAGRANGE系统 LIE对称性守恒量

Synthesis and Crystal Structure of a Novel Diorganotin(Ⅳ) Complex Containing 3,4-Difluorobenzohydroxamato Ligand

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Chinese Chemical Letters 2006年第6期17卷 821-824页

作者： Xian mei shang Ji Zhou WU Qing Shan LI Tongji Pharmaceutical College Huazhong University of Science and Technology Wuhan 430030 School of Pharmaceutical Science Shanxi Medical University Taiyuan 030001

A new five-coordinate mixed-ligand compound, di-n-butyl（3,4-difluorobenzoxy）（3,4-difluorobenzohydroxamato）tin（Ⅳ） 1 was synthesized and characterized by IR, ^1H, ^13C, ^119Sn NMR spectra and single crystal X-ray... 详细信息

关键词： Diorganotin(Ⅳ) crystal structure 3,4-difluorobenzohydroxamic acid.

VIRUS-HOST INTERACTION OF ENTEROVIRUS 71:THE BEGINNING OF AN UNFOLDING STORY

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VIRUS-HOST INTERACTION OF ENTEROVIRUS 71:THE BEGINNING OF AN...