检索结果-南通市图书馆

Joint Detection of Serum Vitamin D,Body Mass Index,and Tumor Necrosis Factor Alpha for the Diagnosis of Crohn’s Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

当代医学科学(英文) 2023年第3期43卷 496-504页

作者： ying ZHENG Jing-hong LI shan-ying liao Yi-ming FU Yan-jun ZHANG Jun-long LIN Xin-bin CHEN Wei-hong SHA Shi-xue DAI Wen-jun MA Department of Nutrition Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China The First School of Clinical Medicine&Nanfang Hospital Southern Medical UniversityGuangzhou 510080China Department of Gastroenterology Guangdong Provincial Geriatrics InstituteNational Key Clinical SpecialtyGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China

Objective Vitamin D(VD)deficiency was reported to contribute to the progression of Crohn’s disease(CD)and affect the prognosis of CD *** study investigated the role of serum VD,body mass index(BMI),and tumor necrosis factor alpha(TNF-α)in the diagnosis of Crohn’s *** CD patients(n=76)and healthy subjects(n=76)were enrolled between May 2019 and December *** serum 25-hydroxyvitamin D[25(OH)D]levels,BMI,and TNF-αlevels,together with other biochemical parameters,were assessed before *** diagnostic efficacy of the single and joint detection of serum 25(OH)D,BMI,and TNF-αwas determined using receiver operating characteristic(ROC)*** The levels of 25(OH)D,BMI,and nutritional indicators,including hemoglobin,total protein,albumin,and high-density lipoprotein cholesterol,were much lower,and the TNF-αlevels were much higher in the CD patients than in the healthy subjects(P<0.05 for all).The areas under the ROC curve for the single detection of 25(OH)D,BMI,and TNF-αwere 0.887,0.896,and 0.838,respectively,with the optimal cutoff values being 20.64 ng/mL,19.77 kg/m^(2),and 6.85 fmol/mL,*** diagnostic efficacy of the joint detection of 25(OH)D,BMI,and TNF-αwas the highest,with an area under the ROC curve of 0.988(95%CI:0.968–1.000).Conclusion The joint detection of 25(OH)D,TNF-α,and BMI showed high sensitivity,specificity,and accuracy in CD diagnosis;thus,it would be effective for the diagnosis of CD in clinical practice.

关键词： Crohn’s disease vitamin D body mass index tumor necrosis factor alpha

KeyEE:Enhancing Low-Resource Generative Event Extraction with Auxiliary Keyword Sub-Prompt

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2024年第2期7卷 547-560页

作者： Junwen Duan Xincheng liao ying An Jianxin Wang Hunan Key Laboratory of Bioinformatics School of Computer Science and EngineeringCentral South UniversityChangsha 410083China Big Data Institute Central South UniversityChangsha 410083China

Event Extraction(EE)is a key task in information extraction,which requires high-quality annotated data that are often costly to *** classification-based methods suffer from low-resource scenarios due to the lack of label semantics and fine-grained *** recent approaches have endeavored to address EE through a more data-efficient generative process,they often overlook event keywords,which are vital for *** tackle these challenges,we introduce KeyEE,a multi-prompt learning strategy that improves low-resource event extraction by Event Keywords Extraction(EKE).We suggest employing an auxiliary EKE sub-prompt and concurrently training both EE and EKE with a shared pre-trained language *** the auxiliary sub-prompt,KeyEE learns event keywords knowledge implicitly,thereby reducing the dependence on annotated ***,we investigate and analyze various EKE sub-prompt strategies to encourage further research in this *** experiments on benchmark datasets ACE2005 and ERE show that KeyEE achieves significant improvement in low-resource settings and sets new state-of-the-art results.

关键词： natural language processing Event Extraction(EE) Multi-Prompt Learning(MPL) low-resource

Chemical defense mediates population density-driven on anuran brain size evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第5期67卷 1076-1078页

作者： ying Jiang Lianju Yuan Wenbo liao Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchong 637009China Key Laboratory of Artificial Propagation and Utilization in Anurans of Nanchong City China West Normal UniversityNanchong 637009China

Dear Editor,The evolutionary arms race between predator and prey is a strong selective force for producing a wide array of defense strategies in animals,including strong limbs,body armor,poisonousness,mimicry,or cryps... 详细信息

关键词： evolution size media

Effects of impregnation sequence on the NH_(3)-SCR activity and hydrothermal stability of a Ce-Nb/SnO_(2) catalyst

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第4期138卷 450-457页

作者： ying Zhu Wenpo shan Zhihua Lian Jingjing Liu Yan Zhang Hong He Center for Excellence in Regional Atmospheric Environment and Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of SciencesNingbo 315800China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Hydrothermal stability is crucial for the practical application of deNO_(x)catalyst on diesel vehicles,for the selective catalytic reduction of NO_(x)with NH_(3)(NH_(3)-SCR).SnO_(2)-based materials possess superior hydrothermal stability,which is attractive for the development of NH_(3)-SCR *** this work,a series of Ce-Nb/SnO_(2)catalysts,with Ce and Nb loading on SnO_(2)support,were prepared by impregnation *** was found that,the NH_(3)-SCR activities and hydrothermal stabilities of the Ce-Nb/SnO_(2)catalysts significantly varied with the impregnation sequences,and the Ce-Nb(f)/SnO_(2) catalyst that firstly impregnated Nb and then impregnated Ce exhibited the best *** characterization results revealed that CeNb(f)/SnO_(2)possessed appropriate acidity and redox ***,the strong synergistic effect between Nb and Sn species stabilized the structure and maintained the dispersion of acid *** study may provide a new understanding for the effect of impregnation sequence on activity and hydrothermal stability and a new environmental-friendly NH_(3)-SCR catalyst with potential applications for NO_(x)removal from diesel and hydrogenfueled engines.

关键词： NO_(x)emission control NH_(3)-SCR Hydrothermal stability Ce-Nb/SnO_(2)catalyst Impregnation sequence

Facet effects on bimetallic ZnSn hydroxide microcrystals for selective electrochemical CO2 reduction

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第8期9卷 1314-1320页

作者： Liu Han Cheng-wei Wang shan-shan Luo ying-tang Zhou Bing Li Ming Liu School of Chemistry and Chemical Engineering Harbin Institute of Technology National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean University

Employing crystal facets to regulate the catalytic properties in electrocatalytic carbon dioxide reduction reaction（eCO2RR） has been well demonstrated on electrocatalysts containing single metals but rarely explored for bimetallic systems. Here, we synthesize Zn Sn（OH）6（ZSO）microcrystals（MCs） with distinct facets and investigate the facet effects in eCO2RR. Electrochemical studies and in situ Fourier Transform Infrared Spectroscopy（in situ-FTIR） reveal that ZSO MCs produce mainly C1 products of HCOOH and CO. The {111} facet of the ZSO MCS exhibits higher selectivity and faradaic efficiency（FE） than that of the {100} facet over a wide range of potentials（-0.9 V ～-1.3 V versus RHE）. Density Functional Theory（DFT） calculations elucidate that the {111} facet is favorable to the adsorption/activation of CO2molecules,the formation of intermediate in the rate-determining step, and the desorption of C1 products of CO and HCOOH molecules.

关键词： ZnSn(OH) 6 Crystal facets Electrochemical carbon dioxide reduction C1 product Density functional theory

Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 805-814页

作者： Hong-Tao shan Jia-Xin He Bing-Yan Zhu Xue-Ting Cao ying-ying Yan Jian-Jun Zhou Hong Huo Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

In this work,poly(3-hexylthiophene)(P3HT)ultrathin films(P3HT-T)were prepared by spin-coating a dilute P3HT solution(in a toluene:o-dichlorobenzene(Tol:ODCB)blend with a volume ratio of 80:20)with ultrasonication and the addition of the nucleating agent bicycle[2.2.1]heptane-2,3-dicarboxylic acid disodium salt(HPN-68L)on glass,Si wafers and indium tin oxide(ITO)*** electrical and mechanical properties of the P3HT-T ultrathin films were investigated,and it was found that the conductivity and crack onset strain(COS)were simultaneously improved in comparison with those of the corresponding pristine P3HT film(P3HT-0,without ultrasonication and nucleating agent)on the same substrate,regardless of what substrate was ***,the conductivity of P3HT-T ultrathin films on different substrates was similar(varying from 3.7 S·cm^(-1)to 4.4 S·cm^(-1)),yet the COS increased from 97%to 138%by varying the substrate from a Si wafer to *** grazing-incidence wide-angle X-ray diffraction(GIXRD),UV-visible(UV-Vis)spectroscopy and atomic force microscopy(AFM),we found that the solid order and crystallinity of the P3HT-T ultrathin film on the Si wafer are highest,followed by those on glass,and much lower on ***,the surface energy and roughness of three substrates were investigated,and it was found that the polar component of the surface energyγp plays a critical role in determining the crystalline microstructures of P3HT ultrathin films on different *** work indicates that the P3HT ultrathin film can obviously improve the stretchability and simultaneously retain similar electrical performance when a suitable substrate is *** findings offer a new direction for research on stretchable CP ultrathin films to facilitate future practical applications.

关键词： P3HT ultrathin film Substrate Crystalline microstructures Polar component of the surface energy Electrical and stretchable performances

Harnessing innate immune pathways for therapeutic advancement in cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin Yuheng liao Hui Yang ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

Unveiling the in-plane anisotropic dielectric waveguide modes in α-MoO_(3) flakes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第7期33卷 631-636页

作者：廖莹陈佳宁 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

The unique in-plane and out-of-plane anisotropy of α-MoO_(3) has attracted considerable interest with regard to potential optoelectronic applications. However, most research has focused on the mid-infrared spectrum, leaving its properties and applications in the visible and near-infrared light spectrum less explored. This study advances the understanding of waveguiding properties of α-MoO_(3) by near-field imaging of the waveguide modes along the [100] and [001] directions of α-MoO_(3) flakes at 633 nm and 785 nm. We investigate the effects of flake thickness and documented the modes' dispersion relationships, which is crucial for tailoring the optical responses of α-MoO_(3) in device applications. Our findings enhance the field of research into α-MoO_(3), highlighting its utility in fabricating next-generation optoelectronic devices due to its unique optically anisotropic waveguide.

关键词： waveguide anisotropic materials near-field imaging van der Waals materials

Exploring the Mechanism,Advancements,and Application of Thermogalvanic Effect in Hydrogels

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第5期42卷 543-556页

作者： Xiaoyu Yang Peng Wang Xiaolong Wu Yongli liao Senyun Liu Wei Duan ying Yue School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBaodingHebei071000 China Hebei Key Laboratory of Electric Machinery Health Maintenance & Failure Prevention North China Electric Power UniversityBaodingHebei071003 China Electric Power Research Institute China South Power GridGuangzhouGuangdong510000 China Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyangSichuan621000 China

The issue of energy consumption has garnered significant interest due to its excessive ***,thermoelectric devices have been getting increased attention,as they can harness waste heat from various sources,such as solar radiation,human body,and industrial ***,the recovery of low-grade heat has been a challenge,resulting in unsustainable energy use and significant *** considerable advances have been made in thermoelectric materials in recent decades,the majority of these devices still primarily employ ***,the emergence of quasi-solid-state thermoelectric materials represents a novel development with profound promise for the environment and *** materials offer several advantages,such as improved energy conversion capacities,cost-effectiveness,versatility,and scalability,to support increased ***,this review explores the application of thermoelectric materials in self-powered sensors,integrated modules,and heat harvesting ***,the potential of high-performance thermocouples based on thermogalvanic effects is assessed,along with the challenges that must be overcome to realize this goal.

关键词： Hydrogel Thermogalvanic effect Thermochemistry Electrolytes Flexible electronics