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Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula

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Journal of Integrative Medicine 2022年第1期20卷 73-82页

作者： Shuai Chen Jin Hu Deng-cheng Lu Hong-yi Liu shan-shan wei College of Basic Medical Sciences Yunnan University of Chinese MedicineKunming 650500Yunnan ProvinceChina Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina Key Laboratory of Syndrome Micro-Differentiation of Yunnan Province Kunming 650500Yunnan ProvinceChina

Objective: Numerous studies have demonstrated the close relationship between chronic stress and blood pressure(BP). Hypertensive subjects exhibit exaggerated reactions to stress, especially higher BP. The mechanisms by which stress affects pre-existing hypertension still need to be explored. Danzhi Xiaoyao Powder(DP), a historical traditional Chinese medicine formula, is a promising treatment for BP control in hypertensive patients under stress. The present study investigated the metabolomic disruption caused by chronic stress and the treatment effect and mechanism of ***: Spontaneously hypertensive rats(SHRs) were subjected to chronic restraint stress(CRS) for 4 weeks. BP was measured via the tail-cuff method, and anxiety-like behavior was quantified using the elevated-plus-maze test. Meanwhile, DP was administered intragastrically, and its effects were observed. Global metabolomic analysis was performed using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, followed by multivariate statistical analysis to detect differential metabolites and ***: DP alleviated the CRS-induced increase in BP and anxiety-like behavior. Systematic metabolic differences were found among the three study groups. A total of 29 differential plasma metabolites were identified in both positive-and negative-ion modes. These metabolites were involved in triglyceride metabolism, amino acid(phenylalanine, tryptophan, and glycine) metabolism, and steroid hormone ***: These findings expose the metabolomic disturbances induced by chronic stress in SHRs and suggest an innovative treatment for this disorder.

关键词： Hypertension Stress Metabolomics Danzhi Xiaoyao Powder

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Microbial hydrolysis of 17β-acetoxy steroidal compounds during aromatization by Arthrobacter simplex

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Acta Chimica Sinica(English Edition) 1983年第1期1卷 81-85页

作者： ZHOU wei-shan(CHOU wei-shan) HU Bo NI Yuan shanghai Institute of Organic Chemistry,Academia Sinica shanghai Institute of Organic Chemistry Academia Sinica

Steroidal compounds containing 17β-acetoxy group after aromatization by Arthrobactersimplex afforded 17β-hydroxy-,17-keto-or unhydrolyzed 17β-acetoxy-ring A-aromatic compou-nds.17-Keto-compounds were probably formed through the oxidation of the corresponding 17 β-hydroxyl group during fermentation with this *** of 17 β-acetoxy group isdependent upon other substituents present in the substrates.

关键词： OH acetoxy steroidal compounds during aromatization by Arthrobacter simplex Microbial hydrolysis of 17

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： shan Ping Yu Emily Choi Michael QJiang Ling wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Studies on the structure and synthesis of arteannuin and its related compounds——Ⅹ.The stereocontrolled synthesis of arteannuin and deoxyarteannuin from arteannuinic acid

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Chinese Journal of Chemistry 1983年第1期 98-99页

作者： XU Xing-xiang ZHU Jie HUANG Da-zhong ZHOU wei-shan(CHOU wei-shan) shanghai Institute of Organic Chemistry,Academia Sinica

Arteannuin(1)is a new sesquiterpene lactone containing a peroxide group and is anantimalarial principle isolated from Artemisia annua ***(2)occurs inthe same plant and was isolated as a metabolite from the urine of patients treated with *** now report the first stereocontrolled synthesis of these two naturally occurringsesquiterpene lactones starting from arteannuinic acid by the reaction sequence shown inScheme 2.

关键词： Studies on the structure and synthesis of arteannuin and its related compounds The stereocontrolled synthesis of arteannuin and deoxyarteannuin from arteannuinic acid

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Multiple B-cell epitope vaccine induces a Staphylococcus enterotoxin B-specific IgG1 protective response against MRSA infection

Multiple B-cell epitope vaccine induces a Staphylococcus ent...

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第十届全国免疫学学术大会

作者： Zhuo Zhao He-Qiang Sun shan-shan wei Bin Li Qiang Feng Jiang Zhu Hao Zeng Quan-Ming Zou Chao Wu National Engineering Research Center of Immunological Products Department of Microbiology and Biochemical Pharmacy College of Pharmacy Third Military Medical University Department of Gastroenterology Xinqiao Hospital Third Military Medical University Department of Pathology Southwest Hospital Third Military Medical University

Aims: We aimed to evaluate the efficacy and immunologic mechanisms of an SEB multiple B-cell epitope vaccine against MRSA ***: Identification of the immunodominant linear B-cell epitopes in MRSA SEB by over-lapping peptide ELISA. Analyse the protective role of the individual immunodominant SEB epitopes against MRSA challenge. Systemically analyse the protective mechanism of the multiple-epitope fusion protein against lethal MRSA challenge, in which the survivals, the bacterial burdens, histological analysis, Polypeptides-specific or SEB-specific antibody titre, antiserum Ig G subclass, and antisera opsonophagocytic-killing of the immunized mice were confirmed. The protective role of Polypeptides against various clinical MRSA isolates infections were ***: Synthetic overlapping peptide ELISA identified three novel B-cell immunodominant SEB epitopes(in addition to those previously known): SEB31-48, SEB133-150, and SEB193-210. Six B-cell immunodominant epitopes(amino acid residues 31-48, 97-114, 133-150, 193-210, 205-222, and 247-261) were sufficient to induce robust Ig G1/Ig G2 bspecific protective responses against MRSA infection. Therefore, we constructed a recombinant MRSA SEB-specific multiple B-cell epitope vaccine Polypeptides by combining the six SEB immunodominant epitopes and demonstrated its ability to induce a robust SEB-specific Ig G1 response to MRSA, as well as a Th2-directing isotype response. Moreover,Polypeptides-induced antisera stimulated synergetic opsonophagocytosis killing of MRSA. Most importantly, Polypeptides was more effective at clearing the bacteria in MRSA-infected mice than the whole SEB antigen, and was able to successfully protect mice from infection by various clinical MRSA isolates. Conclusion: We have mapped the B-cell immunodominant epitopes in SEB by synthetic overlapping peptide ELISA, combined these immunogens to construct a single SEB-specific multiple B-cell epitope vaccine(Polypeptides), and confirm

关键词： Methicillin-resistant Staphylococcus aureus Staphylococcal enterotoxin B B-cell immunodominant epitope Epitope-based vaccine

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中性粒细胞明胶酶相关载脂蛋白在大鼠脑出血后继发性脑损伤中的作用研究

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国际神经病学神经外科学杂志 2016年第4期43卷 292-296页

作者：戴芳王姗姗许宏伟中南大学湘雅医院老年医学科神经内科湖南省长沙市410008 解放军第187中心医院神经内科海南省海口市570100

目的探讨中性粒细胞明胶酶相关载脂蛋白(NGAL)在脑出血(ICH)后继发性脑损伤中的作用。方法采用Ⅶ胶原酶制作ICH模型,将90只雄性SD大鼠随机分为3组:正常对照组(10只)、假手术组(40只)和ICH模型组(40只)。分别在ICH后6 h、24 h、72 h和7 ... 详细信息

目的探讨中性粒细胞明胶酶相关载脂蛋白(NGAL)在脑出血(ICH)后继发性脑损伤中的作用。方法采用Ⅶ胶原酶制作ICH模型,将90只雄性SD大鼠随机分为3组:正常对照组(10只)、假手术组(40只)和ICH模型组(40只)。分别在ICH后6 h、24 h、72 h和7 d四个时间点对大鼠进行神经功能缺损评分;用免疫组化及RT-q PCR来观察不同时间点脑组织NGAL及MMP-9表达情况。结果免疫组化及RT-q PCR结果显示ICH后模型组各时间点均可见大量NGAL、MMP-9阳性细胞及NGAL mRNA表达,且明显高于正常组及假手术组(P<0.05)。ICH模型组NGAL与MMP-9蛋白表达呈正相关(P<0.01)。ICH模型组NGAL、MMP-9蛋白表达均与大鼠神经功能缺损评分呈正相关(P<0.05)。结论 ICH后NGAL表达明显增加,提示NGAL可能参与了脑出血后继发性脑损伤,并可能通过调节MMP-9的活性从而发挥作用,但NGAL是否为MMP-9的上游调控因子尚有待进一步研究。

关键词：脑出血中性粒细胞明胶酶相关载脂蛋白基质金属蛋白酶-9 脑损伤大鼠

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非接触式TYPE A智能卡天线的设计

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湘潭大学自然科学学报 2001年第3期23卷 34-36页

作者：严光文张其善吕善伟北京航空航天大学电子工程系北京100083

依据射频和天线的原理以及国际标准ＩＳＯ１４４４３对射频卡信号的具体要求，给出了Ａ类射频卡　读写器中天线设计的方法．包括天线的基本原理、品质因素Ｑ的确定、天线电器参数的　测试、输入阻抗的匹配等内容．

关键词：智能卡天线射频射频识别

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卷取温度对深冲DP钢组织性能及织构的影响

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钢铁 2016年第12期51卷 74-79页

作者：叶洁云安桂焕刘姗姗刘蔚宁汪志刚江西理工大学材料科学与工程学院江西赣州341000 国家电网公司交流建设分公司北京100031

为研究深冲织构的演变规律,利用OM、TEM和XRD等技术研究了热轧卷取温度对微碳深冲DP钢组织、性能与织构的影响。结果表明,热轧板主要由铁素体+珠光体构成,随卷取温度升高,铁素体晶粒略增大,伸长率逐渐上升;热轧板中钼基碳化物的最佳析... 详细信息

为研究深冲织构的演变规律,利用OM、TEM和XRD等技术研究了热轧卷取温度对微碳深冲DP钢组织、性能与织构的影响。结果表明,热轧板主要由铁素体+珠光体构成,随卷取温度升高,铁素体晶粒略增大,伸长率逐渐上升;热轧板中钼基碳化物的最佳析出温度为700℃;与650和750℃相比,700℃卷取后的退火板能获得较高体积分数(4.0%)马氏体与较细(11.7μm)铁素体的组织特征,同时拥有最强的〈111〉//ND纤维织构和最弱的{001}〈110〉织构,使得其抗拉强度达到455 MPa,塑性应变比r值达1.5。

关键词：双相钢卷取温度织构组织性能

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北京市东城区2013～2015年手足口病病原学实验室检测结果及其流行病学特征分析

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中国生物制品学杂志 2017年第6期30卷 633-636页

作者：李姗姗吴伟刘耀吴垠王超刘英霞北京市东城区疾病预防控制中心北京100009

目的分析北京市东城区2013~2015年手足口病(hand-foot-mouth disease,HFMD)病原学实验室检测结果及其流行病学特征。方法制备2013~2015年北京市东城区的HFMD疑似病例的咽拭子样本312份(包含监测样本225份及疫情样本87份),采用HFMD核酸... 详细信息

目的分析北京市东城区2013~2015年手足口病(hand-foot-mouth disease,HFMD)病原学实验室检测结果及其流行病学特征。方法制备2013~2015年北京市东城区的HFMD疑似病例的咽拭子样本312份(包含监测样本225份及疫情样本87份),采用HFMD核酸检测试剂盒检测样本中的肠道病毒(enterovirus,EV)的型别,并采用细胞培养法对部分EV阳性样本进行病毒分离。结合实验室结果及病例的流行病学特征进行统计学分析。结果 225份HFMD监测样本中,EV阳性112份,其中EV71型阳性20份,柯萨奇病毒A16型(coxsackievirus 16,CA16)阳性37份,其他EV型阳性55份。2013年发生HFMD聚集性疫情3起,均由EV71型引起;2014年发生3起,分别由EV71、CA16和其他型EV引起;2015年发生22起,6起由CA16型引起,3起由EV71型引起,4起由CA6型引起,6起由其他型EV引起,3起由非EV引起。经病毒分离获得EV71阳性菌株10株,CA16型阳性菌株20株。结论北京市东城区2013~2015年HFMD仍以EV71和CA16为主要致病原,CA6阳性率呈上升趋势。应扩展病毒分型检测项目,更好地发现本地区HFMD病原的流行和变异趋势。

关键词：手足口病肠道病毒71型柯萨奇病毒A16型病毒分离

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Pinx1在口腔鳞癌中的表达及意义

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口腔医学研究 2016年第10期32卷 1064-1066页

作者：吕珊珊魏秀峰孙鑫周阳魏玉雪刘桐高旭吉林大学口腔医学院口腔黏膜病科吉林省牙发育及颌骨重塑与再生重点实验室吉林长春130021 吉林大学口腔医学院口腔修复科吉林长春130021

目的:研究Pinx1在口腔鳞状细胞癌(OSCC)中的表达及意义。方法:免疫组织化学染色检测Pinx1在60例OSCC和20例正常口腔黏膜组织(NOM)中的表达情况。结果:Pinx1在NOM上皮中高表达,高表达率为100.00%,在OSCC中高表达率为65.00%,Pinx1高表达... 详细信息

目的:研究Pinx1在口腔鳞状细胞癌(OSCC)中的表达及意义。方法:免疫组织化学染色检测Pinx1在60例OSCC和20例正常口腔黏膜组织(NOM)中的表达情况。结果:Pinx1在NOM上皮中高表达,高表达率为100.00%,在OSCC中高表达率为65.00%,Pinx1高表达率明显低于NOM(P<0.05),随着分化程度的降低,Pinx1表达呈降低趋势(P<0.05),伴有淋巴结转移的病例中Pinx1表达水平显著低于不伴有淋巴结转移的OSCC(P<0.05),Pinx1的表达情况与患者性别年龄无关。结论:Pinx1可能与OSCC的发生、发展及转移有关。

关键词： Pinx1 口腔鳞状细胞癌免疫组织化学

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