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ZYZ451 Protects cardiomyocytes from hypoxia-induced apoptosis by enhancing MnSOD and STAT3 interaction

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中国药理学与毒理学杂志 2015年第S1期29卷 27-28页

作者： shan-shan luo Ya-qi SHEN Li-ming MA Xian-feng GU Yi-zhun ZHU Department of Pharmacology School of Pharmacy Fudan University Shanghai 201203 China Department of Medicinal Chemistry School of Pharmacy Fudan University Shanghai 201203 China Department of Pharmacology Loo Yong Lin School of Medicine National University of Singapore Singapore

OBJECTIVE 3,5-Dimethoxy-4-(2-amino-3-prop-2-ynylsulfanyl-propionyl)-benzoic acid 4-guanidino-butyl ester(ZYZ451)showed excellent cardio-protective effects in our previous ***,its therapeutic potential in vivo and the mechanism remained to be ***,we evaluated cardiac protective role of ZYZ451 in post-myocardial infarction(post-MI)rats,and elucidated the underlying *** Neonatal rat ventricular cardiomyoctys(NRVCs)were separated and subjected to pre-deoxidized(1%O2,5%CO2),and serum-free medium for 4h to obtain ischemic *** ROS,MnSOD activity and cell apoptosis were tested to verify the cardiac protective effects of *** and siRNA for Stat3 were used to determine role of Stat3 played in cardio-protective effectes of *** were isolated from NRVCs to determine expression of Stat3 and *** and coimmunoprecipitation were conducted to determine the interaction between MnSOD and *** apply post-MI model in rats,the rats were subjected to ligation of LAD except for control *** vehicle or ZYZ451(1,2or 5mg·kg-1)or mixture of Leonurine and SPRC(15mg·kg-1)was administered 7dbefore and 3more days after the *** at risk(AAR),apoptosis in AAR,LDH and MDA levels,and MnSOD activity and expression were detected to evaluate the cardiac *** mitochondria were isolated to determine MnSOD and Stat3 expression in ischemia,and coimmunoprecipitaion was performed to verify the interaction between MnSOD and Stat3 in *** ZYZ451 prevented hypoxia induced NRVCs apoptosis via increasing MnSOD activity and inhibiting mitochondrial ROS ***,5,15-DPP(STAT3phosphorylation inhibitor)failed to inhibit MnSOD activity,while knockout of STAT3 resulted in significant reduction of MnSOD activity,followed by increased mitochondrial ROS production and cardiomyocytes apoptosis in ***,protective effects of ZYZ451 were blunted in Stat3 deficient

关键词： hypoxia acute myocardial infarction ROS MnSOD apop

Application of well log normalization in coalfield seismic inversion

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 167-173页

作者： Qing-Xi LIN Su-Zhen SHI shan-shan LI Li luo Juan LI Zi-Liang YU State Key Laboratory of Coal Resources and Mine Safety China University of Mining & Technology (Beijing) Bering 100083China

During the process of coal prospecting and exploration, different measurement time, different logging instruments and series can lead to systematic errors in well logs. Accordingly, all logging curves need to be normalized in the mining area. By studying well-logging normalization methods, and focusing on the characteristics of the coalfield, the frequency histogram method was used in accordance with the condition of the Guqiao Coal Mine. In this way, the density and sonic velocity at marker bed in the non-key well were made to close to those in the key well, and were eventually equal. Well log normalization was completed when this method was applied to the entire logging curves. The results show that the scales of logging data were unified by normalizing coal logging curves, and the logging data were consistent with wave impedance inversion data. A satisfactory inversion effect was obtained.

关键词： well log normalization normalization method frequency histogram seismic inversion

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin luo Hang Li shan Guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

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变电站智能巡检机器人自适应定位算法研究

自动化与仪器仪表 2022年第12期 232-235页

作者：罗珊珊何泽家国网江苏省电力有限公司电力科学研究院南京211103

在变电站智能机器人巡检中,由于受周围复杂环境以及网络信号屏蔽的影响,机器人在行走与驻停时存在定位误差,智能巡检机器人搭载像机的云台也存在转动误差,导致目标会偏离机器人摄像机成像中心,严重情况下造成目标完全偏离像机视野,给后... 详细信息

在变电站智能机器人巡检中,由于受周围复杂环境以及网络信号屏蔽的影响,机器人在行走与驻停时存在定位误差,智能巡检机器人搭载像机的云台也存在转动误差,导致目标会偏离机器人摄像机成像中心,严重情况下造成目标完全偏离像机视野,给后续设备故障判断与预警分析带来一定困难。依据变电站已有目标先验信息约束,提出一种基于移动式单目视觉测量系统求解目标点的三维位姿信息,利用求取的目标点相对像机位姿的三维信息,计算出智能巡检机器人搭载的像机需要校正的偏转角度,确保目标在机器人在不同时刻对应位置处观测到的目标处于像机视野下的相同位置。实验结果表明,本文提出的算法具有较高的目标定位精度和较高的计算效率。

关键词：智能巡检机器人计算机视觉定位变电站图像处理

Magnetic Interactions and Band Gaps of the(CrO_(2))_(2)/(MgH_(2))_(n) Superlattices

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Chinese Physics Letters 2022年第11期39卷 57-62页

作者： Wanfei shan Jiangtao Du Weidong luo Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Institute of Natural Sciences Shanghai Jiao Tong UniversityShanghai 200240China

Lattice superlattices constructed with different materials such as ferromagnets and insulators at atomic scale provide an ideal platform for exploring many emergent physical *** the present work,a new type of superlattices composed of ferromagnetic half-metal CrO_(2),with a thickness of two atomic layers,together with insulating MgH_(2) are *** theoretical studies on the(CrO_(2))_(2)/(MgH_(2))_(n) (n=2,3,4,5,6)superlattices are carried out based on first-principles density-functional theory *** superlattices are ferromagnetic semiconductors with similar intra-layer magnetic exchange couplings between Cr *** the thickness of the MgH_(2) layer increases,the magnetic exchange interaction between inter-layer Cr ions shows oscillating decaying behavior,while the energy band gaps show a small *** understanding of magnetic couplings in these superlattices provides a pathway for constructing new ferromagnetic semiconductors.

关键词： ferromagnetic coupling layer

Automatic location and semantic labeling of landmarks on 3D human body models

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Computational Visual Media 2022年第4期8卷 553-570页

作者： shan luo Qitong Zhang Jieqing Feng State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China

Landmarks on human body models are of great significance for applications such as digital anthropometry and clothing *** diversity of pose and shape of human body models and the semantic gap make landmarking a challenging *** paper,a learning-based method is proposed to locate landmarks on human body models by analyzing the relationship between geometric descriptors and semantic labels of landmarks.A shape alignmentalgorithm is proposed to align human body models to break symmetric ambiguity.A symmetry-awaredescriptor is proposed based on the structure of the human body models,which is robust to both pose and shape variations in human body *** regression algorithm is adopted to establish the correspondence between several descriptors and semantic labels of the *** and qualitative analyses and comparisons show that the proposed method can obtain more accurate landmarks and distinguish symmetrical landmarks ***,a dataset of landmarked human body models is also provided,containing 271 human body models collected from current human body datasets;each model has 17 landmarks labeled manually.

关键词： 3D human body model descriptor land-marking shape alignment

Simple analytical model for depth-averaged velocity in meandering compound channels

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Applied Mathematics and Mechanics(English Edition) 2015年第6期36卷 707-718页

作者： Yuqi shan Chao LIU Maokang luo College of Mathematics Sichuan University State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University College of Water Resource and Hydropower Sichuan University

A simple but applicable analytical model is presented to predict the lat- eral distribution of the depth-averaged velocity in meandering compound channels. The governing equation with curvilinear coordinates is derived from the momentum equation and the flow continuity equation under the condition of quasi-uniform flow. A series of experiments are conducted in a large-scale meandering compound channel. Based on the experimental data, a magnitude analysis is carried out for the governing equation, and two lower-order shear stress terms are ignored. Four groups of experimental data from different sources are used to verify the predictive capability of this model, and good predictions are obtained. Finally, the determination of the velocity parameter and the limitation of this model are discussed.

关键词： meandering compound channel simple analytical model lateral distribu-tion method physical experiment depth-averaged velocity

Computation of Five-Dimensional Grain Boundary Energy

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 634-640页

作者： Yong-Kun luo Rong-shan Qin Department of Materials Imperial College London

Abstract A broken-bond type computational method has been developed for the calculation of the five-dimensional grain boundary energy. The model allows quick quantification of the unrelaxed five-dimensionally specified grain boundary energy in arbitrary orientations. It has been validated on some face-centred cubic metals. The stereo projections of grain boundary energy of ∑3,∑5,∑7, ∑9, ∑11, ∑17b and ∑31a have been studied. The results of Ni closely resemble experimentally determined grain boundary energy distribution figures, suggesting that the overall anisotropy of grain boundary energy can be reasonably approximated by the present simple model. Owing to the overlooking of relaxation matter, the absolute values of energy calculated in present model are found to be higher than molecular dynamic-based results by a consistent magnitude, which is 1 J/m2 for Ni. The coverage of present method forms a bridge between atomistic and meso-scale simulations regarding polycrystalline microstructure.

关键词： Boundaries Grain boundary energy Grain boundary structure