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Effect of nano-selenium loaded with lycium barbarum polysaccharide on the proliferation of lens epithelial cells after UVB damage in vitro

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 9-14页

作者： jing-Xiang Zhong shan-shan jin Kang-Sheng Wu Guo-Cheng Yu Lei-Lei Tu Lian Liu Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina

AIM:To investigate the effect of nano-selenium loaded with different concentrations of lycium barbarum polysaccharide(LBP-Se NPs)on the proliferation of human lens epithelial cells(HLECs)from UV ***:LBP-Se NPs were prepared and their particle size was ***(SRA01/04)were irradiated with UVB for different time(0,10,20,30,40,50,60 min)to construct a damaged model,the survival rate of cells was determined by methylthiazol tetrazolium(MTT)*** 4’,6-Diamidine-2’-phenylindole dihydrochloride(DAPI)staining was used to observe the status of cell nucleus and drug entering cytoplasm through cell membrane in SRA01/04 cells after adding LBP-SENPS loaded with coumarin fluorescence agent 24 h under fluorescence ***01/04 normal and UVB-damaged cells were treated with different amounts of LBP-Se NPs at different concentrations,cells proliferation were ***:The particle size of LBP-Se NPs was stable in the range of 150-200 *** survival rate changes with time after UVB irradiation were statistically *** 10 min of UVB exposure as the time was chosen to construct the cell damage *** DAPI staining,LBPSe NPs were observed to enter the cytoplasm through the cell membrane under fluorescence inverted *** of SRA01/04 at different concentrations of LBPSe NPs were *** survival rate was statistically different compared with the control *** higher the loading concentration of LBP in nano-Se drugs was,the higher the cell proliferation rate was(P<0.05).The lower the concentration of LBP-Se NPs,the higher the cell proliferation rate,showing a negative growth trend(P<0.05).The group with the highest average cell proliferation rate was 0.5μmol/L 2.0 mg/m L LBP-Se NPs(128.80%).When the 2.0 mg/m L LBP-Se NPs group was selected for cell photography,the cell density was higher at 0.5μmol/*** the increase of concentration,SRA01/04 cells appeared more cytoplasm dehydration,cell shrinkage and ap

关键词： lycium barbarum polysaccharide nano-selenium human lens epithelial cells ultraviolet irradiation

Development of a prediction model for enteral feeding intolerance in intensive care unit patients:A prospective cohort study

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1363-1374页

作者： Xue-Mei Lu Deng-Shuai Jia Rui Wang Qing Yang shan-shan jin Lan Chen School of Nursing Shanghai Jiao Tong UniversityShanghai 200025China Department of Nursing Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China

BACKGROUND Enteral nutrition(EN)is essential for critically ill ***,some patients will have enteral feeding intolerance(EFI)in the process of *** To develop a clinical prediction model to predict the risk of EFI in patients receiving EN in the intensive care *** A prospective cohort study was *** enrolled patients’basic information,medical status,nutritional support,and gastrointestinal(GI)symptoms were *** baseline data and influencing factors were *** regression analysis was used to establish the model,and the bootstrap resampling method was used to conduct internal *** The sample cohort included 203 patients,and 37.93%of the patients were diagnosed with *** the final regression analysis,age,GI disease,early feeding,mechanical ventilation before EN started,and abnormal serum sodium were *** the internal validation,500 bootstrap resample samples were performed,and the area under the curve was 0.70(95%CI:0.63-0.77).CONCLUSION This clinical prediction model can be applied to predict the risk of EFI.

关键词： Enteral feeding intolerance Critical care medicine Clinical prediction model Nutrition assessment Nutritional support Critical care nursing

New Taub-NUT black holes with massive spin-2 hair

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 51-58页

作者： Yu-Qi Chen Hai-shan Liu Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China

We consider Einstein gravity extended with quadratic curvature invariants,within which the well-known Ricci-flat Taub-NUT black hole remains a *** analysis of the unstable Lichnerowicz modes in the Taub-NUT background enables us to identify the mass and NUT parameters(m,n)where new Taub-NUT black holes can *** then adopt numerical techniques to construct these new Taub-NUT black holes,which bifurcate away from the Ricci-flat *** the Ricci-flat Taub-NUT,there can exist two new black holes for an appropriate given temperature,making it a total of three if we include the Ricci-flat one.

关键词： higher derivative gravity black hole solution Taub-NUT spacetime

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： shan-shan Jiang Zi-Ran Kang Ying-Xuan Chen jing-Yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

Research on Bast Fiber Extracted from the White Bark of Three Species in the Genus Broussonetia

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Chinese Journal of Polymer Science 2024年第6期42卷 729-738页

作者： shan-shan jin Si-Nong Wang Yan-Yan Huang jing-Yu Zhang Peng Liu Hui Yu Hong-Dong Zhang Yu-Liang Yang Institute for Preservation and Conservation of Chinese Ancient Books Fudan University LibraryFudan UniversityShanghai200433China State key laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China

Against the backdrop of a global paper resource shortage,there is a growing need to identify fast-growing tree species capable of producing long-lasting *** plant species namely Broussonetia kazinoki,Broussonetia papyrifera and hybrid paper mulberry,belong to the Broussonetia genus,were collected from China to study their white bark suitability for pulp and *** chemical composition revealed that the holocellulose content in Broussonetia kazinoki and Broussonetia papyrifera was more than 80%.The molecular weight distribution of several holocellulose/α-cellulose is observed by GPC,which allows us to better observe the changes of various components on the molecular *** yield,lignin,whiteness,and molecular weight of the pulps obtained by NaOH treatment were *** microscope was used to characterize the fiber length-width ratio and ***,the improvement of the fiber rigidity method based on the Kratky-Porod chain model makes it more theoretical and further reveals the influencing factors of fiber *** study demonstrates the high potentiality of these three species for papermaking applications.

关键词： Broussonetia genus Cellulose Alkaline pulping Kratky-Porod chain model Fiber rigidity

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Immune cells:potential carriers or agents for drug delivery to the central nervous system

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Military Medical Research 2025年第1期12卷 121-153页

作者： shan-shan Zhang Ruo-Qi Li Zhong Chen Xiao-Ying Wang Aaron S.Dumont Xiang Fan School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053China Clinical Neuroscience Research Center Department of Neurosurgery and NeurologyTulane University School of MedicineNew OrleansLA 70122USA

Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted ***,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain *** cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug ***,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain *** subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS ***,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.

关键词： Drug delivery systems Immune cells Blood-brain barrier Central nervous system

The gut microbiome promotes locomotion of Drosophila larvae via octopamine signaling

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Insect Science 2025年第1期32卷 277-289页

作者： Juncheng Hu Ran Bi Yuxuan Luo Kaihong Wu shan jin Zhihua Liu Yicong Jia Chuan-Xi Mao State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhanChina

The gut microbiome is a key partner of animals,influencing various aspects of their physiology and *** the diverse behaviors regulated by the gut microbiome,locomotion is vital for survival and reproduction,although the underlying mechanisms remain ***,we reveal that the gut microbiome modulates the locomotor behavior of Drosophila larvae via a specific neuronal type in the *** crawling speed of germ-free(GF)larvae was significantly reduced compared to the conventionally reared larvae,while feeding and excretion behaviors were *** with Acetobacter and Lactobacillus can fully and partially rescue the locomotor defects in GF larvae,respectively,probably due to the highest abundance of Acetobacter as a symbiotic bacterium in the larval gut,followed by ***,the gut microbiome promoted larval locomotion,not by nutrition,but rather by enhancing the brain levels of tyrosine decarboxylase 2(Tdc2),which is an enzyme that synthesizes octopamine(OA).Overexpression of Tdc2 rescued locomotion ability in GF *** findings together demonstrate that the gut microbiome specifically modulates larval locomotor behavior through the OA signaling pathway,revealing a new mechanism underlying larval locomotion regulated by the gut microbiome.

关键词： Drosophila melanogaster larval locomotion microbiome octopamine signaling

Performance and Nutrient Utilization of Layers Fed Diet Supplemented with Microbial Phytase and Cellulase

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Journal of Northeast Agricultural University(English Edition) 2003年第1期10卷 33-39页

作者： WANG Li juan,shan An shan,SONG jin cai (Animal Nutrition Institute,Northeast Agricultural University,Harbin Heilongjiang,150030,PRC) Animal Nutrition Institute Northeast Agricultural UniversityHarbin Heilongjiang150030PRC

A 31 week feeding trial was conducted to investigated the effects of dietary supplementation of microbial phytase and cellulase on performance,nutrients utilization and tibia quality of laying hens fed maize and soybean meal diets.192 18 week old Hisex layers were used in the trial A 2×2×2 factorial design was used in the experiment with three factors of two levels each:0 38% and 0 16% of dietary non phytate P(nP).0 and 300 U·kg -1 of phytase (Ph),and 0 and 0 10% of cellulase (Ce).The results showed that supplementation of 300 U·kg -1 phytase significantly improved utilization of dietary crude ash,CP,Ca,total P and copper (P<0 05),and improved tibia breaking strength (P<0 05).No effect of phytase on performance was *** of 0 10% cellulase decreased feed intake (P<0 05),increased utilization of CF (P<0 05) and Ca(P<0 01),and decreased total tibia ash weight (P<0 05).300 U·kg -1 phytase and 0 10% cellulase exhibited obvious positive interactions to enhance utilization of dietary phytic P and copper (P<0 05).0 16% nP did not reduce performance of the layers,but improved egg shell quality at 20 wks,increased utilization of dietary total P,phytic P and Copper (P<0 01),decreased utilization of dietary CP,increased tibia breaking strength and Ca,Mn contents of tibia(P<0 01)

关键词： microbial phytase cellulase layers performance utilization of nutrientss