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Association of a SLC30A8 Genetic Variant with Monotherapy of Repaglinide and Rosiglitazone Effect in Newly Diagnosed Type 2 Diabetes Patients in China

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Biomedical and Environmental Sciences 2012年第1期25卷 23-29页

作者： JIANG Feng LI Qing HU Cheng ZHANG Rong WANG Cong Rong YU Wei Hui LU Jing Yi tang shan shan BAO Yu Qian XIANG Kun San JIA Wei Ping Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People＇s Hospital Shanghai 200233 China shanghai Diabetes Institute Shanghai 200233 China shanghai Key Laboratory of Diabetes Mellitus Shanghai 200233 China shanghai Clinical Center for Diabetes Shanghai 200233 China

Objective To investigate a potential relationship between Solute carrier family 30 （zinc transporter） member 8 （SLC3OAS） rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients. Methods A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks （104 and 105 patients, respectively）. Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment. An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy. Results Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study. 6 value of homeostasis model assessment of beta cell function （HOMA-B） and 6 value of fasting proinsulin levels were statistically significant between three genotype groups （P=0.0149 and 0.0246, respectively） after rosiglitazone treatment. However, no genotype association was observed in the repaglinide or rosiglitazone group with other parameters. Conclusion The SLC3OA8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in shanghai, China.

关键词： Pharmacogenetics Single nucleotide polymorphisms Solute carrier family 30 member 8 SLC30A8

Preparation and Characterization of Composite Chiral Liquid Crystal Containing L-amino Acid Derivatives

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Wuhan University Journal of Natural Sciences 1998年第2期3卷 251-252页

作者： shan Daqing, tang Hongding, Zhang Xianliangt(College of Chemistry, Wuhan University,Wuhan 430072, China)

A new composite chiral liquid crystal containing L-amino acid derivatives was prepared and their liquid crystal properties were investigated. Results show that they could exhibit liquid crystal through hydrogen bonding.

关键词： Key words liquid crystal L amino acid hydrogen bonding

Highly dispersed Cd cluster supported on TiO_(2) as an efficient catalyst for CO_(2) hydrogenation to methanol

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Chinese Journal of Catalysis 2022年第3期43卷 761-770页

作者： Jijie Wang Jittima Meeprasert Zhe Han Huan Wang Zhendong Feng Chizhou tang Feng Sha shan tang Guanna Li Evgeny A.Pidko Can Li State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Inorganic Systems Engineering Department of Chemical EngineeringDelft University of TechnologyVan der Maaswegthe Netherlands School of Materials Science and Engineering&National Institute for Advanced Materials Nankai UniversityTianjin 300350China University of Chinese Academy of Sciences Beijing 100049China Biobased Chemistry and Technology Wageningen University&Researchthe Netherlands Laboratory of Organic Chemistry Wageningen University&Researchthe Netherlands

The conversion of CO_(2) to methanol with high activity and high selectivity remains challenging owing to the kinetic and thermodynamic limitations associated with the low chemical reactivity exhibited by CO_(2).Herein,we report a novel Cd/TiO_(2) catalyst exhibiting a methanol selectivity of 81%,a CO_(2) conversion of 15.8%,and a CH_(4) selectivity below 0.7%.A combination of experimental and computational studies revealed that the unique electronic properties exhibited by the Cd clusters supported by the TiO_(2) matrix were responsible for the high selectivity of CO_(2) hydrogenation to methanol via the HCOO*pathway at the interfacial catalytic sites.

关键词： CO_(2)hydrogenation Methanol Cd/TiO_(2)catalyst Cd cluster TiO_(2)

Influence of pore structure on thermal stress distribution inside coal particles during primary fragmentation

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Particuology 2024年第2期85卷 49-61页

作者： Kai Qiao shan Zhong Siyang tang Ke Yang Hairong Yue Kui Ma Lei Song Bin Liang School of Chemical Engineering Sichuan UniversityChengdu610065China Institute of New Energy and Low-carbon Technology Chengdu610207China

Thermal stress is an important reason of coal particle primary fragmentation,during which the role of pore structure is *** stress induced fragmentation experiments were conducted with low volatile coal/char particles,and the results show that the fragmentation severity enhances with increasing *** porous thermal stress models were developed with finite element method,and the influences of the pore shape,size,position and porosity on the thermal stress were *** maximum thermal stress inside particle increases with pore curvature,the pore position affects the thermal stress more significantly at the particle center and *** expectation of the maximum tensile thermal stress linearly increases with porosity,making the particles with higher porosity easier to fragment,contrary to the conclusion deduced from the devolatilization *** obtained results are valuable for the analysis of different thermal processes concerning the thermal stresses of the solid feedstocks.

关键词： Coal particle Primary fragmentation Thermal stress Pore structure Porosity

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无泄漏柱塞缸传力密封件的设计优化

机电产品开发与创新 2024年第2期37卷 138-141页

作者：石洋张海涛单葆堂程联军 ZHANG Hong-Xin 青岛大学机电工程学院山东青岛266071 不详

针对所设计的一种无泄漏柱塞缸的筒型密封件进行研究,应用超弹性理论和非线性理论,对密封件层叠型结构进行有限元模拟,分析层叠型结构在加载过程中的应力集中现象。设计样机实验,观察层叠型结构在加载过程中的变形,并与模拟结果进行对... 详细信息

针对所设计的一种无泄漏柱塞缸的筒型密封件进行研究,应用超弹性理论和非线性理论,对密封件层叠型结构进行有限元模拟,分析层叠型结构在加载过程中的应力集中现象。设计样机实验,观察层叠型结构在加载过程中的变形,并与模拟结果进行对比。结果表明:层叠型密封件工作时的应力集中在层叠弯折处,层叠型结构在层叠部分产生的大变形与模拟结果一致。基于模拟结果以层叠角度和层叠距离为优化变量对层叠结构进行优化,以提高较大行程下柱塞缸的性能,并对优化后的柱塞缸进行快进工况的有限元模拟,验证优化设计的合理性。

关键词：密封件结构变形应力集中多目标优化

When quantum dots meet blue phase liquid crystal elastomers:visualized full-color and mechanically-switchable circularly polarized luminescence

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Light(Science & Applications) 2024年第6期13卷 1210-1220页

作者： shan Li Yuqi tang Qingyan Fan Ziyuan Li Xinfang Zhang Jingxia Wang Jinbao Guo Quan Li Key Laboratory of Carbon Fibers and Functional Polymers Ministry of Educationand College of Materials Science and EngineeringBeijing University of Chemical Technology100029BeijingChina Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast UniversityNanjing211189China Materials Science Graduate Program Kent State UniversityKentOH44242USA CAS Key Laboratory of Bio-Inspired Materials and Interfacial Sciences Technical Institute of Physics and ChemistryChinese Academy of Sciences100190BeijingChina

Polymer-based circularly polarized luminescence(CPL)materials with the advantage of diversified structure,easy fabrication,high thermal stability,and tunable properties have garnered considerable ***,adequate and precise tuning over CPL in polymer-based materials remains challenging due to the difficulty in regulating chiral ***,visualized full-color CPL is achieved by doping red,green,and blue quantum dots(QDs)into reconfigurable blue phase liquid crystal elastomers(BPLCEs).In contrast to the CPL signal observed in cholesteric liquid crystal elastomers(CLCEs),the chiral 3D cubic superstructure of BPLCEs induces an opposite CPL ***,this effect is entirely independent of photonic bandgaps(PBGs)and results in a high glum value,even without matching between PBGs and the emission bands of ***,the lattice structure of the BPLCEs can be reversibly switched via mechanical stretching force,inducing on-off switching of the CPL signals,and these variations can be further fixed using dynamic disulfide bonds in the ***,the smart polymer-based CPL systems using the BPLCEs for anti-counterfeiting and information encryption have been demonstrated,suggesting the great potential of the BPLCEs-based CPL active materials.

关键词： circular quantum crystal

基于LC-MS/MS法的芍药苷在正常和肝内胆汁淤积大鼠体内的药代动力学比较研究

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中南药学 2024年第6期22卷 1418-1422页

作者：杨梦换蒋罡陈卫东张善堂王汝琳安徽中医药大学药学院合肥230012 省部共建安徽道地中药材品质提升协同创新中心合肥230012 安徽省立医院药剂科合肥230001

目的比较正常和17α-乙炔基雌二醇诱导的胆汁淤积性肝损伤大鼠体内芍药苷的药代动力学过程的差异。方法采用LC-MS/MS法检测给药后不同时间点大鼠血浆样本中芍药苷的含量,DAS 2.0软件测算两组的药代动力学参数,并进行统计学分析。结果与... 详细信息

目的比较正常和17α-乙炔基雌二醇诱导的胆汁淤积性肝损伤大鼠体内芍药苷的药代动力学过程的差异。方法采用LC-MS/MS法检测给药后不同时间点大鼠血浆样本中芍药苷的含量,DAS 2.0软件测算两组的药代动力学参数,并进行统计学分析。结果与正常大鼠相比,胆汁淤积性肝损伤发生后,芍药苷的t_(1/2Z)、MRT_(0~∞)、AUC和V_(z)/F明显增加,而CL_(z)/F显著降低。结论与正常大鼠相比,胆汁淤积模型大鼠体内芍药苷的浓度更高、消除速度更缓慢。

关键词：芍药苷 17α-乙炔基雌二醇胆汁淤积性肝损伤药代动力学

Characterization,expression dynamics,and potential function of OPA1 for regulation of mitochondrial morphology during spermiogenesis in Phascolosoma esculenta

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Journal of Oceanology and Limnology 2024年第1期42卷 187-200页

作者： Xinming GAO Binbin FENG Chen DU Congcong HOU shan JIN Daojun tang Junquan ZHU Key Laboratory of Applied Marine Biotechnology by the Ministry of Education and Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China College of Ecology Lishui UniversityLishui 323000China

Mitochondria undergo morphological changes during spermatogenesis in some *** mechanism and role of mitochondrial morphology regulation,however,remain somewhat *** this study,we analyzed the molecular characteristics,expression dynamics and subcellular localization of optic atrophy protein 1(OPA1),a mitochondrial fusion and cristae maintenance-related protein,to reveal the possible regulatory mechanisms underlying mitochondrial morphology in Phascolosoma esculenta *** full-length cDNA of the *** opa1 gene(Pe-opa1)is 3743 bp in length and encodes 975 amino *** Pe-OPA1 protein is highly conservative and includes a transmembrane domain,a GTPase domain,two helical bundle domains,and a lipid-interacting *** and protein expression was higher in the coelomic fluid(a site of spermatid development)of male *** and increased first and then decreased from March to ***,their expression during the breeding stage was significantly higher than during the non-breeding stage,suggesting that Pe-OPA1 is involved in *** *** Pe-OPA1 protein was more abundant in components consisting of many spermatids than in components without,indicating that Pe-OPA1 mainly plays a role in the spermatid in coelomic ***,Pe-OPA1 was mainly detected in the spermatid *** experiments showed that the Pe-OPA1 are constitutively expressed and co-localized with mitochondria during spermiogenesis,suggesting its involvement in *** *** results provide evidence for Pe-OPA1's involvement in the regulation of mitochondrial morphology during spermiogenesis.

关键词： optic atrophy protein 1(OPA1) spermiogenesis Phascolosoma esculenta mitochondrial dynamics spermatid

Polyneuropathy organomegaly endocrinopathy M-protein and skin changes syndrome with ascites as an early-stage manifestation:A case report

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World Journal of Clinical Cases 2023年第1期11卷 135-142页

作者： Xiao-Lei Zhou Ying-Hao Chang Lan Li Juan Ren Xiao-Ling Wu Xue Zhang Peng Wu shan-Hong tang Graduate School Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina Department of Infectious Diseases General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina

BACKGROUND Polyneuropathy organomegaly endocrinopathy M-protein and skin changes(POEMS)syndrome is a rare paraneoplastic syndrome caused by a potential plasma cell *** clinical manifestations of POEMS syndrome are *** to the insidious onset and lack of specific early-stage manifestations,POEMS syndrome is easily misdiagnosed or never diagnosed,leading to delayed *** symptoms are usually the first clinical manifestation,while ascites is a rare symptom in patients with POEMS *** SUMMARY A female patient presented with unexplained ascites as an initial symptom,which is a rare early-stage manifestation of the *** 1 year,the patient gradually developed progressive renal impairment,anemia,polyserosal effusion,edema,swollen lymph nodes on the neck,armpits,and groin,and decreased muscle strength of the lower *** patient was eventually diagnosed with POEMS syndrome after multidisciplinary team *** comprised bortezomib+dexamethasone,continuous renal replacement therapy,chest and abdominal closed drainage,transfusions of erythrocytes and platelets,and other symptomatic and supportive *** patient’s condition initially improved after ***,then her symptoms worsened,and she succumbed to the illness and *** Ascites is a potential early manifestation of POEMS syndrome,and this diagnosis should be considered for patients with unexplained ***,multidisciplinary team discussion is helpful in diagnosing POEMS syndrome.

关键词： Polyneuropathy organomegaly endocrinopathy M-protein and skin changes syndrome Ascites Early-stage manifestation Neurogenic damage Vascular endothelial growth factor Case report