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Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure

Defence Technology（防务技术） 2024年第3期33卷 55-65页

作者： Zhiyuan tang Yu Wang Khalil I.Elkhodary Zefeng Yu shan tang Dan Peng State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of Technology116023DalianPR China The Department of Mechanical Engineering The American University in CairoNew Cairo11835Egypt Department of Neurology The Second Hospital of Dalian Medical UniversityDalian116023PR China

Brain tissue is one of the softest parts of the human body,composed of white matter and grey *** mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain ***,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical *** white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical *** such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional *** a constitutive law for multiscale brain tissue using traditional function-based approaches can be very ***,this paper proposes a data-driven approach to establish the desired mechanical model of brain *** focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our *** matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading *** generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal ***,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body *** with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling *** predictions made by our trained model demonstrate sufficient ***,we find that the level of internal blood pressur

关键词： Data driven Constitutive law Anisotropy Brain tissue Internal pressure

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Synthesis of Polyethylenes with In-Chain Isolated Carbonyls from CO_(2)and Ethylene via a Tandem Photoreduction/Polymerization Protocol

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CCS Chemistry 2024年第6期6卷 1591-1599页

作者： Fulin Zhou Haojie Dai shan tang Yongfeng Zhou Frontiers Science Center for Transformative Molecules Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240

Aiming at accessing polyethylene-bearing in-chain degradable functionality,copolymerization of carbon dioxide(CO_(2))with ethylene has long been recognized as a significant but highly challenging ***,most trials have resulted in ethylene homopolymerization because of the endothermic property and high energy barriers of CO_(2)insertion during polymer chain *** we report an unprecedented tandem reaction protocol for the synthesis of polyethylenes with in-chain carbonyls from CO_(2)and ethylene by the combination of photocatalytic CO_(2)reduction and palladium-catalyzed coordination/insertion *** protocol provides an easy way to adjust the carbonyl content(from 0.13 to 12 mol%)and insertion selectivity(up to 99%isolated carbonyls)of the polyethylene copolymers,which enables the polymers tomaintain the main properties of highdensity polyethylene and simultaneously endows them with good *** addition,besides apolar polyethylene copolymers,polar-functionalized polyethylenes with in-chain isolated carbonyls can also be synthesized from CO_(2),ethylene and a polar monomer using the same *** believe our present work sheds new light on the synthesis of degradable polyethylenes by employing CO_(2)as a green carbonyl source.

关键词： carbon dioxide coordination polymerization polyethylene photoreduction photodegradation

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Inverse design of mechanical metamaterial achieving a prescribedconstitutive curve

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 16-22页

作者： Zongliang Du tanghuai Bian Xiaoqiang Ren Yibo Jia shan tang Tianchen Cui Xu Guo State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDepartment of Engineering MechanicsDalian University of TechnologyDalian 116023China Ningbo Institute of Dalian University of Technology Ningbo 315016China

Besides exhibiting excellent capabilities such as energy absorption,phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive *** is facilitated by switching between different patterns under ***,the related inverse design problem is quite challenging,due to the lack of appropriate mathematical formulation and the convergence issue in the post-buckling analysis of intermediate *** this work,periodic unit cells are explicitly described by the moving morphable voids method and effectively analyzed by eliminating the degrees of freedom in void ***,by exploring the Pareto frontiers between error and cost,an inverse design formulation is proposed for unit *** formulation aims to achieve a prescribed constitutive curve and is validated through numerical examples and experimental *** design approach presented here can be extended to the inverse design of other types of mechanical metamaterials with prescribed nonlinear effective properties.

关键词： Metamaterial Pattern-transformation Constitutive curve Inverse design

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Community Residents' Heritage Preservation Intentions and Influencing Factors Based on the Extended Theory of Planned Behavior: A Case Study of Historic Districts in Tianjin

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China City Planning Review 2024年第3期33卷 40-50页

作者： Zhang Tianjie tang shan Liu Jinxin School of Architecture Tianjin University

Community residents are important stakeholders in preserving historic districts. This paper introduces the extended theory of planned behavior to explore the intentions of residents to participate in heritage preservation, and further explains the influencing factors. Seven historic districts in Tianjin are selected as case studies. The results show that the residents' intentions to preserve heritage are positively influenced by three subjective perception factors of heritage preservation attitude, subjective norms, and perceived behavioral control, as well as two objective situational factors of environmental quality of historic district and policy guidance for heritage preservation. Furthermore, the objective situational factors indirectly influence heritage preservation intentions through the subjective perception factors. Based on these findings, this paper puts forward corresponding suggestions to enhance the heritage preservation intentions of community residents.

关键词： theory of planned behavior community residents heritage preservation intention historic districts in Tianjin

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Strengthening pharmacotherapy research for COVID-19-induced pulmonary fibrosis

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World Journal of Clinical Cases 2024年第5期12卷 875-879页

作者： Yan-Miao Liu Jing Zhang Jing-Jing Wu Wei-Wei Guo Fu-shan tang The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Respiratory Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

The global spread of severe acute respiratory syndrome coronavirus 2 has resulted in a significant number of individuals developing pulmonary fibrosis(PF),an irreversible lung *** condition can manifest within a short inter-val following the onset of pneumonia symptoms,sometimes even within a few *** lung transplantation is a potentially lifesaving procedure,its limited availability,high costs,intricate surgeries,and risk of immunological rejection present significant *** optimal timing of medication administration for coronavirus disease 2019(COVID-19)-induced PF remains *** this,it is crucial to explore pharmacotherapy interventions,involving early and preventative treatment as well as pharmacotherapy options for advanced-stage ***,studies have demonstrated disparities in anti-fibrotic treatment based on race and gender *** mutations may also impact therapeutic *** research efforts on pharmacotherapy interventions,while considering relevant pharmacological factors and optimizing the timing and dosage of medication administration,will lead to enhanced,personalized,and fair treatment for individuals impacted by COVID-19-related *** measures are crucial in lessening the burden of the disease on healthcare systems and improving patients'quality of life.

关键词： COVID-19 Pulmonary fibrosis Pharmacotherapy intervention Medication administration Timing Dosage

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Nonreciprocal Photon Blockade Based on Zeeman Splittings Induced by a Fictitious Magnetic Field

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Chinese Physics Letters 2024年第7期41卷 36-46页

作者：苏欣金飚兵唐江山夏可宇 College of Engineering and Applied Sciences National Laboratory of Solid State Microstructuresand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China Research Institute of Superconductor Electronics(RISE)&Key Laboratory of Optoelectronic Devices and Systems with Extreme Performances of MOE School of Electronic Science and EngineeringNanjing UniversityNanjing 210023China

Quantum nonreciprocity, such as nonreciprocal photon blockade, has attracted a great deal of attention due to its unique applications in quantum information processing. Its implementation primarily relies on rotating nonlinear systems, based on the Sagnac effect. Here, we propose an all-optical approach to achieve nonreciprocal photon blockade in an on-chip microring resonator coupled to a V-type Rb atom, which arises from the Zeeman splittings of the atomic hyperfine sublevels induced by the fictitious magnetic field of a circularly polarized control laser. The system manifests single-photon blockade or multi-photon tunneling when driven from opposite directions. This nonreciprocity results from the directional detunings between the countercirculating probe fields and the V-type atom, which does not require the mechanical rotation and facilitates integration. Our work opens up a new route to achieve on-chip integrable quantum nonreciprocity, enabling applications in chiral quantum technologies.

关键词： effect reciprocal quantum

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Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan shan tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

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论贵州民族文学蕴含的“四个共同”理念

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贵州民族研究 2024年第4期45卷 122-128页

作者：秦红平唐善林贵州师范大学文学院贵州贵阳550025

“四个共同”理念是新时代中国共产党处理民族关系的核心理念,是中华民族共同体意识的核心内涵。文章以铸牢中华民族共同体意识为主线,系统探讨贵州民族文学蕴含的“四个共同”理念。通过探析得知:贵州丰富多彩的民族文学,蕴藏着“四个... 详细信息

“四个共同”理念是新时代中国共产党处理民族关系的核心理念,是中华民族共同体意识的核心内涵。文章以铸牢中华民族共同体意识为主线,系统探讨贵州民族文学蕴含的“四个共同”理念。通过探析得知:贵州丰富多彩的民族文学,蕴藏着“四个共同”的主要内涵、基本特征与内生逻辑。在新时代语境下,充分挖掘贵州民族文学“四个共同”的内蕴,激发贵州民族文学的凝聚性,既是铸牢中华民族共同体意识的时代要求,也是贵州铸牢中华民族共同体意识的重要内容。

关键词：贵州民族文学中华民族共同体意识四个共同

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Avoiding misdiagnosis of multilocular thymic cysts as malignant tumors on computer tomography

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World Journal of Clinical Cases 2024年第19期12卷 3671-3675页

作者： Yu-Hong Zhang Yan-Miao Liu Kai-Li Shen Jing-Jing Wu Fu-shan tang Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Traditional Chinese Medicine Central Hospital in Jinchang CityJinchang 737102Gansu ProvinceChina The First Clinical Institute Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

This editorial provides insights from a case report by Sun et al published in the World Journal of Clinical *** case report focuses on a case where a multilocular thymic cyst(MTC)was misdiagnosed as a thymic tumor,resulting in an unnecessary surgical *** MTCs and thymic tumors are rare conditions that heavily rely on radiological imaging for accurate ***,the similarity in their imaging presentations can lead to misinterpretation,resulting in unnecessary surgical *** to the ongoing lack of comprehensive knowledge about MTCs and thymic tumors,we offer a summary of diagnostic techniques documented in recent literature and examine potential causes of *** computer tomography(CT)values surpass 20 Hounsfield units and display comparable morphology,there is a risk of misdiagnosing MTCs as thymic *** various differential diagnostic methods like biopsy,molecular biology,multi-slice CT,CT functional imaging,positron emission tomography/CT molecular functional imaging,magnetic resonance imaging and radiomics,proves advantageous in reducing clinical misdiagnosis.A deeper understanding of these conditions requires increased attention and exploration by healthcare ***,the continued advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the *** advancement and utilization of various diagnostic methods are expected to enhance precise diagnoses,provide appropriate treatment options,and improve the quality of life for patients with thymic tumors and MTCs in the future.

关键词： Thymic tumor Multilocular thymic cyst Misdiagnosis Differential diagnosis Imaging manifestation Computed tomography

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Ganoboninketal C from Ganoderma boninense improves the efficacy of CDDP-based chemotherapy through inhibiting translesion DNA synthesis

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Food Science and Human Wellness 2024年第5期13卷 2982-2992页

作者： Xiaolu Ma Fei Yang Ke Ma Hongyan Shen Junjie Han Kai Wang Yeran Yang Jiawei Zhu Ruiyuan An Qilin Wang Tie-shan tang Bo Zhou Hongwei Liu Caixia Guo College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Genomics and Precision Medicine Beijing Institute of Genomics/China National Center for BioinformationUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Institute of Microbiology University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100101China

Translesion DNA synthesis(TLS)can bypass DNA lesions caused by chemotherapeutic drugs,which usually result in drug *** its key role in mutagenesis and cell survival after DNA damage,inhibition of the TLS pathway has emerged as a potential target for improving the efficacy of DNA-damaging agents such as cisplatin(CDDP),a widely used anticancer ***,few suitable natural TLS inhibitors have been ***,we found that a triterpenoid compound Ganoboninketal C(26-3)from Ganoderma boninense,a traditional Chinese medicine,can impair CDDP-induced TLS polymerase eta(Polη)focus formation,PCNA monoubiquitination as well as ***,26-3 can significantly sensitize tumor cells to CDDP killing and reduce the proportion of cancer stem cells in AGS and promote apoptosis after CDDP ***,26-3 can also sensitize tumor cells to Gefitinib ***,through RNA-seq analysis,we found that 26-3 could abrogate the CDDP-induced upregulation of Polηand PIDD(p53-induced protein with a death domain),2 known factors promoting TLS ***,we found that activating transcription factor 3 is a potential novel TLS *** together,we have identified a natural TLS inhibitor 26-3,which can be potentially used as an adjuvant to improve clinical efficacy.

关键词： Ganoderma boninense Ganoboninketal C Cisplatin chemotherapy Translesion DNA synthesis

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