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Kinetics and Mechanism of the Oxidation of Glycol by Dihydroxyditelluratoargentate(Ⅲ) with Spectrophotometry

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Chemical Research in Chinese Universities 2000年第3期16卷 218-222页

作者： shan jin huan WANG Li SHEN Shi gang SUN Han wen WANG An zhou Department of Chemistry Hebei UniversityBaoding 071002P.R.China

The kinetics of the oxidation of glycol by dihydroxyditelluratoargentate (Ⅲ) complex(DDA) was studied in alkaline medium with spectrophotometry(in a temperature range of 16\^6—40 ℃). The first order rates with respect to glycol and Ag(Ⅲ) were all found. The rates increased with the increase in [OH -] and decreased with the increase in [TeO 2- 4]. No effect was found with the addition of KNO 3 and no free radical was detected. In view of this, the dihydroxymonotelluratoargentate(Ⅲ) species(DMA) is assumed to be the active species. A plausible mechanism involving a two electron transfer is proposed, and the rate equation derived from the mechanism can explain all experimental observations. Activation parameters of the rate determining step and constants are evaluated.

关键词： Dihydroxyditelluratoargentate(Ⅲ) Glycol Redox reaction Kinetics and mechanism

Kinetics and Mechanism of Oxidation of Lactic Acid by Dihydroxyditelluratoargentate(Ⅲ) in Alkaline Medium

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Chemical Research in Chinese Universities 2003年第2期19卷 219-221页

作者： shan jin huan WANG Li LIU Bao sheng SHEN Shi gang SUN Han wen WANG An zhou College of Chemistry and Environment Science Hebei UniversityBaoding 071002P.R.China

The kinetics of the oxidation of lactic acid(Lac) by dihydroxyditelluratoargentate(Ⅲ)[abbreviated as DDA of Ag(Ⅲ)] anions was studied in an aqueous alkaline medium by conventional spectrophotometry in a temperature range of 25- 40 ℃ . The order of the redox reaction of lactic acid and DDA was found to be first order. The rates increased with the increase in and decreased with the increase in . No free radical was detected. In the view of this the dihydroxymonotelluratoargentate(Ⅲ) species(DMA) is assumed to be the active species. A plausible mechanism involving a two electron transfer is proposed, and the rate \{equation\} derived from the mechanism can be used to explain all the experimental results. The activation parameters(25 ℃) and the rate constants of the rate determining step along with the preequilibrium constants at different temperatures were evaluated.

关键词： Dihydroxyditelluratoargentate(Ⅲ) Lactic acid Kinetics and mechanism Redox reaction

Kinetics and Mechanism of Oxidation of Glycol by Dihydroxydiperiodatonickelate ( Ⅳ )Complex in Aqueous Alkaline Medium

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Chemical Research in Chinese Universities 1992年第4期8卷 432-438页

作者： WANG An-zhou, LI Feng-mai, LI Zhi-ting, DING Tian-hui and shan jin-huan (Department of Chemistry, Hebei University, Baoding, 071002)

The kinetics of oxidation of glycol by dihydroxydiperiodato nickelate ( Ⅳ) complex (DDN) was studied by spectrophotometry in aqueous alkaline medium in a temperature range of 25-40℃. The reaction was found to be first order with respect to Ni( Ⅳ ) and also to be first order with respect to glycol. The rate increases with the increase in [OH ] and decreases with the increase in [IO-4], showing that dihydroxymonoperiodatonickelate ( Ⅳ )(DMN) is the reactive species of oxidant. Salt effect indicated that the reaction is of ion-dipole type. No free radical was detected. A mechanism of an inner-sphere two-electron transfer reaction involving a preequilibrium between DDN and DMN is proposed, and the rate equation derived from the mechanism can explain all experimental observations. Activation parameters of the rate-determing step and the equilibrium constants were calculated.

关键词： Dihydroxydiperiodatonickelate (Ⅳ) Glycol Redox reaction Kinetics and mechanism

2,2'-联吡啶催化Cr(Ⅵ)氧化1,3-丁二醇的动力学

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河北大学学报（自然科学版） 2011年第1期31卷 36-41页

作者：单金缓张记英河北大学化学与环境科学学院河北保定071002

采用分光光度法研究了2,2'-联吡啶催化Cr(Ⅵ)氧化1,3-丁二醇的反应动力学.结果表明:反应对Cr(Ⅵ)是准一级,对1,3-丁二醇是一级.在保持准一级的反应条件([1,3-丁二醇]0[Cr(Ⅵ)]0)下,该反应的表观速率常数kobs随[H+]和[bipy]的增加而增... 详细信息

采用分光光度法研究了2,2'-联吡啶催化Cr(Ⅵ)氧化1,3-丁二醇的反应动力学.结果表明:反应对Cr(Ⅵ)是准一级,对1,3-丁二醇是一级.在保持准一级的反应条件([1,3-丁二醇]0[Cr(Ⅵ)]0)下,该反应的表观速率常数kobs随[H+]和[bipy]的增加而增加,增大反应体系的离子强度,速率常数略有增大.提出了该实验的反应机理:Cr(Ⅵ)和2,2'-联吡啶先形成活化络合物,活化络合物又和一分子的1,3-丁二醇反应,该反应和Cr(Ⅵ)直接氧化1,3-丁二醇的反应构成速控步,随后经过几步快速反应生成产物.依此机理能较好地解释实验现象,并且计算了不同温度下的催化常数和热力学参数.

关键词： 2,2′-联吡啶 1,3-丁二醇催化作用 Cr(Ⅵ) 动力学还原反应

Deep learning identification of novel autophagic protein-protein interactions and experimental validation of Beclin 2-Ubiquilin 1 axis in triple-negative breast cancer

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Oncology Research 2025年第1期33卷 67-81页

作者： XIANG LI WENKE jin LIFENG WU huan WANG XIN XIE WEI huanG BO LIU State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy and College of Medical TechnologyChengdu University of Traditional Chinese MedicineChengdu611137China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China

Background:Triple-negative breast cancer(TNBC),characterized by its lack of traditional hormone receptors and HER2,presents a significant challenge in oncology due to its poor response to conventional *** is an important process for maintaining cellular homeostasis,and there are currently autophagy biomarkers that play an effective role in the clinical treatment of *** contrast to targeting protein activity,intervention with proteinprotein interaction(PPI)can avoid unrelated crosstalk and regulate the autophagy process with minimal interference ***:Here,we employed Naive Bayes,Decision Tree,and k-Nearest Neighbors to elucidate the complex PPI network associated with autophagy in TNBC,aiming to uncover novel therapeutic ***,the candidate proteins interacting with Beclin 2 were initially screened in MDA-MB-231 cells using Beclin 2 as bait protein by immunoprecipitation-mass spectrometry assay,and the interaction relationship was verified by molecular docking and CO-IP experiments after *** formation,cellular immunofluorescence,cell scratch and 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)tests were used to predict the clinical therapeutic effects of manipulating candidate ***:By developing three PPI classification models and analyzing over 13,000 datasets,we identified 3733 previously unknown autophagy-related *** network analysis revealed the central role of Beclin 2 in autophagy regulation,uncovering its interactions with 39 newly identified ***,the CO-IP studies identified the substantial interaction between Beclin 2 and Ubiquilin 1,which was anticipated by our model and discovered in immunoprecipitation-mass spectrometry assay ***,in vitro investigations showed that overexpressing Beclin 2 increased Ubiquilin 1,promoted autophagy-dependent cell death,and inhibited proliferation and metastasis in MDA-MB-231 ***:This study not

关键词： Triple-negative breast cancer(TNBC) Autophagy Protein-protein interactions(PPI) Artificial intelligence(AI) Beclin 2 Ubiquilin 1

二(碲酸根)合铜(Ⅲ)酸根氧化乙二醇独甲醚的动力学及机理

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无机化学学报 2000年第6期16卷 888-892页

作者：单金缓王莉申世刚孙汉文刘保生河北大学化学系，保定 071002 河北大学理化中心，保定 071002

在 23～ 39℃区间内用分光光度法在碱性介质中研究了二 (碲酸根 )合铜(Ⅲ)酸根离子氧化乙二醇独甲醚的动力学及机理。实验结果表明反应对二 (碲酸根 )合铜(Ⅲ)酸根离子是准一级，对乙二醇独甲醚是分数级。准一级速率常数 kobs随 [TeO_4... 详细信息

在 23～ 39℃区间内用分光光度法在碱性介质中研究了二 (碲酸根 )合铜(Ⅲ)酸根离子氧化乙二醇独甲醚的动力学及机理。实验结果表明反应对二 (碲酸根 )合铜(Ⅲ)酸根离子是准一级，对乙二醇独甲醚是分数级。准一级速率常数 kobs随 [TeO_4^(2－) ]的增大而减小，随 [OH~－ ]在一定范围内的增加 kobs增加， [OH~－ ]继续增加 kobs趋于常数，且发现有负盐效应。根据实验结果提出了一种含有前期快平衡的反应机理，据此导出了一个能解释全部实验事实的速率方程，并求出速控步的速率常数及 25℃时的活化参数。

关键词：乙二醇独甲醚氧化还原动力学 DTC

碱性介质中分光光度法研究二羟基二(过碘酸根)合银(Ⅲ)氧化谷氨酸的反应动力学及机理

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高等学校化学学报 2005年第4期26卷 706-709页

作者：单金缓霍树营申世刚孙汉文王安周河北大学化学与环境科学学院河北省分析科学与技术重点实验室保定071002

在碱性介质中,用分光光度法研究了二羟基二(过碘酸根)合银(Ⅲ)(DPA)氧化谷氨酸(GA)的反应动力学及其机理.结果表明,反应对DPA为准一级,对GA为一级反应;在保持准一级条件([GA]0[DPA]0)下,表观速率常数随着[OH-]的增加先减小后增加,随着[I... 详细信息

在碱性介质中,用分光光度法研究了二羟基二(过碘酸根)合银(Ⅲ)(DPA)氧化谷氨酸(GA)的反应动力学及其机理.结果表明,反应对DPA为准一级,对GA为一级反应;在保持准一级条件([GA]0[DPA]0)下,表观速率常数随着[OH-]的增加先减小后增加,随着[IO-4]的增加而减小,且有正盐效应.据此提出了此反应的反应机理,由此反应机理推导出来的速率方程可很好地解释全部实验现象,进一步求得速控步骤速率常数k和298.2K时的平衡常数K及活化参数.

关键词：二羟基二(过碘酸根)合银(Ⅲ) 谷氨酸氧化还原反应动力学及机理

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催化动力学光度法测定抗坏血酸的反应动力学

河北大学学报（自然科学版） 2006年第4期26卷 381-384页

作者：单金缓范立霍树营河北大学化学与环境科学学院河北省分析科学技术实验室河北保定071002

研究了溴酸钾氧化甲基橙体系催化动力学测定抗坏血酸(维生素C)的反应动力学规律,实验表明:反应对甲基橙为一级反应,对维生素C也是一级反应,并求得了相应的表观活化能.

关键词：动力学抗坏血酸表观活化能

Cu（Ⅲ）二过碘酸配离子氧化1，3-丙二胺的反应动力学及机理

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河北大学学报（自然科学版） 2010年第1期30卷 43-48页

作者：单金缓王晓倩韩冲王芳河北大学化学与环境科学学院河北保定071002

为了给有机合成反应路径提供有利的依据，用分光光度法研究了在298．2～313．2K的碱性介质中二过碘酸合铜（Ⅲ）（DPC）酸根配离子氧化1，3-丙二胺（PDA）的反应动力学及机理．实验结果表明：反应对氧化剂DPC是一级，对还原剂PDA的表观... 详细信息

为了给有机合成反应路径提供有利的依据，用分光光度法研究了在298．2～313．2K的碱性介质中二过碘酸合铜（Ⅲ）（DPC）酸根配离子氧化1，3-丙二胺（PDA）的反应动力学及机理．实验结果表明：反应对氧化剂DPC是一级，对还原剂PDA的表观反应级数（nap），1〈nap〈2时准一级速率常数kobs随[OH（-]增大而增大，碘酸根离子对反应速率起阻碍作用，且离子强度对反应有弱的负盐效应．据此提出了氧化反应的机理并求出了速控步骤的速率常数及298．2K时的活化参数．

关键词：二过碘酸合铜(Ⅲ) 1,3-丙二胺氧化还原反应