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Evaluation of malignancy using Ki-67,p53,EGFR and COX-2 expressions in gastrointestinal stromal tumors

World Journal of Gastroenterology 2012年第20期18卷 2569-2575页

作者： jing Jiang Mei-shan jin Jian Suo Yin-Ping Wang Liang He Xue-Yuan Cao Division of Clinical Epidemiology Jilin UniversityFirst Hospital Changchun 130021 Jilin Province China Division of Pathology JilinUniversity First Hospital Changchun 130021 Jilin ProvinceChina Department of Gastrointestinal Surgery Jilin University First Hospital Changchun 130021 Jilin Province China

AIM:To investigate the role of expressions of Ki-67, p53,epidermal growth factor receptor(EGFR)and cyclooxygenase-2(COX-2)in gastrointestinal stromal tumor(GIST)grading and prognosis. METHODS:Tumor tissue was collected retrospectively from 96 patients with *** against Ki-67, p53,EGFR and COX-2 were used for immunohistochemical *** grading was designated according to a consensus system and the staining was quantified in 3 categories for each antibody in the statistical analysis. RESULTS:The Ki-67 expression in GISTs was significantly associated with the size of the tumors,mitotic rate and the risk of malignancy(x2=15.51,P=0.02; x2=22.27,P<0.001;x2=20.05;P<0.001).The p53 expression was also significantly correlated with mitotic rate and the risk of malignancy(x2=9.92,P= 0.04;x2=9.97;P=0.04).Over-expression of Ki-67 was strongly correlated with poor survival(x2=10.44, P=0.006),but no correlation was found between the expression of p53,EGFR or COX-2 and survival. Multivariate analysis further demonstrated that Ki-67 expression(relative risk=15.78,95%CI:4.25-59.37) could be used as an independent prognostic value for GIST *** imatinib therapy could improve clinical outcomes in the patients with high risk and intermediate risk of recurrence after complete tumor resections(median survival time:52 mo vs 37 mo, x2=7.618,P=0.006). CONCLUSION:Our results indicated that the expression of Ki-67 could be used as an independent prognostic factor for GIST patients.

关键词： Gastrointestinal stromal tumor Prognosis Ki-67 alteration p53 Epidermal growth factor receptor

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Interface characteristic and mechanical performance of TiAl/Ti_(2)AlNb diffusion bonding joint with pure Ti interlayer

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Rare Metals 2020年第12期39卷 1402-1412页

作者： Lei Zhu Bin Tang Ming-Xuan Ding Yan Liu Xiao-Fei Chen Shao-Peng Yan jin-shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China Shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi'an 710072China

Solid-state diffusion bonding(DB)of TiAl alloy and Ti2 AlNb alloy was carried out using pure Ti as an interlayer at 1000℃under 20 MPa for 60-120 *** effects of bonding times on the interfacial microstructure and mechanical performance of the TiAl/Ti/Ti_(2)AlNb bonded joints at room temperature(RT)were investigated *** results demonstrated that the diffusion layers(DLs)mainly consisted of four characteristic layers,(Ⅰ)single coarseα_(2)phase adjacent TiAl alloy,(Ⅱ)single refinedα_(2)phase at the bonding interface,(Ⅲ)equiaxed/acicularα_(2)phase embedded inβphase adjacent Ti_(2)AtNb alloy and(IV)both equiaxedα_(2)phase and acicular O phase embedded inβphase adj acent Ti_(2)AlNb alloy,*** thickness of the four layers increased with the increasing of the bonding *** growth of DLs is controlled by diffusion and the reaction rate constant k for regionⅠ,Ⅱ,ⅢandⅣare 1.22×10^(-6),1.27×10^(-6),2.6×10^(-7)and 7.7×10^(-7)m·s^(-1/2),***,the interfaceα_(2)grain grows up without *** maximum tensile strength of 281 MPa was maintained at1000℃for 90 min under the pressure of 20 ***,the phase transformation and dynamic recrystallization behavior of the DLs were discussed.

关键词： Sputtering Bonding interface Microstructure Growth kinetics Mechanical performance

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Thermal Scratch on Surface of SUS430 Stainless Steel Strip in Cold Rolling Process

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Journal of Iron and Steel Research International 2014年第3期21卷 282-286页

作者： Chang-sheng LI jin-shan CHEN Wen-long HAN You-yuan LI Bo FU State Key Laboratory of Rolling and Automation Northeastern University Baosteel Stainless Steel Co. Ltd.

The thermal scratch significantly influences the surface quality of the stainless steel in cold strip rolling. The thermal scratch has a close relation to the rolling parameters, the rolls surface and the emulsions used in rolling. In order to explain the thermal scratch on the strip surface, the cold roiling process of SUS430 stainless steel strip was investigated in the laboratory. The thermal scratch defect occurs frequently in the second rolling pass （maximum reduction in height is 32.3 ~）, especially on the lower surface of strips. When concentration and temperature of the emulsion are the same, the thermal scratch on the surface o{ the strip is aggravated with increasing the roll surface roughness. With the same roll surface roughness and emulsion concentration, the thermal scratch is obviously more severe at an emulsion temperature of 63 ℃ than 55 ℃. With the same roll surface roughness and emulsion tempera- ture, the thermal scratch is distinctly weaker at the emulsion concentration of 6 % than that of 3 %.

关键词： stainless steel thermal scratch emulsion roll surface roughness

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Prevention of rockburst by guide holes based on numerical simulations

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Mining Science and Technology 2009年第3期19卷 346-351页

作者： ZHU Qi-hu LU Wen-bo SUN jin-shan LUO Yi CHEN Ming State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan Hubei 430072 China Faculty of Engineering China University of Geosciences Wuhan Hubei 430074 China

We studied variations in the stress field around guide holes drilled during tunnel excavation to understand the mechanical mechanism by which these holes help prevent *** study used elasto-plastic analysis of a circular chamber under non-axisymmetrical *** results showed that the unloading of in-situ stresses, and the forming of a secondary stress field, leads to a severe change in the stress field around the guide *** causes the formation of an X-shaped area of plastic deformation, which prevents the *** a sub-model finite element technique, we analyzed the factors that influence the distribution of the plastic area, such as the guide hole distribution and the in-situ stress *** calculations showed that higher initial stresses result in greater adjustment to the stress *** the stress concentration is greater the size of the plastic area surrounding the guide hole is larger.A multi-row distribution of the guide holes shaped like a quincunx can increase the interconnectivity of the plastic areas and allow the plastic area to extend from the tunnel wall deep into the surrounding *** optimized design was put forward based on the distribution of the plastic area around guide holes and the factors that influence it.

关键词： rockburst guide hole shear failure finite element method sub-model

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Characterization of dwarf mutants and molecular mapping of a dwarf locus in soybean

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Journal of Integrative Agriculture 2016年第10期15卷 2228-2236页

作者： CHENG Wen GAO jin-shan FENG Xing-xing SHAO Qun YANG Su-xin FENG Xian-zhong Key Laboratory of Systems Biology in Universities of shandong/College of Life Science Shandong Normal University Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and Agroecology Chinese Academy of Sciences

Plant height is one of the most important traits in soybean. The semi-dwarf soybean cultivars could improve the ability of lodging resistance to obtain higher yield. To broaden the dwarfism germplasm resources in soybean, 44 dwarf mutants were identified from a gamma rays mutagenized M-2 population. Two of these mutants, Gmdwf1（Glycine max dwarf 1） and Gmdwf2（Glycine max dwarf 2）, were investigated in this study. Genetic analysis showed that both mutants were inherited in a recessive manner and their mutated regions were delimited to a 2.610-Mb region on chromosome 1 by preliminary mapping. Further fine mapping study proved that the two mutants had a common deletion region of 1.552 Mb in the target region, which was located in a novel locus site without being reported previously. The dwarfism of Gmdwf1 could not be rescued by gibberellin（GA） and brassinolide（BR） treatments, which indicated that the biosynthesis of these hormones was not deficient in Gmdwf1.

关键词： soybean dwarf mutant mapping BR GA

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金牡丹不同茶类夏秋茶香气品质差异分析

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食品科学 2025年第2期46卷 171-182页

作者：唐梦婷廖献盛吴先寿魏明秀郑玉成金珊张见明叶乃兴福建农林大学园艺学院农作物遗传育种与综合利用教育部重点实验室福建福州350002 武夷学院中国乌龙茶产业协同创新中心福建武夷山354300 福建谦谦一叶茶业科技有限公司福建寿宁355500 寿宁县茶产业发展中心福建寿宁355500

以‘金牡丹’品种夏、秋季嫩梢为原料,分别加工成绿茶、黄茶、白茶、乌龙茶及红茶,采用顶空固相微萃取-气相色谱-质谱联用技术对夏、秋季的5类茶中的挥发性代谢物进行测定和分析。结果表明,夏茶中鉴定出522种挥发性代谢物,以萜类、酯类... 详细信息

以‘金牡丹’品种夏、秋季嫩梢为原料,分别加工成绿茶、黄茶、白茶、乌龙茶及红茶,采用顶空固相微萃取-气相色谱-质谱联用技术对夏、秋季的5类茶中的挥发性代谢物进行测定和分析。结果表明,夏茶中鉴定出522种挥发性代谢物,以萜类、酯类及醇类为主;秋茶中鉴定出502种挥发性代谢物,以萜类、酯类和杂环化合物为主。香气活性值分析表明,β-紫罗兰酮、α-紫罗兰酮、癸醛、苯甲酸甲酯、香叶醇等是金牡丹绿茶的关键呈香物质;β-紫罗兰酮、2-乙氧基-3-甲基吡嗪、癸醛、苯甲酸甲酯、香叶醇等是金牡丹黄茶的关键呈香物质;香叶醇、苯乙醛、水杨酸甲酯、(E)-芳樟醇氧化物、2-乙氧基-3-甲基吡嗪等是金牡丹白茶的关键呈香物质;吲哚、苯甲酸甲酯、苯乙醛、香叶醇、(E)-芳樟醇氧化物等是金牡丹乌龙茶的关键呈香物质;香叶醇、芳樟醇、苯乙醛、苯甲酸甲酯、水杨酸甲酯等是金牡丹红茶的关键呈香物质。秋茶中呈香物质的贡献、种类与数量均多于夏茶,其中,香叶醇、水杨酸甲酯、苯乙醇等42种关键呈香物质在秋季样品中香气活性值均高于夏季。整体而言,金牡丹茶以花香类为主要香型,秋茶香气品质显著优于夏茶,香叶醇、芳樟醇、2-乙氧基-3-甲基吡嗪、苯甲酸甲酯等14种挥发性代谢物为金牡丹茶品种的关键香气物质。

关键词：金牡丹不同茶类夏秋茶香气品质香气活性值

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Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients

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World Journal of Gastroenterology 2010年第21期16卷 2669-2676页

作者： Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, jin-shan Li, Zhao-Shen Second Mil Med Univ Changhai Hosp Dept Gastroenterol Capsule Endoscopy Study Grp Shanghai 200433 Peoples R China Jianshan Sci & Technol Grp Co Ltd Chongqing 401120 Peoples R China

AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese ***:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology *** capsule endoscopy *** patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and ***:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy *** thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic *** overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with ***,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 *** overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER.

关键词： OMOM capsule endoscopy Obscure gastrointestinal bleeding Small bowel

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Acupuncture therapy for experimental stomach ulcer and c-Fos expression in rats

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World Journal of Gastroenterology 2005年第35期11卷 5517-5520页

作者： Hong Wang Chun-Yang Wang jin-shan Zhang Lan Sun jing-Ping Sun Qing-Hua Tian Xiang-Lan jin Ling Yin Neuroinformatics Center Chinese PLA General HospitalBeijing 100853 China Department of Urology Chinese PLA GeneralHospital Beijing 100853 China Department of Embryology andHistology the Fourth Military Medical University Xi'an 710032Shaanxi Province China

AIM: To determine the role of acupuncture therapy in treating experimental gastric ulcer in ***: Twenty-eight adult male Sprague-Dawley rats were randomly divided into four groups (pre-acupuncture group; acupuncture group; paradistance-acupuncture group;and control group), and pre-acupuncture, paradistanceacupuncture, and control groups received 5 μL acetic acid (200 mL/L HAc) injection after a same course of electroacupuncture (EA) treatment (4 Hz, 0.6 mA, 0.45 ms,45 min for 4 d). The rats in these three groups recovered within 4 d. The acupuncture group received EA therapy for 4 d, after HAc injection. The stomach was dissected to compare the pathological structures of ulcer. Also c-Fos activation in the nuclei of solitary tract (NTS) was observed under microscope after regular immunohistochemistry staining of brain stem ***: The number of ulcers was different among the four groups, especially between control group and paradistance-acupuncture group or pre-acupuncture group. In the latter group, the number of ulcers was much less. The gastric ulcer area was consistent with the histopathological results, indicating that pre-acupuncture had an obvious therapeutic effect on gastric *** had a very modest effect and paradistanceacupuncture had no effect on gastric ulcers. No therapeutic effect was found in the control group. Fos-Li neurons in NTS induced by noxious gastric ulcer showed a significant difference between pre-acupuncture and control ***: Acupuncture before ulceration can obviously alleviate ulcer. The production of c-Fos proves that the vagus nerve mediates the induction of c-Fos in nuclei of solitary tract following experimental ulceration,suggesting that parasympathetic afferents promote the process of noxious visceral stimulation.

关键词： Zusanli acupuncture Ulceration c-Fos Nucleusof solitary tract

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Synthesis and Characterization of Chitosan-Albumin Conjugates as pH-Sensitive Biodegradable Hydrogels

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Chemical Research in Chinese Universities 2011年第2期27卷 329-333页

作者： GUO jin-shan LI Jian-zheng jinG Xia-bin CHEN Xue-si HUANG Yu-bin State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Graduate School of Chinese Academy of Sciences Beij＇ing 100049 P. R. China Department of Materials Science and Engineering Jilin University Changchun 130022 P. R. China

A new kind of biodegradable pH-sensitive drug delivery system was developed via chitosan-albumin conjugate hydrogel. Through changing the feeding modes of reactants, two types of hydrogels（comb-type and reticular-type） were synthesized by amidation reactions between 6-O-succinoylated N-phthaloyl chitosan and albumin. The structures and morphologies of the hydrogels were characterized by SEM. And their water swelling capacity, drug loading and releasing properties at different pH values were also investigated. It was found that the comb-type of hydrogels with looser space construction had better water swelling ratio（more than 400% of its original mass） than the reticular-type of ones did（about 180% of its original mass）. In vitro release experiments of Rifampicin show that the hydrogels provided the controlled release of the entrapped drug for more than 50 h. The drug release rates of both types of hydrogels under acidic condition were lower than those under neutral or basic condition. The introduction of albumin not only improved the hydrophilicity of chitosan, but also provided the possibility of the carrier system combining other biologically active materials more easily to fulfill the delivery and therapy functions.

关键词： Chitosan Albumin Hydrogel pH Sensitive Drug delivery

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Development of an indirect competitive ELISA for simultaneous detection of enrofloxacin and ciprofloxacin

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第11期12卷 884-891页

作者： Hai-tang ZHANG jin-qing JIANG Zi-liang WANG Xin-yao CHANG Xing-you LIU San-hu WANG Kun ZHAO jin-shan CHEN College of Animal Science Henan Institute of Science and Technology Xinxiang 453003 China Henan Higher Education Engineering Technology Research Center for Animal Diseases Control and Residues Supervision Xinxiang 453003 China

Modified 1-ethyl-3-(3-dimethylaminopropy) carbodiimide(EDC) method was employed to synthesize the artificial antigen of enrofloxacin(ENR),and New Zealand rabbits were used to produce anti-ENR polyclonal antibody(pAb).Based on the checkerboard titration,an indirect competitive enzyme-linked immunosorbent assay(ELISA) standard curve was *** assay was sensitive and had a linear range from 0.6 to 148.0 μg/kg(R2=0.9567),with the half maximal inhibitory concentration(IC50) and limit of detection(LOD) values of 9.4 μg/kg and 0.2 μg/kg,*** all the competitive analogues,the produced pAb exhibited a high cross-reactivity to ciprofloxacin(CIP)(87%),the main metabolite of ENR in *** optimization,the matrix effects can be ignored using a 10-fold dilution in beef and 20-fold dilution in *** overall recoveries and coefficients of variation(CVs) were in the ranges of 86%-109% and 6.8%-13.1%,*** can be concluded that the established ELISA method is suitable for simultaneous detection of ENR and CIP in animal tissues.

关键词： Enrofloxacin Ciprofloxacin Indirect competitive ELISA Animal tissues

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