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Diagnostic and prognostic implications of non-high-density lipoprotein cholesterol and homocysteine levels for cognitive impairment in thalamic infarction

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World Journal of Psychiatry 2023年第12期13卷 985-994页

作者： shan-Yao Zhu Wei Ge Huan Zhang Department of Internal Medicine-Neurology Chaohu Hospital Affiliated to Anhui Medical UniversityHefei 238000Anhui ProvinceChina

BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the *** patients with thalamic infarction have an adverse prognosis,which seriously affects their ***,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive *** To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic *** From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)scorehe MoCA *** addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic *** to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(Phere was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(Phere was a significant difference between the control group and the group with normal cognitive function(Phe non-HDL-C and Hcy levels were c

关键词： Thalamic infarction Cognitive impairment Non-high-density lipoprotein cholesterol High homocysteine level Diagnostic value Prognosis Influencing factors Correlation

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C-H···Pd(Ⅱ) interaction-driven homochiral M helix formation of neutral ( R,R)-bis(pyrrol-2-ylmethyleneamino) cyclohexane palladium(Ⅱ) complex

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Chinese Science Bulletin 2007年第11期52卷 1581-1584页

作者： shan XuFeng WU LiZhu ZHANG LiPing TUNG ChenHo Laboratory of Organic Optoelectronic Functional Materials and Molecular Engineering Technical Institute of Physics and Chemistry & Graduate University Chinese Academy of Sciences Beijing 100080 China

A chiral complex of (R,R)-Pd was prepared by reaction of optically pure (R,R)-bis(pyrrol-2-ylmethyl-eneamino) cyclohexane ligand with Pd(OAc)2·2H2O under the base condition at room temperature. The weak intermolecular C-H···Pd interaction was found to be responsible for the homochiral M helix for-mation of the neutral,chiral,mononuclear (R,R)-Pd in the crystal packing.

关键词： X射线晶状结构螺旋状结构交互作用

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On the laws of the iterated logarithm with mean-uncertainty under sublinear expectations

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Probability, Uncertainty and Quantitative Risk 2022年第1期7卷 1-12页

作者： Xiaofan Guo shan Li Xinpeng Li Research Center for Mathematics and Interdisciplinary Sciences Shandong UniversityQingdao 266237ShandongChina Frontiers Science Center for Nonlinear Expectations(Ministry of Education) Shandong UniversityQingdao 266237ShandongChina School of Mathematics Shandong UniversityJinan 250100ShandongChina

A new Hartman-Wintner-type law of the iterated logarithm for independent random variables with mean-uncertainty under sublinear expectations is established by the martingale analogue of the Kolmogorov law of the itera... 详细信息

关键词： Law of the iterated logarithm Mean-uncertainty Upper and lower variances Sublinear expectation

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Accumulation characteristic of protein bodies in different regions of wheat endosperm under drought stress

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Journal of Integrative Agriculture 2016年第12期15卷 2921-2930页

作者： CheN Xin-yu LI Bo SHAO shan-shan WANG Lei-lei ZHU Xiao-wei YANG yang WANG Wen-jun YU Xu-run XIONG Fei Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou University Yangzhou 225009 P.R.China Jiangsu Yanjiang Institute of Agricultural Sciences Nantong 226541 P.R. China

The structural characteristics of protein body accumulation in different endosperm regions of hard wheat cultivar （XM33） and soft wheat cultivar （NM13） under drought stress were investigated. Drought stress treatment was implemented from plant regreening to the caryopsis mature stage. Microscope images of endosperm cells were obtained using resin semi- thin slice technology to observe the distribution and relative area of protein body （PB）. Compared with NM13, relative PB area of XM33 was significantly higher in sub-aleurone endosperm region. The amount of accumulation, including the size and relative area of PB, in two wheat cultivars was higher in sub-aleurone region than that in central region at 18 days post anthesis （DPA）. Drought stress significantly enhanced the sizes and relative areas of PBs in the dorsal and abdominal endosperms in two wheat cultivars. Particularly for dorsal endosperm, drought stress enhanced the relative PB area at 18 DPA and NM13 （5.0% vs. 6.73%） showed less enhancement than XM33 （5.49% vs. 8.96%）. However, NM13 （9.58% vs. 12.02%） showed greater enhancement than XM33 （10.25% vs. 11.7%） at 28 DPA. The protein content in the dorsal and abdominal endosperms of the two wheat cultivars decreased at 12 DPA and then increased until 38 DPA. Drought stress significantly increased the protein contents in the two main regions. From 12 to 38 DPA, the amount of PB accumulation and the protein content were higher in XM33 than those in NM13. The results revealed that PB distribution varied in different endosperm tissues and that the amount of PB accumulation was remarkably augmented by drought stress.

关键词： wheat protein bodies distribution accumulation drought stress

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Electron Momentum Spectroscopy of Ethanethiol Complete Valence Shell

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Chinese Journal of Chemical Physics 2008年第6期21卷 515-520页

作者： Xin-xia Xue Mi Yan Fang Wu Xu shan Ke-zun Xu Xiang-jun Chen hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of China Hefei 230025 China

The binding energy spectra and electron momentum distributions for the complete valence orbitals of ethanethiol were measured for the first time by binary （e, 2e） electron momentum spectroscopy employing non-coplanar symmetric kinematics at an impact energy of 1200 eV plus binding energy. The experimental results are generally consistent with the theoretical calculations using density functional theory and Hartree-Fock methods with various basis sets. A possible satellite line at 17.8 eV in binding energy spectrum was observed and studied by electron momentum spectroscopy.

关键词： Ethanethiol Electron momentum spectroscopy Valence orbital Satellite line Binding energy spectrum

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Supplementing the early diet of broilers with soy protein concentrate can improve intestinal development and enhance short-chain fatty acid-producing microbes and short-chain fatty acids,especially butyric acid

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Journal of Animal Science and Biotechnology 2023年第1期14卷 278-294页

作者： Qianyun Zhang shan Zhang Shu Wu Marianne Hjollund Madsen Shourong Shi Poultry Institute Chinese Academy of Agriculture ScienceYangzhou 225125China. TripleA a/s Bjoernkaervej 16DK‑8783 HornsyldDenmark.

Background:Research on nutrition in early-life commonly focuses on the maturation of the intestine because the intestinal system is crucial for ensuring continued *** explore the importance of early nutrition regulation in animals,soy protein concentrate(SPC)was added to the early diet of broilers to investigate its effects on amino acid digestibility,intestinal development,especially intestinal microorganisms,and broiler metabolites.A total of 192 oneday-old Arbor Acres(AA)male broilers were randomly assigned to two experimental treatments with 8 replicates of 12 *** control group was fed a basal diet(control),and the treatment group was fed a basal diet supplemented with 12%SPC(SPC12)during the first 10 d(starter phase).From d 11 to 21(grower phase)and d 22 to 42(finisher phase),a basal diet was fed to both treatment ***:SPC reduced the pH value and acid-binding capacity of the starter diet(Phe early diet enhanced the gizzard weight(Phe ileum weight(Phe weight and length of the jejunum(Phe relative length of the duodenum and jejunum(Phe same time,SPC enhanced villus height(Phe jejunum and ileum(Phe number of goblet cells in the duodenum(Phe Chao1 index and the ACE index(Phe composition of caecal microflora at d *** also increased the relative abundance of Alistipes,Anaerotruncus,Erysipelatoclostridium,Intestinimonas and Flavonifractor bacteria(Phe same time,the concentrations of caecal butyric acid and total short-chain fatty acids(SCFAs)were also increased in the SPC12 group(Phe results showed that supplementing the starter diet of broilers with SPC has a significant effect on the early development of the intestine and the microflora.

关键词： Broiler Caecal microbiota Intestinal development Short-chain fatty acids Soy protein concentrate

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叶酸缺乏影响胚胎干细胞H3K9巴豆酰化和神经发育相关基因表达

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陆军军医大学学报 2024年第14期46卷 1666-1675页

作者：陈晨何学佳王珊首都儿科研究所生物化学与免疫学研究室北京100020 北京大学首都儿科研究所教学医院生物化学与免疫学研究室北京100020

目的采用染色质免疫共沉淀测序技术(chromatin immunoprecipitation sequencing,ChIP-seq)分析叶酸正常小鼠胚胎干细胞(mouse embryonic stem cells,mESCs)与叶酸缺乏mESCs组蛋白H3K9巴豆酰化(H3K9cr)修饰的全基因图谱,以期探究叶酸缺乏条件下mESCs中H3K9cr全基因组状态变化以及受到调控的通路基因。方法mESCs分为叶酸正常组(FA=4 mg/L,FA4)和叶酸缺乏组(FA=0 mg/L,FA0),利用Western blot和免疫组织化学染色分别检测叶酸缺乏mESCs和神经管畸形(neural tube defects,NTDs)小鼠胚脑组织中H3K9cr蛋白表达水平;利用ChIP-seq技术对获得的特异性结合的DNA片段展开序列鉴定,对差异表达基因进行基因本体论(gene ontology,GO)以及京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路分析并可视化,分析叶酸缺乏条件下mESCs全基因组并对受调控基因进行验证。结果叶酸缺乏mESCs和NTDs小鼠胚脑组织中整体H3K9cr水平降低(P<0.05),叶酸缺乏mESCs中Bdnf、Pax6、App等神经发育相关基因下调(P<0.05),FA4与FA0两组差异富集基因的KEGG通路富集于轴突引导、神经活性配体-受体相互作用、谷氨酸能突触等与神经系统相关的通路。结论胚胎干细胞中叶酸缺乏通过H3K9cr修饰参与调控神经发育相关基因,提示组蛋白巴豆酰化修饰可能参与叶酸缺乏引起的神经发育类疾病。

关键词：叶酸缺乏组蛋白巴豆酰化 ChIP-seq 神经发育

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Orbit Design Elements of Chang’e 5 Mission

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Space(Science & Technology) 2021年第1期2021卷 28-49页

作者： Zhong-Sheng Wang Zhanfeng Meng shan Gao Jing Peng Beijing Institute of Spacecraft System Engineering Beijing 100094China

The three key orbit design technologies employed in the Chang’e 5 mission are identified and discussed in this paper:orbit design for lunar orbit rendezvous and docking,orbit design for precision lunar landing and inclination optimization,and orbit design for Moon-to-Earth ***,an overview of the Chang’e 5 mission profile is presented,which is followed by detailed discussions of the three key orbit design technologies,including an introduction of the tracking-based orbit design *** data are provided to demonstrate the correctness of the designs.

关键词： discussions orbit Earth

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Large-Sized Ankylosaur(Dinosauria) from the Lower Cretaceous Jiufotang Formation of Western Liaoning,China

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1060-1065页

作者： JI Shu-an ZHANG Lijun ZHANG Shudong ZHANG Lijun 1 JIANG shan Institute of Geology Chinese Academy of Geological Sciences Key Laboratory of Stratigraphy andPaleontology Ministry of Land and Resources Beijing 100037 China Administration Bureau of Fossil Resource Protection of Liaoning Province Shenyang 110032 Liaoning China Administration Branch of Fossil Protection Bureau of Land and Resources of Kazuo County Kazuo122300 Liaoning China Shenyang Center of the China Geological Survey Shenyang 110034 Liaoning China

Two incomplete bones referred to ankylosaur scapulocoracoid and humerus are described, which were discovered from the Early Cretaceous Jiufotang Formation of Dachengzi Town, Kazuo County, Liaoning Province. Ankylosaur dinosaurs have ever been found in the Lower Cretaceous Yixian, Fuxin and Sunjiawan Formations of western Liaoning. The occurrence of ankylosaurs within Jiufotang Formation improves our knowledge on the ankylosaur stratigraphic distribution. Based on the length of scapulocoracoid, the new dinosaur is estimated to exceed 6.0 meters long, representing the largest ankylosaur in western Liaoning.

关键词： Kazuo County Liaoning Province Lower Cretaceous Jiufotang Formation Ankylosauria

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A meaningful learning method for zero-shot semantic segmentation

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Science China(Information Sciences) 2023年第11期66卷 35-53页

作者： Xianglong LIU Shihao BAI shan AN Shuo WANG Wei LIU Xiaowei ZHAO Yuqing MA State Key Lab of Software Development Environment Beihang University JD health International Inc.

Zero-shot semantic segmentation, which is developed to segment unseen categories, has attracted increasing attention due to its strong practicability. Previous approaches usually applied semantic-visual mapping based on seen categories to unseen categories, and thus failed to generate meaningful unseen visual representations and struggled to balance the seen and unseen concepts in the classifier. To overcome the above limitations, we propose a novel meaningful learning method that could be embedded into any generationbased zero-shot semantic segmentation model, borrowing the idea from the educational psychology field. The proposed meaningful learning method refers to the process that the new concepts could be learned by relating to existing comprehensible concepts and harmoniously incorporated into the concept schema. Specifically, we introduce a generator with conjugate conceptual correlation(G3C) which generates meaningful unseen visual information through anchoring into existing concepts. Moreover, simulating the rational thinking mechanism,we introduce a fast-slow concept modulator to alleviate the noisy over-correlation problem introduced by G3C and further construct a comprehensive concept schema. Extensive experiments conducted on three benchmarks demonstrate the superior performance of our method, especially according to the commonlyacknowledged h-m Io U(e.g., 4% improvement on the Pascal-VOC dataset).

关键词： meaningful learning zero-shot learning semantic segmentation conjugate conceptual correlation fast-slow conceptual modulator

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