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Acta Mathematica Sinica,English Series 2009年第12期25卷 2133-2156页

作者： fu shan LI School of Mathematical Sciences Qufu Normal University Qufu 273165 P. R. China

By Galerkin finite element method, we show the global existence and uniqueness of weak solution to the nonlinear viscoelastic full Marguerre-von Karman shallow shell equations.

关键词： global solution viscoelastic Marguerre-von Karman shallow shell

Convergence of the Solution to General Viscoelastic Koiter Shell Equations

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1683-1688页

作者： fu shan LI School of Mathematical Sciences Qufu Normal University Qufu 273165 P. R. China and Institute of Mathematics Fudan University Shanghai 200433 P. R. China

By applying the inequality of Korn＇s type without boundary conditions on a general surface, we prove that the scaled displacement of the two-dimensional linearly viscoelastic Koiter＇s shell converges to the solution... 详细信息

关键词： Koiter's shells Korn's inequality membrane shells

Existence and Uniqueness of Positive Solutions for Some Singular Boundary Value Problems with Linear functional Boundary Conditions

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Acta Mathematica Sinica,English Series 2011年第10期27卷 2073-2084页

作者： Zeng Qin ZHAO fu shan LI School of Mathematical Sciences Qufu Normal University Qufu 273165 P. R. China

By using the upper and lower solution method and fixed point theory, we investigate some nonlinear singular second-order differential equations with linear functional boundary conditions. The nonlinear term f（t, u） is nonincreasing with respect to u, and only possesses some integrability. We obtain the existence and uniqueness of the C[0, 1] positive solutions as well as the C1 [0, 1] positive solutions.

关键词： Linear functional boundary condition decreasing function positive solution upper and lower solution method fixed point theorem

Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun fu-shan Wang Yan Gao fu-Qing Wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

A nano-structured TiO_(2)/CuO/Cu_(2)O coating on Ti-Cu alloy with dual function of antibacterial ability and osteogenic activity

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Journal of Materials Science & Technology 2022年第2期97卷 201-212页

作者： Yuan Zhang shan fu Lei Yang Gaowu Qin Erlin Zhang Key Laboratory for Anisotropy and Texture of Materials(MoE) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China

Bacteria-associated infection and poor osseointegration are two main reasons for orthopedic implant ***-Cu alloy exhibited excellent antibacterial property,but still presented unsatisfied osteogenic ***,Ti-Cu alloy was surface modified by an alkali-heat treatment in this paper to improve the osteogenic ability without reduction in antibacterial ability.A TiO_(2)/CuO/Cu_(2)O composite coating with nanostructure was deposited on Ti-Cu *** coating showed increased roughness and great *** tests indicated that the modified Ti-Cu alloy exhibited stronger antibacterial ability against Staphylococcus aureus(***)than Ti-Cu ***,cell experiments demonstrated that the composite coating promoted initial adhesion and spreading of MC3T3-E1 cells,enhanced alkaline phosphatase(ALP)activities as well as extracellular matrix(ECM)mineralization,and significantly upregulated osteogenesis-related gene *** was suggested that the nano-structured TiO_(2)/CuO/Cu_(2)O coating on Ti-Cu alloy might provide a potential strategy for orthopedic implant failure.

关键词： Ti-Cu alloy Alkali-heat treatment Antibacterial property Osteogenic activity

Polybrominated diphenyl ethers in soil from three typical industrial areas in Beijing, China

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Journal of Environmental Sciences 2013年第12期25卷 2443-2450页

作者： Yongfei Zhang shan fu Xinchun Liu Zheng Li Yuan Dong State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences

Areas containing industrial facilities belonging to three different typical industries that may cause pollution by polybrominated diphenyl ethers （PBDEs） in Beijing, China were investigated. Specifically, the areas contained a solid waste incineration plant, a chemical factory, and a heat and power plant. Investigation of the pollution status of PBDEs in the surface soil from areas around these industries revealed the highest concentration of 42 PBDE congeners （118 ng/g, dry mass） at the solid waste incineration plant. In the other two plants, the highest concentrations were both 26 ng/g （dry mass）. Among the PBDE homologues, the PBDE contamination at all sites showed similar congener compositions, with BDE 209 being the dominant congener. Our findings established the first contamination status of three typical industrial areas in Beijing. furthermore, the total concentrations of 42 PBDE congeners tended to decrease as the distance from the investigated plants increased. Overall, these plants were identified as potential pollution sources of PBDEs in Beijing. Moreover, Pearson correlation analysis revealed that the major PBDE source in Beijing may be associated with the technical deca-BDE and penta-BDE mixture. Based on the data obtained in this preliminary investigation, further study of the potential of these sources to emit PBDEs in Beijing is warranted.

关键词： different industry areas pollution source polybrominated diphenyl ethers soil

Human factors quantification via boundary identification of flight performance margin

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Chinese Journal of Aeronautics 2014年第4期27卷 977-985页

作者： Yang Changpeng Yin Tangwen Zhao Weina Huang Dan fu shan School of Aeronautics and Astronautics Shanghai Jiao Tong University

A systematic methodology including a computational pilot model and a pattern recognition method is presented to identify the boundary of the flight performance margin for quantifying the human factors. The pilot model is proposed to correlate a set of quantitative human factors which represent the attributes and characteristics of a group of pilots. Three information processing components which are influenced by human factors are modeled： information perception, decision making, and action execution. By treating the human factors as stochastic variables that follow appropriate probability density functions, the effects of human factors on flight performance can be investigated through Monte Carlo（MC） simulation. Kernel density estimation algorithm is selected to find and rank the influential human factors. Subsequently, human factors are quantified through identifying the boundary of the flight performance margin by the k-nearest neighbor（k-NN） classifier. Simulation-based analysis shows that flight performance can be dramatically improved with the quantitative human factors.

关键词： Computational pilot model Flight performance Human factors quantification Monte Carlo simulation Pattern recognition

Multiple hierarchy risk assessment with hybrid model for safety enhancing of unmanned subscale BWB demonstrator flight test

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Chinese Journal of Aeronautics 2019年第12期32卷 2612-2626页

作者： Yi LU Shuguang ZHANG Zejing ZHANG Xuan ZHANG Peng TANG shan fu Department of Automation School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Transportation Science and Engineering Beihang UniversityBeijing 100083China Airworthiness Technologies Research and Management Center China Aviation Polytechnology EstablishmentBeijing 100028China China Electronic Product Reliability and Environmental Testing Research Institute Guangzhou 510610China School of Energy and Power Engineering Beihang UniversityBeijing 100083China

To explore the low-speed characteristics of the Blended-Wing-Body(BWB)configuration for future civil aircraft,a series of unmanned subscale demonstrators have been developed and tested by our research *** this process,specific safety risks deriving from uncertain design features,system unreliability,and insufficient personnel experience caused continuous flight test mishaps and the risk mechanism was not *** and trial-and-error learning driven safety improvements took few effects on mishap prevention,so our focus was turned to look for systematic safety *** paper establishes a systems theory based hybrid model to integrate the physical system reliability analysis techniques with the system dynamics method for illustrating the multiple risk interactions of the demonstrator flight test involving organizational,human resource and technical system *** the prior BB-5 demonstrator as a case,the hybrid model simulation represents its historical risk evolution process,which verifies the model rational*** risk control strategies reduced the mishap rate of a new demonstrator called BB-6 *** paper also shows the extended hybrid model can be applied on safety management of unmanned aerial vehicles from the initial period of vehicle development.

关键词： Blended-wing-body Demonstration flight test Markov analysis Risk assessment Strategy experiment System dynamics Systems theory

Elafibranor:A promising treatment for alcoholic liver disease,metabolic-associated fatty liver disease,and cholestatic liver disease

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World Journal of Gastroenterology 2024年第40期30卷 4393-4398页

作者： Hang Zhang Xuan Dong Lei Zhu fu-shan Tang Department of Clinical Pharmacy Key Laboratory of Basic Pharmacology of Guizhou Province and School of PharmacyZunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina Key Laboratory of Clinical Pharmacy in Zunyi City Zunyi Medical UniversityZunyi 563006Guizhou ProvinceChina

Liver diseases pose a significant threat to human *** effective therapeutic agents exist for some liver diseases,there remains a critical need for advancements in research to address the gaps in treatment options and improve patient *** article reviews the assessment of Elafibranor's effects on liver fibrosis and intestinal barrier function in a mouse model of alcoholic liver disease(ALD),as reported by Koizumi et al in the World Journal of *** summarize the impact and mechanisms of Elafibranor on ALD,metabolic-associated fatty liver disease,and cholestatic liver disease based on current *** also explore its potential as a dual agonist of PPARα/δ,which is undergoing Phase III clinical trials for metabolic-associated *** goal is to stimulate further investigation into Elafibranor's use for preventing and treating these liver diseases and to provide insights for its clinical application.

关键词： Elafibranor Peroxisome proliferator activated receptor Liver fibrosis Alcoholic liver disease Metabolic-associated fatty liver disease Metabolic-associated steatohepatitis Cholestatic liver disease Primary biliary cholangitis Liver diseases

Bioconcentration kinetics of PCBs in various parts of the lifecycle of the tadpoles Xenopus laevis

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Journal of Environmental Sciences 2007年第3期19卷 374-384页

作者： ZHAO Rong-biao SUN Da-yu fu shan WANG Xiao-fei ZHAO Ru-song State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China. Shenyang Chemical Technology Institute Shenyang 110142 China

Polychlorinated biphenyls （PCBs） in Xenopus laevis have been reported only for a few congeners. Additionally, there is very little information on the ability of Xenopus laevis to bioconcentrate PCBs. To address these issues, the tadpole Xenopus laevis was exposed to Aroclor 1254 mixtures in water at room temperature for 110 d followed by an additional 110 d of nonspiked PCBs in the water for the control group. During the whole process, bioconcentration factors （BCFs） of PCBs ranged from 1180 to 15670. For most PCB congeners, the highest and lowest bioconcentrations of the kinetic curves were found to be remarkably simultaneous, respectively. All 141 PCB congeners under the same experimental conditions had no linear correlation on the lgBCF versus lgKow relationship. The relationship between lgBCFs and lgKow followed a parabolic pattern indicative of selective bioconcentration, suggesting that the kinetic curves of the PCB congeners observed in the lifecycle of the tadpoles may be concentrated due to the amphibian special species and internal metabolism. In contrast, lgBCFs for PCBs were inversely related to lgKow, suggesting that a metabolism of the higher Kow PCB congeners occurred. These results support the author＇s conclusion that the tadpole Xenopus laevis plays major roles in the bioconcentration of PCB congeners, and demonstrated that the exposure kinetic curves of PCB congeners are complex. Besides the amphibian metamorphous development, the lifecycle of the tadpole Xenopus laevis also may be of importance in determining the bioconcentration of PCB congeners.

关键词： PCBs tadpole Xenopus laevis bioconcentration exposure kinetics