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Short Form of Weinstein Noise Sensitivity Scale(NSS-SF): Reliability, Validity and Gender Invariance among Chinese Individuals

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Biomedical and Environmental Sciences 2018年第2期31卷 97-105页

作者： ZHONG Tao chung pak-kwong LIU Jing Dong Faculty of Social Science Hong Kong Baptist University

Objective Independent from noise exposure, noise sensitivity plays a pivotal role in people＇s noise annoyance perception and concomitant health deteriorations. The present study empirically investigated the psychometric properties of the Chinese version of the Weinstein Noise Sensitivity Scale-Short Form （CNSS-SF）, the widely used inventory measuring individual differences in noise *** In total, 373 Chinese participants （age = 21.41 ± 3.36） completed the online, anonymous questionnaire package. Examination of the CNSS-SF＇s reliability （internal consistency）, factorial validity through validation and cross-validation, nomological validity and measurement invariance across gender groups were *** The Cronbach alpha coefficients and composite reliabilities indicated sufficient reliability of the CNSS-SF. Two confirmatory factor analyses （CFA）, in two randomly partitioned groups of participants, substantiated the factorial validity of the scale. The nomological validity of the scale was also corroborated by the significant positive association of its score with the trait anxiety score. Measurement invariance of the CNSS-SF was also found across genders via multi-group *** Though not without limitations, findings from the present research provide promising evidence for the utility of the scale in measuring noise sensitivity among the Chinese population. The availability of the CNSS-SF can promote research related to environmental noise and health in China, as well as facilitate cross-cultural comparisons.

关键词： Environmental noise Individual differences Cross-cultural validation Measurement Publichealth

The role of gene variants in the pathogenesis of neurodegenerative disorders as revealed by next generation sequencing studies:a review

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Translational Neurodegeneration 2017年第1期6卷 245-255页

作者： Shirley Yin-Yu Pang Kay-Cheong Teo Jacob Shujui Hsu Richard Shek-Kwan Chang Miaoxin Li pak-chung sham Shu-Leong Ho Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong KongPeople’s Republic of China Centre for Genomic Sciences University of Hong KongHong KongPeople’s Republic of China Department of Medical Genetics Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouPeople’s Republic of China Key Laboratory of Tropical Disease Control(SYSU) Ministry of EducationGuangzhouPeople’s Republic of China

The clinical diagnosis of neurodegenerative disorders based on phenotype is difficult in heterogeneous conditions with overlapping *** does not take into account the disease etiology or the highly variable clinical course even amongst patients diagnosed with the same *** advent of next generation sequencing(NGS)has allowed for a system-wide,unbiased approach to identify all gene variants in the genome *** the plethora of new genes being identified,genetic rather than phenotype-based classification of Mendelian diseases such as spinocerebellar ataxia(SCA),hereditary spastic paraplegia(HSP)and Charcot-Marie-Tooth disease(CMT)has become widely *** has also become clear that gene variants play a role in common and predominantly sporadic neurodegenerative diseases such as Parkinson’s disease(PD)and amyotrophic lateral sclerosis(ALS).The observation of pleiotropy has emerged,with mutations in the same gene giving rise to diverse phenotypes,which further increases the complexity of phenotype-genotype *** mechanisms of pleiotropy include different downstream effects of different mutations in the same gene,presence of modifier genes,and oligogenic *** directions include development of bioinformatics tools and establishment of more extensive public genotype/phenotype databases to better distinguish deleterious gene variants from benign polymorphisms,translation of genetic findings into pathogenic mechanisms through in-vitro and in-vivo studies,and ultimately finding disease-modifying therapies for neurodegenerative disorders.

关键词： Next generation sequencing Neurodegenerative diseases Genetics Pleiotropy

Coagulation factors and the incidence of COVID-19 severity:Mendelian randomization analyses and supporting evidence

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1976-1978页

作者： Yao Zhou Xinyi Qian Zipeng Liu Hongxi Yang Tong Liu Kexin Chen Yaogang Wang pak chung sham Ying Yu Mulin Jun Li The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Tianjin Medical UniversityTianjinChina Centre for PanorOmic Sciences-Genomics and Bioinformatics Cores The University of Hong KongHong KongChina National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjinChina

Dear Editor,The evolving pandemic of coronavirus disease 19(COVID-19),is arousing alarm to public *** to epidemiological and observational investigations,coagulopathy was frequently seen in severe COVID-19 *** coagulation factors such as D-dimer,prothrombin time(PT);von Willebrand factor(VWF),platelet count,and fibrinogen were documented to be important predictors of critically ill patients with COVID-19 in many retrospective observational studies and were substantially discussed before(see Supplementary Notes),yet the causality from specific coagulation factors to the incidence of COVID-19 severity and the underlying mechanism remains elusive.

关键词： severity supporting Notes

Pacing technology:advances in pacing threshold management

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第8期11卷 634-638页

作者： Chu-pak LAU chung-wah SIU Cardiology Division Department of MedicineQueen Mary HospitalThe University of Hong Kong

Over the last five decades,pacemaker therapy has undergone remarkable technological advances with increasing sophistication of pacemaker ***,device longevity has remained one of the major issues in pacemaker design ever since the first endocardial pacing lead implantation in *** addition to various hardware design to enhance device longevity,software-based solutions to minimize pacing energy and yet with good safety margin have also been *** with desire and need of fully automatic pacing system in increasingly busy pacemaker clinic,several manufacturers have introduced different automatic threshold management *** article summarizes the current state-of-the-art management in pacing threshold in the modern pacemakers.

关键词： Pacemaker Threshold management Autocapture

Assessing acceptance in mindfulness with direct-worded items:The development and initial validation of the Athlete Mindfulness Questionnaire

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Journal of Sport and Health Science 2017年第3期6卷 311-320页

作者： Chun-Qing Zhang pak-Kwong chung Gangyan Si Department of Physical Education Hong Kong Baptist University Department of Health and Physical Education Hong Kong Institute of Education

Purpose:The purpose of the current study was to develop and validate a sport-specific mindfulness measure,the Athlete Mindfulness Questionnaire(AMQ),through 5 related studies using 4 separate samples of Chinese *** AMQ is a 3-factor measure designed to assess mindfulness that reflects present-moment attention,awareness,and acceptance in a sport ***:In Study 1,an initial pool of items was generated based on previous literature,existing mindfulness scales,as well as interviews with and feedback from the athletes,coaches,and mindfulness *** support for the 3-factor structure of the AMQ was established via exploratory factor analysis in Study 2,and cross-validated through confirmatory factor analysis in Studies 3 and *** Study 5,a modified 3-factor AMQ with direct-worded acceptance items was examined in a fourth independent ***:Convergent and concurrent validities of the acceptance subscale failed to be established in Studies 3 and 4 which may be due to the inattention and confusion of the athletes whilst interpreting the reverse-worded items.A modified 16-item AMQ in Study 5 displayed satisfactory model fit and acceptable internal *** importantly,convergent and concurrent validities of the 16-item AMQ were ***3 subscales showed significant positive associations with mindfulness,flow,well-being,and positive affect and significant negative associations with experiential avoidance,burnout,and negative ***:The AMQ is a psychometrically sound measure of mindfulness in a sport *** importance of using direct-worded acceptance items is discussed.

关键词： Athlete Mindfulness Reliability Scale Sport Validity

A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings

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Chinese Science Bulletin 2011年第32期56卷 3394-3397页

作者： LUI Simon S Y sham.pak CHAN Raymond C K CHEUNG Eric F C Neuropsychology and Applied Cognitive Neuroscience Laboratory Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Castle Peak Hospital Department of Psychiatry the University of Hong Kong

The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关键词：精神病患者稳定家庭早期原理预计香港面部表情识别

Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders

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World Journal of Stem Cells 2019年第2期11卷 55-72页

作者： Qiang Liu Mo-Xian Chen Lin Sun Chloe U Wallis Jian-Song Zhou Li-Juan Ao Qi Li pak C sham Department of Surgery The Chinese University of Hong Kong School of Rehabilitation Kunming Medical University Department of Psychology Weifang Medical University Medical Sciences Division University of Oxford Mental Health Institute of the Second Xiangya Hospital Central South University Department of Psychiatry the University of Hong Kong State Key Laboratory of Brain and Cognitive Sciences Center for Genomic Sciences the University of Hong Kong

Autism and autism spectrum disorders(ASD) refer to a range of conditions characterized by impaired social and communication skills and repetitive behaviors caused by different combinations of genetic and environmental influences. Although the pathophysiology underlying ASD is still unclear, recent evidence suggests that immune dysregulation and neuroinflammation play a role in the etiology of ASD. In particular, there is direct evidence supporting a role for maternal immune activation during prenatal life in neurodevelopmental conditions. Currently, the available options of behavioral therapies and pharmacological and supportive nutritional treatments in ASD are only symptomatic. Given the disturbing rise in the incidence of ASD, and the fact that there is no effective pharmacological therapy for ASD, there is an urgent need for new therapeutic options. Mesenchymal stem cells(MSCs) possess immunomodulatory properties that make them relevant to several diseases associated with inflammation and tissue damage. The paracrine regenerative mechanisms of MSCs are also suggested to be therapeutically beneficial for *** the underlying pathology in ASD, including immune system dysregulation and inflammation, represent potential targets for MSC therapy. This review willfocus on immune dysfunction in the pathogenesis of ASD and will further discuss the therapeutic potential for MSCs in mediating ASD-related immunological disorders.

关键词： Autism spectrum disorders Mesenchymal stem cells Major histocompatibility complex Inflammation Maternal immune activation Cell therapy

Analytical solution for one-dimensional nonlinear consolidation of saturated multi-layered soil under time-dependent loading

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Journal of Ocean Engineering and Science 2021年第1期6卷 21-29页

作者： Pyol Kim Hyong-Sik Kim Chol-U pak chung-Hyok Paek Gun-Hyang Ri Hak-Bom Myong Faculty of Geology Kim Il Sung UniversityPyongyang 999093Democratic People’s Republic of Korea

This paper presents analytical solutions for one-dimensional nonlinear consolidation of saturated multi-layered soil under time-dependent *** solutions are derived for one-dimensional nonlinear consolidation of multi-layered soil subjected to constant loading and ramp *** proposed solutions are verified through the comparison with the existing solutions for double-layered soil and singlelayered soil,which shows the proposed solutions are more general ones for one-dimensional nonlinear consolidation of saturated soils subjected to time-dependent *** on the proposed solutions,nonlinear consolidation behavior of saturated multi-layered soil under time-dependent loading is investigated.

关键词： Saturated soil Multi-layered Nonlinear consolidation Analytical solution

Interleukin-18 levels in the hippocampus and behavior of adult rat offspring exposed to prenatal restraint stress during early and late pregnancy

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Neural Regeneration Research 2020年第9期15卷 1748-1756页

作者： Mo-Xian Chen Qiang Liu Shu Cheng Lei Lei Ai-Jin Lin Ran Wei Tomy C.K.Hui Qi Li Li-Juan Ao pak C.sham School of Rehabilitation Kunming Medical UniversityKunmingYunnan ProvinceChina Department of Surgery The Chinese University of Hong KongHong Kong Special Administrative RegionChina Department of Rehabilitation China Resources&WISCO General HospitalWuhanHubei ProvinceChina Department of Rehabilitation Medicine the Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Institute of Basic Medicine Shandong Academy of Medical SciencesJinanShandong ProvinceChina Department of Psychiatry The University of Hong KongHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administrative RegionChina Centre for Genomic Sciences The University of Hong KongHong Kong Special Administrative RegionChina

Exposure to maternal stress during prenatal life is associated with an increased risk of neuropsychiatric disorders, such as depression and anxiety, in offspring. It has also been increasingly observed that prenatal stress alters the phenotype of offspring via immunological mechanisms and that immunological dysfunction, such as elevated interleukin-18 levels, has been reported in cultures of microglia. Prenatal restraint stress(PRS) in rats permits direct experimental investigation of the link between prenatal stress and adverse outcomes. However, the majority of studies have focused on the consequences of PRS delivered in the second half of pregnancy, while the effects of early prenatal stress have rarely been examined. Therefore, pregnant rats were subjected to PRS during early/middle and late gestation(days 8–14 and 15–21, respectively). PRS comprised restraint in a round plastic transparent cylinder under bright light(6500 lx) three times per day for 45 minutes. Differences in interleukin-18 expression in the hippocampus and in behavior were compared between offspring rats and control rats on postnatal day 75. We found that adult male offspring exposed to PRS during their late prenatal periods had higher levels of anxiety-related behavior and depression than control rats, and both male and female offspring exhibited higher levels of depression-related behavior, impaired recognition memory and diminished exploration of novel objects. Moreover, an elevated level of interleukin-18 was observed in the dorsal and ventral hippocampus of male and female early-and late-PRS offspring rats. The results indicate that PRS can cause anxiety and depression-related behaviors in adult offspring and affect the expression of interleukin-18 in the hippocampus. Thus, behavior and the molecular biology of the brain are affected by the timing of PRS exposure and the sex of the offspring. All experiments were approved by the Animal Experimentation Ethics Committee at Kunming Medical U

关键词： behavior depression dorsal hippocampus interleukin-18 prenatal restraint stress recognition memory sex ventral hippocampus