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nm23H1 expression and its role in the evolution of non-gastrointestinal malignancies

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World Journal of Gastroenterology 2009年第4期15卷 506-507页

作者： shailendra kapoor 26-Hoffman Estates Schaumburg

The role of nm23H1 genetic instability is not limited to gastrointestinal malignancies.A similar close relationship exists between nm23H1 genetic instability and other non gastrointestinal systemic *** instance,in oral malignant melanomas with lymphoid metastasis,the nm23H1 expression is significantly lower in contrast to tumors with no lymphoid ***,increased metastasis is seen in non small cell lung cancers following down regulation of nm23H1 in conjunction with KAI-1 down regulation. There is an inverse relationship between tumor stage and metastasis and nm23H1 expression in individuals with prostate carcinomas and a similar relationship exists between microsatellite instability of the nm23H1 gene and ovarian *** instance,nearly 70.5%of stageⅠ-Ⅱovarian tumors express nm23H1 in sharp contrast to only 25%of stageⅢ-Ⅳovarian *** is clearly evident,nm23H1 has a major role in gastrointestinal and non-gastrointestinal *** coming few years will hopefully see the development of new strategies by virtue of which we can alter nm23H1 expression and thus decrease the risk of metastasis in malignant tumors.

关键词： nm23H1 Non small cell lung cancers Prostate carcinomas Nasopharyngeal carcinomas

Opioid/naloxone prolonged release combinations for opioid induced constipation

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World Journal of Gastroenterology 2012年第29期18卷 3921-3922页

作者： shailendra kapoor Formerly University of Illinois at Chicago MechanicsvilleVA 23111United States

I read with great interest the recent article by Chen et al in a recent issue of your esteemed *** article is highly thought *** emerging therapeutic alternative for opioid induced constipation is the emergence of opioid/naloxone prolonged release *** instance,naloxone when administered in a 1:2 ratio with oxycodone reverses the inhibitory effect of oxycodone on the gastrointestinal *** advantage of oxycodone/naloxone prolonged release(OXN) is that while its anti-nociceptive efficacy is equivalent to that of oxycodone prolonged release(OXC),it significantly decreases the "Bowel Function Index" thereby ameliorating symptoms of opioid induced constipation to a large *** et al in a recent study have reported a decrease in the bowel function index from 38.2 to ***,L wenstein et al in another recent study have reported that following a month of therapy,complete spontaneous bowel movements per week is increased from one in OXC therapy to three in OXN therapy.

关键词： Opiod naloxone Cancer Morphine Carcinogenesis

Emerging role of berbamine as an anti-cancer agent in systemic malignancies besides chronic myeloid leukemia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第9期13卷 761-762页

作者： shailendra kapoor 2300 East Cary Street Richmond VA 23223USA

The recent article by Liang et al. （2011）, pub- lished in Journal of Zhejiang University-SCIENCE B （Biomedicine ＆ Biotechnology）, is highly interesting. Interestingly, the past few years have seen the in- creasing application of berbamine as an anti-cancer agent in other systemic malignancies besides chronic myeloid leukemia. For instance, berbamine administration alters the Bcl-2/Bax ratio and mitigates cell migration and thereby augments the anti-proliferative ability of trichostatin A in non-small cell lung cancers （Duan et al., 2010）. Similarly, berbamine inhibits p65 trans- location, up-regulates A20 and increases the activa- tion of the GADD45/c-Jun N-terminal kinase （JNK） pathway, thereby enhancing cellular apoptosis in multiple myelomas （Liang et al., 2009a; 2009b）. Similarly, alteration of the nuclear factor-kappa B （NF-~B） pathway results in enhanced apoptosis in lymphomas （Duet al., 2010）.

关键词： CLC number R55

Management of constipation in the elderly: Emerging therapeutic strategies

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World Journal of Gastroenterology 2008年第33期14卷 5226-5227页

作者： shailendra kapoor Department of Family Medicine University of Illinois at ChicagoChicago IL 60612 United States

A number of new, novel strategies for managing constipation in the elderly have emerged over the past few years. Prucalopride is one such new agent that is highly effi cacious in managing chronic constipation. In fact, Camilleri et al in a recent study reported that the average number of bowel movements increased by at least one in nearly 47% of the patients who were administered a dose of 4 mg. Lubiprostone is another new agent recently approved by the FDA that shows efficacy in managing the symptoms of constipation. Neostigmine has also been successfully used for the management of recalcitrant constipation. Most of these studies have used subcutaneous neostigmine. Symbiotic yogurt containig components, such as Bifidobacterium and fructoligosaccharide, have also been recently shown to be highly effective in improving symptoms of constipation. Elderly patients especially those in hospices and nursing homes are often on opiods for pain management. Constipation secondary to opioid use is extremely common in nursing homes. Subcutaneous methylnaltrexone has recently been shown to be highly effective in the management of opioid-related constipation, and was recently approved by the FDA. Sacral nerve stimulation is another emerging strategy. A recent analysis by Mowatt et al supports the eff icacy of this technique. Botulinum toxin is another agent that has already been successfully used for the management of chronic, refractory constipation in children and may be very effective for elderly constipation. Further larger studies are needed to confi rm the fi ndings noted in these studies. Constipation is clearly a major issue in the elderly and these new, emerging strategies will hopefully improve the quality of life and relieve the symptoms of constipation in this population.

关键词： Constipation Prucalopride Lubiprostone Neostigmine Methylnaltrexone

Curcumin and its emerging intraocular benefits

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 85-86页

作者： shailendra kapoor 75 Crossing Place MechanicsvilleVA 23223USA

I read with great interest the recent article 'Curcumin inhibits proliferation of human lens epithelialcells: a proteomic analysis'by Hu et al. (2012), pub-lished in Journal of Zhejiang University-SCIENCE B(Biomedicin... 详细信息

关键词：眼科学白内障治疗疗效

Artesunate and its emerging anti-neoplastic effects:beyond its role in attenuating tumor growth in osteosarcomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第12期13卷 1029-1030页

作者： shailendra kapoor 75 Crossing Place MechanicsvilleVA 23223USA

I read with great interest the recent article "Artesunate inhibits growth and induces apoptosis inhuman osteosarcoma HOS cell

关键词：药理学性质药物实验

Rare facial dermatological lesions associated with Demodex infection,besides acne vulgaris

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 421-422页

作者： shailendra kapoor 2300 East Cary Street Richmond VA 23223USA

I have read with great interest the recent article ＂A meta-analysis of association between acne vulgaris and Demodex infestation＂ by Zhao et al. （2012）, published in Journal of Zhejiang University SCIENCE B （Biomedicine ＆ Biotechnology）（another two articles by Zhao et al. （2011a; 2011b） are also related to Demodex infestation）. The article is highly thought provoking. Interestingly, Demodex infestation may be associated with a number of other facial dermatological lesions besides ache vulgaris.

关键词： CLC number R384.4 R757.3

Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology

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World Journal of Gastroenterology 2009年第17期15卷 2170-2171页

作者： shailendra kapoor Kristin 24 Schaumburg IL 60195 United States

Nigella sativa decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion of insulin besides having a negative impact on glucose absorption from the intestinal mucosa. N. sativa administration protects hepatic tissue from deleterious effects of toxic metals such as lead, and attenuates hepatic lipid peroxidation following exposure to chemicals such as carbon tetrachloride.

关键词： Nigella sativa Thymoquinone Colon cancer Glutathione-S transferase Schistosomiasis

Lubiprostone:Clinical applications beyond constipation

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World Journal of Gastroenterology 2009年第9期15卷 1147-1147页

作者： shailendra kapoor Kristin 24 SchaumburgIL 60195 United States

In comparison to polyethylene glycol,lubiprostone offers other advantages and is increasingly being used as an adjunctive agent in diagnostic as well as management strategies not only in gastroenterology, but in other *** instance,lubiprostone exerts beneficial effects in cystic fibrosis *** augmernts the chloride secretion in these cells by activating non-cystic fibrosis transmembrane regulator(CFTR) secretion of chloride by afflicted respiratory epithelia. Lubiprostone also seems to improve visualization of the gastrointestinal tract during procedures such as *** is especially true if the lubiprostone is administered prior to bowel cleansing with agents such as polyethylene glycol electrolyte(PEG-E). Lubiprostone also enhances and stimulates contraction in colonic as well as gastric muscles and may thus further contribute as a prokinetic *** these effects,lubiprostone also causes hyperpolarization in other tissues such as uterine muscle *** may prove to be of significant clinical benefit in the management of uterine pathologies in the near future.

关键词： Lubiprostone Cystic fibrosis Colonoscopy Uterine muscle Prokinetic agent