检索结果-南通市图书馆

Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第5期12卷 973-990页

作者： Abdullah A.Ghawanmeh Gomaa A.m.Ali H.Algarni shaheen m.sarkar Kwok Feng Chong Faculty of Industrial Sciences & Technology Universiti Malaysia PahangGambang26300 KuantanMalaysia Chemistry Department Faculty of ScienceAl-Azhar UniversityAssiut71524Egypt Department of Physics Faculty of SciencesKing Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Research Center for Advanced materials Science (RCAmS) King Khalid UniversityAbha 61413P. O. Box 9004Saudi Arabia Bernal Institute Department of Chemical SciencesUniversity of LimerickCastletroyV94 LimerickIreland

Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption *** has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer ***,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer ***,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target *** this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ***,swelling kinetics,drug release profile and biological activity in vivo and in vitro are *** biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio *** from that,the clinical potential of GO based hydrogels and its major challenges are addressed in ***,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug *** is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration.

关键词： graphe ne oxide cancer nan otechnology hydrogel nanocarrier drug delivery

Autophagy in neuroinflammation after traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第5期19卷 951-952页

作者： Chinmoy sarkar marta m.Lipinski Shock Trauma and Anesthesiology Research(STAR)CenterDepartment of AnesthesiologyUniversity of Maryland School of MedicineBaltimoreMDUSA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimoreMDUSA

Traumatic brain injury(TBI)is an acquired injury of the brain caused by the impact of external forces on the brain(maas et al.,2008).It is a major cause of death and disability among people of all ages(maas et al.,2008).The primary mechanical injury to the brain initiates a cascade of secondary biochemical events that lead to acute and chronic neurodegeneration and activation of inflammatory pathways(maas et al.,2008).Both brain-resident microglia and blood-derived myeloid cells-macrophages and monocytes that infiltrate the brain due to injury-induced blood-brain barrier damage,contribute to the inflammatory responses after TBI(morganti et al.,2015).

关键词： damage death after

Facile synthesis of hierarchical NiO/NiFe_(2)O_(4) microsphere composite as efficient visible photocatalyst for 2,4-DCP degradation

在线全文

学校读者我要写书评

暂无评论

Rare metals 2024年第4期43卷 1580-1588页

作者： Shabana shaheen Shuai Xu Ji Bian Amir Zada Zi-Qing Zhang Yang Qu Li-Qiang Jing Key Laboratory of Functional Inorganic materials Chemistry(ministry of Education) International Joint Research Center and Lab for Catalytic TechnologySchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Department of Chemistry Abdul Wali Khan UniversityMardan23200Pakistan

It is highly desired to develop efficient photocatalysts with recycling property for practical application to degrade toxic ***,nanosheet-assembled NiFe_(2)O_(4)microspheres with commendable activity are successfully synthesized by a facile solvothermal reaction with NH4F as the modifier,and their photoactivities are further improved by coupling with NiO through an in situ growth *** optimized nickel oxide(NiO)/nickel ferrite(NiFe_(2)O_(4))microsphere composite(5NiO/NFO-4)exhibits a satisfactory photocatalytic activity for 2,4-dichlorophenol(2,4-DCP)degradation under visible-light irradiation,which is attributed to its wide visible-light response,well-designed hierarchical structure and enhanced charge transfer and separation by coupling NiO as a high-level energy platform to accept ***,it is found that the NiO/NiFe_(2)O_(4)microsphere photocatalysts can be easily collected and recycled owing to the distinctive magnetic *** work provides a feasible route to rational design visible-light-driven photocatalysts with high-activity for environmental remediation and purification with good recyclability.

关键词： NiFe_(2)O_(4) microspheres NiO/Fe_(2)O_(4) composite Charge separation Visible-light photocatalysis 2 4-Dichlorophenol degradation

Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第1期15卷 24-33页

作者： Rupak Desai Nishanth Katukuri Sumaja Reddy Goguri Azra Kothawala Naga Ruthvika Alle meena Kumari Bellamkonda Debankur Dey Sharmila Ganesan minakshi Biswas Kuheli sarkar Pramoda Prattipati Shaylika Chauhan Independent Researcher Independent ResearcherAtlantaGA 30079United States Department of Internal medicine Mayo ClinicRochesterMN 55902United States Department of medicine Chalmeda Anand Rao Institute of Medical SciencesTelangana 505001India Department of medicine Jawaharlal Nehru Medical CollegeBelgaum 590010India Department of medicine Narayana Medical CollegeAndhra PradeshNellore 524003India Department of medicine Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research FoundationVijaywada 521286India Department of medicine Medical College KolkataKolkata 700073India Department of medicine P.E.S.Institute of Medical Sciences and ResearchAndhra Pradesh 517425India Department of medicine Shaheed Ziaur Rahman Medical CollegeBogra 5800Bangladesh Department of medicine College of Medicine and J.N.M HospitalKalyani 741235India Department of medicine Jawaharlal Nehru Medical College IndiaKarnatakaBelagavi 590010India Department of Internal medicine Geisinger Health SystemWikes-BarrePA 18702United States

BACKGROUND Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events(mACCE).However,the relationship between prediabetes and mACCE in atrial fibrillation(AF)patients has not been extensively ***,this study aimed to establish a link between prediabetes and mACCE in AF *** To investigate a link between prediabetes and mACCE in AF *** We used the National Inpatient Sample(2019)and relevant ICD-10 Cm codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes,excluding *** primary outcome was mACCE(all-cause inpatient mortality,cardiac arrest including ventricular fibrillation,and stroke)in AF-related *** Of the 2965875 AF-related hospitalizations for mACCE,47505(1.6%)were among patients with *** prediabetes cohort was relatively younger(median 75 vs 78 years),and often consisted of males(56.3%vs 51.4%),blacks(9.8%vs 7.9%),Hispanics(7.3%vs 4.3%),and Asians(4.7%vs 1.6%)than the non-prediabetic cohort(Pmia,smoking,obesity,drug abuse,prior myocardial infarction,peripheral vascular disease,and hyperthyroidism(all Pmore frequently required home health care(23.6%vs 21.0%)and had higher *** adjusting for baseline characteristics or comorbidities,the prediabetes cohort with AF admissions showed a higher rate and significantly higher odds of mACCE compared to the non-prediabetic cohort[18.6%vs 14.7%,odds ratio(OR)1.34,95%confidence interval 1.26-1.42,Pmales had a stronger association(aOR 1.43)compared to females(aOR 1.22),whereas on the race-wise comparison,Hispanics(aOR 1.43)and Asians(aOR 1.36)had a stronger association with mACCE with prediabetes vs whites(aOR 1.33)and blacks(aOR 1.21).CONCLUSION This population-

关键词： Prediabetes Atrial fibrillation Cardiovascular disease risk major adverse cardiovascular and cerebrovascular events Stroke mortality

Optimization and application of UVC irradiation for prevention of fungal biodeterioration of vegetable tanned and chrome tanned leather

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Leather Science and Engineering 2022年第2期4卷 380-393页

作者： Eshita Jhahan Subarna Bhattacharyya Anirban Chaudhuri Nirmal sarkar shaheen Akhtar Punarbasu Chaudhuri School of Environmental Studies Jadavpur UniversityKolkata 700032India Department of Environmental Science University of CalcuttaKolkataIndia.

UV-C irradiation critically effects the growth of micro-fungi and also deteriorate leather materials. In the present study vegetable tanned and chrome tanned leather were infected with pure cultures of Aspergillus niger and Aspergillus flavus, which were isolated from stored leather materials. UV-C light (λ = 254 nm) was applied on infected leather for 15 and 60 min. The changes in leather qualities were examined through weight, tensile strength, scanning electron microscope, energy dispersive X-ray and Fourier transform infrared spectroscopy study after 15 and 30 days of fungal inoculation. Vegetable tanned leather was more vulnerable in case of fungal attack than chrome tanned leather while A. flavus showed more influence on leather deterioration than A. niger. The results showed that weight loss after 30 days for 15 and 60 min irradiation exposure was 1.3% compared to A. flavus infected leather (3.93%). The tensile strength of vegetable and chrome tanned UV irradiated leather was increased by 44% and 7% respectively. The scanning electron microscopic images exhibit the limited presence of conidiophores in UV-C exposed leather which confirmed the potentiality of irradiation for controlling fungal growth. The infrared spectral analysis of UV-C exposed infected leather samples showed neither shifting of wavenumber nor displacement of any functional groups. Alto-gether the efficacy of UV-C irradiation against biodeterioration of leather was concluded to be effective. This method can be used to control fungal growth without compromising the leather quality.

关键词： Aspergillus Biodeterioration Leather SEm Tensile strength UV-C

N-acetyl-L-leucine: a promising treatment option for traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第9期17卷 1957-1958页

Traumatic brain injury(TBI)is a mechanical injury to the brain,which can be sustained due to falls,accidents,contact sports or in combat *** is a serious health problem-affecting people of all ages *** per the recent epidemiological study,more than 55 million people suffer from TBI annually(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019),and its prevalence has increased by almost 8.4%between 1990 and 2016(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019).Depending on severity,TBI can lead to premature death and disability.

关键词： sustained Traumatic injury

Efficient removal of heavy metals from electroplating wastewater using polymer ligands

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2016年第2期10卷 352-361页

作者： md. Lutfor RAHmAN shaheen m. sarkar mashitah mohd YUSOFF Faculty of Industrial Sciences & Technology Universiti Malaysia Pahang 26300 Gambang Kuantan Malaysia

Poly（hydroxamic acid）-poly（amidoxime） che- lating ligands were synthesized from poly（methyl acrylate-co-acrylonitrile） grafted acacia cellulose for removing toxic metal ions from industrial wastewaters. These ligands showed higher adsorption capacity to copper （2.80 mmol. g-l） at pH 6. In addition, sorption capacities to other metal ions such as iron, zinc, chromium, and nickel were also found high at pH 6. The metal ions sorption rate （tl/2） was very fast. The rate of adsorption of copper, iron, zinc, chromium, nickel, cobalt, cadmium and lead were 4, 5, 7, 5, 5, 8, 9 and 11 min, respectively. Therefore, these ligands have an advantage to the metal ions removal using the column technique. We have successfully investigated the known concentration of metal ions using various parameters, which is essential for designing a fixed bed column with ligands. The wastewater from electroplating plants used in this study, having chromium, zinc, nickel, copper and iron, etc. For chromium wastewater, ICP analysis showed that the Cr removal was 99.8% and other metal ions such as Cu, Ni, Fe, Zn, Cd, Pb, Co and mn removal were 94.7%, 99.2%, 99.9%, 99.9%, 99.5%, 99.9%, 95.6% and 97.6%, respectively. In case of cyanide wastewater, the metal removal, especially Ni and Zn removal were 96.5 and 95.2% at higher initial concentra- tion. For acid/alkali wastewater, metal ions removing for Cd, Cr and Fe were 99.2%, 99.5% and 99.9%, respectively. Overall, these ligands are useful for metal removal by column method from industrial wastewater especially plating wastewater.

关键词： heavy metals adsorption wastewater chelat-ing ligands plating industry

High current limits in chemical vapor deposited graphene spintronic devices

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第4期16卷 4233-4239页

作者： Daria Belotcerkovtceva J.Panda m.Ramu Tapati sarkar Ulrich Noumbe m.Venkata Kamalakar Department of Physics and Astronomy Uppsala UniversityBox 516Uppsala SE-75120Sweden Department of materials Science and Engineering Uppsala UniversityBox 35Uppsala SE-75103Sweden

Understanding the stability and current-carrying capacity of graphene spintronic devices is key to their applications in graphene channel-based spin current sensors,spin-torque oscillators,and potential spin-integrated ***,despite the demonstrated high current densities in exfoliated graphene,the current-carrying capacity of large-scale chemical vapor deposited(CVD)graphene is not ***,the grainy nature of chemical vapor deposited graphene and the presence of a tunnel barrier in CVD graphene spin devices pose questions about the stability of high current electrical spin *** this work,we observe that despite structural imperfections,CVD graphene sustains remarkably highest currents of 5.2×10^(8)A/cm^(2),up to two orders higher than previously reported values in multilayer CVD graphene,with the capacity primarily dependent upon the sheet resistance of ***,we notice a reversible regime,up to which CVD graphene can be operated without degradation with operating currents as high as 108 A/cm^(2),significantly high and durable over long time of operation with spin valve signals observed up to such high current *** the same time,the tunnel barrier resistance can be modified by the application of high *** results demonstrate the robustness of large-scale CVD graphene and bring fresh insights for engineering and harnessing pure spin currents for innovative device applications.

关键词： chemical vapor deposited(CVD)graphene high current density graphene spintronics spin integrated circuits graphene spin valve

Kenaf cellulose-based poly(amidoxime) ligand for adsorption of rare earth ions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare metals 2019年第3期38卷 259-269页

作者： md Lutfor Rahman mohd Sani Sarjadi Sazmal Effendi Arshad mashitah m. Yusoff shaheen m. sarkar Baba musta Faculty of Science and Natural Resources Universiti Malaysia Sabah Faculty of Industrial Sciences and Technology University Malaysia Pahang

A well-known adsorbent, poly(amidoxime)ligand, was prepared from polyacrylonitrile(PAN) grafted kenaf cellulose, and subsequent characterization was performed by Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscope(FESEm) and inductively coupled plasma mass spectrometry(ICP-mS).The adsorption capacities of the prepared ligand for rare earth metals are found to be excellent, with adsorptions of La^(3+), Ce^(3+), Pr^(3+), Gd^(3+) and Nd^(3+) experimentally determined to be 262, 255, 244, 241 and 233 mg·g^(-1), respectively, at pH 6. The experimental values of the adsorption of rare earth metals are well matched with the pseudosecond-order rate equation. The reusability of the adsorbent is examined for seven cycles of sorption/desorption,demonstrating that the proposed adsorbent could be reused for over seven cycles without any significant loss in the original removal capability of the ligand.

关键词： Adsorption Poly(amidoxime) Rare earths Separation Kenaf cellulose