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Premature Tapetum Degeneration: a Major Cause of Abortive Pollen Development in Photoperiod Sensitive Genic Male Sterility in Rice

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Journal of Integrative Plant Biology 2009年第8期51卷 774-781页

作者： Yinlian Shi sha zhao Jialing Yao College of Life Science and Technology Huazhong Agricultural University Wuhan 430070 China

Photoperiod-sensitive genic male-sterile （PSGMS） rice （Oryza sativa L.）, a natural mutant found in the rice cultivar Nongken 58, is very useful for the development of hybrid rice cultivars. Despite its widespread use in breeding programs, the initial stage of the abortive development of PSGMS rice and the possible cytological mechanisms of pollen abortion have not been determined. In the present study, a systematic cytological comparison of the anther development of PSGMS rice with its normal fertile counterpart is conducted. The results show that pollen abortion in PSGMS rice first occurs before the pollen mother cell （PMC） stage, and continues during the entire process of pollen development until pollen degradation. The abortive process was closely associated with the abnormal behavior of the tapetum. Although tapetum degeneration in PSGMS rice initiates already at the PMC stage, it proceeds slowly and does not complete until the breakdown of the pollen. Such cytological observations were supported by the results of the TUNEL （TdT-mediated dUTP Nick End Labeling） assay, which detects DNA fragmentation resulting from programmed cell death （PCD）, indicating that the premature tapetum degeneration is in the process of PCD.

关键词： male-sterility Oryza sativa programmed cell death tapetum ultrastructure

亚硝酸盐氮急性胁迫对刺参“鲁海2号”非特异性免疫的影响

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海洋渔业 2024年第3期46卷 353-360页

作者：王琦胡炜李成林韩莎姚琳琳赵斌山东省海洋科学研究院山东省智慧海洋牧场重点实验室(筹)山东青岛266104

为探索刺参(Apostichopus japonicus)“鲁海2号”对亚硝酸盐氮的适应性,在实验室条件下,开展了不同浓度亚硝酸盐氮(0、4.0、15.8、63.0、251.0和1000.0 mg·L^(-1))对刺参“鲁海2号”的急性胁迫实验,在胁迫后1、3、6、9、12、24、48、72... 详细信息

为探索刺参(Apostichopus japonicus)“鲁海2号”对亚硝酸盐氮的适应性,在实验室条件下,开展了不同浓度亚硝酸盐氮(0、4.0、15.8、63.0、251.0和1000.0 mg·L^(-1))对刺参“鲁海2号”的急性胁迫实验,在胁迫后1、3、6、9、12、24、48、72、96 h测定各浓度组刺参体腔液中酸性磷酸酶(ACP)、碱性磷酸酶(AKP)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性以及丙二醛(MDA)含量变化。结果显示,仅亚硝酸盐氮浓度1000.0 mg·L^(-1)处理组刺参有死亡,死亡率随胁迫时间延长而升高;在亚硝酸盐氮胁迫下,刺参“鲁海2号”体腔液中ACP、AKP、SOD、CAT活性总体呈现先升高后降低的趋势,MDA含量随胁迫时间延长而升高。研究表明,在低于4.0 mg·L^(-1)亚硝酸盐氮胁迫下,刺参“鲁海2号”体内非特异性免疫酶可以维持正常生理功能;但在高浓度亚硝酸盐氮胁迫下,其非特异性免疫能力显著下降。在刺参“鲁海2号”养殖生产中,建议水体亚硝酸盐氮浓度应控制在4.0 mg·L^(-1)以下,为新品种创造良好的养殖环境,更好地体现出良种增产的优势。

关键词：刺参“鲁海2号” 亚硝酸盐氮急性胁迫非特异性免疫

基于SFED和RBS响应区间边界的φ-OTDR振动定位研究

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应用激光 2024年第4期44卷 178-186页

作者：路泽永刘欣赵亚丽高超沙洲河北石油职业技术大学电气与电子系河北承德067000 河北省仪器仪表工程技术研究中心河北承德067000 河北石油职业技术大学数理部河北承德067000 河北石油职业技术大学工业技术中心河北承德067000 天津大学精密测试技术及仪器国家重点实验室天津300072

针对传统管道泄漏监测系统的空间分辨率易受探测脉冲宽度限制的问题,提出一种用瑞利后向散射(Rayleigh back scattered, RBS)响应区间边界结合空-频能量分布定位分布式光纤振动入侵事件的方法。利用空间频率能量分布显示RBS响应区间的... 详细信息

针对传统管道泄漏监测系统的空间分辨率易受探测脉冲宽度限制的问题,提出一种用瑞利后向散射(Rayleigh back scattered, RBS)响应区间边界结合空-频能量分布定位分布式光纤振动入侵事件的方法。利用空间频率能量分布显示RBS响应区间的左边界来表征振动入侵事件的准确位置。采用不同宽度的探测脉冲对设计的相敏光学时域反射仪(φ-optical time-domain reflectometer,φ-OTDR)系统进行振动检测实验,研究了RBS响应区间随探测脉冲宽度变化的特性。然后通过3种不同环境下的振动测试,验证了采用空-频能量和RBS响应区间边界相结合的方法进行振动定位的可行性和优越性,实验证明采用提出的方法,在采样率为50 MS/s时,系统定位精度为2 m。

关键词：空-频能量分布响应区间左边界瑞利后向散射振动定位

青贮玉米与籽粒玉米间作生产性能和营养品质综合评价

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饲料研究 2024年第11期47卷 114-119页

作者：徐艳霞杨曌王洪宝孙芳王晓龙柴华李莎莎吴玥黑龙江省农业科学院畜牧兽医分院黑龙江齐齐哈尔161005 黑龙江省牧草育种与种质资源利用工程技术研究中心黑龙江齐齐哈尔161005 黑龙江省草原与牧草育种重点实验室黑龙江齐齐哈尔161005 黑龙江省农业科学院畜牧研究所黑龙江哈尔滨150086

试验旨在确定不同基因型玉米间作后的生产性能。采用青贮玉米和籽粒玉米间作,研究不同间作模式对群体鲜草产量、穗产量、干物质含量以及饲用品质的影响。结果显示,与单作相比,H14处理(龙牧7号与裕丰303以2∶2间作)的穗产量、鲜草产量和... 详细信息

试验旨在确定不同基因型玉米间作后的生产性能。采用青贮玉米和籽粒玉米间作,研究不同间作模式对群体鲜草产量、穗产量、干物质含量以及饲用品质的影响。结果显示,与单作相比,H14处理(龙牧7号与裕丰303以2∶2间作)的穗产量、鲜草产量和干物质含量均高于其他组合处理。H20处理(单播北农青贮208)粗蛋白含量最高,为15.71%,其次是H14(龙牧7号与裕丰303以2∶2间作)处理,粗蛋白含量为15.38%。H4处理(龙牧7号与裕丰303以3∶1间作)粗脂肪含量最高,为2.80%,显著高于其他各组合处理(P<0.05)。H22处理(单播籽粒玉米裕丰303)淀粉含量最高为36.69%,其次是H21(单播籽粒玉米先玉335)处理和H2(北农青贮208与裕丰303以1∶3间作)处理,淀粉含量分别为35.11%和35.10%。H20(单播北农青贮208)的相对饲喂价值为160.44,其次是H18(京科青贮932与裕丰303以2∶2间作)相对饲用价值为159.56。研究表明,通过隶属函数综合评价结果显示,与单作相比,龙牧7号青贮玉米与裕丰303籽粒玉米以2∶2间作其隶属函数值最大,生产性能最高,其次是京科青贮932与裕丰303以2∶2间作,隶属函数值位居第二,而北农青贮208与裕丰303以1∶3间作隶属函数值排名第三。

关键词：籽粒玉米青贮玉米间种综合评价

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Hydrodynamic behavior of an internally circulating fluidized bed with tubular gas distributors

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Particuology 2013年第6期11卷 664-672页

作者： Wenli zhao Tiefeng Wang Chenjing Wang Zuoliang sha Beijing Key Laboratory of Green Reaction Engineering and Technology Department of Chemical EngineeringTsinghua University Tianjin Key Laboratory of Marine Resources and Chemistry Tianjin University of Science and Technology

To better understand the hydrodynamic behavior of an internally circulating fluidized bed, solids holdup in the down-comer （Eso）, solids circulation rate （Gs） and gas bypassing fraction （from down-comer to riser y^R, and from riser to down-comer yRD） were experimentally studied. The effects of gas velocities in the riser and in the down-comer （UR and UD）, orifice diameter in the draft tube （dor）, and draft tube height （HR） were investigated. Experimental results showed that increase of gas velocities led to increase in Gs and yDR, and slight decrease in yeD. Larger orifice diameter on the draft tube led to higher 8sD, Gs and yDR, but had insignificant influence on YRD. with increasing draft tube height, both Gs and YDR first increased and then decreased, while yRD first decreased and then increased. Proposed correlations for predicting the hydrodynamic parameters agreed reasonably well with experimental values.

关键词： Internally circulating fluidized bed Solids holdup Solids circulation rate Gas bypassing fraction

A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of Pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua Pan Xiao-Hong Zhang sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-Rong Sun Hui Gao Yun-Peng Dai Shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-Rong Li Liang-Chun Yang Ye-Ming Wu Huan-Min Wang Xin Sun Xiao-Jun Yuan Department of Pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology Department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China Department of Pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China Department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China Department of Pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China Department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China Department of Pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China Department of Pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(R+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFP)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,R+,and E+were independent risk factors for *** with a declining AFP>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter Prospective study Survival

基质理化性质对黄檗幼苗生物量及生理指标的影响

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温带林业研究 2024年第1期7卷 1-8页

作者：赵杰赵秋玲沙红张晶武山县林业和草原局甘肃武山741300 甘肃省小陇山林业科学研究所甘肃天水741022

【目的】探讨不同基质配比理化性质对黄檗幼苗生物量及生理指标的影响,揭示黄檗幼苗对基质理化性质的适应性,旨在为黄檗优质容器苗的生产提供科学的理论依据与技术支撑。【方法】以黄檗1年生幼苗为试验材料,以田园土、泥炭土为基质原料... 详细信息

【目的】探讨不同基质配比理化性质对黄檗幼苗生物量及生理指标的影响,揭示黄檗幼苗对基质理化性质的适应性,旨在为黄檗优质容器苗的生产提供科学的理论依据与技术支撑。【方法】以黄檗1年生幼苗为试验材料,以田园土、泥炭土为基质原料,按照不同体积比例配置成9种基质,采用单因素随机区组试验设计,比较9种基质理化性质及不同配比基质容器苗生物量和生理指标的差异性,并对其进行相关性分析。【结果】9种配比基质的理化性质存在显著差异。其密度、电导率、持水量、pH值范围分别为0.303~2.1 g·cm^(-3)、0.15~0.47 mS·cm^(-1)、1.3%~2.95%、6.11~8.31,添加泥炭土各基质的有机质、碱解氮、有效磷、速效钾、全N、全P均显著高于田园土,密度则显著低于田园土,5个配比基质(M2、M3、M4、M5、M6)的理化性质较好。基质中随着添加泥炭体积分数的增加,苗木的生物量、质量指数及叶绿素含量整体呈增加的趋势,泥炭土添加体积分数≥50%基质的有机质、碱解氮、有效磷、速效钾、全N、全P均显著高于田园土,其中M4配比基质(泥炭土:田园土=3:1)中苗木的生物量、质量指数和叶绿素含量最高,表现出明显的优势。相关性分析显示,基质的pH值、全N、全P与黄檗幼苗的大部分生物量之间存在显著或极显著的负相关关系,叶绿素含量与有机质、碱解氮、有效磷、速效钾呈显著正相关。【结论】田园土中添加不同比例泥炭土显著改变基质的理化性质,泥炭土添加体积分数≥50%的基质配比其理化性质均较好。添加泥炭体积75%的基质其育苗效果最好,是黄檗容器育苗的理想基质。

关键词：理化性质黄檗生物量生理性状

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新型冠状病毒感染治疗药物基因组学研究进展

中华医院感染学杂志 2024年第14期34卷 2235-2240页

作者：董丽莎张仕钊贾建军尹彤解放军总医院第二医学中心国家老年疾病临床医学研究中心老年医学研究所北京100853

新型冠状病毒(SARS-CoV-2)感染席卷全球之际,由于缺乏特异性治疗药物,许多非标签药物被紧急用于新型冠状病毒感染(COVID-19)的治疗.药物基因组学不仅在心血管、肿瘤、免疫等领域已广泛应用于临床,在COVID-19的疫情防控、精准用药和疫苗... 详细信息

新型冠状病毒(SARS-CoV-2)感染席卷全球之际,由于缺乏特异性治疗药物,许多非标签药物被紧急用于新型冠状病毒感染(COVID-19)的治疗.药物基因组学不仅在心血管、肿瘤、免疫等领域已广泛应用于临床,在COVID-19的疫情防控、精准用药和疫苗研发中也发挥了潜在的临床应用价值.本文针对COVID-19药物基因组学进行了文献调研和总结,重点描述了抗病毒小分子药物、激素类药物、免疫调节药物和非甾体抗炎药对治疗COVID-19疗效和安全性影响,新型冠状病毒疫苗的药物基因组学进展,以及与COVID-19严重程度密切相关的基因变异.此外,我们还针对COVID-19患者精准用药的关键临床影响因素之一药物间相互作用进行了阐述,旨在为COVID-19的精准诊疗提供参考依据.

关键词：新型冠状病毒感染药物基因组学精准用药抗病毒药物疫苗

A retrospective study of 2228 cases with eyelid tumors

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1835-1841页

作者： sha-sha Yu Yun zhao Hong zhao Jin-Yong Lin Xin Tang Clinical College of Ophthalmology Tianjin Medical University Tianjin 300020 China Tianjin Eye Hospital Tianjin 300020 China Tianjin Key Laboratory of Ophthalmology and Visual Science Tianjin 300020 China Tianjin Eye Institute Tianjin 300020 China

AIM： To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS： In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin： epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS： Most eyelid tumors were epidermal in origin（1080, 48.5%）, followed by miscellaneous（885, 39.7%） and adnexal tumors（263, 11.8%）. Among all the tumors, 292（13.1%） were malignant lesions, 1910（85.7%） benign and 26（1.1%） premalignant lesions. Most malignant tumors originated from epidermal cells（60.0%）, followed by adnexal cells（34.6%）. The most common malignant tumors were basal cell carcinomas（56.5%） followed by sebaceous carcinoma（34.6%）, squamous cell carcinomas（3.8%） and lymphoma/plasmocytoma（1.7%）. The benign and premalignant eyelid lesions mostly originated from epidermal cells（46.4%） followed by miscellaneous cell sources（45.2%）, including melanocytic nevus（33.8%）, seborrheic keratosis（13.7%）, squamous cell papilloma（13.0%） and epidermal cysts（11.5%）. CONCLUSION： Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.

关键词： eyelid tumors benign tumors malignant tumor basal cell carcinoma sebaceous carcinoma squamous cell carcinoma melanocytic nevus