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Antioxidative Effect of Luteolin Pretreatment on Simulated Ischemia/Reperfusion Injury in Cardiomyocyte and Perfused Rat Heart

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Chinese Journal of Integrative Medicine 2017年第7期23卷 518-527页

作者： ZHANG Rui-qu LI Dong-ye XU Tong-da zhu sha-sha PAN Huan-jun FANG Fang WU Xin SUN Hong Institute of Cardiovascular Disease Research Xuzhou Medical College Xuzhou Jiangsu Province 221002 China Department of Physiology Xuzhou Medical College XuzhouJiangsu Province 221002 China

Objective：To investigate the antioxidative effect and mechanism of luteolin on rat cardiomyocytes and isolated hearts fol owed by simulated ischemia/reperfusion（SI/R） injury. Methods：The left ventricular cardiomyocytes and the isolated hearts from adult rats were subjected to SI/R injury. The experiment groups included control, SI/R, luteolin ＋ SI/R（Lut ＋ SI/R）, vitamin E（Vit E）＋ SI/R, and LY294002 ＋ luteolin ＋ SI/R（LY ＋ Lut ＋ SI/R） groups. Cell viability, shortening amplitude, lactate dehydrogenase（LDH） release, superoxide dismutase（SOD） activity, the production of reactive oxygen species（ROS） and malondialdehyde（MDA）, expression levels of Akt, phosphorylated Akt, NOX2（gp91phox）, NOX2 m RNA, mitogen-activated protein kinase（p38 MAPK） and phosphorylated p38 MAPK were al measured after 3-h simulated ischemia and 2-h simulated reperfusion procedure in cardiomyocytes. Vit E was used as a standard control. The contractile function of isolated hearts was further observed after they were subjected to 30-min global ischemia and 120-min reperfusion. Results：Pretreatment with 8-μmol/L luteolin substantially increased cel viability and shortening amplitude, while reducing evidence of oxidative stress-induced damage in the cel s. In addition, the expression of NOX2, NOX2 m RNA and phosphorylation of p38 MAPK were al downregulated. Furthermore, pretreatment with 40-μmol/L luteolin improved the recovery of myocardial contractile function fol owing SI/R-induced injury, and luteolin markedly increased phosphorylation of Akt. However, all of the above effects were partially inhibited by the phosphatidylinositol 3-kinase（PI3K） inhibitor, LY294002. Conclusions：Luteolin prevents SI/R-induced myocardial damage by reducing oxidative stress-induced injury in isolated rat hearts and cardiomyocytes, and the cardioprotection induced by luteolin was partial y mediated by the PI3K/Akt pathway.

关键词： luteolin cardiomyocyte ischemia/reperfusion cardioprotection

Generation of hyperentangled state encoded in three degrees of freedom

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Science China(Physics,Mechanics & Astronomy) 2023年第10期66卷 10-21页

作者： Peng Zhao Meng-Ying Yang sha zhu Lan Zhou Wei Zhong Ming-Ming Du Yu-Bo Sheng College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

Hyperentanglement, the simultaneous entanglement in more than one degree of freedom(DOF), plays an important role in quantum communication and quantum information processing for it can effectively increase the channel capacity. Existing hyperentanglement sources mainly focus on the generation of the hyperentanglement in two DOFs. In this paper, we design the generation protocols for three kinds of hyperentanglement encoded in three DOFs with the practical coherent pulses sources, including the polarization-frequency-space hyperentanglement, the polarization-frequency-time-bin hyperentanglement, and the polarizationspace-time-bin hyperentanglement. These protocols exploit the spontaneous parametric down-conversion(SPDC) process and the Sagnac interferometer. The three protocols are all based on feasible experimental condition and may have potential applications in future hyperentanglement-based quantum communication and quantum information processing protocols.

关键词： hyperentanglement generation Sagnac interferometer spontaneous parametric down-conversion

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High thermoelectric performance at room temperature of n-type Mg_(3)Bi_(2)-based materials by Se doping

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Journal of Magnesium and Alloys 2022年第4期10卷 1024-1032页

作者： Xiaobo Mo Jiansong Liao Guocai Yuan sha zhu Xiaobo Lei Lihong Huang Qinyong Zhang Chao Wang Zhifeng Ren Key Laboratory of Fluid and Power Machinery of Ministry of Education School of Materials Science&EngineeringXihua UniversityChengdu 610039China Clean Energy Materials and Engineering Center State Key Laboratory of Electronic Thin Film and Integrated DeviceSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Physics and TcSUH University of HoustonHoustonTX 77204United States

Bi_(2)Te_(3) based alloys have been the most widely used thermoelectric material at low temperature for many *** we report Se doped n-type Mg_(3)Bi_(2) based materials with a thermoelectric figure-of-merit ZT of 0.82 at 300 K and a peak ZT of 1.24 at 498 K,which is comparable to the n-type Bi_(2)Te_(3) and Te doped Mg_(3)Bi_(1.4)Sb_(0.6).The improved thermoelectric performance is benefited from the high carrier concentration and mobility as well as the thermal conductivity *** reduced resistivity increased the power factor at all measured temperatures,leading to a higher engineering ZT(ZTeng)and engineering power factor(PFeng)for n-type Mg_(3)Bi_(2).The n-type Mg_(3)Bi_(1.4)Sb_(0.6) materials are promising for thermoelectric power generation and cooling applications near room temperature.

关键词： Mg_(3)Bi_(2) Zintl compound Thermoelectric Se-doping

Astrometric Reduction of Saturnian Satellites with Cassini-ISS Images Degraded by Trailed Stars

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Research in Astronomy and Astrophysics 2023年第3期23卷 85-92页

作者： Qing-Feng Zhang Meng-Qi Liu Yan Li Lin-Peng Wu Zhi-Qiang Wang Li-sha zhu Zhan Li Department of Computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China Department of Financial Technology School of ManagementGuangzhou Xinhua UniversityGuangzhou 510520China

The Imaging Science Subsystem(ISS)mounted on the Cassini spacecraft has taken a lot of images,which provides an important source of high-precision astrometry of some planets and ***,some of these images are degraded by trailed ***,these degraded images cannot be used for *** this paper,a new method is proposed to detect and compute the centers of these trailed stars *** method is then performed on the astrometry of ISS images with trailed ***,we provided 658 astrometric positions between 2004 and 2017 of several satellites that include Enceladus,Dione,Tethys,Mimas and *** with the JPL ephemeris SAT427,the mean residuals of these measurements are 0.11 km and 0.26 km in *** decl.,*** standard deviations are 1.08 km and 1.37 km,*** results show that the proposed method performs astrometric measurements of Cassini ISS images with trailed stars effectively.

关键词： stars trail Saturn

Prognostic values of optic nerve sheath diameter for comatose patients with acute stroke:An observational study

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World Journal of Clinical Cases 2022年第33期10卷 12175-12183页

作者： sha zhu Chao Cheng Liu-Liu Wang Dian-Jiang Zhao Yuan-Li Zhao Xian-Zeng Liu Department of Neurology Peking university international hospitalBeijing 102206China Department of Radiology Peking University International HospitalBeijing 102206China Department of Intensive Care Unit Peking University International HospitalBeijing 102206China Department of Neurosurgery China National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalBeijing 100070China

BACKGROUND Optic nerve sheath diameter(ONSD)measurement is one of the non-invasive methods recommended for increased intracranial pressure(ICP)*** This study aimed to evaluate the roles of optic nerve sheath diameter(ONSD)and ONSD/eyeball transverse diameter(ETD)ratio in predicting prognosis of death in comatose patients with acute stroke during their *** A total of 67 comatose patients with acute stroke were retrospectively *** ONSD and ETD were measured by cranial computed tomography(CT)*** patients underwent cranial CT scan within 24 h after coma *** were divided into death group and survival group according to their survival status at *** differences of the ONSD and ONSD/ETD ratio between the two groups and their prognostic values were *** The ONSD and ONSD/ETD ratio were 6.07±0.72 mm and 0.27±0.03 in the comatose patients,*** ONSD was significantly greater in the death group than that in the survival group(6.32±0.67 mm vs 5.65±0.62 mm,t=4.078,P5.7 mm or the ONSD/ETD ratio was>*** indexes could be used as prognostic tools for comatose patients with acute *** ONSD/ETD ratio was more stable than the ONSD alone,which would be preferred in clinical practice.

关键词： Optic nerve sheath diameter Eyeball transverse diameter Coma Intracranial pressure Stroke Prognosis

Stimulated-Brillouin-scattering-based arbitrarily phase coded microwave waveform transmitter with anti-dispersion transmission

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Chinese Optics Letters 2022年第8期20卷 69-74页

作者： sha zhu Kunpeng Zhai Wei Li Ning Hua zhu College of Microelectronics Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Electronic Electrical and Communication EngineeringCenter of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

We focus on photonic generation and transmission of microwave signals in this *** on dual-pumped stimulated Brillouin scattering,a single-sideband(SSB)optical signal with high sideband rejection ratio is *** with a phase-modulated optical carrier,an arbitrarily phase coded microwave signal is generated after photoelectric *** SSB modulation can eliminate the fiber-dispersion-induced power dispersion naturally,and the phase modulation of the optical carrier can achieve arbitrary phase encoding and suppress background *** proposed scheme can achieve both generation and anti-dispersion transmission of arbitrarily phase coded signals simultaneously,which is suitable for one-to-multi long-distance radar networking.

关键词： microwave photonics phase coded signal anti-dispersion transmission optical signal processing

The immune landscape and prognostic immune key genes potentially involved in modulating synaptic functions in prostate cancer

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The immune landscape and prognostic immune key genes potenti...

Clinical and oncologic findings of extraprostatic extension on needle biopsy in de novo metastatic prostate cancer

第十四届全国免疫学学术大会

作者： sha zhu Xu Han School of Basic Medical Sciences Zhengzhou University

Background:Increasing evidence has indicated an association between differentially expressed genes(DEGs) in tumor infiltrating immune cells and clinical *** aim of this research is to investigate the influence of tumor microenvironment on gene expression profile of tumor infiltrating immune cells(TIICs) and to identify their potential markers for modulating immune cell function in prostate ***:In our research,CIBERSORT algorithm was utilized to calculate the proportion of the TIICs in 182 cases from the TCGA *** differential expression analysis was conducted using R,and then the functional and pathway enrichment of the DEGs were analyzed using Database for Annotation,Visualization and Integrated Discovery database,followed by integrated regulatory network ***:As a result,nTreg,B cells,Th1 and DC cells were significantly increased,accompanied by largely decreased of NK and NKT *** immune-related gene correlation analysis showed that the signature gene expression extent of CD8 T cells were positively associated with CD4 memory activated T cells,but negatively correlated with that of CD4 memory resting T *** addition,a total of 128 differentially expressed genes were *** analysis obtained six hub genes,of which three prognostic-associated potential checkpoints molecules including CAV1,FLNA,and VCL were mainly involved in biological processes associated with regulation of organic substance and synaptic ***:This study provides a comprehensive understanding of the landscape of TIICs and roles of the hub genes which may be valuable markers in PCa diagnosis and immunotherapy.

关键词： Tumor infiltrating immune cells Immune landscape Prostate cancer Immunological synapse Prognostic

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Asian Journal of Andrology 2020年第4期22卷 427-431页

作者： Jun-Ru Chen Jin-Ge Zhao sha zhu Meng-Ni Zhang Ni Chen Jian-Dong Liu Guang-Xi Sun Peng-Fei Shen Hao Zeng Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Pathology West China HospitalSichuan UniversityChengdu 610041China

This study aimed to explore the clinical and oncologic findings in patients with de novo metastatic prostate cancer(mPCa)and extraprostatic extension(EPE)on *** retrospectively evaluated data on 630 patients with de novo mPCa between January 2009 and December 2017 in the West China Hospital(Chengdu,China),including evaluating the relationships between EPE and other variables and the association of EPE with survival outcomes by the Chi-square test,Kaplan–Meier curves,and the Cox proportional-hazards *** was found in 70/630 patients,making a prevalence of 11.1%.The presence of EPE on biopsy was associated with higher Gleason scores and higher incidence of neuroendocrine differentiation(NED),intraductal carcinoma of the prostate(IDC-P),and perineural invasion(PNI).Compared with those without EPE,patients with EPE had shorter castration-resistant prostate cancer-free survival(CFS;median:14.1 vs 17.1 months,P=0.015)and overall survival(OS;median:43.7 vs 68.3 months,P=0.032).According to multivariate analysis,EPE was not an independent predictor for *** analyses demonstrated that patients with favorable characteristics,including negative NED or IDC-P status,Eastern Cooperative Oncology Group(ECOG)score<2,and prostate-specific antigen(PSA)<50 ng ml−1,had worse prognoses if EPE was *** patients with PSA<50 ng ml−1,EPE was a negative independent predictor for OS(hazard ratio[HR]:4.239,95%confidence interval[CI]:1.218–14.756,P=0.023).EPE was strongly associated with other aggressive clinicopathological features and poorer CFS and *** data suggest that EPE may be an indicator of poor prognosis,particularly in patients,otherwise considered likely to have favorable survival outcomes.

关键词： extraprostatic extension metastatic prostate cancer prevalence prognosis

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关岭歪梳苗苗语名词性短语的语序

民族语文 2021年第1期 23-34页

作者：朱莎中国社会科学院大学(研究生院) 北京102488

本文考察歪梳苗苗语名词性短语的语序类型。通过测试和验证,发现除N(head)+N、N+Adj等符合SVO型语言蕴涵共性外,G+N、Num+CL+N、Rel+N等与SVO型语言蕴涵共性相悖,这是语言影响导致的。

关键词：歪梳苗苗语名词性短语语序类型语言接触