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Attributes of cancer patients admitted to the emergency department in one year

World Journal of Emergency Medicine 2014年第2期5卷 85-90页

作者： Muallaoglu Sadik Karagün Ozlem Mertsoylu Huseyin Besen AliAyberk sezer ahmet Ozyilkan Ozgur Department of Medical Oncology School of Medicine Baskent University Department of Emergency School of Medicine Baskent University Department of Medical Oncology Van Training and Research Hospital

BACKGROUND： Cancer patients frequently visit the emergency department （ED） with various symptoms of cancer. The purpose of this study was to determine the clinical characteristics and 1-year survival rate of cancer patients in the ED of a university hospital. METHODS： We conducted a retrospective review of 408 cancer patients who visited the ED between January 2011 and December 2011. Patient information on demographics, chief complaints, findings, and survival was gathered from the hospital registry and corresponding health administration. RESULTS： The study included 240 （58.8%） males and 168 （41.2%） females with a median age of 57.9 years （range 19-87）. Regarding cancer staging, 266 patients （65.3%） had metastatic disease and 142 （34.7%） had local and Ioco-regional disease. The hospitalization rate was 59.6%. The most common symptoms were shortness of breath （23.2%）, pain （17.8%）, fever （14.2%）, and nausea/vomiting （14.4%）. The most common cancer sites were the lung （32.5%）, gastrointestinal system （25.4%）, and breast （9.3%）. The initial evaluation determined progressive disease （42.4%）, chemotherapy effects （20.7%）, infections （17.2%）, radiotherapy effects （4.7%）, extravasation （1.8%）, anemia （1.4%）, and unknown （11.3%）. During follow up, 191 （46.8%） patients died after admission to the ED. The 1-year overall survival of all patients was 7.3 months. CONCLUSIONS： Symptom management in cancer patients is a complex multifaceted concern for the emergency physician. Because of the increasing prevalence of cancer patients, emergency physicians should develop consensus algorithms in collaboration with the relevant disciplines to manage the commonly encountered problems.

关键词： Cancer Oncology Emergency department Surviva

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Investigation of the effects of radial clearance on the screw conveyor performances for different inclinations

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Particuology 2024年第9期92卷 72-80页

作者： Berna Bolat Birgül Aşçıoğlu Temiztaş Enes sezer Department of Mechanical Engineering Yıldız Technical University34349BeşiktaşİstanbulTurkey

Screw conveyors are widely used for bulk material *** study investigates the critical role of radial clearance,the gap between the screw and the conveyor body,on performance across various inclination *** Discrete Element Method(DEM)is employed to analyze the effects of different radial clearances on conveyor performance for concrete aggregate and sand as bulk *** efficiencies and capacity losses serve as key performance indicators,quantitatively assessed for each radial clearance and inclination *** validation is conducted to corroborate the *** the study,the optimal radial clearance was identified as 1.5 to 3 times of the particle *** optimal clearance minimizes the material jamming and increases the performance for screw conveyors with different inclinations and bulk material types as a result.

关键词： Screw conveyors Radial clearance Discrete element method(DEM) Volumetric efficiency Conveyor performance

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Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends

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Journal of Magnesium and Alloys 2021年第2期9卷 392-415页

作者： Nurettin sezer Zafer Evis Muammer Koç Division of Sustainable Development College of Science and EngineeringHamad Bin Khalifa UniversityQatar FoundationEducation CityDohaQatar Engineering Sciences Middle East Technical UniversityPO Box 06800AnkaraTurkey University of Karabük Turkey

Synthetic grafting needs improvements to eliminate secondary surgeries for the removal of implants after healing of the defected *** scaffolds are engineered to serve as temporary templates,which support the affected tissue and gradually degrade through the healing *** mechanical function to withstand the anatomic loading conditions,scaffolds should also provide a decent biological function for the diffusion of nutrients and oxygen to the cells,and excretion of the wastes from the cells to promote the new tissue growth and ***,the degradation byproducts of the scaffolds should be safe to the human *** of such multifunctional scaffolds requires selection of the right material,design,and manufacturing *** has been recognized as the prominent biodegradable metal with regards to its mechanical properties matching to that of human bone,degradability in the body fluid,and its ability to stimulate new tissue *** with intricate porous structures can be designed according to the patient-specific anatomic data using computer aided *** manufacturing(AM)is the right method to materialize these models rapidly with reasonably acceptable range of dimensional ***,the recent research trend is to develop ideal scaffolds using biodegradable Mg through AM *** review compiles and discusses the available literature on the AM of biodegradable Mg parts from the viewpoints of material compositions,process conditions,formation quality,dimensional accuracy,microstructure,biodegradation,and mechanical *** current achievements are summarized together,and future research directions are identified to promote clinical applications of biodegradable Mg through the advancement of AM.

关键词： Magnesium Alloy Implant Tissue scaffold Additive manufacturing Biodegradation

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On the Gauss-Weierstrass Summability of Multiple Trigonometric Series at μ-smoothness Points

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Acta Mathematica Sinica,English Series 2011年第4期27卷 741-746页

作者： Sinem sezer Ilham A. ALIEV Department of Mathematics Akdeniz University 07058 Antalya Turkey

The notion of μ-smoothness points of periodic functions of several variables is introduced and the rate of convergence of the Gauss-Weierstrass means of relevant Fourier series at these points is investigated.

关键词： Multiple Fourier series Fourier transform Gauss-Weierstrass summability modulus ofcontinuity

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ROBUST TRADING RULE SELECTION AND FORECASTING ACCURACY

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Journal of Systems Science & Complexity 2014年第1期27卷 169-180页

作者： SCHMIDBAUER Harald ROSCH Angi sezer Tolga TUNALIOGLU Vehbi Sinan Department of Business Administration Istanbul Bilgi University Santral Campus 34060 Eyiip IstanbulTurkey. FOM University of Applied Scienees Study Centre Munich Arnulfstr. 30 80335 Miinchen Germany. DIME University of Genoa Via Opera Pia 15 16145 Genoa Italy.

Trading rules performing well on a given data set seldom lead to promising out-of-sample results, a problem which is a consequence of the in-sample data snooping bias. Efforts to justify the selection of trading rules by assessing the out-of-sample performance will not really remedy this predica- ment either, because they are prone to be trapped in what is known as the out-of-sample data-snooping bias. Our approach to curb the data-snooping bias consists of constructing a framework for trading rule selection using a-priori robustness strategies, where robustness is gauged on the basis of time- series bootstrap and multi-objective criteria. This approach focuses thus on building robustness into the process of trading rule selection at an early stage, rather than on an ex-post assessment of trading rule fitness. Intra-day FX market data constitute the empirical basis of the proposed investigations. Trading rules are selected from a wide universe created by evolutionary computation tools. The authors show evidence of the benefit of this approach in terms of indirect forecasting accuracy when investing in FX markets.

关键词： A-priori robustness data-snooping bias efficient market hypothesis evolutionary com-putation intra-day FX markets time-series bootstrap trading rule selection.

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Assessing the publication output in the field of forensic science and legal medicine using Web of Science database from 2011 to 2020

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Forensic Sciences Research 2022年第4期7卷 748-760页

作者： Bedirhan sezer Öner Metin Orbay Department of Forensic Medicine Faculty of MedicineAmasya UniversityAmasyaTurkey Department of Mathematics and Science Faculty of EducationAmasya UniversityAmasyaTurkey

The aim of this study was ***,it analyzed the characteristics of the publication outputs for the Legal Medicine(LM)category using the Web of Science(WoS)database during ***,it discussed the distribution of the papers for the 25 most productive countries/regions in terms of quality and quantity,such as the h-index and GDP per ***,it investigated the trend and temporal stability of the journal impact factor(JIF)and determined the percentage of the journal *** findings suggested that the number of papers,the average number of pages of the papers,the average number of cited references in the papers,the average number of authors per paper,the percentage of open access papers,as well as international and domestic collaboration tended to increase ***,the productivity was limited when compared to the whole WoS database,since there was no significant change in the number of the *** countries/regions with the highest number of publications were not those that made the most impact in terms of the widespread impact of the *** level of international cooperation and the funding for the research had dramatic impact on the visibility of *** average JIF has increased significantly while the journal self-citation rates have decreased in a similar *** journals have had very stable(have not fluctuated)impact factors over *** the period studied,the journals with the higher impact factors(Q1,Q2)published many more papers than journals with the lower impact factors(Q3,Q4).

关键词： Bibliometrics citation analysis forensic science legal medicine Web of Science

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Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 40-47页

作者： Zeynep Gural sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov Semen Onder ahmet Kizir Ethem N Oral Department of Radiation Oncology Acibadem University Medical Faculty Department of Medical Oncology Istanbul Bilim University Department of Radiation Oncology Istanbul Medical FacultyIstanbul University Department of General Surgery Academia of Clinical Science of Bogazici Department of Medical Biophysics Harran University Medical Faculty Department of Radiology Bezm-i AlemUniversity Department of Pathology Istanbul Medical FacultyIstanbul University

AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, *** Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies.

关键词： Hyperfractionated accelerated radiotherapy Rectal cancer Neoadjuvant chemoradiotherapy

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LSTM RNN:detecting exploit kits using redirection chain sequences

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Cybersecurity 2021年第1期4卷 386-400页

作者： Jonah Burgess Philip O’Kane Sakir sezer Domhnall Carlin Centre for Secure Information Technologies(CSIT) Queen’s University BelfastNorthern Ireland Science ParkQueen’s RoadBelfast BT39DTUK

While consumers use the web to perform routine activities,they are under the constant threat of attack from malicious *** when visiting‘trusted’sites,there is always a risk that site is compromised,and,hosting a malicious *** this scenario,the injected script would typically force the victim’s browser to undergo a series of redirects before reaching an attacker-controlled domain,which,delivers the actual *** these malicious redirection chains aim to frustrate detection and analysis efforts,they could be used to help identify web-based *** upon previous work,this paper presents the first known application of a Long Short-Term Memory(LSTM)network to detect Exploit Kit(EK)traffic,utilising the structure of HTTP *** are processed as sequences,where each timestep represents a redirect and contains a unique combination of 48 *** experiment is conducted using a ground-truth dataset of 1279 EK and 5910 benign redirection ***-parameters are tuned via K-fold cross-validation(5f-CV),with the optimal configuration achieving an F1 score of 0.9878 against the unseen test ***,we compare the results of isolated feature categories to assess their importance.

关键词： Exploit kits Malware LSTM

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Clinical,Biochemical,and Radiological Retrospective Analysis in Patients with Adrenal Incidentaloma-A Secondary Publication

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Proceedings of Anticancer Research 2024年第1期8卷 129-139页

作者： Zeynep Ebru Eser Ramazan Gen Kadir Eser Kerem sezer Esen Akbay Department of Nephrology Mersin University HospitalMersinTurkey Mersin University Hospital Department of EndocrinologyMersinMersinTurkey Mersin University Hospital Department of Medical OncologyMersinMersinTurkey

Objective:To evaluate the epidemiological,demographic,clinical features,treatment approaches,and survival of patients followed up for adrenal ***:Data from 46 patients who were treated and followed up due to adrenal incidentaloma in the Endocrinology Department of Mersin University Health Research and Application Hospital between 2010 and 2014 were retrospectively ***:Of the cases included in the study,13 were male,33 were female,and the mean age was 54.09±10.7 *** most common reason for admission was abdominal pain in 34.78%of the patients,the most commonly diagnosed radiological method was dynamic adrenal CT in 60.87%,and the most common location was the left adrenal *** mean lesion diameter was between 26.8±16.5 *** frequency of hypertension was 50%,obesity 47.8%,type 2 diabetes 21.7%,osteoporosis 42.8%,and metabolic syndrome 41.3%.According to hormonal evaluation results,non-functional adrenal adenoma(NFAA)was found in 82.61%,subclinical Cushing’s syndrome(SCS)in 15.21%,and aldosteronoma in 2.1%.Myelolipoma,pheochromocytoma,and adrenocortical adenoma were diagnosed in 8 cases undergoing *** patient died due to liver *** hormonal activation or growth in lesion size was detected during the follow-up of the ***:Due to the very different pathological and radiological appearances of adrenal incidentaloma,it is important to evaluate demographic,etiological,clinical,laboratory,and radiological data as a whole in the treatment and follow-up.

关键词： Adrenal incidentaloma Subclinical Cushing’s syndrome Non-functional adrenal adenoma Diagnosis Treatment

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Anti-microsporidial effect of thymoquinone on Encephalitozoon intestinalis infection in vitro

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Asian Pacific Journal of Tropical Biomedicine 2020年第1期10卷 42-46页

作者： Ulfet Cetinkaya Gülay sezer Arzuv Charyyeva Halil Bayraktar Health Vocational College Erciyes UniversityKayseriTurkey School of Medicine Department of PharmacologyErciyes UniversityKayseriTurkey Genkok Genome and Stem Cell Centre Department of Molecular Biology and GeneticsErciyes UniversityKayseriTurkey Life Science Research Centre Faculty of ScienceOstrava UniversityOstravaCzech Republic

Objective:To evaluate the anti-microsporidial effects of the active component of Nigella sativa seeds,thymoquinone,against Encephalitozoon intestinalis using an in vitro ***:Anti-microsporidial effect of thymoquinone against Encephalitozoon intestinalis was evaluated by using various concentrations of thymoquinone(0,1,5,10,15,20,30,35,and 40μM)and sterile dimethyl *** time PCR was used to evaluate the inhibitory effects of thymoquinone on the life cycle of Encephalitozoon ***:The cytotoxic effect of thymoquinone on HEK293 cell line was observed with 30,35,and 40μM concentrations of thymoquinone after 24,48,and 72 hours of *** was observed that 10,15,20,and 30μM concentrations of thymoquinone decreased the spore density compared with the control;however,it was significant only at 30μ***:Thymoquinone shows potent anti-microsporidial effects against Encephalitozoon intestinalis in the in vitro model;however,the toxic concentrations of thymoquinone are also toxic to the host cells.

关键词： Microsporidia Thymoquinone Nigella sativa Antiparasitic Encephalitozoon intestinalis

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