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Spontaneous xenogeneic GvHD in Wilms'tumor Patient-Derived xenograft models and potential solutions

Animal Models and Experimental Medicine 2022年第4期5卷 389-396页

作者： seyed mostafa monzavi Ahad Muhammadnejad Maryam Behfar Amir Arsalan Khorsand Samad Muhammadnejad Abdol-Mohammad Kajbafzadeh Department of Applied Cell Sciences School of Advanced Technologies in MedicineTehran University of Medical SciencesTehranIran Pediatric Urology and Regenerative Medicine Research Center Tehran University of Medical SciencesTehranIran Gene Therapy Research Center Digestive Diseases Research InstituteTehran University of Medical SciencesTehranIran Cancer Biology Research Center Cancer Institute of IranTehran University of Medical SciencesTehranIran PDX Platform Biomarker Evaluation and Supervision Team for Personalized MedicineMolecular Tumor BoardCancer Institute of IranTehran University of Medical SciencesTehranIran Pediatric Cell and Gene Therapy Research Center Tehran University of Medical SciencesTehranIran

Severely immunocompromised ***-PrkdcIl2rg(NOG)mice are among the ideal animal recipients for generation of human cancer *** of human solid tumors having abundant tumor-i nfiltrating lymphocytes(TILs)can induce xenogeneic graft-versus-host disease(xGvHD)following engraftment and expansion of the TILs inside the animal ***’tumor(WT)has not been recognized as a lymphocyte-predominant ***,3 consecutive generations of NOG mice bearing WT patient-derived xenografts(PDX)xenotransplanted from a single donor showed different degrees of inflammatory symptoms after transplantation before any therapeutic *** the initial generation,dermatitis,auto-amputation of digits,weight loss,lymphadenopathy,hepatitis,and interstitial pneumonitis were *** antibiotic treatment,no response was noticed,and thus the animals were prematurely euthanized(day 47 posttransplantation).Laboratory and histopathologic evaluations revealed lymphoid infiltrates positively immunostained with anti-human CD3 and CD8 antibodies in the xenografts and primary tumor,whereas no microbial infection or lymphoproliferative disorder was *** of the next generation that lived longer(91 days)developed sclerotic skin changes and more severe *** symptoms were milder in the last *** xenografts of the last 2 generations also contained TILs,and lacked lymphoproliferative *** systemic immunoinflammatory syndrome in the absence of microbial infection and posttransplant lymphoproliferative disorder was suggestive of *** there are few reports of xGvHD in severely immunodeficient mice xenotransplanted from lymphodominant tumor xenografts,this report for the first time documented serial xGvHD in consecutive passages of WT PDX-bearing models and discussed potential solutions to prevent such an undesired complication.

关键词： graft-versus-host disease patient-derived xenograft models tumor-infiltrating lymphocytes Wilms’tumor

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Er_(2)TiO_(5)@Ag nanocomposites:Enhanced photocatalysis and bacteria inactivation,and cytotoxicity

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Journal of Rare Earths 2024年第5期42卷 851-858,I0002页

作者： Mehdi Nazeri Hossein Sedaghat Reza Rafiei Mohammad Amin Farzin seyed mostafa Hosseinpour Mashkani Department of Parasitology and Mycology Kashan University of Medical SciencesKashanIran Department of Microbiology Kashan University of Medical SciencesKashanIran General Medicine Student School of MedicineKashan University of Medical SciencesKashanIran Student Research Committee Kashan University of Medical SciencesKashanIran Institute for Biomedical Materials and Devices School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyNSW2007Australia

In this study,we successfully synthesized Er_(2)TiO_(5)@Ag nanocomposites(NCPs) using the ultrasonicmediated sol-gel technique to create a multifunctional material with enhanced photocatalytic and antibacterial *** visible light photocatalytic activities of Er_(2)TiO_(5) nanoparticles(NPs) and Er_(2)TiO_(5)@Ag NCPs were systematically evaluated under various conditions,including different concentrations of Basic Blue 41(BB 41) dye and *** results reveal a remarkable improvement in the photocatalytic degradation efficiency of Er_(2)TiO_(5)@Ag NCPs(95%) compared to Er_(2)TiO_(5) NPs(80%).Furthermore,the antibacterial efficacy of Er_(2)TiO_(5) NPs and Er2TiO_5@Ag NCPs were extensively examined against Gram-positive and Gram-negative ***,Er_(2)TiO_(5)@Ag NCPs exhibit significantly higher minimum bactericidal concentration(MBC) values compared to Er_(2)TiO_(5) *** antibacterial effect of Er_(2)TiO_(5)@Ag NCPs is particularly pronounced against *** and Pseudomonas aeruginosa,while demonstrating moderate effects on Escherichia coli and Enterococcus *** assess the biocompatibility of the synthesized materials,we investigated their internalization by MCF-7 ***,both Er_(2)TiO_(5) NPs and Er_(2)TiO_(5)@Ag NCPs are found to be effectively internalized by the cells,suggesting their potential application in biomedical ***,our study unveils the exceptional potential of Er_(2)TiO_(5)@Ag NCPs as a dual-action solution,simultaneously possessing enhanced photocatalytic efficiency and potent antibacterial *** multifunctional nanocomposite not only outperforms Er_(2)TiO_(5) and Ag but also paves the way for innovative applications in sustainable environmental remediation and advanced biomedical technologies,promising a brighter and cleaner future.

关键词： Rare earth catalysis Nanocomposite Er_(2)TiO_(5)@Ag Antibacterial activity Photocatalysis Cytotoxicity

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Electrodeposition of nanostructured Ti/(Ru+Ti+Ce)O_2 coatings

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Rare Metals 2018年第1期37卷 13-20页

作者： seyed mostafa Peyghambari Mardali Yousefpour Faculty of Materials and Metallurgical Engineering Semnan University

A nanostructured ternary coating of Ti/（Ru ＋ Ti ＋ Ce）O2 was prepared by the conventional electrodeposition on the titanium substrate as the cathode with different numbers of coating layers. The main objective of this work was to study nanostructured coatings of ceramic materials. For this purpose, the amount of precursor materials in the electrolyte was a variable parameter. Furthermore, the salt of TiCl4/RuCl3·xH2 O/Ce（NO3）3·6 H2 O with different amounts, hydrogen peroxide, methanol, and distilled water were used as an aqueousunaqueous bath. In addition, the coated samples were put to heat at 300, 450, 650, and 850℃ in an electric furnace for1 h. The crystalline phase of the coating was characterized by X-ray diffraction（XRD）. The chemical composition and microstructure of the coating were studied using energydispersive spectroscopy（EDS） and scanning electron microscopy analysis（SEM）. Moreover, the electrochemical measurement of Ti/（Ru ＋ Ti ＋ Ce）O2 coatings was carried out. Results show that with the increase in the number of coating layers, the quality of morphology is ***, the best quality of coatings is obtained at six layers on the titanium substrate with electrolyte including TiO2/RuO2/CeO2 with the molar ratio of 70：5：25 after heat treatment at 450 ℃ for 1 h. Besides,with the increase in Ce02 content from 5 wt% to 25 wt% and the number of coating layers, higher thickness of about（20.0±0.1） μm and minimum over potential for chlorine evolution were obtained.

关键词： Oxides Coating Heat treatment Interface Thin films

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Experimental and numerical analysis of beam to column joints in steel structures

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Frontiers of Structural and Civil Engineering 2018年第4期12卷 642-661页

作者： Gholamreza ABDOLLAHZADEH seyed mostafa SHABANIAN Faculty of Civil Engineering Babol Noshirvani University of TechnologyBabolIran

The behaviors such as extreme non-elastic response, constant changes in roughness and resistance, as well as formability under extreme loads such as earthquakes are the primary challenges in the modeling of beam-to-column connections. In this research, two modeling methods including mechanical and neural network methods have been presented in order to model the complex hysteresis behavior of beam-to-column connections with flange plate. First, the component-based mechanical model will be introduced in which every source of transformation has been shown only with geometrical and material properties. This is followed by the investigation of a neural network method for direct extraction of information out of experimental data. For the validation of behavioral curves as well as training of the neural network, the experiments were carried out on samples with real dimensions of beam-to-column connections with flange plate in the laboratory. At the end, the combinational modeling framework is presented. The comparisons reveal that the combinational modeling is able to display the complex narrowed hysteresis behavior of the beam-to-column connections with flange plate. This model has also been successfully employed for the prediction of the behavior of a newly designed connection.

关键词： beam to column connections experiments component method neural network model combinational modeling

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Droplets diameter distribution using maximum entropy formulation combined with a new energy-based sub-model

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Chinese Journal of Chemical Engineering 2016年第11期24卷 1625-1630页

作者： seyed mostafa Hosseinalipour Hadiseh Karimaei Ehsan Movahednejad Energy and Environmental Lab Dpt Mech. Eng. Iran University of Science and Technology 16846-13114 Narmak Tehran lran University of California Berkeley USA

The maximum entropy principle(MEP) is one of the first methods which have been used to predict droplet size and velocity distributions of liquid sprays. This method needs a mean droplets diameter as an input to predict the droplet size distribution. This paper presents a new sub-model based on the deterministic aspects of liquid atomization process independent of the experimental data to provide the mean droplets diameter for using in the maximum entropy formulation(MEF). For this purpose, a theoretical model based on the approach of energy conservation law entitled energy-based model(EBM) is presented. Based on this approach, atomization occurs due to the kinetic energy loss. Prediction of the combined model(MEF/EBM) is in good agreement with the available experimental data. The energy-based model can be used as a fast and reliable enough model to obtain a good estimation of the mean droplets diameter of a spray and the combined model(MEF/EBM) can be used to well predict the droplet size distribution at the primary breakup.

关键词： Mean droplets diameter Energy conservation Maximum entropy formulation (MEF) Size distribution Statistical thermodynamics Mathematical modeling

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An agent-based simulation with NetLogo platform to evaluate forward osmosis process(PRO Mode)

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2487-2494页

作者： mostafa Taherian seyed Mahmoud Mousavi Hooman Chamani Chemical Engineering Department Faculty of Engineering Ferdowsi University of Mashhad Research Center of Membrane Processes and Membrane Faculty of Engineering Ferdowsi University of Mashhad

Forward osmosis(FO), as an emerging technology, is influenced by different factors such as operating conditions,module characteristics, and membrane properties. The general aim of this study was to develop a suitable(flexible,comprehensive, and convenient to use) computational tool which is able to simulate osmosis through an asymmetric membrane oriented in pressure retarded osmosis(PRO) mode in a wide variety of scenarios. For this purpose, an agent-based model was created in NetLogo platform, which is an easy-to-use application environment with graphical visualization abilities and well suited for modeling a complex system evolving over time. The simulation results were validated with empirical data obtained from literature and a great agreement was observed. The effect of various parameters on process performance was investigated in terms of temperature,cross-flow velocity, length of the module, pure water permeability coefficient, and structural parameter of the membrane. Results demonstrated that the increase in all parameters, except structural parameter of the membrane and the length of module led to the increase of average water flux. Moreover, nine different draw solutes were selected in order to assess the influence of net bulk osmotic pressure difference between the draw solution(DS) and feed solution(FS)(known as the driving force of FO process) on water flux. Based on the findings of this paper, the performance of FO process(PRO mode) can be efficiently evaluated using the NetL ogo platform.

关键词： Agent-based model Forward osmosis (PRO mode) Membranes Net Logo platform Simulation Water flux

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Flow-mode synthesis of biodiesel under simultaneous microwave–magnetic irradiation

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2551-2559页

作者： Behzad Khedri mostafa mostafaei seyed Mohammad Safieddin Ardebili Mechanics of Biosystems Engineering Department Razi UniversityKermanshahIran Biosystems Engineering Department Shahid Chamran University of AhvazAhvazIran

In this study,aiming at optimization of a novel continuous biodiesel production system was developed by combining technologies based on microwaves and magnetic *** affecting microwave-assisted biodiesel(alkyl esters)production reaction were analyzed in this *** factors included magnetic field intensity(0,0.225 and 0.450 T),microwave power(400,821,and 1181 W),percentages of KOH and Na OH catalysts at constant concentrations of 1 wt%(0,50%and 100%),and percentages of ethanol and methanol at a constant molar ratio of 6:1(0,50%and 100%).Response Surface Methodology(RSM)was used to optimize the reaction ***-based analysis indicated that,all independent parameters had significant effects on the reaction *** of the investigations reveal that the largest effects on the conversion efficiency were due to type of alcohol and magnetic field *** optimized conditions were found to be a magnetic field intensity of 0.331 T,a microwave power of 677.77 W,catalyst percentages of 30.35%and 69.65%for KOH and Na OH,respectively,and alcohol percentages of 80.47%and 19.53%for methanol and ethanol,*** the optimal conditions,yield of the reaction was 96.2%.

关键词： Biodiesel Microwave Magnetic field Transesterification Waste cooking oil

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Numerical study of power production from tidal energy in the Khuran Channel and its feedback on background hydrodynamics

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Acta Oceanologica Sinica 2022年第5期41卷 173-182页

作者： Davood Shariatmadari seyed mostafa Siadatmousavi Cyrus Ershadi Civil Engineering Department Faculty of Technology and EngineeringUniversity of HormozganHormozganBandar Abbas***Iran School of Civil Engineering Iran University of Science and TechnologyTehran***Iran

This study focuses on the development of a farm of tidal turbines in the Khuran *** important factors include the location of turbines and their hydrodynamic effects on the environment.A three-dimensional circulation model for the Persian Gulf is employed for the comprehensive evaluation of the tidal energy potential throughout the study *** model is validated by using in situ observations of water level and current *** appropriate potential points for extracting the tidal energy were identified in the Persian Gulf using the model *** Khuran Channel,located in the north of Qeshm Island,was found to be the best place to extract tidal energy inside the Persian *** adding the term of momentum losses to the governing equations,the feedback of extracting energy on the hydrodynamic around Qeshm Island was *** simulation results show that the average daily power production of a tidal farm with 99 turbines for one month is approximately 1.3 *** tidal farm also has a significant impact on the water level inside the Khuran Channel,especially near the tidal farm where these fluctuations exceed 4 *** change in the current speed caused by wake reaches 0.4 m/*** effects were active up to 7 km downstream of the *** current velocity was also estimated to be 1.6 m/s and 2.1 m/s during the spring and ebb tides within the channel,respectively.

关键词： renewable energy tidal energy Khuran Channel tidal horizontal axis turbine turbine farm Delft3D

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Microstructure Modification of Powder Compact of Al-Zn-Mg Nanostructured Alloy by a Semisolid Thermomechanical Processing

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Acta Metallurgica Sinica(English Letters) 2016年第1期29卷 39-45页

作者： Mohsen Hajizamani mostafa Alizadeh seyed Ahmad Jenabali-Jahromi Department of Metals Institute of Science and High Technology and Environmental SciencesGraduate University of Advanced Technology Department of Materials Science and Engineering School of EngineeringShiraz University

A thermomechanical process （TMP） consisting of three cycles of cold pressing at 154 MPa and liquid-phase sintering at 600 ℃ for 30 min in each cycle was applied to modify the microstructure of nanostructured A1-Zn-Mg alloy. The alloy powders were produced by mechanical alloying. Also, solid-state sintering at 550℃ for 90 min was done to compare the results with those obtained from the TMP. The powders and the thermomechanically （TM） processed samples were analyzed by XRD to reveal the present phases in addition to calculating the crystallite size changes by the Wil- liamson-Hall method. Moreover, scanning electron microscope was employed to observe the morphology of the powder and the microstructures of the sintered and the TM processed samples. The results revealed that the TMP affected the microstructure noticeably as well as the microhardness by removing the continuous grain boundary porosities and uniform distribution of the intermetallic phase particles as well as obtaining a near globular microstructure after the second cycle. Also, the average grain sizes in the first and the second cycles of the TMP were lower than those of the sintered sample. Furthermore, nanocrystalline grains were stable up to the second cycle of the TMP.

关键词： Thermomechanical processing AI-Zn-Mg alloy Intermetallics Sintering Grain growth

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Seasonal variation of the double diffusion processes at the Strait of Hormuz

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Acta Oceanologica Sinica 2017年第1期36卷 26-34页

作者： AZIZPOUR Jafar CHEGINI Vahid SIADATMOUSAVI seyed mostafa Iranian National Institute for Oceanography and Atmospheric Science Tehran ***Iran Iran University of Science and Technology Tehran ***Iran

Profiles of salinity and temperature were measured in the strait of Hormuz（SH） during the winter of 2012, spring and summer of 2013. To investigate the double diffusion（DD） processes, Turner（TU） angle values are calculated in all the stations in the SH. Different TU angle values correspond to salt fingering（SF）, diffusive convection（DC）and stable stratification. The distributions of the two forms of DD were plotted vertically along transects in the eastern, central and western part of the SH, and corresponding DD processes were described. The results show that both SF and DC occurred in most part of the study area. Two different water masses（the Indian Ocean surface water and the Persian Gulf water） were evident at the SH, and SF and DC were evident at the interface of two water masses. Due to evaporation, SF occurred in the surface layer of most Stations throughout the year. In the eastern part of the SH, occurrences of DC were more feasible in wintertime. SF was the main phenomenon at the end of hot season. For central part, SF occurred throughout the year in water column. In the western part,water column was stable in summer and DC happened in most part of water column in winter.

关键词： double diffusion diffusive convection salt fingering Turner angle Strait of Hormuz

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