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Prevalence of hepatitis C virus infection among hemodialysis patients in the Middle-East: A systematic review and meta-analysis

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World Journal of Gastroenterology 2017年第1期23卷 151-166页

作者： Soheil Ashkani-Esfahani seyed moayed alavian Mohammad Salehi-Marzijarani Baqiyatallah Research Center for Gastro-enterology and Liver Diseases Baqiyatallah University of Medical Sciences Student Research Committee Shiraz University of Medical Sciences Department of Biostatistics Shiraz University of Medical Sciences

AIM To determine hepatitis C virus(HCV)infection prevalence in each country of the Middle-East and the overall prevalence of the *** In this systematic review,we gathered all documents related to HCV infection prevalence among hemodialysis patients in 17 middle-east countries from April 2006 to March *** selected only cross-sectional studies that had proper sampling and measurement methods as well as a valid statistical *** After screening of 7311 documents,56 studies were selected reporting the prevalence of HCV infection among hemodialysis patients from 10 countries of the *** countries including United Arab Emirates,Afghanistan,Qatar,Bahrain,Kuwait,Oman,Israel,and Cyprus did not have any relevant document;thus,their latest reports were just *** performed the meta-analysis and determined the prevalence rates for each country as well as the whole *** overall HCV infection prevalence among hemodialysis patients in the region was reported to be 25.3%;Egypt and Syria had the highest reported rates while Iran and Lebanon had the *** investigations are still needed to provide more reliable databases,find main risk factors,and to improve diagnosis and treatment plans,particularly in higher prevalent *** Controlling the prevalence and improving the management methods of HCV infection among hemodialysis patients are of a great concern in the Middle-East region.

关键词： Hepatitis C Hemodialysis Prevalence Middle-East Meta-Analysis Review

Prevalence of hepatitis C virus infection and its related risk factors in drug abuser prisoners in Hamedan-Iran

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World Journal of Gastroenterology 2005年第26期11卷 4085-4089页

作者： Amir Houshang Mohammad Alizadeh seyed moayed alavian Khalil Jafari Nastaran Yazdi Research Center for Gastroenterology and Liver Disease Shaheed Beheshti University of Medical Sciences Tehran Iran Baghiatalah University of Medical Sciences Tehran Iran Hamedan University of Medical Sciences Hamedan Iran

AIM:Recent studies in Iran has shown that prevalence of hepatitis C virus (HCV) infection among Iranian prisoners is high, in spite of low HCV seroprevalence in general population. METHODS: This study was carried out in the central prison of Hamedan - Iran, in year 2002. Inmates were interviewed using a standard questionnaire including demographic, imprisonment history and HCV-related risk behaviors items. Thereafter, the sera drawn from the participants were tested for anti-HIV and anti-HCV antibodies. RESULTS: A total number of 427 drug abuser inmates participated in our study. Three hundred and ninety-seven (93%) were men and 30 (7%) were women. Total number of IV drug abusers (IDA) and non-IV drug abusers (NIDA) was 149 (34.9%) and 278 (65.1%), respectively. The overall rate of antibody positivity among inmates was 0.9% for HIV and 30% for HCV. Of all IDAs, 31.5% and of NIDAs, 29.1% had serological evidence of HCV infection. CONCLUSION: The seroprevalence of HCV infection among drug abuser prisoners in comparison with the general population in Iran, is very high (30% vs in italics 0.2%). Our results indicate the importance of policies to prevent transmission of HCV infection during and following incarceration.

关键词： Hepatitis C virus Prisoners Drug abusers Iran

Preliminary report of hepatitis B virus genotype prevalence in Iran

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World Journal of Gastroenterology 2006年第32期12卷 5211-5213页

作者： seyed-moayed alavian Hossein Keyvani Mahdi Rezai Neda Ashayeri Homa Mohammad Sadeghi Department of Internal Medicine Baqiatollah Medical University Tehran Hepatitis Center92 Vesal Shirazi StreetBoolvar KeshavarzPO Box 14155/3651TehranIran Department of Virology Iran University of Medical Sciences Hemmat ExpresswayTehranIran Student's Research Committee Iran University of Medical Sciences Hemmat ExpresswayTehranIran

AIM： To determine the prevalence of hepatitis B virus （HBV） genotypes in Iranian hepatitis B surface antigen （HBsAg） carriers, chronic hepatitis B and cirrhotic patients. METHODS： A total of 109 HBsAg-positive patients were included in this study. HBV genotypes were determined by using INNO-LiPA methodology which is based on the reverse hybridization principle. RESULTS： The distribution of patients with different stages of liver disease was as follows： 95 （86.4%） chronic hepatitis, 11 （10%） liver cirrhosis, and 3 （2.7%） inactive carrier. Of the chronic hepatitis and liver cirrhosis patients, 26.4% were HBeAg-positive while 70% were HBeAg-negative. Genotype D was the only detected type found in all patients. CONCLUSION： Classifying HBV into genotypes has to be cost-effective and clinically relevant. Our study indicates that HBV genotype D prevails in the Mediterranean area, Near and Middle East, and South Asia. Continued efforts for understanding HBV genotype through international co-operation will reveal further virological differences of the genotypes and their clinical relevance.

关键词： Hepatitis B virus Genotype Chronic Hepatitis B Cirrhosis

Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

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World Journal of Gastroenterology 2010年第33期16卷 4169-4175页

作者： Nargess Ebrahimi Daryani Nasser Ebrahimi Daryani seyed moayed alavian Ali Zare seyed-Mohammad Fereshtehnejad Mohammad Reza Keramati Mohammad Reza Pashaei Peiman Habibollahi Department of Gastroenterology and Hepatology Tehran University of Medical Sciences Center for Gastroenterology and Liver Disease Baqiatallah University of Medicine and Tehran Hepatitis Center Department of Pathology Firouzgar HospitalIran Uni- versity of Medical Sciences Gastrointestinal & Liver Disease Research Center(GILDRC) Iran University of Medical Sciences Department of Surgery Iran University of Medical Sciences

AIM:To characterize the histopathologic specifications of non-alcoholic steatohepatitis(NASH)according to age and ***:An analytical cross-sectional study was conducted in two private gastroenterology clinics on biopsy proven patients suffering from *** histopathologic findings as well as demographic and laboratory data of the patients at the time of biopsy were gathered retrospectively from clinical *** grading and staging of histopathologic findings were performed according to the Brunt method after reevaluation of the slides by a *** were divided into two groups according to age(belowand above 55 years).Mean quantitative grade of all pathologic findings were also calculated according to Brunt scoring ***:A total number of 77 NASH patients,consisting of 58 males(75.3%)and 19(24.7%)females with a mean age of 41.99±11.80 years(range,18-70 years),were *** mean age(48.72±13.99 years vs 39.74±10.16 years,P=0.004)and aspartate aminotransferase level(75.11±29.68 U/L vs 52.78± 25.00 U/L,P=0.002)was significantly higher in female *** quantitative grade of hepatosteatosis was significantly higher in females(2.00±0.82 vs 1.59 ±0.68,P=0.031)compared to *** four percent(34/65)of young patients had mild hepatosteatosis (GradeⅠ)while only one patient(11.2%)in the older group had gradeⅠ*** aged≥55 had significantly more severe hepatosteatosis(GradeⅢ) (44.4%vs 9.5%,P=0.007)and the mean quantitative grade of hepatosteatosis was significantly higher among them(2.33±0.71 vs 1.56±0.67,P=0.002).Multivariate analysis after omitting the confounding role of age revealed a higher grade of hepatosteatosis in female patients(P=0.010).CONCLUSION:These findings point toward the possible influence of age in the severity of steatohepatitis,portal and lobar inflammation in patients suffering from NASH while gender independently might contribute to the level of steatohepatitis.

关键词： Non-alcoholic steatohepatitis Age Gender Histopathologic findings

Intra-familial prevalence of hepatitis B virologic markers in HBsAg positive family members in Nahavand, Iran

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World Journal of Gastroenterology 2005年第31期11卷 4857-4860页

作者： Amir Houshang Mohammad Alizadeh Mitra Ranjbar Shahin Ansari seyed moayed alavian Hamid Mohaghegh Shalmani Leila Hekmat Mohammad Reza Zali Research Center for Gastroenterology and Liver Disease Hemedan University of Medical Sciences Baghiatallah University of Medical Sciences

AIM, To determine the prevalence of hepatitis B in Nahavand and evaluate the HBsAg positive prevalence in families with a member who was confirmed to have HBV infection. METHODS： This study was performed in two phases. In the first phase, 1 824 subjects in Nahavand city were selected. The interviewers visited the houses of chosen families to flU the questionnaire and take the blood samples. All subjects signed an informed consent before interviews and blood sampling. The samples were evaluated for HBV virologic markers. In the second phase, 115 HBsAg-positive cases were enrolled and evaluated for HBV virologic markers. RESULTS： The prevalence of positive HBsAg in Nahavand was 2.3%. The most frequent relatives of index cases were sons and daughters （32.2% and 23.5% respectively）. Twelve （11%） of all family members were HBsAg positive. Fifty （56.2%） were isolated HBsAb positive and only one person （2.5%） was isolated HBcAb positive. The higher rates of HBsAg marker were detected in the brothers （1-25%） and fathers （1-12.5%）. The infection rate in husbands and wives of index cases was 10%. Only two （16.7%） of all HBsAg-positive participants reported previous HBV vaccination. CONCLUSION： The prevalence of intr-familial HBV infection is lower in Nahavand of Iran compared to other studies. More attention should be paid to HBV vaccination and risk-lowering activities.

关键词： Intra-familial prevalence Hepatitis B Nahavand Iran

Hepatitis C resistance to NS5A inhibitors:Is it going to be a problem?

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World Journal of Hepatology 2018年第9期10卷 543-548页

作者： Heidar Sharafi seyed moayed alavian Baqiyatallah Research Center for Gastroenterology and Liver Diseases Baqiyatallah University of Medical SciencesTehran ***Iran Middle East Liver Diseases Center Tehran ***Iran

Treatment of hepatitis C virus(HCV) infection has evolved greatly through the recent decade. The availability of direct-acting antiviral agents(DAAs) targeting the functional proteins of HCV has resulted in the introduction of DAA-based combination therapies,providing an optimal rate of treatment success. Among the DAAs,NS5 A inhibitors are used in most of the introduced and approved HCV antiviral regimens. Resistance-associated substitutions(RASs) are amino acid substitutions in HCV protein sequences that result in decreased antiviral efficacy of the HCV DAAs. Among the HCV RASs,the NS5 A RASs were found to effectively modify and decrease treatment response to NS5 A inhibitor-containing regimens. As a baseline predictor of treatment response,NS5 A RAS draws attention for pretreatment testing in targeted patient groups. Given NS5 A RASs are either naturally-occurring or DAA-selected,the application of NS5 A RAS testing can be considered in two settings of NS5 A inhibitor-na?ve patients and NS5 A inhibitor-experienced patients. Less than 5% of NS5 A inhibitor-na?ve patients harbor naturally-occurring NS5 A RAS with high resistance level(> 100 X resistance foldchange). In NS5 A inhibitor-na?ve patients,NS5 A RAS testing accompanied by treatment optimization cannot increase treatment response more than 2%-3%,while in NS5 A inhibitor-experienced patients,> 75% are found to have NS5 A RASs > 100 X and NS5 A RAS testing in this group of patients seems to be reasonable. This editorial will address the debate on the application of NS5 A RAS testing and will discuss if the NS5 A RAS testing has any role in clinical management of hepatitis C.

关键词： Direct-acting antiviral agent Hepatitis C NS5A Resistance Treatment

Clinical, virologic and phylogenetic features of hepatitis B infection in Iranian patients

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World Journal of Gastroenterology 2008年第35期14卷 5448-5453页

作者： Golnaz Bahramali Majid Sadeghizadeh Samad Amini-Bavil-Olyaee seyed-moayed alavian Abbas Behzad-Behbahani Ahmad Adeli Mohammad-Reza Aghasadeghi Safieh Amini Fereidoun Mahboudi Department of Genetics Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115-175Iran Biotechnology Department Pasteur Institute of IranTehran 13164IranMohammad-Reza AghasadeghiSafieh AminiHepatitis and HIV DepartmentPasteur Institute of IranTehran 13164Iran Baqiyatallah Research Center for Gastroenterology and Liver Diseases Tehran Hepatitis CenterTehran 14155-3651Iran Medical Technology Research Center School of Paramedical SciencesShiraz University of Medical SciencesShiraz ***Iran Biotechnology Department Pasteur Institute of IranTehran 13164Iran Hepatitis and HIV Department Pasteur Institute of IranTehran 13164Iran

AIM： To characterize the clinical, serologic and virologic features of hepatitis B virus （HBV） infection in Iranian patients with different stages of liver disease.METHODS： Sixty two patients comprising of 12 inactive carriers, 30 chronic hepatitis patients, 13 patients with liver cirrhosis and 7 patients with hepatocellular carcinoma （HCC） were enrolled in the study. The HBV S, C and basal core promoter （BCP） regions were amplified and sequenced, and the clinical, serologic, phylogenetic and virologic characteristics were investigated.RESULTS： The study group consisted of 16 HBeAgpositive and 46 HBeAg-negative patients. Anti-HBepositive patients were older and had higher levels of ALT, ASL and bilirubin compared to HBeAg-positive patients. Phylogenetic analysis revealed that all patients were infected with genotype D （mostly ayw2）. The G1896A precore （PC） mutant was detected in 58.1% patients. HBeAg-negative patients showed a higher rate of PC mutant compared to HBeAg-positive patients （2,2 = 9.682, P = 0.003）. The majority of patients with HCC were HBeAg-negative and were infected with PC mutant variants. There was no significant difference in the occurrence of BCP mutation between the two groups, while the rate of BCP plus PC mutants was higher in HBeAg-negative patients （2,2 = 4.308, P = 0.04）. In the HBV S region, the genetic variability was low, and the marked substitution was P120T/S, with a rate of 9.7% （n = 6）.CONCLUSION： In conclusion, HBV/D is the predominant genotype in Iran, and the nucleotide variability in the BCP and PC regions may play a role in HBV disease outcome in HBeAg-negative patients.

关键词： Hepatitis B virus Clinical and virologic features Genetic variability Phylogenetic analysis

Elevated alanine aminotransferase activity is not associated with dyslipidemias,but related to insulin resistance and higher disease grades in non-diabetic non-alcoholic fatty liver disease

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 702-706页

作者： Mohammad Ebrahim Ghamar-Chehreh Mohsen Amini Hossein Khedmat seyed moayed alavian Fatemeh Daraei Reza Mohtashami Reza Hadi Bent-Al-Hoda Beyram Saeed Taheri The Internist Research Center Baqiyatallah Research Center for Gastroenterology and Liver Diseases Baqiyatallah University of Medical Sciences Dr.Taheri Medical Research Group

Objective:To explore demographic and metabolic factors associated with increased alanine aminotransferase(ALT)activity in non-diabetic non-alcoholic fatty liver disease(NAFLD)***:Overall 372 patients who consecutively attended to Gastroenterology Clinic of Baqiyatallah University of Medical Sciences,Tehran,Iran awere diagnosed as NAFLD entered into *** criteria were having diabetes mellitus and fasting blood glucose over126 mg/dL,active hepatitis B virus infection,having hepatitis C virus positive serology,and to be under corticosteroid *** levels were considered pathologically high when it was over30 IU/L for men and over 19 IU/L for ***:Bivariate analyses using t test and chisquare test showed that patients with pathologically augmented ALT levels had significantly higher NAFLD grades in their ultrasonographic evaluations(P=0.003).Moreover,these patients represented significantly higher homeostatic model assessment levels(P=0.003),levels of serum insulin(P=0.002),fasting blood glucose(P<0.001),and uric acid(P=0.02).The prevalence of insulin resistance was also higher in patients with increased serum ALT *** logistic regression models showed that ultrasonographic grading of NAFLD(P=0.027)and insulin resistance(P=0.013)were the only variables significantly associated with abnormal ALT ***:This study shows that the associations of increased ALT serum levels in NAFLD patients are different from what are supposed *** excluding diabetic patients from our population,we find that increased ALT levels are not associated with dyslipidemias but are independently associated with insulin resistance and NAFLD grading on ultrasonographic *** studies are needed to confirm our results.

关键词： Alanine aminotransferase Non-alcoholic fatty liver disease Insulin resistance Fasting blood glucose Ultrasonographic evaluation Diabetes mellitus Metabolic factor Serum insulin Dyslipidemia

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

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World Journal of Gastroenterology 2015年第47期21卷 13225-13239页

作者： Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec seyed moayed alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami Department of Physiology and Experimental Medicine Hospital for Sick Children Research Institute University of Toronto Young Researchers and Elite Club Ardabil Branch Islamic Azad University Department of Human Anatomy and Cell Science College of Medicine Faculty of Health Sciences University of Manitoba The Children's Hospital Research Institute of Manitoba University of Manitoba Department of Clinical and Experimental Medicine Division of Otorhinolaryngology Link?ping University Baqiyatallah Research Center for Gastroenterology and Liver Diseases (BRCGL) Department of Clinical Biochemistry School of Medicine Zahedan University of Medical Sciences Department of Pathology and Organ Transplant Research Center Shiraz University of Medical Sciences Department of Biochemistry National University of Ireland Galway Health Policy Research Centre Shiraz University of Medical Sciences Manitoba Center for Proteomics and Systems Biology University of Manitoba Department of Medical Microbiology and Infectious Diseases The Children's Hospital Research Institute of Manitoba University of Manitoba

AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected ***: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy,

关键词： Cell fate Cell death Hepatocyte Viralinfection Endoplasmic reticulum stress