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Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review

World Journal of Gastroenterology 2017年第28期23卷 5097-5114页

作者： Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda seyed fazel Nabavi Leo R Fitzpatrick seyed Mohammad Nabavi Anupam Bishayee Department of Integrative oncology Breast Cancer Research CenterMotamed Cancer InstituteACECR Department of Recombinant Protein Breast Cancer Research CenterMotamed Cancer InstituteACECR Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical Sciences Research Group on Community Nutrition and oxidative Stress and CIBERo BN-Physiopathology of obesity and Nutrition University of Balearic IslandsPalma de Mallorca Applied Biotechnology Research Center Baqiyatallah University of Medical Sciences Department of Pharmaceutical and Biomedical Sciences California Northstate University College of Pharmacy Department of Pharmaceutical Sciences College of PharmacyLarkin University

The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.

关键词： Antioxidant Inflammation Gastrointestinal tract Flavonoids Polyphenols

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Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens

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World Journal of Gastroenterology 2006年第33期12卷 5368-5374页

作者： Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan fazel Shokri Department of Immunology School of Public Health Tehran University of Medical Sciences Tehran Iran Department of Virology School of Public Health Tehran University of Medical Sciences Tehran Iran Division of Virology Institute of Biomedical and Life Science University of Glasgow Glasgow United Kingdom Monoclonal Antibody Research Center Avesina Research Center Tehran Iran

AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” ***: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these ***: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants.

关键词： Hepatitis B surface antigen Hepatitis B virus Mutant Epitope mapping Vaccination Monoclonal antibody

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Multi-objective design optimization of a large-scale directdrive permanent magnet generator for wind energy conversion systems

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Frontiers in Energy 2014年第2期8卷 182-191页

作者： Arash Hasssanpour ISFAHANI Amirhossein Haji-seyed BOROUJERDI saeed HASANZADEH Everette Energy LLC Dallas 75225 USA Faculty of Electrical and Engineering Islamic Azad University Islamshahr Branch Tehran 33147-67653 Iran Facuty of Electrical and Computer Engineering Qom University of Technology Qom 1519-37195 Inan

This paper presents a simukaneous multi- objective optimization of a direct-drive permanent magnet synchronous generator and a three-blade horizontal-axis wind turbine for a large scale wind energy conversion system. Analytical models of the generator and the turbine are used along with the cost model for optimization. Three important characteristics of the system i.e.,the total cost of the generator and blades, the annual energy output and the total mass of generator and blades are chosen as objective functions for a multi-objective optimization. Genetic algorithm （GA） is then employed to optimize the value of eight design parameters including seven generator parameters and a turbine parameter resulting in a set of Pareto optimal solutions. Four optimal solutions are then selected by applying some practical restrictions on the Pareto front. One of these optimal designs is chosen for finite element verification. A circuit-fed coupled time stepping finite element method is then performed to evaluate the no-load and the full load performance analysis of the system including the generator, a rectifier and a resistive load. The results obtained by the finite element analysis （FEA） verify the accuracy of the analytical model and the proposed method.

关键词： permanent magnet synchronous generator wind turbine direct-drive multi-objective optimization,

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Warpage and Shrinkage Optimization of Injection-Molded Plastic Spoon Parts for Biodegradable Polymers Using Taguchi, ANOVA and Artificial Neural Network Methods

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Journal of Materials Science & Technology 2016年第8期32卷 710-720页

作者： Erfan Oliaei Behzad Shiroud Heidari seyed Mohammad Davachi Mozhgan Bahrami saeed Davoodi Iman Hejazi Javad Seyfi Applied Science Nano Research Group ASNARKA P.C. *** Tehran Iran Macromolecular Science and Engineering University of Michigan Ann Arbor Michigan 48109-2136. United States Department of Chemical Engineering Shahrood Branch Islamic Azad University RO. Box 36155-163 Shahrood lran

In this study, it is attempted to give an insight into the injection processability of three self-prepared polymers from A to Z. This work presents material analysis, injection molding simulation, design of ex- periments alongside considering all interaction effects of controlling parameters carefully for green biodegradable polymeric systems, including polylactic acid （PLA）, polylactic acid-thermoplastic poly- urethane （PLA-TPU） and polylactic acid-thermoplastic starch （PLA-TPS）. The experiments were carried out using injection molding simulation software Autodesk Moldflov~~ in order to minimize warpage and volumetric shrinkage for each of the mentioned systems. The analysis was conducted by changing five significant processing parameters, including coolant temperature, packing time, packing pressure, mold temperature and melt temperature. Taguchi＇s [.27 （35） orthogonal array was selected as an efficient method for design of simulations in order to consider the interaction effects of the parameters and reduce spu- rious simulations. Meanwhile, artificial neural network （ANN） was also used for pattern recognition and optimization through modifying the processing conditions. The Taguchi coupled analysis of variance （ANOVA） and ANN analysis resulted in definition of optimum levels for each factor by two completely different methods. According to the results, melting temperature, coolant temperature and packing time had significant influence on the shrinkage and warpage. The ANN optimal level selection for minimiza- tion of shrinkage and/or warpage is in good agreement with ANOVA optimal level selection results. This investigation indicates that PLA-TPU compound exhibits the highest resistance to warpage and shrink- age defects compared to the other studied compounds.

关键词： Injection molding simulation Yaguchi Artificial neural networks Biodegradable plastic Disposable spoons

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Performance and emission characteristics of a diesel engine operating on different water in diesel emulsion fuels:optimization using response surface methodology(RSM)

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Frontiers in Energy 2019年第4期13卷 636-657页

作者： seyed saeed HOSEINI Mohammad Amin SOBATI School of Chemical Engineering Iran University of Science and Technology(IUST)Tehran 16765163Iran

The nitrogen oxide(NOx)release of diesel engines can be reduced using water in diesel emulsion fuel without any engine *** the present paper,different formulations of water in diesel emulsion fuels were prepared by ultrasonic *** water droplet size in the emulsion,polydisperisty index,and the stability of prepared fuel was examined,***,the performance characteristics and exhaust emission of a single cylinder air-cooled diesel engine were investigated using different water in diesel emulsion *** effect of water content(in the range of 5%-10% by volume),surfactant content(in the range of 0.5%-2% by volume),and hydrophilic-lipophilic balance(HLB)(in the range of 5-8)was examined using Box-Behnken design(BBD)as a subset of response surface methodology(RSM).Considering multi-objective optimization,the best formulation for the emulsion fuel was found to be 5%water,2% surfactant,and HLB of 6.8.A comparison was made between the best emulsion fuel and the neat diesel fuel for engine performance and emission characteristics.A considerable decrease in the nitrogen oxide emission(-18.24%)was observed for the best emulsion fuel compared to neat diesel fuel.

关键词： water in diesel emulsion fuel hydrophiliclipophilic balance(HLB) response surface methodology(RSM) emulsion stability engine performance exhaust emission

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Thermal comfort analysis of earth-sheltered buildings: The case of meymand village, Iran

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Frontiers of Architectural Research 2022年第6期11卷 1214-1238页

作者： Amirreza Khaksar Amir Tabadkani seyed Majid Mofidi Shemirani Aso Hajirasouli saeed Banihashemi Shady Attia Department of Architecture Faculty of Art and ArchitectureIslamic Azad UniversityMashhadIran School of Architecture and Built Environment Deakin UniversityGeelong Waterfront CampusAustralia Iran University of Science and Technology School of Architecture and Urban PlanningTehranIran School of Architecture and Built Environment Queensland University of TechnologyAustralia Design&Built Environment School University of CanberraAustralia Sustainable Building Design Lab Dept.UEEFaculty of Applied ScienceUniversity of LiegeLiegeBelgium

Vernacular buildings are known for their localized passive settings to provide comfortable indoor environment without air conditioning *** alternative is the consistent ground temperature over the year that earth-sheltered envelopes take the benefit;however,ensuring annual indoor comfort might be ***,this research monitors the indoor thermal indicators of 22 earth-sheltered buildings in Meymand,Iran with a warmdry ***,the observations are used to validate the simulation results through two outdoor and indoor environmental parameters,air temperature and relative humidity during the hottest period of the *** indicated that the main thermal comfort differences among case studies were mainly due to their architectural layouts where the associated variables including length,width,height,orientation,window-to-wall ratio,and shading depth were optimized through a linkage between Ladybug-tools and Genetic Algorithm(GA)concerning adaptive thermal comfort model definition and could enhance the annual thermal comfort by 31%.

关键词： Earth-sheltered buildings Adaptive thermal comfort Building simulation Optimization Field measurement Architectural context

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Kinetic studies of the oxidative coupling of methane over the Mn/Na_2WO_4/SiO_2 catalyst

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Journal of Natural Gas Chemistry 2009年第1期18卷 25-34页

作者： seyed Mehdi Kamali Shahri seyed Mehdi Alavi Reaction Engineering Lab. Chemical Engineering Department Iran University of Science and Technology Tehran-Iran

Oxidative coupling of methane is a direct way to obtain C2 hydrocarbon, and Mn-Na-W/SiO2 catalyst is the most promising among all the catalysts. The 2%Mn/5%Na2WO4/SiO2 catalyst was prepared by the incipient wetness impregnation method. A 7-step heterogeneous reaction model of the oxidative coupling of methane to C2 hydrocarbons was conducted by co-feeding methane and oxygen at a total pressure of 1 bar over the catalyst. The kinetic measurements were carried out in a micro-catalytic fixed bed reactor. The kinetic data were obtained at the appropriate range of reaction conditions （4 kPa〈Po2 〈20 kPa, 20 kPa〈PcH4〈80 kPa, 800 ℃〈T〈900℃）. The proposed reaction kinetic scheme consists of three primary and four consecutive reaction steps. The conversions of hydrocarbons and carbon oxides were evaluated by applying Langmuir-Hinshelwood type rate equations. Power-law rate equation was applied only for the water-gas shift reaction. In addition, the effects of operating conditions on the reaction rate were studied. The proposed kinetic model can predict the conversion of methane and oxygen as well as the yield of C2 hydrocarbons and carbon oxides with an average accuracy of ± 15%.

关键词： kinetic model oxidative coupling of methane reaction rate

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Assessment of fracture process in forta and polypropylene fiber-reinforced concrete using experimental analysis and digital image correlation

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Frontiers of Structural and Civil Engineering 2022年第12期16卷 1633-1652页

作者： seyed Hamid KALALI Hamid ESKANDARI-NADDAF seyed Ali EMAMIAN Department of Civil Engineering Hakim Sabzevari UniversitySabzevar ***Iran

This paper aims to characterize the evolution of the fracture process and the cracking behavior in fortaferro(FF)and polypropylene(PP)fiber-reinforced concrete under the uniaxial compressive loading using experimental analysis and digital image correlation(DIC)on the surface *** this purpose,6 mix designs,including two FF volume fractions of 0.10%,and 0.20%and three PP volume fractions of 0.20%,0.30%,and 0.40%,in addition to a control mix were evaluated according to compressive strength,modulus of elasticity,toughness index,and stress–strain *** influence of fibers on the microstructural texture of specimens was analyzed by scanning electron microscope(SEM)*** show that FF fiber-reinforced concrete specimens demonstrated increased ductility and strength compared to PP *** results revealed that the major crack and fracture appeared at the peak load of the control specimen due to brittleness and sudden gain of large lateral strain,while a gradual increase in micro-crack quantity at 75%of peak load was observed in the fiber specimens,which thenbegan to connect with each other up to the final *** accuracy of the results supports DIC as a reliable alternative for the characterization of the fracture process in fiber-reinforced concrete.

关键词： fiber-reinforced concrete forta-ferro and polypropylene fiber fracture process cracking behavior digital image correlation

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Large-scale seismic isolation through regulated liquefaction： a feasibility study

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 579-595页

作者： seyed Amin Mousavi Morteza Bastami seyed Mehdi Zahrai School of Civil Engineering College of Engineering University of Tehran Tehran Iran International Institute of Earthquake Engineering and Seismology TehranIran Center of Excellence for Engineering and Management of Civil Infrastructures School of Civil Engineering Faculty of EngineeringUniversity of Tehran Tehran Ivan

Using controlled liquefaction, a seismic isolation technique is introduced by which a large area with dozens of structures can be seismically isolated. The proposed Large Scale Seismic Isolation （LSSI） is in many ways similar to conventional base isolations. The required bearing is provided by a fully undrained pre-saturated liquefiable layer which has substantial vertical stiffness/capacity and minimal lateral stiffness. Moreover, required energy dissipation would be provided through material damping and Biot flow-induced damping within the liquefied layer. LSSI consists of a thick non- liquefiable crust layer and an underlying engineered pre-saturated liquefiable layer bounded by two impermeable thin clay layers. The liquefiable layer should be designed to trigger liquefaction as soon as possible within the early seconds of a design level seismic event. Adopting the energy-based GMP liquefaction theory, optimum gradation of the liquefiable layer is also investigated. It tumed out that LSSI would effectively reduce acceleration response spectrum within short to medium periods. Contribution of the proposed LSSI is more pronounced in the case of stronger ground motions such as near field events as well as ground motions with longer return periods.

关键词： liquefaction seismic isolation effective stress analysis ground response analysis passive control

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Application of Game Theory in Social Science

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Sociology Study 2014年第1期4卷 85-90页

作者： saeed seyed Agha Banihashemi School of International Relations of Ministry of MOFA Iran

Game theory is a tool for making decision for all scientists which it can predict the future. So many times, not only in professional life but in private life game theory can help people to make best decision. What make this article different with other game theory article is that it has written for arts science which they are not so much fluent in maths. The object of this article is to demonstrate the possibilities of game theory as an instrument for study of social science. The approach used to describe elementary games theoretic models as an integral part of social science with a collection of example to understand subject better. This paper addresses to theoreticians and practitioners of social science not particularly versed in game theory, rather than to those who are fluent in its mathematical language and intricacies.

关键词： Game theory social science application

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