检索结果-南通市图书馆

Efficient drug and gene delivery to liver fibrosis:rationale, recent advances, and perspectives

Acta Pharmaceutica Sinica B 2020年第7期10卷 1279-1293页

作者： Somayeh Mahdinloo seyed hossein kiaie Ala Amiri Salar Hemmati Hadi Valizadeh Parvin Zakeri-Milani Faculty of Pharmacy Tabriz University of Medical ScienceTabriz ***Iran Nano Drug Delivery Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Faculty of Basic Sciences Islamic Azad UniversityScience and Research BranchTehran ***Iran Drug Applied Research Center Tabriz University of Medical SciencesTabriz ***Iran Drug Applied Research Center and Faculty of Pharmacy Tabriz University of Medical SciencesTabriz ***Iran Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy Tabriz University of Medical SciencesTabriz ***Iran

Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix,and no specific medical therapy is approved for that until *** to liver metabolic capacity for drugs,the fragility of drugs,and the presence of insurmountable physiological obstacles in the way of targeting,the development of efficient drug delivery systems for anti-fibrotics seems *** have explored articles with a different perspective on liver fibrosis over the two decades,then collected and summarized the information by providing corresponding in vitro and in vivo *** have discussed the mechanism of hepatic fibrogenesis with different ways of fibrosis induction in ***,the critical chemical and herbal anti-fibrotics,biological molecules such as micro-RNAs,siRNAs,and growth factors,which can affect cell division and differentiation,are ***,drug and gene delivery and therapeutic systems on in vitro and in vivo models are summarized in the data *** review article enlightens recent advances in emerging drugs and nanocarriers and represents perspectives on targeting strategies employed in liver fibrosis treatment.

关键词： Liver fibrosis Hepatic stellate cell Drug delivery Gene therapy Lipid nanoparticle Viral and non-viral vector Herbal anti-fibrotic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immune checkpoints in targetedi-mmunotherapy of pancreatic cancer:New hope for clinical development

引用

Acta Pharmaceutica Sinica B 2021年第5期11卷 1083-1097页

作者： seyed hossein kiaie Mohammad Javad Sanaei Masoud Heshmati Zahra Asadzadeh Iman Azimi Saleh Hadidi Reza Jafari Behzad Baradaran Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Nano Drug Delivery Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran School of Pharmacy and Pharmacology College of Health and MedicineUniversity of TasmaniaHobart 7001TasmaniaAustralia Clinical Biochemistry Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran Solid Tumor Research Center Cellular and Molecular Medicine InstituteUrmia University of Medical SciencesUrmia ***Iran Department of Immunology and Genetics School of MedicineUrmia University of Medical SciencesUrmia ***Iran

Immunotherapy has been recently considered as a promising alternative for cancer ***,targeting of immune checkpoint(ICP)strategies have shown significant success in human ***,despite remarkable success of cancer immunotherapy in pancreatic cancer(PCa),many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus *** this process,immunosuppression in the tumor microenvironment(TME)is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy *** this paper,the latest findings on the ICPs,which mediate immunosuppression in the TME have been *** addition,different approaches for targeting ICPs in the TME of PCa have been *** review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa.

关键词： Immune checkpoint Pancreatic cancer Tumor microenvironment Immunotherapy Clinical development

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Correlation of the mean activity coefficient of aqueous electrolyte solutions using an equation of state

引用

Chinese Journal of Chemical Engineering 2016年第10期24卷 1456-1463页

作者： seyed hossein Mazloumi Chemical Engineering Department Faculty of EngineeringFerdowsi University of Mashhad

Accurate calculation of thermodynamic properties of electrolyte solution is essential in the design and optimization of many processes in chemical industries. A new electrolyte equation of state is developed for aqueous electrolyte solutions. The Carnahan-Starling repulsive model and an attractive term based on square-well potential are adopted to represent the short range interaction of ionic and molecular species in the new electrolyte EOS. The long range interaction of ionic species is expressed by a simplified version of Mean Spherical Approximation theory （MSA）. The new equation of state also contains a Born term for charging free energy of ions. Three adjustable parameters of new eEOS per each electrolyte solution are size parameter, square-well potential depth and square-well potential interaction range. The new eEOS is applied for correlation of mean activity coefficient and prediction of osmotic coefficient of various strong aqueous electrolyte solutions at 25℃ and 0.1 MPa. In addition, the extension of the new eEOS for correlation of mean activity coefficient and solution density of a few aqueous electrolytes at temperature range of 0 to 100℃ is carried out.

关键词： Aqueous electrolyte solution Electrolyte equation of state Activity coefficient Osmotic coefficient Solution density

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of residual structural strain caused by the addition of Co3O4 nanoparticles on the structural, hardness and magnetic properties of an Al/Co3O4 nanocomposite produced by powder metallurgy

引用

International Journal of Minerals,Metallurgy and Materials 2020年第3期27卷 384-390页

作者： seyed Rahim Kiahosseini hossein Ahmadian Department of Engineering Damghan Branch Islamic Azad University

Al composites are of interest due to their appropriate ratio of strength to *** our research,an Al/Co3O4 nanocomposite was generated using a sintering *** powders of Al with various Co3O4 nanoparticle contents(0 wt%,0.5 wt%,1.0 wt%,1.5 wt%,2.0 wt%,and2.5 wt%)were first blended using planetary milling for 30 min,and compressed in a cylindrical steel mold with a diameter of 1 cm and a height of5 cm at a pressure of 80 *** samples were evaluated with X-ray diffractometry(XRD),scanning electron microscopy(SEM),Vickers hardness,and a vibrating sample magnetometer(VSM).Although the crystallite size of the Al particles remained constant at 7–10 nm,the accumulation of nanoparticles in the Al particle interspace increased the structural tensile strain from 0.0045 to 0.0063,the hardness from HV 28 to HV 52 and the magnetic saturation from 0.044 to 0.404 emu/g with an increase in Co3O4 nanoparticle content from 0 wt%to 2.5 wt%.

关键词： Residual strain Vickers hardness vibrating sample magnetometer scanning electron microscopy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced microstructural and mechanical properties of Stellite/WC nanocomposite on Inconel 718 deposited through vibration-assisted laser cladding

引用

International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 327-334页

作者： hossein hosseini-Tayeb seyed Mahdi Rafiaei Daneshpajoohan Pishro Higher Education Institute IsfahanIran Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayeganIsfahanIran

Stellite-21/WC nanopowders were deposited on Inconel through vibration-assisted laser cladding with different laser *** and scanning electron microscopy,hardness measurements,and wear characterizations were employed to understand the microstructural and mechanical behaviors of the *** showed that varying the cooling rate exerted remarkable effects on the microstructure of the as-cladded ***,increasing the laser power from 150 W to 250 W increased the heat input and the *** was affected by the scanning rate and powder feeding rate at a high laser power of 250 *** WC nanoparticles were added as reinforcement,the dilution magnitude intensified while the hardness value increased from HV 350 to HV *** wear characterizations indicated that the composites containing 3 wt%WC nanoparticles possessed the highest wear resistance.

关键词： Stellite WC nanoparticles mechanical properties laser cladding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computational analysis of neutronic effects of ThO_2 rods loaded in CANDU 6 fuel assemblies

引用

Nuclear Science and Techniques 2016年第4期27卷 14-20页

作者： seyed Mohammad Mirvakili Zohreh Gholamzadeh seyed Amir hossein Feghhi Reactor Research School Nuclear Science and Technology Research Institute Department of Radiation Application Shahid Beheshti UniversityG.C

Thorium as a suitable fertile with higher natural resources in comparison with uranium resources has been remarkably considered by different nuclear energy user countries in the last decades. Its prominent features such as suitable possibility for power flattening of a nuclear reactor, applicable breeder blanket to produce^(233)U fissile as well as neutron leakage prevention from a nuclear core has caused its application as power flatter, breeder material or other aimed utilizations be evaluated by the researches. In the present study, neutronics of a modeled CANDU 6loaded with Th O_2 and UO_2fuel rods have been computationally studied. The study aimed at reprocessing of burned Th O_2 seeds at CANDU 6 reactor to recover the total produced uranium, which is to be going under another compound fuel cycle. The obtained results showed all the core reactivity coefficients are sufficiently negative. The modeled core 949 GWd burn-up concluding in 99.99 %depletion of^(235)U initial loads. 18.38 kg of^(233) U was produced in the burnt Th O_2 fuel after 1-year burn-up time. In addition, 31.84 kg of^(239) Pu was produced in the UO_2 spent fuel rods after the burn-up time. After a proposed cooling time, about 50.01 kg of^(233)U will be available in the spent Th O_2 fuel.

关键词： CANDU堆中子泄漏燃料组件稳定杆计算核反应堆燃烧时间自然资源

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design feasibility of gamma camera without collimator based on specific arrangement of the detectors

引用

Nuclear Science and Techniques 2016年第4期27卷 120-126页

作者： hossein Akbari-Lalimi seyed Ali Shafiei Geriatric Care Research Center Rafsanjan University of Medical Sciences Department of Medical Physics Mashhad University of Medical Sciences Department of Physiology and Pharmacology School of Medicine Qom University of Medical Sciences

In gamma camera and single-photon emission computerized tomography, the collimator removes most photons. Here, a gamma camera without collimator utilizes a specific arrangement of detectors. Instead of bending beams(like a lens) or directing beams(by parallel hole collimator), changes are created in detectors' field of view(FOV), so that each detector's FOV looks different from others. Simulation proved this theory, with 98 detectors(2 cm 9 1.41 cm) arranged in a zigzag manner for Monte Carlo simulation. A radioactive source with energy of140 ke V was situated on the detectors' faces. Sixty projections, each 3(0 –179) apart, were simulated by Monte Carlo N-Particle(MCNP) 4C code, rotating detectors around a radioactive point. The band containing the radioactive source is clearly visible in each *** obtained after simulation in different projections were reconstructed, and point source location emerged correctly. Simulation of gamma camera with zigzag arrangement of detectors and MCNP-4C code demonstrated that one could string the space and determine radioactive source by image reconstruction without using collimators, solely through these special detectors' distribution.

关键词：探测器准直器 γ相机蒙特卡洛模拟计算机断层扫描单光子发射设计布置

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multidisciplinary design optimization of a dual-spin guided vehicle

引用

Defence Technology（防务技术） 2024年第7期37卷 133-148页

作者： Jalal Karimi Mohammad Reza Rajabi seyed hossein Sadati seyed Mahid hosseini Department of Aerospace Engineering Malek Ashtar University of TechnologyTehranIran

In this research,a Multidisciplinary Design Optimization approach is proposed for the dual-spin guided flying projectile design considering external and internal parts of the body as design *** this way,a parametric formulation is *** related disciplines,including structure,aerodynamics,guidance,and control are *** total mass,maximum aerodynamic control effectiveness,minimum miss distance,maximum yield stress in all subsystems,controllability and gyroscopic stability constraints are some of objectives/constraints taken into *** problem is formulated in All-At-Ones Multidisciplinary Design Optimization approach structure and solved by Simulated Annealing and minimax *** optimal configurations are evaluated in various *** resulted optimal configurations have met all design objectives and constraints.

关键词： Flying projectile optimal design All-at-ones multidisciplinary optimization Structure discipline Guidance and control discipline Aerodynamic discipline

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Energy efficiency of small buildings with smart cooling system in the summer

引用

Frontiers in Energy 2022年第4期16卷 651-660页

作者： Yazdan DANESHVAR Majid SABZEHPARVAR seyed Amir hossein HASHEMI Department of Civil Engineering Qazvin BranchIslamic Azad UniversityQazvin 314199-15195Iran Department of Industrial Engineering Collage of EngineeringKaraj BranchIslamic Azad UniversityKaraj 31499-68111Iran

In this paper,a novel cooling control strategy as part of the smart energy system that can balance thermal comfort against building energy consumption by using the sensing and machine programming technology was *** this goal,a general form of a building was coupled by the smart cooling system(SCS)and the consumption of energy with thermal comfort cooling of persons simulated by using the EnergyPlus software and compared with similar buildings without *** the beginning of the research,using the data from a survey in a randomly selected group of hundreds and by analyzing and verifying the results of the specific relationship between the different groups of people in the statistical society,the body mass index(BMI)and their thermal comfort temperature were obtained,and the sample building was modeled using the EnergyPlus *** result show that if an intelligent ventilation system that can calculate the thermal comfort temperature was used in accordance with the BMI of persons,it can save up to 35%of the cooling load of the building yearly.

关键词： smart home heating and cooling systems saving energy optimal consumption of energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Simulation of the Mechanical Properties of Sintered and Bonded Perforated Hollow Sphere Structures (PHSS)

引用

Journal of Materials Science & Technology 2010年第8期26卷 730-736页

作者： Andreas chsner seyed Mohammad hossein hosseini Markus Merkel Department of Applied Mechanics Technical University of Malaysia Centre for Mass and Mechanical Transport in Engineering Materials The University of Newcastle CallaghanNewSouth Wales 2308Australia Department of Mechanical Engineering University of Applied Sciences Aalen

This paper investigated the uniaxial mechanical properties of a new type of hollow sphere structures. For this new type, the sphere shell was perforated by several holes in order to open the inner sphere volume and surface. The mechanical properties, i.e. elastic properties and initial yield stress of perforated hollow sphere structures （PHSS） in a primitive cubic arrangement were numerically evaluated for different hole diameters and different joining techniques of the hollow spheres. The results are compared to classical configurations without perforation.

关键词： Mechanical properties Cellular material Porous structure Finite element method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：