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<i>In vitro</i>analysis of T cell responses induced by breast tumor cell lysate pulsed with autologous dendritic cells

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Advances in Bioscience and Biotechnology 2012年第2期3卷 126-136页

作者： Nowruz Delirezh seyed Mohammad Moazzeni Fazel Shokri Mohammad ali Shokrgozar Morteza Morteza Atri Hamid Karbassian Cancer Institute Imam Hospital Tehran University of Medical Science Tehran Iran Department of Cellular and Molecular Institute of Biotechnology Urmia University Urmia Iran Department of Immunology School of Health Tehran University of Medical Science Tehran Iran Department of Immunology School of Medical Science Trabiat Modares University Tehran Iran Department of Surgery Athieh Hospital Tehran Iran National Cell Bank of Iran Pasteur Institute of Iran Tehran Iran

In this In vitro study, T cell responses induced by breast tumor cell lysate pulsed monocyte-derived DCs were analyzed in terms of proliferation, specific cytotoxicity and cytokine-release in order to use in immunotherapeutic settings. Nylon wool enriched T lymphocytes from 5 patients with breast cancer stimulated In vitro with tumor cell lysate pulsed monocyte-derived DCs and their proliferation response were analyzed by [3H] thymidine uptake test. Specific cytotoxic activity of tumor antigen primed T cells after three rounds weekly stimulation was evaluated by flow cytometry, and interferon-γ (IFN-γ) and interleukin-4 (IL-4) cytokines release assay was carried out 24 hours after last stimulation in the supernatant of primed T cells using commercially available ELI-SA kits. T cell proliferation assay revealed that tumor cell lysate pulsed DCs could stimulate autologous T cell proliferation response with stimulation indices 4.9 - 30. T cell mediated cytotoxicity assay demonstrated that tumor antigen primed T cells could significantly kill autologous tumor cells more than normal cells (P γ and IL-4 in response to restimulation by antigen pulsed DCs which were dominated by IFN-γ production in 2 and IL-4 production in 3 out of 5 patients. Our result suggested that breast tumor antigen pulsed DCs could elicit effective specific antitumor T cell responses In vitro, therefore, tumor antigen pulsed DC vaccination may be considered as a novel strategy for immunotherapy of patients with breast cancer refractory to standard modalities.

关键词： Breast Lysate Dendritic Cells T Cell

Benthic Foraminiferal and Calcareous Algae Assemblages in the Tirgan Formation (Urgonien Facies Type) in South Flank of Ghorogh Syncline (North of Chenaran), NE Iran

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Open Journal of Geology 2017年第6期7卷 796-805页

作者： Hoda Yavarmanesh seyed Hamid Vaziri ali Asghar Aryaei Davood Jahani Mohsen Pourkermani Ebrahim Khademi Bouriabadi Department of Geology North Tehran Branch Islamic Azad University Tehran Iran Department of Geology Mashhad Branch Islamic Azad University Mashhad Iran Department of Geology University of Tehran Tehran Iran

In this research, the Tirgan Formation in the south flank of Ghorogh Syncline (north of Chenaran), northeastern Iran with the thickness of 251 was studied. This section consists of limestone, marly limestone and shale with impressions of echinoderms toxasteridae family, many of foraminifera from orbitolinidae family and also lots of calcareous algae that create facies variation along with other non-skeletal allochems. Micropaleontological investigation has been carried out on 90 thin-sections. These criteria reveal that an equivalent of the Urgonian facies type (in France-Swiss area) and open marine, low depth sedimentary basin are extended in the Kopet-Dagh basin. In this article, we tried to introduce some of the important foraminiferal and calcareous algal assemblages of this area.

关键词： Tirgan Formation Ghorogh Syncline Foraminifera Calcareous Algae

The efficacy of a first aid training course for drivers： an experience from northern Iran

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Chinese Journal of Traumatology 2014年第5期17卷 289-292页

作者： Mohammad ali Vakili ali Mohjervatan seyed Taghi Heydari Armin Akbarzadeh Nazanin Sadat Hosini Farideh alizad Peyman Arasteh Mohammad Javad Moghasemi Health Management and Social Development Research Center Golestan University of Medical Sciences Gorgan Iran Researcher Center for Disaster Management and Emergency Medicine Golestan University of Medical Sciences Gorgan Iran Research Center for Social Determinants of Health Jahrom University of Medical Sciences Jahrom Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran

Objective：To evaluate the efficacy of a first aid training course for a group of ***：This study comprised 500 drivers,randomly selected from the road transport *** underwent a course of first aid training and the results were evaluated at 0-3 and 4-6 months after ***：Both quantitative and qualitative improvements were observed in the drivers＇ efficacy in giving first *** the rate of correct interventions was higher at 4-6 months than at 0-3 *** exception was airway management which was not favorably improved after ***：The first aid training course for drivers is beneficial and helpful for prehospital care system in road traffic accidents.

关键词： Drive First aid training Iran

Isolation and pathogenicity identification of avian paramyxovirus type 1 （Newcastle disease） virus from a flock of ostriches in Iran

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Isolation and pathogenicity identification of avian paramyxo...

Species Spectrum of <I>Nocardia</I>spp. Isolated from Suspected Tuberculosis Patients

The 15th World Veterinary Poultry Congress

作者： Reza Momayez Pouya Gharakhani seyed ali Pourbakhsh Reza Toroghi Mansour Banani Avian diseases diagnosis and research Razi institute/KarajIran. Azad University of Kraj School of Veterinary Medicine/KarajIran Avian diseases diagnosis and research Razi institute/KarajIran. Avian diseases diagnosis and research Razi institute/KarajIran. Avian diseases diagnosis and research Razi institute/KarajIran.

＜正＞Newcastle disease virus（NDV）was isolated and identified for the first time from a flock of ostriches sus- pected to ND in *** the flock aged 4 months,some of the ostriches died from the *** main clini- cal sig...

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Health 2015年第7期7卷 847-858页

作者： Abdolrazagh Hashemi-Shahraki Saeed Zaker Bostanabad Parvin Heidarieh Nasrin Sheikhi Maryam Biranvand seyed Mohammad Alavi Leonid Petrovich Titov Azar Dokht Khosravi seyed ali Nojoumi Health Research Institute Infectious and Tropical Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Microbiology Department Islamic Azad University-Parand Branch Tehran Iran Department of Microbiology School of Medicine Alborz University of Medical Sciences Alborz Iran Microbiology Unit Masoud Laboratory Tehran Iran The Republican Research and Practical Center for Epidemiology and Microbiology Minsk City Belarus Microbiology Unit Pasteur Institute of Iran Tehran Iran

Traditionally Nocardia asteroids was considered the predominant species of causing no-cardiosis. The improved identification of isolates using molecular techniques have shown that the genus exhibits considerable taxonomic complexity and phenotypic base identification can be ambiguous. The aim of this study was to assess the species distribution of Nocardia strains mostly recovered from patients suspected of having tuberculosis, during three years period (2009-2012). The clinical isolates were identified to species level using conventional tests and genotypic methods using single and multi locus sequence analysis (MLSA) of 16S rRNA, gyrB and secA1 genes. Nocardiosis was diagnosed in 46 patients. The most frequent underlying condition were organ transplantation (6 patients;13%), cancer (6 patients;13%), human immunodeficiency virus (HIV) (6 patients;13%), non-infectious chronic lung disease (5 patients;10.8%) and tuberculosis (4 patients;8.7%). Nocardia species was recovered from 46 different clinical specimens, the most common of which was bronchoalveolar lavage (BAL) (43.5%). Eleven different Nocardia species were identified: N. asteroides (n = 12), N. cyriacigeorgica (n = 9), N. farcinica (n = 7), N. wallacei (n = 6), N. carnea (n = 3), N. otitidiscaviarum (n = 3), N. abscessus (n = 1), N. arthritidis (n = 1), N. kruczakiae (n = 1), N. nova (n = 2) and N. veterana (n = 1). In conclusion, infection caused by Nocardia species appears to be more common than generally appreciated. The current study provides further evidence that Nocardia species are capable of causing a wide range of human diseases in healthy and immunocompromised patients. MLSA is a reliable method for accurate species identification of Nocardia isolates and would be more feasible for routine use in clinical laboratories.

关键词： Nocardia Infection Identification MLSA

Comparison of Established Risk Factors among Type 2 Diabetic Patients with or without Retinopathy in Golestan Hospital, Ahvaz 2010

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Open Journal of Endocrine and Metabolic Diseases 2014年第10期4卷 225-229页

作者： Homeira Rashidi ali Kasiri seyed Mahmoud Latifi Ferdos Zaman Hajieh Shahbazian Armaghan Moravej Aleali Health Research Institute Diabetes Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

The aim of this study was to establish diabetic retinopathy correlation with several risk factors. A prospective study including 256 type II diabetic patients who referred to diabetes’s clinic was designed. All patients underwent physical & retina examination and then completed questionnaire including duration of DM, cardiovascular disease, stroke, chronic kidney disease, smoking, and kind of treatment, blood pressure, BMI, abdominal & hip circumference. Results of HbA1C, total cholesterol, HDL & LDL cholesterol, TG, FBS, creatinine, 24-h urine microalbumin were recorded. Data were analyzed by SPSS version 17 with K2, independent samples T, and logistic regression. Of 256 types II diabetic patients 81 & 175 were men and women respectively. Mean age of subject was 54 ± 10.27. Prevalence of diabetic retinopathy was 22.3% & macula edema 0.5% & PDR 6% & NPDR 14%;diabetic retinopathy was associated with duration of DM & BMI (P = 0, P = 0.43 respectively). Mean of FBS 191 ± 83 vs. 165.7 ± 74.5 (P = 0.03), HbA1c 9.1 ± 2 vs. 8.5 ± 1.9 (P = 0.02), 24-h urine microalbumin 181.2 ± 404.7 vs. 60.2 ± 236 (P = 0.03), Systolic blood pressure 124.3 ± 21.3 vs. 118.5 ± 17.8 (p = 0.04) differed between diabetic patients with or without diabetic retinopathy. There were no significant difference between subject with & without diabetic retinopathy in total cholesterol LDL, HDL, TG, Cr, Diastolic BP, types of treatment, cardiovascular disease, chronic kidney disease, stroke & smoking. This study showed prevalence of diabetic retinopathy was high and it associated with duration of DM, BMI, FBS, HbA1C, 24-h urine albumin, and systolic blood pressure.

关键词： Diabetic Retinopathy Type II DM Retinopathy Risk Factors

Evaluation of Insulin Resistance Indices in Type 2 Diabetic Patients Treated with Different Anti-Diabetic Drugs

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Open Journal of Endocrine and Metabolic Diseases 2016年第2期6卷 95-101页

作者： Mohammad-ali Ghaffari seyedeh-Arefeh Payami seyed-Peyman Payami Damoon Ashtary-Larky Abdolrahim Nikzamir Ghorban Mohammadzadeh Cellular and Molecular Research Center Department of Clinical Biochemistry School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Clinical Biochemistry School of Medicine Ahvaz Jundishapour University of Medical Science Ahvaz Iran Health Research Institute Diabetes Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Clinical Biochemistry School of Medicine Shahid Beheshti University of Medical Science Tehran Iran Hyperlipidemia Research Center Department of Clinical Biochemistry Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

Clinically, determination of insulin resistance is important for diabetic patients. We evaluated the relationship among 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices in type 2 diabetic patients. The study included 40 patients with type 2 diabetes. Patients divided into three groups based on their medication: metformin, metformin + glibenclamide and metformin + glitazone. Fasting blood sugar, and lipid profile were measured by enzymatic method, serum insulin, and C-peptide were measured by ELISA method. Insulin resistance was calculated by using of 20/(fasting C-peptide × fasting plasma glucose), HOMA-IR and QUICKI indices. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index and other parameters in all studied groups except QUICKI in metformin group showed a significant correlation with 20/(fasting C-peptide × fasting plasma glucose) index (r = 0.56 and p = 0.03). There was a significant correlation between HOMA-IR and QUICKI indices in all studied groups. There was no significant relationship between 20/(fasting C-peptide × fasting plasma glucose) index with other clinical parameters. On the other hand, our data strongly suggested a significant correlation between HOMA-IR and QUICKI indices in studied subjects with type 2 diabetes.

关键词： Type 2 Diabetes Insulin Resistance HOMA-IR QUICKI 20/(Fasting C-Peptide × Fasting Plasma Glucose)

Evaluation of Ecological Capability of Amygdalus Scoparia Habitat Condition in Bolhasan Dezfol of Iran Zone by Using of MCDA Method

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Evaluation of Ecological Capability of Amygdalus Scoparia Ha...

Pattern of injury in Shiraz

International Conference on Environmental Engineering and Applications（ICEEA 2011）

作者： seyed ali Jozi Nasrin Moradi Majd Sahar Rezaian Nona Jesmani Tafti Islamic Azad University Department of Environment North Tehran Branch Tehran Iran Department of Environment Islamic Azad UniversityScience and Research Branch-Khuzestan Ahwaz Iran Islamic Azad University Department of Environment Shahrood BranchShahrood Iran

Bolhasan forest region with 5725 hectare area lies in east north of the *** region belongs to natural forests in *** regard of the fact that the area is mainly arrested by valuable species of Amygdalus Scopartia,it is imperative to consider principled exploitation,development and revival *** identify ecological needs to provide questionnaire Delphi method were 64 and natural resources experts and university *** this study,37 criteria defined 27 criteria were selected as the definitive *** evaluation of the conditions in the region was fulfilled by weighing the criteria with Analysis Hierarchy Process（AHP） in the Expert Choice soft *** this research,evaluation of the criteria,by AHP and geographic data setting was followed by display of ecological power status by means of such method and transfer of the inputs on the *** of the research indicate that about 599 hectare [35.59 percent] of Bolhasan forest region is in high,471 hectare [27.97 percent] in good and 614 hectare [26.44 percent] in weak situation.

关键词： Evaluation Amygdalus Scopartia ecological power Analysis Hierarchy Process city of Dezful Bolhasan region of Iran

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Chinese Journal of Traumatology 2008年第1期11卷 8-12页

作者： Ahmad-Reza Soroush Shahram Ghahri-Saremi Mehdi Rambod seyed-ali Malek-Hosseini Saman Nick-Eghbal ali Khaji Department of Surgery Shariati General Hospital Tehran University of Medical Sciences Tehran 14114 Iran Obesity Research Center Research Institute for Endocrine Sciences Shaheed Beheshti University of Medical Sciences Tehran 14114 Iran Department of Surgery Nemazi General Hospital Shiraz University of Medical Sciences Shiraz 71937 Iran Sina Trauma Research Center Sina General Hospital Tehran University of Medical Sciences Tehran 11364 Iran

Objective： Injury is a major neglected health problem in developing countries. The first step in dealing with injury problem is to identify the injury patterns and characteristics. Therefore, we aimed to demonstrate the current status of trauma admissions to hospitals in Shiraz, as a major city of Iran. Methods： A hospital-based study was conducted in 2002. All injured patients admitted during 6 months in emergency departments of two general hospitals of Shiraz, Nemazi and Chamran were included. Results： A total of 1 765 injured patients were registered during the study period, with mean age of 33 years. Manual workers were the most vulnerable group among occupational categories. Inner-city roads were the most common place of injury and traffic accident was the major cause of injury. Overally, falling injury was the second common cause of injury in males and the first cause in females （ especially at the age of over 60）. Conclusion： As other studies conducted in our society, traffic accidents are the major cause of morbidity and mortality and this can emphasize on the obligation to take legislative action in the field of driving and road safety, directing resources and educating the public and raising the awareness of the community in prevention of this iceberg-like problem.

关键词： Trauma Iran Traffic accident Shiraz