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Exenatide promotes regeneration of injured rat sciatic nerve

Neural Regeneration Research 2017年第4期12卷 637-643页

作者： Ersin Kuyucu Bilal Gumus Oytun Erbas Fatih Oltulu arslan Bora Department of Orthopedics and Traumatology Faculty of Medicine Istanbul Medipol University Istanbul Turkey Orthopedics Clinic Antalya State Hospital Antalya Turkey Department of Physiology Ege University Faculty of Medicine Izmir Turkey Department of Histology Clinic Ege University Faculty of Medicine Izmir Turkey Department of Orthopedics and Traumatology Izmir Ataturk Training and Educational Research Hospital Izmir Turkey

Damage to peripheral nerves results in partial or complete dysfunction. After peripheral nerve injuries, a full functional recovery usually cannot be achieved despite the standard surgical repairs. Neurotrophic factors and growth factors stimulate axonal growth and support the viability of nerve cells. The objective of this study is to investigate the neurotrophic effect of exenatide （glucagon like peptide-1 analog） in a rat sciatic nerve neurotmesis model. We injected 10 [ag/d exenatide for 12 weeks in the experimental group （n = 12） and 0.1 mL/d saline for 12 weeks in the control group （n = 12）. We evaluated nerve regeneration by conducting electrophysiological and motor functional tests. Histological changes were evaluated at weeks 1, 3, 6, and 9. Nerve regeneration was monitored using stereomicroscopy. The electrophysiological and motor functions in rats treated with exenatide were improved at 12 weeks after surgery. Histological examination revealed a significant increase in the number of axons in injured sciatic nerve following exenatide treatment confirmed by stereomicroscopy. In an experimentally induced neurotmesis model in rats, exenatide had a positive effect on nerve regeneration evidenced by electromyography, functional motor tests, histological and stereomicroscopic findings.

关键词： nerve regeneration sciatic nerve glucagon like peptid 1 electromyography stereomicroscopy histology neural regeneration

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Magnetic resonance imaging evaluation of head and neck involvement in IgG4-related disease

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Asian Pacific Journal of Tropical Medicine 2023年第6期16卷 276-283页

作者： Umur Anil Pehlivan Kamil Karaali Hatice Deniz Ilhan Mehmet Soy Didem arslan Omer Kaya Rabia Miray Kisla-Ekinci Burcak Cakir-Pekoz Ummuhan Cay Arbil Acikalin Ahmet Muhtesem Agildere Department of Radiology Başkent University Adana Dr.Turgut Noyan Application and Research CenterAdanaTurkey Department of Radiology Akdeniz University Faculty of MedicineAntalyaTurkey Department of Ophthalmology Akdeniz University Faculty of MedicineAntalyaTurkey Department of Internal Medicine and Rheumatology Bahçelievler Medical ParkAltınbaşUniversity Faculty of MedicineİstanbulTurkey Department of Internal Medicine and Rheumatology Çukurova University Faculty of MedicineAdanaTurkey Department of Radiology Çukurova University Faculty of MedicineAdanaTurkey Department of Pediatric Rheumatology Adana City Training and Research HospitalAdanaTurkey Department of Radiology Adana City Training and Research HospitalAdanaTurkey Department of Pediatric Infectious Disease Çukurova University Faculty of MedicineAdanaTurkey Department of Pathology Çukurova University Faculty of MedicineAdanaTurkey Department of Radiology Başkent University Faculty of MedicineAnkaraTurkey

Objective:To evaluate the radiological features of IgG4-related disease(IgG4-RD)in the head and neck ***:In this radiology-based study,radiological features,clinical,laboratory,pathological findings,and prognosis of nine patients with head and neck involvement diagnosed with IgG4-RD were investigated ***:The median age of the patients was 38 years(range:2.5-79 years),and there were six males and three *** most common symptoms and clinical findings of the patients were eyelid and lacrimal gland swelling,painless exophthalmos,and *** most common site of involvement on MRI was the *** involvement was followed by branches of the trigeminal nerve,sinonasal cavity,cervical lymph nodes,and dural *** most common and remarkable imaging features were T2 hypointensity and diffuse homogeneous contrast ***:Head and neck involvement of the IgG4-RD,has specific imaging features that can help with ***,early diagnosis and better outcomes can be achieved with increasing awareness of these features of this relatively new pathology.

关键词： IgG4 Head and neck imaging Magnetic resonance imaging Orbit Perineural spreading

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SPSSNet: a real-time network for image semantic segmentation

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Frontiers of Information Technology & Electronic Engineering 2020年第12期21卷 1770-1782页

作者： Saqib MAMOON Muhammad arslan MANZOOR Fa-en ZHANG Zakir ALI Jian-feng LU School of Computer Science and Engineering Nanjing University of Science&TechnologyNanjing 210094China Alnnovation Beijing 100080China

Although deep neural networks(DNNs)have achieved great success in semantic segmentation tasks,it is still challenging for real-time applications.A large number of feature channels,parameters,and floating-point operations make the network sluggish and computationally heavy,which is not desirable for real-time tasks such as robotics and autonomous *** approaches,however,usually sacrifice spatial resolution to achieve inference speed in real time,resulting in poor *** this paper,we propose a light-weight stage-pooling semantic segmentation network(SPSSN),which can efficiently reuse the paramount features from early layers at multiple stages,at different spatial *** takes input of full resolution 2048×1024 pixels,uses only 1.42×10~6 parameters,yields 69.4%m Io U accuracy without pre-training,and obtains an inference speed of 59 frames/s on the Cityscapes *** can run directly on mobile devices in real time,due to its light-weight *** demonstrate the effectiveness of the proposed network,we compare our results with those of state-of-the-art networks.

关键词： Real-time semantic segmentation Stage-pooling Feature reuse

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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

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International Journal of Oral Science 2013年第2期5卷 92-97页

作者： Abdullah Seckin Ertugrul Ugur arslan Recep Dursun Sema Sezgin Hakki Department of Periodontology Faculty of DentistryYuzuncu Yil University Department of Microbiology Selcuklu Medical FacultySelcuk University Department of Dermatology Baskent Research Hospital Department of Periodontology Faculty of DentistrySelcuk University

Oral lichen planus （OLP） is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms （Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 （18 chronic periodontitis （OLPP） and 9 gingivitis （OLPG）） patients diagnosed with OLP along with 26 （13 chronic periodontitis （HP） and 13 gingivitis （HG）） healthy non-OLP patients. The multiplex polymerase chain reaction （PCR）with subsequent reverse hybridization method （micro-IDent） was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients （OLPG and OLPP） were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients （HG and HP）, these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens＇ percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathoRenic microorganisms in the progress of periodontal diseases of OLP.

关键词： Aggregatibacter actinomycetemcomitans oral lichen planus Porphyromonas gingivalis Prevotel/a intermedia Tannerel/a forsythia Treponema denticola

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Joint Non-Orthogonal Multiple Access (NOMA) & Walsh-Hadamard Transform: Enhancing the Receiver Performance

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China Communications 2018年第9期15卷 160-177页

作者： Muhammad Rehan Usman Arsla Khan Muhammad arslan Usman Soo young Shin Department of Electrical Engineering The Superior College (University Campus) Department of IT Convergence Engineering Kumoh National Institute of Technology (KIT) Department of Electrical Engineering COMSATS University Islamabad Lahore Campus

Non-orthogonal multiple access(NOMA) is a new access method to achieve high performance gains in terms of capacity and throughput, so it is currently under consideration as one of the candidates for fifth generation(5 G) technologies. NOMA utilizes power domain in order to superimpose signals of multiple users in a single transmitted signal. This creates a lot of interference at the receive side. Although the use of successive interference cancellation(SIC) technique reduces the interference, but to further improve the receiver performance, in this paper, we have proposed a joint Walsh-Hadamard transform(WHT) and NOMA approach for achieving better performance gains than the conventional NOMA. WHT is a well-known code used in communication systems and is used as an orthogonal variable spreading factor(OVSF) in communication systems. Application of WHT to NOMA results in low bit error rate(BER) and high throughput performance for both low and high channel gain users. Further, it also reduces peak to average power ratio(PAPR) of the user signal. The results are discussed in terms of comparison between the conventionalNOMA and the proposed technique, which shows that it offers high performance gains in terms of low BER at different SNR levels, reduced PAPR, high user throughput performance and better spectral efficiency.

关键词：存取方法接收装置多重直角表演连接产量性能通讯系统

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Importance of antimicrobial susceptibility testing for the management of eradication in Helicobacter pylori infection

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World Journal of Gastroenterology 2017年第16期23卷 2854-2869页

作者： Nazli arslan ozlem Yilmaz Ebru Demiray-Gürbüz Department of Medical Microbiology Faculty of MedicineDokuz Eylül UniversityInciraltiIzmir 35340Turkey

The management of Helicobacter pylori(H. pylori) infection treatment differs from the common treatment protocol for other infectious diseases. Because culture-or molecular-guided approaches face several practical issues, such as the invasive procedures required to obtain gastric biopsy specimens and the lack of availability of routine laboratory testing in some places, H. pylori treatment includes the administration of two or three empirically selected antibiotics combined with a proton pump inhibitor rather than evidence-based eradication treatment. The efficacy of empirical therapy is decreasing, mostly due to increasing multiple resistance. Multiresistance to levofloxacin, clarithromycin, and metronidazole, which are commonly used in empirical treatments, appears to have increased in many countries. Mutations play a primary role in the antimicrobial resistance of H. pylori, but many different mechanisms can be involved in the development of antibiotic resistance. Determining and understanding these possible mechanisms might allow the development of new methods for the detection of H. pylori and the determination of antimicrobial resistance. A treatment based on the detection of antimicrobial resistance is usually more effective than empirical treatment. Nevertheless, such an approach before treatment is still not recommended in the Maastricht guidelines due to the difficulty associated with the routine application of available cultureor molecular-based susceptibility tests, which are usually administered in cases of treatment failure. The management of first and rescue treatments requires further research due to the steadily increase in antimicrobial resistance.

关键词： Helicobacter pylori Antimicrobial resistance Antimicrobial susceptibility testing Susceptibility-guided therapy Treatment management

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A case of Aerococcus urinae septicemia: an unusual presentation and severe disease course

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Chinese Medical Journal 2005年第15期118卷 1318-1320页

作者： Kivanc Serefhanoglu Hale Turan Rafi Dogan Hakan Gullu Hande arslan Department of Infectious Diseases and Clinical Microbiology Konya Medical Research and Teaching Center Baskent University Selcuklu/KONYA TR-42080 TurkeyDepartment of Infectious Diseases and Clinical Microbiology Konya Medical Research and Teaching Center Baskent University Selcuklu/KONYA TR-42080 TurkeyDepartment of Anesthesiology and Reanimation Konya Medical Research and Teaching Center Baskent University Selcuklu/KONYA TR-42080 Turkey Department of Cardiology Konya Medical Research and Teaching Center Baskent University Selcuklu/KONYA TR-42080 Turkey Department of Infectious Diseases and Clinical Microbiology Baskent University Bahcelievler/ANKARA Turkey

Aerococcus urinae （A. urinae ）, a catalasenegative, Gram-positive coccus, is a newlyemerged pathogen in clinical and microbiological practice, which was first reported in 1989 and designated in 1992. Most infections occur in the urinary tract, especially in elderly with local or systemic predisposing conditions such as diabetes mellitus, malignancy, urethral stricture or prostate hyperplasia.

关键词： A. urinae leucopoenia fatal disease course

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Investigation of performance and emission characteristics of waste cooking oil as biodiesel in a diesel engine

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Petroleum Science 2018年第2期15卷 396-404页

作者： Yahya Ulusoy Rldvan arslan Yucel Tekin Ali Surmen Alper Bolat Remzi Sahin Department of Agricultural Machinery/Automotive Technology Uludag UniversityBursaTurkey Department of Automotive Engineering Uludag UniversityBursaTurkey Turk Traktor ve Ziraat Makineleri Co. AnkaraTurkey Department of Mechanical Engineering KTO Karatay UniversityKonyaTurkey

Biodiesel is one of the most popular prospective alternative fuels and can be obtained from a variety of sources. Waste frying oil is one such source along with the various raw vegetable oils. However, some specific technical treatments are required to improve certain fuel properties such as viscosity and calorific value of the biodiesel being obtained from waste cooking oil methyl ester （WCOME）. Various treatments are applied depending on the source and therefore the composition of the cooking oil. This research investigated the performance of WCOME as an alternative biofuel in a four-stroke direct injection diesel engine. An 8-mode test was undertaken with diesel fuel and five WCOME blends. The best compromise blend in terms of performance and emissions was identified. Results showed that energy utilization factors of the blends were similar within the range of the operational parameters （speed, load and WCOME content）. Increasing biodiesel content produced slightly more smoke and NOx for a great majority of test points, while the CO and THC emissions were lower.

关键词： Waste cooking oil Methyl ester Biodiesel Alternative fuels Vehicle emissions

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Petrogenesis of the late Cretaceous Turnagol intrusion in the eastern Pontides:Implications for magma genesis in the arc setting

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Geoscience Frontiers 2013年第4期4卷 423-438页

作者： Abdullah Kaygusuz Ferkan Sipahi Nurdane Ilbeyli Mehmet arslan Bin Chen Emre Aydincakir Department of Geological Engineering.Gumushane University Department of Geological Engineering Akdeniz University Department of Geological Engineering.Karadeniz Technical University Department of Geological Engineering.Peking University

A series of Cretaceous plutons is present in the eastern Pontides of northeastern Turkey. The Turnag61 intrusion is the least studied and, thus, the least understood plutons in the orogen. This intrusion consists of hornblende-biotite granodiorites emplaced at 78 Ma based on LA-ICP-MS U-Pb zircon dating. It is of sub- alkaline affinity, belongs to the medium- to high-K calc-alkaline series, and displays features typical of I- type granites. The rocks of the intrusion are enriched in large-ion lithophile elements and light rare earth- elements with negative Eu anomalies （EuJEu＊ = 0.69-0.82）, but are deficient in high-field-strength elements. They have a small range of （87Sr/S6Sr）i （0.7060 0.7063）, ENd （-2.6 to 3.1）, and 6180 （＋8.1 to ＋9.1） values. Their Pb isotopic ratios are 206pb/204pb = 18.63-18.65, ＇207Tpb/204pb = 15.62-15.63, and 208pb/204pb 38.53-38.55. The fractionation of plagioclase, hornblende, and Fe-Ti oxides had key functions in the evolution of the Turnag61 intrusion. The crystallization temperatures of the melts ranged from 758 to 885 ℃ as determined by zircon and apatite saturation thermometry. All these characteristics, combined with the low values of K20/Na20 and （Na20 ＋ K20）/（FeOt ＋ MgO ＋ TiO2）, as well as the high values of （CaO ＋ FeOt ＋ MgO ＋ TiO2）, suggest an origin by dehydration melting from a metabasaltic lower crustal source.

关键词： Turnagl intrusion Late Cretaceous Sr-Nd-Pb-O isotope U-Pb zircon dating Eastern Pontides Turkey

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Collision Observation-Based Optimization of Low-Power and Lossy IoT Network Using Reinforcement Learning

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Computers, Materials & Continua 2021年第4期67卷 799-814页

作者： arslan Musaddiq Rashid Ali Jin-Ghoo Choi Byung-Seo Kim Sung-Won Kim Department of Information and Communication Engineering Yeungnam UniversityGyeongsan-si8541South Korea School of Intelligent Mechatronics Engineering Sejong UniversitySeoul05006South Korea Department of Software and Communications Engineering Hongik UniversitySeoul30016South Korea

The Internet of Things(IoT)has numerous applications in every domain,e.g.,smart cities to provide intelligent services to sustainable *** next-generation of IoT networks is expected to be densely deployed in a resource-constrained and lossy *** densely deployed nodes producing radically heterogeneous traffic pattern causes congestion and collision in the *** the medium access control(MAC)layer,mitigating channel collision is still one of the main challenges of future IoT ***,the standardized network layer uses a ranking mechanism based on hop-counts and expected transmission counts(ETX),which often does not adapt to the dynamic and lossy environment and impact *** ranking mechanism also requires large control overheads to update rank *** resource-constrained IoT devices operating in a low-power and lossy network(LLN)environment need an efficient solution to handle these *** learning(RL)algorithms like Q-learning are recently utilized to solve learning problems in LLNs devices like ***,in this paper,an RL-based optimization of dense LLN IoT devices with heavy heterogeneous traffic is *** proposed protocol learns the collision information from the MAC layer and makes an intelligent decision at the network *** proposed protocol also enhances the operation of the trickle timer algorithm.A Q-learning model is employed to adaptively learn the channel collision probability and network layer ranking states with accumulated reward *** on a simulation using Contiki 3.0 Cooja,the proposed intelligent scheme achieves a lower packet loss ratio,improves throughput,produces lower control overheads,and consumes less energy than other state-of-the-art mechanisms.

关键词： Internet of Things RPL MAC protocols reinforcement learning Q-learning

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