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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： Jian-bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan Zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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载荷数据和对日导引律修正星敏安装矩阵算法

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航空学报 2024年第13期45卷 322-334页

作者：陈炳龙王磊刘帮周衡中国科学院微小卫星创新研究院上海201306

先进天基太阳天文台卫星(ASO-S)主要任务是对日观测。为实现高精度高稳定度需求,卫星采用星敏感器(STR)和光纤陀螺的扩展卡尔曼滤波算法进行姿态确定。在轨因受到地气光影响,卫星装配的3台STR交替有效。为了减弱装配测量偏差引起定姿使... 详细信息

先进天基太阳天文台卫星(ASO-S)主要任务是对日观测。为实现高精度高稳定度需求,卫星采用星敏感器(STR)和光纤陀螺的扩展卡尔曼滤波算法进行姿态确定。在轨因受到地气光影响,卫星装配的3台STR交替有效。为了减弱装配测量偏差引起定姿使用星敏切换时的姿态指向控制误差,需统一3台STR的测量基准。同时,修正STR相对载荷测量基准的偏差,提高卫星对日指向控制精度。ASO-S载荷之一的白光太阳望远镜(WST)入轨后即可开机测量太阳全日面图像,经图像处理后得到太阳中心二维指向偏差角。同时,另一载荷太阳导行镜(SGT)可直接测量太阳中心二维指向偏差角。结合载荷对日观测数据和卫星对日指向控制导引律,提出一种星载STR安装矩阵在轨修正算法。通过仿真验证了STR安装矩阵修正算法的正确性,与仿真中星敏模型的安装矩阵相比,使用10幅WST全日面图像计算STR安装矩阵的精度优于3″;利用300 s SGT数据计算STR安装矩阵的精度优于0.2″。以ASO-S在轨遥测数据进行算法验证,卫星对日指向控制偏差与SGT测量太阳中心偏差角间的偏差值优于15″,将STR相对SGT的装配测量精度提高了1.5倍。

关键词：高精度高稳定度二维指向偏差角太阳导行镜导引律安装矩阵

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Frontal Sinus Fractures: Management at the Yalgado Ouedraogo University Hospital Centre (Burkina Faso)

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Open Journal of Stomatology 2024年第1期14卷 42-54页

作者： Arsène Coulibaly Patrik Gane-bang Joseph Wend-Toin Biogo Ibraïma Traoré Tarcissus Konsem Department of Maxillofacial Surgery Regional University Hospital Centre of Ouahigouya Ouahigouya Burkina Faso Department of Stomatology and Maxillofacial Surgery Regional Hospital Centre of Banfora Banfora Burkina Faso Department of Neurosurgery Regional University Hospital Centre of Ouahigouya Ouahigouya Burkina Faso Department of Stomatology and Maxillofacial Surgery Souro SANOU University Hospital Centre Bobo Dioulasso Burkina Faso Department of Stomatology and Maxillofacial Surgery Yalgado OUEDRAOGO University Hospital Centre Ouagadougou Burkina Faso

Introduction: Frontal sinus fractures are potentially serious. They are defined as a solution of continuity, open or closed, of one or both bone tables of the frontal sinus. This study aims to report on the management of them at the Yalgado OUEDRAOGO University Hospital Centre. Methodology: It is a descriptive cross-sectional study with retrospective collection from January 01, 2016 to December 31, 2018. Patients with frontal sinus fractures were managed at the Yalgado OUEDRAOGO University Hospital Centre through CT-scan proof. Results: Over three years, a total of 102 cases of frontal sinus fractures were collected with 29.9 years as average age. There were 96 men. Workers in the informal sector and pupils/students represented 58.90% of patients. The residence of the patients was urban in 68.80% of cases and rural in 31.40%. Road traffic accidents (RTAs) happened in 90.20%, and involved 2-wheelers in 98.20%. None of these drivers was wearing a helmet. The type III frontal fracture of Ioannides et al. represented 51.9% of cases. In 89.21% of cases, other facial and/or cranioencephalic injuries were compounded to frontal sinus fractures. No surgical management was observed in 82 (80.39%) patients and surgical management in 20 (19.61%) patients. The outcome was favourable, but sequelae and/or complications were noted in 10 patients who had surgery and 30 patients who did not. Conclusion: These results enforce helmet wearing for all riders of two-wheeled machines. In addition, vaccinations to prevent meningitis in frontal sinus fractures with dural breach should be systematic.

关键词： Management Frontal Sinus Fracture Burkina Faso

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Longitudinal associations of cardiovascular health and vascular events with incident dementia

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Stroke & Vascular Neurology 2024年第4期9卷 418-428,I0066-I0130页

作者： Ya-Nan Ou Kevin Kuo Liu Yang Ya-Ru Zhang Shu-Yi Huang Shi-Dong Chen Yue-Ting Deng Yu Guo Rui-Qi Zhang bang-Sheng Wu Lan Tan Qiang Dong Jian-Feng Feng Wei Cheng Jin-Tai Yu Department of Neurology Qingdao Municipal HospitalQingdao UniversityQingdaoShandongPeople's Republic of China Department of Neurology and National Center for Neurological Disorders Huashan HospitalState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiPeople's Republic of China Institute of Science and Technology for Brain-inspired Intelligence Fudan UniversityShanghaiPeople's Republic of China Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityMinistry of EducationShanghaiPeople's Republic of China

Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented.A comprehensive study to illuminate the distinctive associations across different dementia types is still *** study is sought to:(1)determine the clinical validity of Framingham General Cardiovascular Risk Score(FGCRS)for dementia assessment and(2)examine the associations between cardiovascular diseases and the risk of *** A total of 432079 dementia-free individuals at baseline from UK Biobank were *** Cox proportional hazard models were used to investigate the prospective associations for FGCRS and a series of cardiovascular diseases with all-cause dementia(ACD)and its major components,Alzheimer’s disease(AD)and vascular dementia(VaD).Results During a median follow-up of 110.1 months,4711 individuals were diagnosed with *** was associated with increased risks across the dementia *** stratification analysis,high-risk groups have demonstrated the greatest dementia burdens,particularly to *** 74 traits,9 adverse associations,such as chronic ischaemic heart disease(ACD:HR=1.354;AD:HR=1.269;VaD:HR=1.768),atrioventricular block(ACD:HR=1.562;AD:HR=1.556;VaD:HR=2.069),heart failure(ACD:HR=1.639;AD:HR=1.543;VaD:HR=2.141)and hypotension(ACD:HR=2.912;AD:HR=2.361;VaD:HR=3.315)were *** distinctions were also found,with atrial fibrillation,cerebral infarction,and haemorrhage only associated with greater risks of ACD and *** By identifying distinctive associations between cardiovascular diseases and dementia,this study has established a comprehensive‘mapping’that may untangle the long-standing *** has demonstrated its predictivity beyond cardiovascular diseases burdens,suggesting potential opportunities for implantation.

关键词： cardiovascular diseases supporting

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基于太阳导行镜测量的高精度姿态确定算法

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系统工程与电子技术 2024年第1期46卷 245-253页

作者：陈炳龙王磊刘帮周衡中国科学院微小卫星创新研究院上海201306

先进天基太阳天文台卫星(advanced space-based solar observatory satellite,ASO-S)的主要任务是对日观测,对卫星姿态确定精度提出了较高的要求。为此,提出了一种新的姿态确定算法使用ASO-S科学载荷太阳导行镜(Sun guide telescope,SGT... 详细信息

先进天基太阳天文台卫星(advanced space-based solar observatory satellite,ASO-S)的主要任务是对日观测,对卫星姿态确定精度提出了较高的要求。为此,提出了一种新的姿态确定算法使用ASO-S科学载荷太阳导行镜(Sun guide telescope,SGT)测量卫星指向与太阳中心的偏差角,以及对光纤陀螺(fiber optic gyro,FOG)和星敏感器(star trackor,STR)测量值进行姿态确定。将卫星本体系姿态四元数矢部和FOG常值零位漂移作为状态变量,STR和SGT观测值作为测量变量,设计扩展卡尔曼滤波器(extended Kalman filter,EKF)。通过数学仿真验证本文所设计姿态确定算法的正确性与稳定性。最后,利用ASO-S在轨遥测数据进行验证,基于SGT测量的姿态确定算法可显著提高卫星非对日方向的姿态角估计精度,可优于0.2″(3σ)。

关键词：对日观测姿态确定太阳导行镜扩展卡尔曼滤波器

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考虑连续山体影响的耐张型悬索支撑输电结构风振响应分析

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工程力学 2024年第S1期41卷 31-37页

作者：王涛王邦杰李正良哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090 哈尔滨工业大学重庆研究院重庆401151 重庆大学土木工程学院重庆400045 风工程及风资源利用重庆市重点实验室(重庆大学) 重庆400045

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系... 详细信息

针对适用于山区的新型输电结构——悬索支撑输电结构,为了评估连续山体数量对该结构性能的影响,该文进行了连续山体影响下边界层风洞试验;基于试验数据,分析了平均和脉动风速在不同数量连续山体影响下的演变趋势,并给出了平均风修正系数和脉动风修正系数的建议公式;提出了连续山体影响下悬索支撑输电结构的风致非线性动力分析方法;针对位于某耐张段的悬索支撑输电结构,评估了其风致动力响应受不同数量连续山体的影响。研究结果表明:当连续山体数量增加时,在山顶处,平均风修正系数先增大后平稳,在背风面山脚处,平均风修正系数先增大后减小,而最大脉动风修正系数呈现先减小后增大的趋势;就导线、支撑导线悬索的跨中位移和跨中张力而言,其均值和标准差随着连续山体数量增加呈现先减小再增加后逐渐平稳的趋势;不同数量连续山体对导线、支撑导线悬索跨中位移均值影响较为显著,对其标准差影响较小,而对于跨中张力则恰好相反。

关键词：连续山体风洞试验悬索支撑输电结构耐张段风振

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Integrated gut microbiota,plasma metabolomics and network pharmacology to reveal the anti-ischemic stroke effect of cooked rhubarb

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Traditional Medicine Research 2024年第9期9卷 1-13页

作者： Ting Li Lan-Fang Tan Lin Shen Jie-Hui Kuang Si-Kai Zhan bang Liu Jia-Le Cai Sheng-Wang Liang Ming-Hua Xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province School of Chinese Materia MedicaGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization Guangxi Institute of BotanyChinese Academy of SciencesGuilin 541006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527300China

Background:Cooked rhubarb(CR)is obtained by steaming raw rhubarb(Rheum palmatum L.,Rheum officinale Baill.,or Rheum tanguticum *** Balf.)with millet *** is used as a traditional Chinese medicine for treating cerebral stroke,where patients often face severe *** study explored the pharmacological effects and mechanisms of CR against ischemic stroke(IS)in *** used integrated analysis of gut microbiota,metabolomics,and network ***:The compounds in CR were identified using LC-MS/*** impact of CR on rat middle cerebral artery occlusion/reperfusion(MCAO/R)-induced cerebral infarct size and brain tissue pathology was assessed through 2,3,5-triphenyl tetrazolium chloride and HE *** in hemorheology were measured by evaluating blood viscosity,and serum levels of pro-inflammatory cytokine were also *** microbiota composition was analyzed through 16S rRNA gene *** metabolites were examined using untargeted metabolomics and Spearman correlation *** pseudo-germ-free test was used to determine whether tumour necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)improvement in IS are dependent on gut ***:In vivo studies showed CR enhances neurobehavioral function in MCAO/R rats and reduces cerebral infarction *** also ameliorates brain and intestinal barrier damage caused by *** also decreased inflammation and oxidative stress in IS ***,CR promotes the growth of Akkermansia and Verrucomicrobia,aiding in intestinal barrier ***,CR primarily influences the primary bile acid biosynthesis *** pseudo-germ-free experiment and network pharmacology confirmed TNF-αand IL-1βas potential *** relies on gut microbiota for its anti-inflammatory effects to improve ***:Cooked rhubarb offers neuroprotective benefits by enhancing beneficial bacteria abundance and regulating bile acid *** emerges as a potential therapeutic agent for

关键词： cooked rhubarb ischemic stroke gut microbiota metabolomics

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： Yu-Qin Wang Di Pan Zhi-Yuan Yao Yu-Qi Li Peng-Fei Qu Run-bang Wang Qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic Liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMI<25 kg/m2,n=51)and the overweight/obese group(BMI≥25 kg/m2,n=75).Short-term prognosis was evaluated using mRECIST criteria,with subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** Median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

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Medical imaging for the diagnosis,recurrence and metastasis evaluation of clear cell sarcoma

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World Journal of Clinical Cases 2024年第29期12卷 6258-6261页

作者： Wen-Jing Wang Xia Wang Dong-Ming Hui Jun-bang Feng Chuan-Ming Li Department of Medical Imaging Chongqing University Central HospitalChongqing 400014China Department of Radiology Chongqing Western HospitalChongqing 400050China

Clear cell sarcoma(CCS)of soft tissue is extremely rare,accounting for approximately 1%of all soft tissue *** is very difficult to diagnose CCS based on clinical *** resonance imaging(MRI)provides highresolution images of soft tissues and pathological features such as mucus,necrosis,bleeding,and fat through high and low signals on T1 weighted image(T1WI)and T2 weighted image(T2WI).On the other hand,the paramagnetism of melanin in CCS shortens the relaxation time of T1 and T2,and high signal intensity on T1WI and low signal intensity on T2WI can be *** is different from most other soft tissue *** present,the treatment method for CCS is surgical *** can effectively display the tumour edge,extent of surrounding oedema,and extent of fat involvement,which is highly important for guiding surgical resection and predicting postoperative *** an invasive sarcoma,CCS has a high risk of *** of the pathological condition of the resected tumour,MRI or computed tomography(CT)should be performed every 1-2 years to assess recurrence at the primary site and to screen for metastasis in the lungs,liver,and *** necessary,PET-CT can be performed to evaluate the overall condition of the patient.

关键词： Clear cell sarcoma Recurrence Metastasis Computed tomography Magnetic resonance imaging Editorial

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PEMFC冷启动过程阻抗谱及特征频率分析

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汽车工程 2024年第2期46卷 269-280页

作者：陶阿邦陶建建魏学哲同济大学汽车学院上海201804 同济大学新能源工程中心上海201804

为优化质子交换膜燃料电池(PEMFC)冷启动过程,提供足量的反馈数据十分必要,常见的阻抗谱和等效电路因其获取周期较长,无法提供足量且实时的反馈。为此,本文在COMSOL中建立冷启动阻抗模型,结合试验分析其阻抗谱变化,分别在高、中、低频... 详细信息

为优化质子交换膜燃料电池(PEMFC)冷启动过程,提供足量的反馈数据十分必要,常见的阻抗谱和等效电路因其获取周期较长,无法提供足量且实时的反馈。为此,本文在COMSOL中建立冷启动阻抗模型,结合试验分析其阻抗谱变化,分别在高、中、低频区间提出特征频率1 kHz、50 Hz和1 Hz用于表征燃料电池冷启动过程。研究发现,上述特征频率在冷启动的前、中、后3个阶段变化显著,在特征频率1 kHz、50 Hz和1 Hz下阻抗的变化倍率分别为0.38、0.31和1.47。相较于获取完整的阻抗谱和拟合等效电路,在保留了特征信息的情况下提高了采集数据的实时性。因此,可利用特征频率点的阻抗表征冷启动过程,为实时监测冷启动内部状态提供条件。

关键词：质子交换膜燃料电池阻抗谱冷启动解析阻抗模型等效电路模型

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