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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN kim YUN SUN LEE seung MYUNG DONG HYO JUNG kim DA EUN LEE HYEON WOONG KANG MYEONG JIN kim JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Machine Learning-Assisted Fabrication of PCBM-Perovskite Solar Cells with Nanopatterned TiO2 Layer

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Energy & Environmental Materials 2024年第4期7卷 223-230页

作者： Siti Norhasanah Sanimu Hwa-Young Yang Jeevan Kandel Ye-Chong Moon Gangasagar Sharma Gaudel seung-Ju Yu Yong Ju kim Sejung kim Bong-Hyun Jun Won-Yeop Rho Graduate School of Integrated Energy-AI Jeonbuk National University School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Department of Herbal Medicine Resources College of Environmental and Bioresource Sciences Jeonbuk National University School of Chemical Engineering Jeonbuk National University Department of Bioscience and Biotechnology Konkuk University School of International Engineering and Science Jeonbuk National University

To unlock the full potential of PSCs,machine learning （ML） was implemented in this research to predict the optimal combination of mesoporous-titanium dioxide （mp-TiO2） and weight percentage （wt%） of phenyl-C61-butyric acid methyl ester （PCBM）,along with the current density(Jsc),open-circuit voltage (Voc),fill factor （ff）,and energy conversion efficiency （ECE）.

关键词： machine learning nanopatterning PCBM perovskite solar cells prediction

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Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea,2010-2018

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World Journal of Gastroenterology 2024年第9期30卷 1154-1163页

作者： Seulji kim Hyun Jung Lee seung Woo Lee Sanghyun Park Seong-Joon Koh Jong Pil Im Byeong Gwan kim Kyung-Do Han Joo Sung kim Department of Internal Medicine Korea Institute of Radiological and Medical SciencesSeoul 01812South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea

BACKGROUND Inflammatory bowel disease(IBD)was previously regarded as a Western disease;however,its incidence is increasing in the *** epidemiology of IBD in Asia differs significantly from the patterns in the *** To comprehensively investigate the epidemiology of IBD in South Korea,inclu-ding its incidence,prevalence,medication trends,and *** We analyzed claims data from the Health Insurance Review and Assessment Service and Rare and Intractable Diseases(RIDs),operated by the National Health Insurance Service of South *** with IBD were identified based on the International Classification of Diseases,Tenth Revision,and RID diagnostic codes for Crohn’s disease(CD)and ulcerative colitis(UC)from 2010 to *** In total,14498 and 31409 patients were newly diagnosed with CD and UC,respectively,between 2010 and *** annual average incidence of CD was 3.11 cases per 105 person-years,and that of UC was 6.74 cases per 10^(5) *** 2014,the incidence rate of CD has been stable,while that of UC has steadily increased,shifting the peak age group from 50-year-olds in 2010 to 20-year-olds in *** CD and UC prevalence increased consistently over the study period;the use of 5-aminosali-cylates and corticosteroids gradually decreased,while that of immunomodulators and biologics steadily increased in both CD and *** clinical outcomes of IBD,such as hospitalization and surgery,decreased during the study *** The CD incidence has been stable since 2014,but that of UC has increased with a shift to a younger age at peak incidence between 2010 and *** clinical outcomes improved over time,with increased use of immunomodu-lators and biologics.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Incidence Prevalence

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Long cycle-life aqueous Zn battery enabled by facile carbon nanotube coating on Cu current collector

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Carbon Energy 2024年第6期6卷 151-164页

作者： Beom-Keun Cho Sung-Ho Huh So Hee kim seungho Yu Jong-Seong Bae Jung-Keun Yoo seung-Ho Yu Department of Chemical and Biological Engineering Korea UniversitySeoulRepublic of Korea Advanced Analysis Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Energy Storage Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST School Division of Energy and Environment TechnologyKorea University of Science and TechnologySeoulRepublic of Korea Busan Center Korea Basic Science Institute(KBSI)BusanRepublic of Korea Carbon Composites Department Composites Research DivisionKorea Institute of Materials Science(KIMS)ChangwonRepublic of Korea

As an alternative to Li-ion batteries,aqueous Zn batteries have gained attention due to the abundance of Zn metal,low reduction potential(-0.76 V *** hydrogen electrode),and high theoretical capacity(820 mAh g^(-1))of multivalent Zn2+***,the growth of Zn dendrites and the formation of irreversible surface reaction byproducts pose challenges for ensuring a long battery lifespan and ***,the Cu foil coated with a single-walled carbon nanotube(SWCNT)layer using a facile doctor blade casting method is *** SWCNT-coated Cu foil demonstrates a significantly longer battery lifespan compared to the bare Cu in the half-cell *** operando optical microscopy imaging,we are able to provide intuitive evidence that Zn deposition occurs between the carbon nanotube(CNT)coating and Cu substrate,in agreement with the computational ***,with various imaging techniques,the flat morphology and homogeneous distribution of Zn beneath the SWCNT layer are *** addition,the full-cell using CNT-coated Cu exhibits a long cycle life compared to the control group,thereby demonstrating improved electrochemical performance with limited Zn for the cycling process.

关键词： aqueous Zn battery carbon nanotube operando imaging surface coating

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Ethyl acetate fraction of Sargassum pallidum extract attenuates particulate matter-induced oxidative stress and inflammation in keratinocytes and zebrafish

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 137-146页

作者： Wook Chul kim Ji-Won Park Bohyun Yun WonWoo Lee Kyung-Min Choi seung-Hong Lee Department of Medical Science Soonchunhyang UniversityAsan 31538Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do 58762Republic of Korea Department of Pharmaceutical Engineering Soonchunhyang UniversityAsan 31538Republic of Korea

Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and ***:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and *** production of nitric oxide(NO),intracellular ROS,prostaglandin E_(2)(PGE_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT ***,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish ***:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGE_(2) in PM-induced HaCaT *** addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κ***,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in ***:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.

关键词： Particulate matter Inflammation Oxidative stress Sargassum pallidum Ethyl acetate fraction Zebrafish

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Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2)Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun Yoo Hoang Van Quy Inpyo Lee seung Taek Jo Tae Ei Hong JunHo kim Dae-Hwang Yoo Jinwook Shin Walter Commerell Dae-Hwan kim Jong Wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

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Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance

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Cellular & Molecular Immunology 2024年第4期21卷 393-408页

作者： Sujin Lee Yeunjung Ko Hyun Woo Lee Won Joon Oh hun Gi Hong Dinuka Ariyaratne Se Jin Im Tae Jin kim Department of Immunology Graduate School of Basic Medical ScienceSungkyunkwan University School of MedicineSuwon16419Republic of Korea Department of Immunology and Molecular Medicine Faculty of Medical SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Present address:Immunology and Microbiology Graduate Program Baylor College of MedicineHoustonTX77030USA

Marginal zone(MZ)B cells,which are splenic innate-like B cells that rapidly secrete antibodies(Abs)against blood-borne pathogens,are composed of heterogeneous ***,we showed that MZ B cells can be divided into two distinct subpopulations according to their CD80 expression ***80^(high)MZ B cells exhibited greater Ab-producing,proliferative,and IL-10-secreting capacities than did CD80^(low)MZ B ***,CD80^(high)MZ B cells survived 2-Gy whole-body irradiation,whereas CD80^(low)MZ B cells were depleted by irradiation and then repleted with one month after *** of CD80^(low)MZ B cells led to accelerated development of type II collagen(CII)-induced arthritis upon immunization with bovine ***80^(high)MZ B cells exhibited higher expression of genes involved in proliferation,plasma cell differentiation,and the antioxidant ***80^(high)MZ B cells expressed more autoreactive B cell receptors(BCRs)that recognized double-stranded DNA or CII,expressed more immunoglobulin heavy chain sequences with shorter complementarity-determining region 3 sequences,and included more clonotypes with no N-nucleotides or with B-1a BCR sequences than CD80^(low)MZ B *** transfer experiments showed that CD21^(+)CD23^(+)transitional 2 MZ precursors preferentially generated CD80^(low)MZ B cells and that a proportion of CD80^(low)MZ B cells were converted into CD80^(high)MZ B cells;in contrast,CD80^(high)MZ B cells stably remained CD80^(high)MZ B *** summary,MZ B cells can be divided into two subpopulations according to their CD80 expression levels,Ab-producing capacity,radioresistance,and autoreactivity,and these findings may suggest a hierarchical composition of MZ B cells with differential stability and BCR specificity.

关键词： Marginal Zone B Cell CD80 Autoreactivity Radioresistance

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PagMYB128 regulates secondary cell wall formation by direct activation of cell wall biosynthetic genes during wood formation in poplar

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Journal of Integrative Plant Biology 2024年第8期66卷 1658-1674页

作者： Yuanyuan Hao Fachuang Lu seung-Won Pyo Min-Ha kim Jae-Heung Ko Xiaojing Yan John Ralph Quanzi Li State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Department of Biochemistry and DOE Great Lakes Bioenergy Research Center Wisconsin Energy InstituteUniversity of Wisconsin-MadisonWisconsin 53726USA Department of Plant&Environmental New Resources Kyung Hee UniversityYongin 17104Korea

The biosynthesis of cellulose,lignin,and hemicelluloses in plant secondary cell walls(SCWs)is regulated by a hierarchical transcriptional regulatory *** network features orthologous transcription factors shared between poplar and Arabidopsis,highlighting a foundational similarity in their genetic ***,knowledge on the discrepant behavior of the transcriptional-level molecular regulatory mechanisms between poplar and Arabidopsis remains *** this study,we investigated the function of PagMYB128 during wood formation and found it had broader impacts on SCW formation compared to its Arabidopsis ortholog,*** poplar trees overexpressing PagMYB128 exhibited significantly enhanced xylem development,with fiber cells and vessels displaying thicker walls,and an increase in the levels of cellulose,lignin,and hemicelluloses in the *** contrast,plants with dominant repression of PagMYB128 demonstrated the opposite *** sequencing and reverse transcription–quantitative polymerase chain reaction showed that PagMYB128 could activate SCW biosynthetic gene expression,and chromatin immunoprecipitation along with yeast one-hybrid,and effector–reporter assays showed this regulation was *** analysis revealed that PagSND1(SECONDARY WALL-ASSOCIATED NAC-DOMAIN PROTEIN1)directly regulates PagMYB128 but not cell wall metabolic genes,highlighting the pivotal role of PagMYB128 in the SND1-driven regulatory network for wood development,thereby creating a feedforward loop in SCW biosynthesis.

关键词： cellulose hemicellulose lignin PagMYB128 Populus transcription factor wood formation

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A Plasma Membrane Polarity Sensor Harnessing Conjoined Twisted Intramolecular Charge Transfer Modulation and Charge Number Control Strategy

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CCS Chemistry 2024年第3期6卷 733-748页

作者： Yu-Qiang Zhao Le Yu Liping Zhu Jinsong Liang Ying Zhou Jong seung kim College of Chemical Science and Technology Yunnan UniversityKunming 650091 Department of Chemistry Korea UniversitySeoul 02841 TheranoChem Incorporation Seoul 02856

Polarity is a critical microenvironmental factor of the plasma membrane,which can offer valuable insights into various biological ***,we proposed a novel strategy for the construction of fluorescent agents to measure plasma membrane polarity by conjoining twisted intramolecular charge transfer(TICT)modulation and charge number *** is shown that compounds with a stronger TICT tendency are more sensitive to polarity shifts due to the number of dialkylated amino groups present(from 1 to 3),and the molecules with two or more charged centers remain in the plasma ***,we developed two fluorescent agents with high polarity sensitivity,excellent turn-on ratios,and superior ability,to target the plasma *** the wash-free fluorescence imaging and fluorescence lifetime tests,our designed agent could detect plasma membrane polarity with high precision,allowing effective distinction between cancer cells and normal cells based on their differences in plasma membrane ***,both fluorescence and fluorescence lifetime changes of the plasma membrane in the ferroptosis model established by Sorafenib confirmed an increase in plasma membrane polarity during cell ferroptosis.

关键词： membrane polarity fluorescence agents fluorescence imaging fluorescence lifetime imaging

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Electronic structure tuning of layered double hydroxides for electrochemical sensing and its biomedical applications

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Science China Chemistry 2024年第11期67卷 3614-3630页

作者： Kun Wang Zhiying Cao Qihang Ding Jiyoung Yoo Nem Singh Heemin Kang Lin Wang Lin Xu Jong seung kim School and Hospital of Stomatology Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Jilin University State Key Laboratory on Integrated Optoelectronics Collage of Electronic Science and Engineering Jilin University Department of Chemistry Korea University Department of Materials Science and Engineering Korea University

Modifying the electrodes of electrochemical sensors is critical to enhance sensitivity, selectivity, and stability, ultimately improving both their effectiveness and performance. In this paper, recent advancements in electrochemical sensors are reviewed,focusing on the utilization of layered double hydroxides(LDHs). The first section explores the advantageous and disadvantageous aspects of electrochemical sensing. Benefits include rapid response, ease of operation, and cost-effectiveness,while drawbacks concern the potential instability of prolonged use, susceptibility to interference, and the risk of biomolecule inactivation. Following this, the second section delves into the synthesis, constituents, and structure of LDHs. Moreover, after introducing the chemical mechanisms and functions of LDHs in electrochemical sensors, we concentrate on diverse modifying materials of LDHs and their different performances. Finally, the applications of LDHs in electrochemical sensing across different fields are discussed. This review aims to facilitate the continued advancement for applying LDHs in electrochemical sensors, as well as inspire the evolution of electrochemical sensing technology.

关键词： layered double hydroxides electrochemical sensor biological field modified electrode

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