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Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

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Q690高强钢及其焊接构件的疲劳性能

钢结构（中英文） 2024年第5期39卷 27-33页

作者：陈韡钟国辉香港理工大学土木与环境工程学院中国香港999077 香港理工大学国家钢结构工程技术研究中心香港分中心中国香港999077

高强钢指屈服强度fy不小于460 MPa的钢材,因其良好的材料性能已被逐步应用于建筑和桥梁中。与普通强度钢材相比,高强钢具有更高的屈服强度,可以减小构件的尺寸,且较薄的钢板厚度可以减少焊接工作量、提高焊接质量,从而避免厚板带来的焊... 详细信息

高强钢指屈服强度fy不小于460 MPa的钢材,因其良好的材料性能已被逐步应用于建筑和桥梁中。与普通强度钢材相比,高强钢具有更高的屈服强度,可以减小构件的尺寸,且较薄的钢板厚度可以减少焊接工作量、提高焊接质量,从而避免厚板带来的焊接问题。疲劳损伤一直以来是桥梁结构最为关键的服役问题之一,在国内外现行的结构设计规范中并没有包含针对高强钢材疲劳性能的设计标准。对Q690高强钢及其焊接件的疲劳性能进行了系统性的试验研究,确定Q690高强钢及其焊后的疲劳强度,以推进Q690高强钢在实际工程中的应用。首先对Q690高强钢及其焊接件的标准试件进行单调拉伸试验,确定其材料性能,在Q690焊接件进行试验前对试件进行了腐蚀处理,目的是更为直观地在试验中观察到焊材、热影响区和母材的分布,试验确定颈缩发生的位置为热影响区。根据单调拉伸试验得到的材料力学性能确定了多级疲劳荷载,并对Q690高强钢及焊接光滑圆棒试件进行系列高周-低应变疲劳试验,确定了Q690高强钢母材及其焊接试件的疲劳寿命,并根据试验值拟合出疲劳曲线(S-N曲线)。疲劳试验得到Q690焊接件的疲劳极限为420.0 MPa,Q690母材的疲劳极限为668.8 MPa,结果表明Q690高强钢焊后疲劳极限有明显降低,但Q690高强钢母材及其焊接试件的疲劳极限均远远高于欧洲规范的设计值(母材:118 MPa,焊接件:82.5 MPa)。对Q690焊接试件进行了硬度试验,确定其沿纵向的硬度分布,发现焊材区的硬度最高约为328 HV,在热影响区有明显的软化现象,硬度为240 HV,说明Q690高强钢焊后硬度差异较大。对疲劳破坏后的Q690焊接件断口试件进行了腐蚀试验,发现疲劳裂纹起源于焊材区而非热影响区。并且对断口试件进行了扫描式电子显微镜观察,在疲劳断面发现非金属夹杂物。根据电镜观察的结果,分析了疲劳断口的微观现象,确定疲劳裂纹源及扩展过程,得到初始缺陷是影响Q690焊接件疲劳性能关键因素的结论。

关键词：高强钢焊接接头疲劳性能

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Iterative Semi-Supervised Learning Using Softmax Probability

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Computers, Materials & Continua 2022年第9期72卷 5607-5628页

作者： Heewon chung Jinseok Lee Department of Biomedical Engineering College of Electronics and InformationKyung Hee UniversityYongin-siGyeonggi-do17104Korea

For the classification problem in practice,one of the challenging issues is to obtain enough labeled data for ***,even if such labeled data has been sufficiently accumulated,most datasets often exhibit long-tailed distribution with heavy class imbalance,which results in a biased model towards a majority *** alleviate such class imbalance,semisupervised learning methods using additional unlabeled data have been ***,as a matter of course,the accuracy is much lower than that from supervised *** this study,under the assumption that additional unlabeled data is available,we propose the iterative semi-supervised learning algorithms,which iteratively correct the labeling of the extra unlabeled data based on softmax *** results show that the proposed algorithms provide the accuracy as high as that from the supervised *** validate the proposed algorithms,we tested on the two scenarios:with the balanced unlabeled dataset and with the imbalanced unlabeled *** both scenarios,our proposed semi-supervised learning algorithms provided higher accuracy than previous *** is available at https://***/Heewonchung92/iterative-semi-learning.

关键词： Semi-supervised learning class imbalance iterative learning unlabeled data

Dyna-QUF:Dyna-Q based univector field navigation for autonomous mobile robots in unknown environments

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Journal of Central South University 2013年第5期20卷 1178-1188页

作者： VIET Hoang-huu CHOI seung-yoon chung Tae-choong Department of Computer Engineering Kyung Hee University

A novel approach was presented to solve the navigation problem of autonomous mobile robots in unknown environments with dense obstacles based on a univector field method. In an obstacle-free environment, a robot is ensured to reach the goal position with the desired posture by following the univector field. Contrariwise, the univector field cannot guarantee that the robot will avoid obstacles in environments. In order to create an intelligent mobile robot being able to perform the obstacle avoidance task while following the univector field, Dyna-Q algorithm is developed to train the robot in learning moving directions to attain a collision-free path for its navigation. Simulations on the computer as well as experiments on the real world prove that the proposed algorithm is efficient for training the robot in reaching the goal position with the desired final orientation.

关键词：自主移动机器人环境导航智能移动机器人目标位置移动方向现实世界 Q算法

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Analytic Feynman Integrals of Functionals in a Banach Algebra Involving the First Variation

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Chinese Annals of Mathematics,Series B 2016年第2期37卷 281-290页

作者： Hyun Soo chung Vu Kim TUAN seung Jun CHANG Department of Mathematics Dankook University Department of Mathematics University of West Georgia

This paper deals with the analytic Feynman integral of functionals on a Wiener space. First the authors establish the existence of the analytic Feynman integrals of functionals in a Banach algebra S_α. The authors then obtain a formula for the first variation of integrals. Finally, various analytic Feynman integration formulas involving the first variation are established.

关键词：巴拿赫代数积分泛函泛函分析费曼 Wiener空间积分公式

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Defect engineering of ternary Cu-In-Se quantum dots for boosting photoelectrochemical hydrogen generation

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Carbon Energy 2023年第12期5卷 215-228页

作者： Shi Li Sung-Mok Jung Wookjin chung Joo-Won Seo Hwapyong Kim Soo Ik Park Hyo Cheol Lee Ji Su Han seung Beom Ha In Young Kim Su-Il In Jae-Yup Kim Jiwoong Yang Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Chemical Engineering Dankook UniversityYonginRepublic of Korea Department of Chemistry and Nanoscience College of Natural ScienceEwha Womans UniversitySeoulRepublic of Korea Energy Science and Engineering Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea

Heavy-metal-free ternary Cu–In–Se quantum dots(CISe QDs)are promising for solar fuel production because of their low toxicity,tunable band gap,and high light absorption *** defects significantly affect the photophysical properties of QDs,the influence on photoelectrochemical hydrogen production is not well ***,we present the defect engineering of CISe QDs for efficient solar-energy *** acid–base reactions between metal halide–oleylamine complexes and oleylammonium selenocarbamate are modulated to achieve CISe QDs with the controlled amount of Cu vacancies without changing their *** them,CISe QDs with In/Cu=1.55 show the most outstanding photoelectrochemical hydrogen generation with excellent photocurrent density of up to 10.7 mA cm-2(at 0.6 VRHE),attributed to the suitable electronic band structures and enhanced carrier concentrations/lifetimes of the *** proposed method,which can effectively control the defects in heavy-metal-free ternary QDs,offers a deeper understanding of the effects of the defects and provides a practical approach to enhance photoelectrochemical hydrogen generation.

关键词： copper-indium-selenide defect engineering photoelectrochemical hydrogen generation quantum dots solar hydrogen

A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment:Evidence for erectile restoration and cavernous nerve regeneration

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Asian Journal of Urology 2022年第3期9卷 287-293页

作者： Eric chung AndroUrology Centre BrisbaneQLDAustralia University of Queensland Princess Alexandra HospitalBrisbaneQLDAustralia Macquarie University Hospital SydneyNSWAustralia

Objective:The following article explores our evolving understandings of the role of regenerative technology as an effective penile rehabilitation tool in men with erectile dysfunction(ED)in the setting of prostate cancer(PCa)treatment and PCa ***:This narrative clinical review paper summarizes what is currently known about various modalities of regenerative therapy in restoring spontaneous erectile function(EF)in men following PCa treatment with an emphasis on penile rehabilitation ***:Conventional medical therapy often does not reverse underlying endothelial dysfunction or promote neuro-vasculogenesis to preserve penile health in men with *** the past decade,there has been considerable interest in the role of regenerative therapy to restore endothelial dysfunction and ED without future dependency on medical *** therapy can be classified into cellular-based(immunomodulators,stem cells,and platelet-rich plasma),biomaterials(nerve graft transfer),and device-related technology(low-intensity shockwave).Although published literature shows early promise in the role of regenerative technology for ED,there is a paucity of high-quality clinical trials in the setting of penile rehabilitation and PCa survivorship to support their use as standard care and be adopted in clinical guidelines.

关键词： Regenerative therapy Low-intensity shockwave therapy Stem cell therapy Platelet-rich plasma Immunomodulator Nerve transfer Erectile dysfunction Penile rehabilitation

Efficient solar fuel production enabled by an iodide oxidation reaction on atomic layer deposited MoS_(2)

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Carbon Energy 2023年第12期5卷 200-214页

作者： Young Sun Park Gyumin Jang Inkyu Sohn Hyungsoo Lee Jeiwan Tan Juwon Yun Sunihl Ma Jeongyoub Lee Chan Uk Lee Subin Moon Hayoung Im seung-Min chung seungho Yu Hyungjun Kim Jooho Moon Department of Materials Science and Engineering Yonsei UniversitySeoulRepublic of Korea School of Electrical and Electronic Engineering Yonsei UniversitySeoulRepublic of Korea Energy Storage Research Center Korea Institute of Science and TechnologySeoulRepublic of Korea

Oxygen evolution reaction(OER)as a half-anodic reaction of water splitting hinders the overall reaction efficiency owing to its thermodynamic and kinetic *** oxidation reaction(IOR)with low thermodynamic barrier and rapid reaction kinetics is a promising alternative to the ***,we present a molybdenum disulfide(MoS_(2))electrocatalyst for a high-efficiency and remarkably durable anode enabling ***_(2)nanosheets deposited on a porous carbon paper via atomic layer deposition show an IOR current density of 10 mA cm^(–2)at an anodic potential of 0.63 V with respect to the reversible hydrogen electrode owing to the porous substrate as well as the intrinsic iodide oxidation capability of MoS_(2)as confirmed by theoretical *** lower positive potential applied to the MoS_(2)-based heterostructure during IOR electrocatalysis prevents deterioration of the active sites on MoS_(2),resulting in exceptional durability of 200 ***,we fabricate a two-electrode system comprising a MoS_(2)anode for IOR combined with a commercial Pt@C catalyst cathode for hydrogen evolution ***,the photovoltaic–electrochemical hydrogen production device comprising this electrolyzer and a single perovskite photovoltaic cell shows a record-high current density of 21 mA cm^(–2)at 1 sun under unbiased conditions.

关键词： iodide oxidation reaction molybdenum sulfide photovoltaic-electrochemical hydrogen production solar hydrogen

Autocompletion of repetitive stroking with image guidance

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Computational Visual Media 2023年第3期9卷 581-596页

作者： Yilan Chen Kin chung Kwan Hongbo Fu School of Creative Media City University of Hong KongTat Chee AvenueKowloonHong Kong SARChina University of Konstanz University Street 1078464 KonstanzGermany

Image-guided drawing can compensate for a lack of skill but often requires a significant number of repetitive strokes to create *** automatic stroke synthesis methods are usually limited to predefined styles or require indirect manipulation that may break the spontaneous flow of *** present an assisted drawing system to autocomplete repetitive short strokes during a user's normal drawing *** draw over a reference image as usual;at the same time,our system silently analyzes the input strokes and the reference to infer strokes that follow the user's input style when certain repetition is *** can accept,modify,or ignore the system's predictions and continue drawing,thus maintaining fluid control over *** key idea is to jointly analyze image regions and user input history to detect and predict *** proposed system can effectively reduce the user's workload when drawing repetitive short strokes,helping users to create results with rich patterns.

关键词： interaction autocompletion digital drawing prediction texture synthesis