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Effect of dexamethasone injection into Zusanli(ST 36) acupoint on ovalbumin-induced allergic rhinitis

Journal of Traditional Chinese Medicine 2019年第3期39卷 307-314页

作者： Na-Ra han seung-jun han Phil-Dong Moon Sungwei Hong Hyeongjin Kim Yanhua Li Hyung-Min Kim Hyun-Ja Jeong Department of Pharmacology College of Korean Medicine Kyung Hee University Seoul 02447 Republic of Korea Department of Korean Medicine Graduate School of Wonkwang University Iksan 54538 Republic of Korea Department of Pharmacology Graduate School Kyung Hee University Seoul 02447Republic of Korea Department of Clinical Korean Medicine Graduate School Kyung Hee University Seoul 02447 Republic of Korea Department of Food Science & Technology and Research Institute for Basic Science Hoseo UniversityChungnam 31499 Republic of Korea

OBJECTIVE:To investigate the effects of acupunc ture with dexamethasone(***)on allergic rhini tis(AR)by injecting dexamethasone into the Zusan li(ST 36)***:Thirty 6-week-old female BALB/c mice were sensitized on days 1,5,and 14 by intraperitoneal injection of 100 pg of ovalbumin(OVA).The mice were then randomly divided into six groups(n =5 in each group).Five groups were sensitized intranasally with 2μL of 1.5 mg of OVA for 10 consecutive days,while one group was sensitized intranasally with PBS in a similar manner as a negative control *** hour before each administration of intranasal OVA,two groups were orally administered either a control vehicle(distilled water;AR control group)or 200 pg/kg Dex(*** group),while three groups received *** at Zusanli(ST36)with Dex concentrations of 2,20,and 200μg/kg for each group,*** symptoms were evaluated by measuring the rubbing score,which comprised the number of nose,ear,and eye rubs that occurred in the initial 10 min after OVA intranasal provocation on the 10 th *** isolated spleen,serum,and nasal mucosal tissue after measuring the rubbing *** weight was measured using an electronic *** levels of IgE,thymic stromal lymphopoietin,tumor necrosis factor-a,intercellular adhesion molecule-1,and macrophage-inflammatory protein-2 in serum or nasal mucosal tissue were measured using enzyme-linked immunosorbent *** serum histamine levels of OVA-sensitized AR mice were measured using O-phthaldialdehyde *** blot analysis was performed on nasal mucosal tissue ***:*** significantly reduced the rubbing score,spleen weight,serum IgE,and serum histamine in OVA-sensitized *** significantly decreased the serum levels of inflammatory cytokines(thymic stromal lymphopoietin and tumor necrosis factor-a)in OVA-sensitized *** significantly reduced the nasal mucosal levels of inflammatory markers(intercellular adhesion molecule-l

关键词： Dexamethasone Point ST36 (Zusanli) Pharmaceutical research Acupuncture Rhinitis,allergic Ovalbumin Thymic stromal lymphopoietin

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Effects of Bifidobacterium lactis BLa80 on fecal and mucosal flora and stem cell factor/c-kit signaling pathway in simulated microgravity rats

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World Journal of Gastroenterology 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu Chen Tong Zhou Zhe-Yi han jun Xiao Jian-Feng Ma Wen Ma Peng Zang Ying Chen Graduate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Laboratory of Aerospace Nutrition and Food Engineering China Astronaut Research and Training CenterBeijing 100094China Department of Gastroenterology The Air Force Medical CenterBeijing 100142China Department of Blood Transfusion Air Force Medical CenterBeijing 100142China

BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility *** pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal ***,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal *** cells are the pacemakers of gastrointestinal *** To investigate the effects of Bifidobacterium lactis(***)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit *** The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 *** tail group was given *** BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/***&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and *** fecal flora and mucosal flora of rats in each group were detected by 16S *** Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic *** microgravity reduced the expressions of SCF and c-kit,and increased the express

关键词： Simulated microgravity Rat Intestinal flora Gastrointestinal motility Stem cell factor/c-kit signaling pathway

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Influence of Zn and Mg Alloying on the Corrosion Resistance Properties of Al Coating Applied by Arc Thermal Spray Process in Simulated Weather Solution

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Acta Metallurgica Sinica(English Letters) 2018年第6期31卷 591-603页

作者： han-seung Lee seung-jun Kwon Jitendra Kumar Singh Mohamed A.Ismail Department of Architectural Engineering Hanyang University Department of Civil Engineering Hannam University Department of Civil and Construction Engineering Faculty of Engineering and ScienceCurtin University Malaysia

In this study,Al–Zn and Al–Mg coatings were deposited on steel substrates by an arc thermal spray process.X-ray diffraction and scanning electron microscopy were used to characterize the deposited coatings and corrosion *** circuit potential（OCP）,electrochemical impedance spectroscopy,and potentiodynamic studies were used to assess the corrosion characteristics of these coatings after exposure according to the Society of Automotive Engineers（SAE）J2334 solution of varying *** solution simulates an industrial environment and contains chloride and carbonate ions that induce corrosion of the deposited ***,the Al–Mg alloy coating maintained an OCP of approximately-0.911 V versus Ag/Ag Cl in the SAE J2334 solution even after 792 h of *** indicates that it protects the steel sacrificially,whereas the Al–Zn coating provides only barrier-type protection through the deposition of corrosion *** Al–Mg coating acts as a self-healing coating and provides protection by forming Mg_6Al_2（OH）_（16）CO_3（Al–Mg layered double hydroxides）.Mg_6Al_2（OH）_（16）CO_3has interlocking characteristics with a morphology of plate-like nanostructures and an ion-exchange ability that can improve the corrosion resistance properties of the *** presence of Zn in the corrosion products of the Al–Zn coating allows dissolution,but,at the same time,Zn_5（OH）_6（CO_3）_2and Zn_6Al_2（OH）_（16）CO_3are formed and act to reduce the corrosion rate.

关键词： Self-healing coating Corrosion Arc thermal spray Electrochemical impedance spectroscopy

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang han Jia Tuo Liu Yuzhen Yang jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

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干细胞的趋电性迁移及机制

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中国组织工程研究 2025年第23期29卷 4984-4992页

作者：韩芳舒晴贾绍辉田峻武汉体育学院运动医学院湖北省武汉市430079 武汉大学中南医院骨科康复科湖北省武汉市430071

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,... 详细信息

背景:随着对干细胞技术研究的深入,如何使其准确归巢成为临床应用中的一大难题。除药物和趋化因子等信号的诱导外,电场也被广泛应用于指导干细胞的定向迁移,并可增强其迁移速度和定向性。目的:旨在分析总结电场对干细胞迁移特性的影响,同时综述可能的作用机制。方法:通过检索Pub Med和中国知网数据库,收集截至2024年3月的相关文献,英文检索词:“stem cells,direct current electric field,pulsed electric field,migration,electric field device,mechanism”;中文检索词:“干细胞,直流电场,脉冲电场,迁移,电场装置,机制”。排除不能获取全文和与主题无关的文献。结果与结论:根据筛选要求共纳入58篇文献,包括中文文献15篇及英文文献43篇。文献以脂肪间充质干细胞、骨髓间充质干细胞、神经干细胞、表皮干细胞、人胚胎干细胞和人诱导性多功能干细胞为研究对象,在迁移装置中研究电场的不同参数对上述干细胞迁移的影响及其机制。(1)电场作为一种简单、无创且稳定的干预方式在指导干细胞定向迁移的过程中起着积极作用;(2)不同类型的干细胞发生趋电性迁移的方向不同,同时大部分干细胞的迁移速度和定向性是随着电场强度增加而增加的;(3)不同的电场装置在观测干细胞迁移时的侧重点不同,可根据实验目的而择优选择相关装置;(4)不同干细胞趋电性迁移的机制不完全相同,多数干细胞迁移过程中有MAPK通路、ROCK活化以及PI3K功能的参与,同时还有其他蛋白质复合物与信号通路参与调控该过程;(5)除电场参数不同之外,细胞本身的衰老情况和培养环境也会对趋电性迁移的结果产生影响。总而言之,电场作为一种影响干细胞迁移特性的重要信号,与其他新兴材料结合在组织工程应用中展现出了一定的潜力,有望在指导干细胞归巢方面发挥更加重要的作用,促进骨组织再生和修复以及神经系统、自身免疫系统以及肿瘤等疾病的研究取得更大的突破。

关键词：干细胞电场趋电性迁移机制归巢效应物理因子电场装置细胞衰老培养环境

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Electrochemical characteristics of HVOF spray coated layer with WC-27NiCr and WC-10Co4Cr for Al bronze

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中国有色金属学会会刊：英文版 2012年第S3期22卷 753-759页

作者： Min-su han seung-jun LEE Min-sung KIM Seok-ki JANG Seong-jong KIM Division of Marine Engineering Mokpo Maritime University

Among the environmentally friendly marine energies,tidal current power plants require low cost because they do not need to construct a large *** power is particularly reliable energy source because the power generation capacity is predictable regardless of weather or *** materials or stainless steel have been used as materials of blades for current power ***,their strength and welding performance generated many problems in field *** alloys with excellent cavitation resistance and corrosion resistance were applied as blade materials to improve the durability of copper *** were coated with WC-27NiCr and WC-10Co4Cr using the high velocity oxy-fuel (HVOF) *** metal spray coating technology has the advantage in terms of the selection of materials for cost effectiveness and environmental effects of corrosion because the properties of the coat layer can be controlled *** with WC-27NiCr and WC-10Co4Cr by HVOF,WC-27NiCr shows better corrosion resistance *** reason for this seems to be that corrosion resistance improves and a stable passive film forms due to the effects of Ni and Cr.

关键词： tidal power copper alloys HVOF coating corrosion resistance

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Effect of Plastic Anisotropy on the Formability of Aluminum 6016-T4 Sheet Material

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Chinese Journal of Mechanical Engineering 2017年第3期30卷 625-631页

作者： Young-Suk KIM seung-han YANG kyungpook national university Daegu 41566Republic of Korea

Sheet metal formed of lightweight materials such as aluminum sheeting has received great attention related to the reduction of vehicle emissions. This paper evaluates the anisotropic yield locus using Kuwabara＇s biaxial tensile tester and stretches formability using Hecker＇s hemispheri- cal punch stretching test for aluminum 6016-T4 sheet material. The anisotropic yield locus of the A16016-T4 sheet measured is fitted well by the modified Drucker yield func- tion. Moreover the best fitting to the experimental stress- strain curve from the tensile test was obtained by taking an appropriate hardening model. Analytical study to predict the stretch formability by using Hora＇s Modified Maximum Force Criterion （MMFC） was performed. The predicted forming limit curves （FLC） based on various yield functions were compared with the experiments and discussed.

关键词： Anisotropic yield function AluminumA16016-T4 Biaxial tensile test Forming limit curve

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Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches

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World Journal of Pediatrics 2020年第6期16卷 566-574页

作者： seung Beom han Soo-Young Lee Department of Pediatrics Daejeon St.Mary's Hospital.College of MedicineThe Catholic University of Korea64 Daeheung-ro.Jung-guDaejeon 34943Republic of Korea Department of Pediatrics.Bucheon St.Mary's Hospital College of MedicineThe Catholic University of Korea327 Sosa-roWonmi-gu.Bucheon 14647Republic of Korea

Background Macrophage activation syndrome(MAS)is a rare,life-threatening complication of Kawasaki disease(KD).Early recognition and treatment of MAS are very important,but sometimes it is difficult to distinguish MAS from a severe form of *** sources A PubMed search was performed in Clinical Queries using the key terms“macrophage activation syndrome or secondary hemophagocytic lymphohistiocytosis(HLH)”and“Kawasaki disease”.Results KD patients with MAS show high intravenous immunoglobulin(IVIG)resistance and coronary *** is also as high as MAS in other *** fever greater than 10 days is highly associated with development of MAS in *** is observed in more than two-thirds of KD patients with *** is often the earliest laboratory finding of *** is highly specific and sensitive for detecting MAS in KD;so,ferritin levels should be checked if there are unexplained clinical exacerbations in KD *** the under-recognition of MAS in KD,it is prudent to consider resistant KD as occult/subclinical *** KD patients with MAS have good outcomes on immune ***,if KD patients fulfill the HLH-2004 diagnostic criteria,they may undergo longer and more intensive treatment than *** The possible existence of MAS should be taken into account when a KD patient shows persistent fever,splenomegaly,thrombocytopenia,hyperferritinemia,or IVIG *** under-diagnosis of MAS in patients with KD is an important issue to be ***,however,there is a possibility of over-treatment of MAS in patients with KD.

关键词： Macrophage activation syndrome Kawasaki disease Children

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Geosynthetics used to stabilize vegetated surfaces for environmental sustainability in civil engineering

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 56-65页

作者： Jie han jun GUO Department of Civil Environmental and Architectural Engineering the University of Kansas Lawrence KS 66044 USA

Geosynthetics, factory-manufactured polymer materials, have been successfully used to solve many geotechnical problems in civil engineering. Two common applications are earth stabilization and erosion control. Geosynthetics used for earth stabilization include but are not limited to stabilized slopes, walls, embankments, and roads. Geosynthetics used for erosion control are mostly related to slopes, river channels and banks, and pond spillways. To enhance environmental sustainability, vegetation has been increasingly planted on the facing or surfaces of these earth structures. Under such a condition, geosynthetics mainly function as surficial soil stabilization while vegetation provides green appearance and erosion protection of earth surfaces. Recently, geosynthetic or geosynthetic-like material has been used to form green walls outside or inside buildings to enhance sustainability. Geosynthetics and vegetation are often integrated to provide combined benefits. The interaction between geosynthetics and vegetation is important for the sustainability of the earth and building wall surfaces. This paper provides a review of the current practice and research in the geosynthetic stabilization of vegetated earth and building surfaces for environmental sustainability in civil engineering with the emphases on geosynthetic used for erosion protection, geosynthetic-stabilized slopes, geosynthetic-stabilized unpaved shoulders and parking lots, and geosynthetic-stabilized vegetated building surfaces.

关键词： erosion geosynthetic stabilization sustainability vegetation

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Optimum condition by mechanical characteristic evaluation in friction stir welding for 5083-O Al alloy

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中国有色金属学会会刊：英文版 2009年第B09期19卷 17-22页

作者： Min-Su han seung-jun LEE Jae-Cheul PARK Seok-Cheol KO Yong-Bin WOO Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Chungnam Regional Innovation Agency

The mechanical characteristies for friction stir welding (FSW) of 5083-O Al alloy were evaluated. The results show that in FSW at 800 r/min and 124 mm/min, a weld defect is observed at the start point. However, the button shape at the end point is good and the stir zone has a soft appearance. At 267 mm/min, a void occurs at the button. A slight weld defect and rough stir zone are seen both at the start and end points at 342 mm/min. Moreover, at the bottom, a tunnel-type void is observed from an early stage to the end point, and at 1 800 r/min, a weld defect can be found from an early stage to the end point. These defects are rough with imperfect joining due to excessive rotation speed and high physical force. Weld fractures relative to rotational and travel speeds are observed at the stir zone. The optimum FSW conditions are a welding speed of 124 mm/min and a rotational speed of 800 r/min.

关键词：搅拌摩擦焊接摩擦特性机械性能铝合金焊缝缺陷评估优化氧

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