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Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays

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Microsystems & Nanoengineering 2018年第1期4卷 541-549页

作者： song Zhang Yilin song Mixia Wang Guihua Xiao Fei Gao Ziyue Li Guoxian Tao Ping Zhuang Feng Yue Piu Chan Xinxia Cai State Key Laboratory of Transducer Technology Institute of ElectronicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China Wincon TheraCells Biotechnologies Co. Ltd.Nanning 530002China Department of Neurobiology Xuanwu HospitalCapital Medical UniversityThe Beijing Key Laboratory of Parkinson's DiseaseBeijing 100053China

Parkinson’s disease(PD)is characterized by a progressive degeneration of nigrostriatal dopaminergic *** precise mechanisms are still *** the neuronal communications are inherently electrical and chemical in nature,dual-mode detection of PD-related neuroelectrical and neurochemical information is essential for PD *** nucleus(STN)highfrequency stimulation(HFS)can improve most symptoms of PD patients and decrease the dosage of antiparkinsonian *** mechanism of STN-HFS for PD still remains *** this study,a silicon-based dual-mode microelectrode array(MEA)probe was designed and fabricated,and systematic dual-mode detection methods were *** recording sites were modified using Pt nanoparticles and Nafion to improve the signal-to-noise(SNR)*** evaluate its applicability to PD research,in vivo electrophysiological and electrochemical detection was performed in normal and hemiparkinsonian models,*** comparison of the dual-mode signals,we demonstrated the following in a PD monkey:(1)the maximum dopamine concentration in the striatum decreased by 90%;(2)the spike firing frequency increased significantly,especially in the region of the cortex;(3)the spectrogram analysis showed that much power existed in the 0–10 Hz frequency band;and(4)following repeated subthalamic nucleus high-frequency stimulation trials,the level of DA in the striatum increased by 16.5μM,which led to a better elucidation of the mechanism of *** dual-mode MEA probe was demonstrated to be an effective tool for the study of neurological disorders.

关键词： dual mode implantable MEA non-human primate Parkinson's disease STN-HFS

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Organic compositions of lacustrine source rocks in Jiyang super-depression and its implication to petroleum geology

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Chinese Science Bulletin 2006年第5期51卷 573-584页

作者： ZHANG Linye song Yitao WANG Guangli HUANG Difan Institute of Geological Sciences Shengli Oilfield Co. Ltd. Dongying 257015 China Institute of Petroleum Exploration and Development CNPC Beijing 100083 China Key Laboratories for Petroleum Formation Mechanisms Chinese Ministry of Education Petroleum University of China Beijing 102249 China

The compositions of organic matter in four immature source rocks from Tertiary strata of Jiyang super-depression, the most typical continental rift subsidence basin in East China, have been stud- ied by different extracting methods with CHCl3, MAC and CS2/NMP, respectively. The results suggest that there are great differences among the chemical compositions of organic matter in the source rocks derived from different depositional environments. About 79% of all the organic matter exists by non- covalent bond in the Es4 source rocks which were deposited under the saline lacustrine, indicating that its organic matter is not the real kerogen, but mainly composed of soluble organic matter which is easy to generate hydrocarbon at lower temperature. This is why the immature oils were derived from Es4 source rocks in Dongying depression. In contrast, around 60% of organic matter exists by covalent bond in Es3 source rocks which were deposited under the deep brackish-fresh lacustrine, showing that Es3 source rocks are mainly composed of kerogen producing mature hydrocarbon at higher temperature. The thermal simulation experiments, upon the remaining solid source rocks which were sequentially extracted by the three solvents, have been carried out. The chloroform extracts from the simulation product have been compared with the other three solvent extracts gained at room temperature. It is obvious that re-markable odd/even predominance (OEP) is mainly the characteristic of soluble organic matter; phytane mostly exists in the soluble organic matter by means of non-covalent bonds and characteristics of soluble organic matter are similar to these in immature oils produced in Jiyang super-depression.

关键词：有机成分 CS2/NMP混合溶剂非共价键未成熟生油岩可溶有机质石油地质学不成熟石油

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Distribution of sand dunes and sand shifts along the southern fringe of the Mu Us Desert since the Ming Dynasty

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Chinese Science Bulletin 2007年第22期52卷 3128-3138页

作者： DENG Hui SHU ShiGuang song YuQin XING FuLai College of Environmental Sciences Peking University Beijing 100871 China Archaeological Research Institution of Shaanxi Province Xi'an 710054 China

This article takes the two segments of the Ming Great Walls,Dabian and Erbian,and their associated barracks and forts as geographical references. Based on a detailed scrutiny of historical records of the Ming and Qing dynasties,and on field surveys,the southern boundaries of the sand dunes and sand shifts of the Mu Us Desert in the Ming and Qing dynasties are carefully reconstructed. A comparison of the southern boundaries of the sand dunes and sand shifts of the Mu Us Desert in Ming and Qing with the modern boundary revealed in remote sensing imagery clearly shows that the southern boundary of dunes and shifts in the Mu us Desert has expanded only in a few areas and on a small scale. In the area to the south of Changle Fort,along the direction of annually prevailing winds,sand drifts have pene-trated through the Jialu River valley into the loess region and have formed a sand strip of 32 km long and 3 km wide. To the east of Qingping Fort,sand drifts penetrated toward the eastern loess region through the Luhe River valley and have formed another sand strip of 8 km long and 2 km wide. Gener-ally speaking,though the intensity of human activity has been increasing in this area since the Ming Dynasty,the Mu Us Desert has not significantly expanded toward the southeast or southwest. The sand-loess boundary in the southern fringe of the Mu Us Desert has been almost unchanged since the Ming Dynasty.

关键词：明朝长城地理位置兵营

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Transarterial injection of H101 in combination with chemoembolization overcomes recurrent hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第18期17卷 2353-2355页

作者： Qing He Yang Liu Qing Zou Yong-song Guan Department of Oncology West China Hospital of Sichuan University Chengdu 610041 Sichuan Province China

Transcatheter arterial chemoembolization (TACE) has become the standard treatment modality for unresectable hepatocellular carcinoma (HCC). Nonetheless, the clinical outcomes in patients with unresectable HCC are often unsatisfactory, especially in those with recurrent HCC. H101, an E1B gene deleted adenovirus, is known to have a significant antitumor activity. In addition, local injection of H101 can enhance the effect of antitumor therapies (chemotherapy and radiotherapy). Transarterial H101 gene injection in combination with TACE may help to control refractory and recurrent HCC. In this study, we report a 55-year-old patient with recurrent HCC which was treated with transarterial injection of H101 in combination with TACE, leading to a good clinical prognosis of the patient.

关键词： Hepatocellular carcinoma H101 Transcatheter arterial chemoembolization Therapy

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Anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer: A meta-analysis

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World Journal of Gastroenterology 2015年第14期21卷 4365-4372页

作者： Qi-Bin song Qi Wang Wei-Guo Hu Department of Oncology Renmin Hospital of Wuhan University

AIM: To investigate the correlation between Kirsten rat sarcoma viral oncogene homolog(KRAS) status and the therapeutic effects of anti-epidermal growth factor receptor(EGFR) monoclonal antibodies(Mo Abs) in metastatic colorectal cancer(m CRC).METHODS: Randomized controlled trials(RCTs) were identified and the association between KRAS mutation and clinical outcome in m CRC patients treated with anti-EGFR Mo Abs was *** RCTs wereincluded in this ***-free survival and overall survival were used to assess the strength of the relationship between KRAS mutation and clinical ***: In first-line treatment, survival benefit was confined to patients with wild-type *** regimens and angiogenesis inhibitor treatment influenced the results of the *** KRAS m CRC patients did not seem to benefit from oxaliplatin-based chemotherapy(PFS: HR = 0.88, 95%CI: 0.70-1.10; OS: HR = 0.93, 95%CI: 0.82-1.04).Clinical benefit in m CRC patients was limited to therapeutic regimens which included anti-EGFR Mo Abs and fluorouracil-based therapy(PFS: HR = 0.77, 95%CI: 0.69-0.86; OS: HR = 0.85, 95%CI: 0.75-0.95).When anti-EGFR Mo Abs were used as second- or further-line treatment, clinical benefit was still confined to patients with wild-type ***: KRAS status is a potential predictive marker of clinical benefit due to anti-EGFR Mo Ab therapy in m CRC patients.

关键词： Colorectal neoplasm Kirsten rat sarcoma viral onco

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Extracorporeal membrane oxygenation combined with continuous renal replacement therapy for the treatment of severe burns:current status and challenges

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Burns & Trauma 2021年第1期9卷 401-408页

作者： Huapei song Zhiqiang Yuan Yizhi Peng Gaoxing Luo State Key Laboratory of Trauma Burn and Combined InjuryInstitute of Burn ResearchSouthwest HospitalThird Military Medical University(Army Medical University)30 Gaotanyan StreetChongqing 400038China

Severe burns often cause various systemic complications and multiple organ dysfunction syndrome,which is the main cause of *** lungs and kidneys are vulnerable organs in patients with multiple organ dysfunction syndrome after *** membrane oxygenation(ECMO)and continuous renal replacement therapy(CRRT)have been gradually applied in clinical practice and are beneficial for severe burn patients with refractory respiratory failure or renal ***,the literature on ECMO combined with CRRT for the treatment of severe burns is ***,we focus on the current status of ECMO combined with CRRT for the treatment of severe burns and the associated challenges,including the timing of treatment,nutrition support,heparinization and wound management,catheter-related infection and drug dosing in *** the advancement of medical technology,ECMO combined with CRRT will be further optimized to improve the outcomes of patients with severe burns.

关键词： Severe burns Extracorporeal membrane oxygenation Continuous renal replacement therapy Multiple organ dysfunction syndrome Acute kidney injury Acute respiratory distress syndrome

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Compensation modification of plastic gear tooth profile considering meshing deformation

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Frontiers of Mechanical Engineering 2024年第5期19卷 111-128页

作者： Mingyong LIU Yaole song Xinguang HAN Jun HU Chunai YAN Hubei Agricultural Machinery Engineering Research and Design Institute Hubei University of TechnologyWuhan 430068China Intelligent Manufacturing Institute Wuchang Institute of TechnologyWuhan 430065China

The plastic gear is widely used in agricultural equipment,electronic products,aircraft,and other fields because of its light weight,corrosion resistance,and self-lubrication ***,it has a limited range of working conditions due to the low modulus and thermal deformation of the material,especially in high-speed and heavy-duty situations.A compensation modification method(CMM)is proposed in this paper to restrain the heat production of the plastic gear tooth surface by considering the meshing deformation,and the corresponding modification formulas are *** the position of the maximum contact pressure(CP)and the relative sliding velocity(RSV)of the tooth surface resulted in a 30%lower steady-state temperature rise of the modified plastic gear tooth surface than that of the unmodified plastic ***,the temperature rise of plastic gear with CMM is reduced by 19%compared with the traditional modification of removal ***,the influences of modification index and the segment number of modification on the meshing characteristics of plastic gear with CMM are discussed,such as maximum CP and steadystate temperature rise,RSV,transmission error,meshing angle,and contact ratio.A smaller segment number and modification index are beneficial to reduce the temperature rise of plastic gear with ***,an experiment is carried out to verify the theoretical analysis model.

关键词： plastic gear compensation modification meshing deformation temperature rise tooth profile

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Genomic survey of bZIP transcription factor genes related to tanshinone biosynthesis in Salvia miltiorrhiza

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Acta Pharmaceutica Sinica B 2018年第2期8卷 295-305页

作者： Yu Zhang Zhichao Xu Aijia Ji Hongmei Luo Jingyuan song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of China Institute of Medicinal Plant Development Peking Union Medical College & Chinese Academy of Medical Sciences

Tanshinones are a class of bioactive components in the traditional Chinese medicine Salvia miltiorrhiza, and their biosynthesis and regulation have been widely studied. Current studies show that basic leucine zipper(bZIP) proteins regulate plant secondary metabolism, growth and developmental processes. However, the b ZIP transcription factors involved in tanshinone biosynthesis are ***, we conducted the first genome-wide survey of the b ZIP gene family and analyzed the phylogeny,gene structure, additional conserved motifs and alternative splicing events in S. miltiorrhiza. A total of 70 Smb ZIP transcription factors were identified and categorized into 11 subgroups based on their phylogenetic relationships with those in Arabidopsis. Moreover, seventeen Smb ZIP genes underwent alternative splicing events. According to the transcriptomic data, the Smb ZIP genes that were highly expressed in the Danshen root and periderm were selected. Based on the prediction of b ZIP binding sites in the promoters and the co-expression analysis and co-induction patterns in response to Ag^+ treatment via quantitative real-time polymerase chain reaction(qRT-PCR), we concluded that Smb ZIP7 and Smb ZIP20 potentially participate in the regulation of tanshinone biosynthesis. These results provide a foundation for further functional characterization of the candidate Smb ZIP genes, which have the potential to increase tanshinone production.

关键词： bZIP genes Salvia miltiorrhiza Phylogenetic analysis Expression pattern analysis Tanshinone biosynthesis

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New Exact Solutions and Evolution of Solitons in Background Waves for(2+1)-Dimensional Modified Dispersive Water-Wave System

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Communications in Theoretical Physics 2008年第10期50卷 938-942页

作者： MA song-Hua JIANG Yong-Qing FANG Jian-Ping College of Mathematics and Physics Lishui University Lishui 323000 China

With the help of the conditional similarity reduction method, some new exact solutions of the （2＋1）- dimensional modified dispersive water-wave system （MDWW） are obtained. Based on the derived solution, we invest... 详细信息

关键词： conditional similarity reduction method modified dispersive water-wave system exact solutions evolution background waves

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Synthesis and Characterization of Ferrocenyl Substituted Styryl Octasilsesquioxane

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Chinese Chemical Letters 2006年第4期17卷 427-430页

作者： Xiao Yan song Hai Ping GENG Qi Fang LI College of material science and engineering Beijing University of Chemical Technology Beijing 100029

4-（2-Ferrocenylethenyl）-phenyl-POSS Fc-CH=CH-C6H6-（C5H9）7Si8O12 （FEPS, Fc： ferrocene）, containing metal and C=C double bond, was firstly synthesized as a mixture of E/Z isomers by the Wittig reaction. The chemi... 详细信息

关键词： Polyhedral silsesquioxane ferrocene Wittig reaction synthesis.

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