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World Journal of Gastroenterology 2012年第25期18卷 3215-3222页

作者： Myeong Jun Song Si Hyun Bae Ie Ryung Yoo Chung-Hwa Park Jeong Won jang Ho Jong Chun Byung Gil Choi Hae Giu Lee Jong Young Choi seung Kew Yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Nuclear Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM： To investigate the correlation of 18F-fluorodeoxy- glucose （18F-FDG） positron emission tomography （PET） with clinical features and the prediction of treatment response. METHODS： A total of 83 hepatocellular carcinoma （HCC） patients undergoing 18F-FDG PET before transar- terial chemolipiodolization with systemic chemo-infusion between October, 2006 and May, 2009 were retrospec-tively enrolled. The patients included 68 men and 15 women （mean age, 60 ~ 10.7 years）. The effect of 18F- FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors. The PET parameters of maximal standardized uptake value of the tumor （Tsuvmax）, the ratio of the tumor maximal standardized uptake value （SUV） to the liver maximal SUV （Tsuvmax/Lsuwax） and the ratio of tumor maximal SUV to the liver mean SUV （msuvmax/LSUVrnean） were tested as predictive factors. RESULTS： Among the 3 SUV parameters, the TSUV- =maxdLsuvmean ratio （cutoff value of 1.90） was significantly associated with tumor burden including tumor size, tu- mor number, α-fetoprotein levels and tumor stage （P 〈 0.001, P = 0.008, P = 0.011, P 〈 0.001, respectively）. The objective response rates in patients with a high SUV ratio （≥ 1.90） were significantly better than those with a low SUV ratio （〈 1.90）（P = 0.020）. The overall survival rates of patients exhibiting a low Tsuvmax/Lsu- Vmean ratio （〈 1.90） and those with a high SUV ratio （≥1.90） was 38.2 and 10.3 mo, respectively （P 〈 0.01）. However, the time to progression showed no significant difference between the groups （P = 0.15）. CONCLUSION： 18F-FDG PET can be an important predictor of HCC treatment. In particular, the Tsuvmax/ Lsuwean ratio （cutoff value of 1.90） can provide useful information in treatment prognosis for HCC patients treated with Iocoregional therapy.

关键词： 18F-fluorodeoxyglucose positron emissiontomography Transarterial chemolipiodolization withsystemic chemo-infusion Treatment response Predic-tive factor, Overall survival

Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules

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World Journal of Gastroenterology 2005年第14期11卷 2072-2079页

作者： seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park School of Biological Sciences Seoul National University SeoulKorea Hepatology Center and Laboratory of Hepatocarcinogenesis Bundang Jesaeng General Hospital KyungkidoKorea School of Chemistry Seoul National University SeoulKorea Department of Pathology Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea General Surgery Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea Internal Medicine Samsung Medical Center Sungkyunkwan University School of MedicineSeoulKorea

AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related ***: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically ***: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic ***: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis.

关键词： Heat shock protein Hepatocellular carcinoma Dysplastic nodule Hepatocarcinogenesis Immunohisto-chemistry Dot immunoblot analysis

EXPERIMENTAL INVESTIGATION ON THE THRESHOLD CHLORIDE CONCENTRATION FOR CORROSION INITIATION IN REINFORCED CONCRETE STRUCTURES

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EXPERIMENTAL INVESTIGATION ON THE THRESHOLD CHLORIDE CONCENT...

Effects of feeding a diet containing Gymnema sylvestre extract: attenuating progression of obesity in C57BL/6J mice

第十八届国际反应堆结构力学大会

作者： Byung Hwan Oh seung Yup jang Dept. of Civil Engineering Seoul National University Korea Railroad Research Korea

＜正＞ The corrosion of steel reinforcement in concrete is of great concern in recent years as the durability is becoming more important in concrete structures. Especially, chloride-induced corrosion of reinforcing steel is increasingly important in many countries due to increased use of sea sand and heavy construction of marine structures. Although many investigators have studied the mechanism of chloride-induced corrosion, the chloride ion concentration that causes the initiation of steel corrosion in concrete - a most important parameter in determining the durability life and/or service life of concrete structures - is still ambiguous and needs further study. This threshold concentration for corrosion initiation is known to be affected by a number of factors including cement content, type of binder, chloride binding,

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 425-431页

作者： Hyeon-Jeong Kim Seong-Ho Hong seung-Hee Chang Sanghwa Kim Ah Young Lee Yoonjeong jang Orkhonselenge Davaadamdin Kyeong-Nam Yu Ji-Eun Kim Myung-Haing Cho Laboratory of Toxicology College of Veterinary Medicine Seoul National University Graduate Group of Tumor Biology Seoul National University Graduate School of Convergence Science and Technology Seoul National University Advanced Institutes of Convergence Technology Seoul National University Institute of Green Bio Science Technology Seoul National University

Objective: To investigate the effect of Gymnema sylvestre extract(GS) on initial anti-obesity, liver injury, and glucose homeostasis induced by a high-fat diet(HFD). Methods: The dry powder of GS was extracted with methanol, and gymnemic acid was identified by high performance liquid chromatography as deacyl gymnemic acid. Male C57BL/6J mice that fed on either a normal diet, normal diet containing 1 g/kg GS(CON+GS) HFD, or HFD containing 1.0 g/kg GS(HFD+GS) for 4 weeks were used to test the initial anti-obesity effect of GS. Body weight gain and food intake, and serum levels about lipid and liver injury markers were measured. Histopathology of adipose tissue and liver stained with hematoxylin and eosin(H&E) and oil-red O were analyzed. After 4 weeks of GS extract feeding, intraperitoneal glucose tolerance test(IPGTT) was performed. Results: The methanol extracts of GS exerted significant anti-obesity effects in HFD+GS group. They decreased body weight gain, a lower food and energy efficiency ratio, and showed lower serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein(LDL)-cholesterol, very-low density lipoprotein(VLDL)-cholesterol and leptin compared with the HFD group. The decreases of abdominal as well as epididymal fat weight and adipocyte hypertrophy, lipid droplets in liver, and serum levels of aspartate aminotransferase(AST) and alanine transaminase(ALT) were also observed. The CON+GS group showed an effect of glucose homeostasis compared to the CON group. Conclusions: This study shows that GS provide the possibility as a key role in an initial anti-obesity effects feeding with a HFD.

关键词： Gymnema sylvestre extract Obesity Adipocyte Body weight gain High-fat diet Liver injury

Rationally designed graphene channels for real-time sodium ion detection for electronic tongue

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InfoMat 2023年第7期5卷 43-58页

作者： Chung Won Lee Sang Eon Jun seung Ju Kim Tae Hyung Lee Sol A.Lee Jin Wook Yang Jin Hyuk Cho Shinyoung Choi Cheol-joo Kim Soo Young Kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

Monitoring taste-inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue(E-tongue).Particularly from the five major tastes,the highly selective,sensitive detection of Na^(+)in real-time is *** is due to the saltiness of food is the key ingredient in most ***,existing Na^(+)detecting devices have relatively low performances of selectivity,sensitivity,and lack of on–off ***,conventional devices significantly deteriorate in capac-ity due to repetitive usage or lifetime shortage by degradation of the sensing ***,a graphene-based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this *** act as a receptor and a molecular sieve,respectively,to enhance selectivity and sensitivity and elon-gate the life expectancy of the *** device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off *** fabricated device has highly selective,sensitive Na^(+)detection properties compared to other 10 molecule/ionic *** on–off functions of the device were available,also possesses a long lifespan of at least 220 ***,it can precisely discriminate real beverages containing Na^(+),which can be observed by principal component analysis *** features offer the possibility of ascending to a platform for E-tongues in near future.

关键词： electronic tongue graphene microfluidic channels Na^(+)sensors solution-gated field-effect transistors

Functional magnetic resonance imaging of cerebellar activation and lateralization during verbal and visuospatial tasks

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Neural Regeneration Research 2010年第3期5卷 226-231页

作者： Mi-Hyun Choi Su-Jeong Lee Jae-Woong Yang Jin-seung Choi Hyung-Sik Kim Jeong-Han Yi Gye-Rae Tack soon-Cheol Chung Byung-Chan Min Se-Jin Park Jong-Rak Park Jae-Hoon Jun Department of Biomedical Engineering Research Institute of Biomedical Engineering College of Biomedical & Health Science Konkuk University Department of Industrial & Management Engineering Hanbat National University Division of Technology Services National Center for Standard Reference Data Korea Research Institute of Standards and Science Department of Photonic Engineering Chosun University

BACKGROUND： Previous studies have analyzed cerebral activation and lateralization of cognitive functions, as well as cerebellar function with reference to high-level cognitive processing. However, there has been very little research on systematization and diversification. In particular, there are no reports on cerebellar lateralization, although reliable results have been reported on cerebral lateralization. OBJECTIVE： This study analyzed cerebellar activation and lateralization in relation to verbal and visuospatial tasks using functional magnetic resonance imaging （fMRI）. DESIGN, TIME AND SETTING： A block design for fMRI observation was performed at the fMRI Laboratory, Brain Science Research Center, Korea Advanced Institute of Science and Technology from May 2006 to September 2008. PARTICIPANTS： Sixteen healthy, male, college students, aged （23.3 ± 0.5） years, and 16 healthy, male, college students, aged （21.5 ± 2.3） years, participated in the study, respectively. METHODS： Verbal and visuospatial tasks were presented while functional brain images were acquired using a 3T fMRI system. Verbal analogy testing required the subject to select the word with the same relationship as one of the given words. Verbal antonym testing required the subject to select the word with a different meaning among four words. Visuospatial tasks involved selecting a shape that corresponded to a given figure with four examples, as well as selecting a development figure of a diagram. MAIN OUTCOME MEASURES： Changes in cerebellar activation and lateralization between two cognition tasks. RESULTS： Bilateral hemisphere Iobules VI and IX, right hemisphere Iobule VIII, bilateral hemisphere Iobules Crus I, and vermis Iobule IV, V, and Vl were closely related to verbal tasks in comparison to visuospatial tasks. Conversely, bilateral hemisphere Iobules IV and V, as well as the right hemisphere Iobule VI, were closely related to visuospatial tasks compared to verbal tasks. There was no great differe

关键词： cerebellum lateralization functional magnetic resonance imaging verbal and visuospatial tasks neuroimaging neural regeneration

Isolated recurrence of Intracranial granulocytic sarcoma mimicking a falx meningioma in acute myeloblastic leukemia

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Isolated recurrence of Intracranial granulocytic sarcoma mim...

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： soon Ki Sung Won Ho Cho seung Heon Cha Pusan National University Yangsan Hospital Pusan National University Hospital

＜正＞PURPOSE:Intracranial granulocytic sarcomas are rare tumors,which are composed of immature granulocytic cells. Although it has been well known that these tumors are associated with acute myeloblastic leukemia（AM...

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纯净空间——一个诊所的三个主题

现代装饰(理论) 2003年第3期 12-31页

作者： jang soon-Gak

一.保持诊所高度开放室内建筑将设计师意图赋予的功能组合起来表现为某种形体。这不只是形式与功能的简单组合。基于3个不同主题的One Mind多科诊所希望向外界展示出其丰富多彩的室内空间,因此,诊所应有一个不同于传统封闭格局的更开放... 详细信息

一.保持诊所高度开放室内建筑将设计师意图赋予的功能组合起来表现为某种形体。这不只是形式与功能的简单组合。基于3个不同主题的One Mind多科诊所希望向外界展示出其丰富多彩的室内空间,因此,诊所应有一个不同于传统封闭格局的更开放的形象。为达目的安装了双层的玻璃幕墙使

关键词：诊所光源 of is that 辐射源自然光

A recovery method using recently updated record information in shared-nothing spatial database cluster

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重庆邮电学院学报（自然科学版） 2004年第5期16卷 32-35页

作者： JEONG Myeong ho jang Yong ll PARK soon young BAE Hae young Dept. of Computer Science and Engineering Inha UniversityKoreaDept. of Computer Science and Engineering Inha UniversityKoreaDept. of Computer Science and Engineering Inha UniversityKoreaDept. of Computer Science and Engineering Inha UniversityKorea

A shared nothing spatial database cluster is system that provides continuous service even if some system failure happens in any node. So, an efficient recovery of system failure is very important. Generally, the existing method recovers the failed node by using both cluster log and local log. This method, however, cause several problems that increase communication cost and size of cluster log. This paper proposes novel recovery method using recently updated record information in shared nothing spatial database cluster. The proposed technique utilizes update information of records and pointers of actual data. This makes a reduction of log size and communication cost. Consequently, this reduces recovery time of failed node due to less processing of update operations.

关键词：空间数据库日志文件记录系统串最近更新记录