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In situ observation of atomic movement in a ferroelectric film under an external electric field and stress

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Nano Research 2018年第7期11卷 3824-3832页

作者： Hyeon jun Lee Er-Jia Guo Taewon Min seung Hyun Hwang Su Yong Lee Kathrin Dorr Jaekwang Lee Ji Young Jo School of Materials Science and Engineering Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea Quantum Condensed Matter Division Oak Ridge National Laboratory Oak Ridge TN 37830 USA Institute for Physics Martin-Luther-University Halle-Wittenberg Halle 06099 Germany Department of Physics Pusan National University Busan 46241 Republic of Korea Pohang AccelerotorLaboratory Pohang 37673 Republic of Korea

Atomic movement under application of external stimuli （i.e., electric field or mechanical stress） in oxide materials has not been observed due to a lack of experimental methods but has been well known to determine the electric polarization. Here, we investigated atomic movement arising from the ferroelectric response of BiFeO3 thin films under the effect of an electric field and stress in real time using a combination of switching spectroscop）6 time-resolved X-ray microdiffraction, and in situ stress engineering. Under an electric field applied to a BiFeO3 film, the hysteresis loop of the reflected X-ray intensity was found to result from the opposing directions of displaced atoms between the up and down polarization states. An additional shift of atoms arising from the linearly increased dielectric component of the polarization in BiFeO3 was confirmed through gradual reduction of the diffracted X-ray intensity. The electric-field- induced displacement of oxygen atoms was found to be larger than that of Fe atom for both ferroelectric switching and increase of the polarization. The effect of external stress on the BiFeO3 thin film, which was controlled by applying an electric field to the highly piezoelectric substrate, showed smaller atomic shifts than for the case of applying an electric field to the film, despite the similar tetragonality.

关键词： in situ measurement atomic displacementunder electric field time-resolved X-ray microdiffraction ferroelectrics in situ strain engineering

Multiplexed DNA-functionalized graphene sensor with artificial intelligence-based discrimination performance for analyzing chemical vapor compositions

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Microsystems & Nanoengineering 2023年第2期9卷 113-125页

作者： Yun Ji Hwang Heejin Yu Gilho Lee Iman Shackery Jin Seong Youngmo jung seung-Hyun Sung Jongeun Choi Seong Chan jun School of Mechanical Engineering Yonsei University500Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

This study presents a new technology that can detect and discriminate individual chemical vapors to determine the chemical vapor composition of mixed chemical composition in situ based on a multiplexed DNA-functionalized graphene(MDFG)nanoelectrode without the need to condense the original vapor or target *** the best of our knowledge,our artificial intelligence(Al)-operated arrayed electrodes were capable of identifying the compositions of mixed chemical gases with a mixed ratio in the early *** innovative technology comprised an optimized combination of nanodeposited arrayed electrodes and artificial intelligence techniques with advanced sensing capabilities that could operate within biological limits,resulting in the verification of mixed vapor chemical *** selective sensors that are tolerant to high humidity levels provide a target for"breath chemovapor fingerprinting"for the early diagnosis of *** feature selection analysis achieved recognition rates of 99%and above under low-humidity conditions and 98%and above under humid conditions for mixed chemical *** 1D convolutional neural network analysis performed better,discriminating the compositional state of chemical vapor under low-and high-humidity conditions almost *** study provides a basis for the use of a multiplexed DNA-functionalized graphene gas sensor array and artificial intelligence-based discrimination of chemical vapor compositions in breath analysis applications.

关键词： humidity functional intelligence

Novel monoclonal antibody against beta 1 integrin enhances cisplatin efficacy in human lung adenocarcinoma cells

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The Journal of Biomedical Research 2016年第3期30卷 217-224页

作者： Min-Young Kim Woon-Dong Cho Kwon Pyo Hong Da Bin Choi Jeong won Hong Soseul Kim Yoo Ri moon seung-Myoung Son Ok-jun Lee Ho-Chang Lee Hyung Geun Song Department of Pathology Chungbuk National University College of MedicineCheongju28644Republic of Korea Research Institute Chungbuk National University College of MedicineCheongju28644Republic of Korea

The use of anti-beta 1 integrin monoclonal antibody in lung cancer treatment has proven beneficial. Here, we developed a novel monoclonal antibody （mAb）, called P5, by immunizing mice with human peripheral blood mononuclear cells （PBMC）. Its anti-tumor effect is now being tested, in a clinical phase Ⅲ trial, in combinato- rial treatments with various chemical drugs. To confirm that P5 indeed binds to beta 1 integrin, cell lysates were immunoprecipitated with commercial anti-beta 1 integrin mAb （TS2/16） and immunoblotted against P5 to reveal a 140 kDa molecular weight band, as expected. Immunoprecipitation with P5 followed by LC/MS protein sequence analysis further verified P5 antigen to be beta 1 integrin. Cisplatin treatment upregulated cell surface expression of beta 1 integrin in A549 cells, while causing inhibition of cell growth. When cells were co-treated with different concentrations of P5 mAb, the cisplatin-mediated inhibitory effect was enhanced in a dose-dependent manner. Our findings show that a combinatorial treatment of P5 mAb and cisplatin in A549 cells resulted in a 30% increase in apoptosis, compared to baseline, and significantly more when compared to either the cisplatin or P5 alone group. The entire peptide sequences in CDR from variable region of Ig heavy and light chain gene for P5 mAb are also disclosed. Together, these results provide evidence of the beneficial effect of P5 mAb in combinatorial treatment of human lung adenocarcinoma.

关键词： CD29 beta 1 integrin lung adenocarcinoma monoclonal antibody cisplatin

Fundamentals and comprehensive insights on pulsed laser synthesis of advanced materials for diverse photo-and electrocatalytic applications

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Light(Science & Applications) 2022年第9期11卷 2018-2064页

作者： Jayaraman Theerthagiri K Karuppasamy seung jun Lee R.Shwetharani Hyun-Seok Kim S.K Khadheer Pasha Muthupandian Ashokkumar Myong Yong Choi Core-Facility Center for Photochemistry&Nanomaterials Department of ChemistryResearch Institute of Natural SciencesGyeongsang National UniversityJinju 52828Republic of Korea Division of Electronics and Electrical Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Centre for Nano and Material Sciences Jain UniversityJain Global CampusKanakapuraBangalore 562112 KarnatakaIndia Department of Physics Vellore Institute of Technology(Amaravati Campus)Amaravati522501 GunturAndhra PradeshIndia School of Chemistry University of MelbourneParkville CampusMelbourneVIC 3010Australia

The global energy crisis is increasing the demand for innovative materials with high purity and functionality for the development of clean energy production and *** development of novel photo-and electrocatalysts significantly depends on synthetic techniques that facilitate the production of tailored advanced *** emerging use of pulsed laser in liquid synthesis has attracted immense interest as an effective synthetic technology with several advantages over conventional chemical and physical synthetic routes,including the fine-tuning of size,composition,surface,and crystalline structures,and defect densities and is associated with the catalytic,electronic,thermal,optical,and mechanical properties of the produced ***,we present an overview of the fundamental understanding and importance of the pulsed laser process,namely various roles and mechanisms involved in the production of various types of nanomaterials,such as metal nanoparticles,oxides,non-oxides,and carbon-based *** mainly cover the advancement of photo-and electrocatalytic nanomaterials via pulsed laser-assisted technologies with detailed mechanistic insights and structural optimization along with effective catalytic performances in various energy and environmental remediation ***,the future directions and challenges of pulsed laser techniques are briefly *** review can exert practical guidance for the future design and fabrication of innovative pulsed laser-induced nanomaterials with fascinating properties for advanced catalysis applications.

关键词： insight synthesis comprehensive

Flower morphology of Allium(Amaryllidaceae)and its systematic significance

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Plant Diversity 2024年第1期46卷 3-27页

作者： Ju Eun Jang Shukherdorj Baasanmunkh Nudkhuu Nyamgerel seung-Yoon Oh jun-Ho Song Ziyoviddin Yusupov Komijlon Tojibaev Hyeok Jae Choi Department of Biology and Chemistry Changwon National UniversityChangwon51140Republic of Korea Department of Forest Biodiversity and Herbarium Korea National ArboretumPocheon11186Republic of Korea Department of Biology Chungbuk National UniversityCheongju28644Republic of Korea International Joint Lab for Molecular Phylogeny and Biogeography Institute of BotanyAcademy of Sciences of UzbekistanTashkent100125Uzbekistan

Allium is a complicated genus that includes approximately 1000 *** its morphology is well studied,the taxonomic importance of many morphological traits,including floral traits,are poorly ***,we examined and measured the floral characteristics of 87 accessions of 74 Allium taxa(belonging to 30 sections and nine subgenera)from Central to Eastern Asian *** then examined the taxonomic relationships between select flower characteristics and a phylogenetic tree based on ITS *** results confirm that floral morphology provides key taxonomic information to assess species delimitation in *** found that perianth color is an important characteristic within the ***,Polyprason,and *** ***,Cepa,and Rhizirideum,significant characteristics include ovary shape,perianth shape,and inner tepal *** species in ***,the key taxonomic character is ovule number(only one ovule in per locule).In the ***,Cepa,Polyprason,and Reticulatobulbosa,which belong to the third evolutionary line of Allium,hood-like appendages occur in the ovary,although these do not occur in *** results also indicated that the flower morphology of several species in some sections are not clearly distinguished,e.g.,***(***)and ***(***).This study provides detailed photographs and descriptions of floral characteristics and information on general distributions,habitats,and phenology of the studied taxa.

关键词： Allium Flower morphology Pistil character Statistical analysis Significant characteristic Species level

Potentiostatic corrosion protection technology under cavitation condition for 5083-H116 Al alloy

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Transactions of Nonferrous Metals Society of China 2013年第11期23卷 3206-3214页

作者： seung-jun LEE Young-Soo PARK Seong-Jong KIM Division of Marine Engineering Mokpo Maritime University Division of Maritime Transportation Science College of Maritime Sciences Korea Maritime and Ocean University

This study aims to characterize the cavitation damage behavior of aluminum alloys in seawater and thus to enhance its cavitation resistance. Potentiostatic experiments were performed under various potential conditions to determine the optimum protection potentials, at which cavitation damage was suppressed. A potential range was selected for the experiment from -2.2 to -1.4 V, which corresponded to the concentration and activation polarization regions on the cathodic polarization curve of the 5083-H116 alloy. After the experiments, the current density-time behavior was investigated, and the degree of surface damage was observed using three-dimensional microscopy and scanning electron microscopy （SEM）, The optimum protection potential was determined to be in the range of-l.9 to -1.5 V under which the cavitation damage was reduced significantly.

关键词： Al alloy cavitation potentiostatic experiment seawater

Defect Engineering in Earth-Abundant Cu_(2)ZnSnSe_(4) Absorber Using Efficient Alkali Doping for Flexible and Tandem Solar Cell Applications

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Energy & Environmental Materials 2024年第2期7卷 249-256页

作者： Muhammad Rehan Ara Cho Inyoung Jeong Kihwan Kim Asmat Ullah jun-Sik Cho Joo Hyung Park Yunae Jo Sung jun Hong seung Kyu Ahn SeJin Ahn Jae Ho Yun Jihye Gwak Donghyeop Shin Photovoltaics Research Department Korea Institute of Energy Research(KIER)152-Gajeong-roYuseong-guDaejeon 34129Korea Department of Renewable Energy Engineering University of Science and Technology(UST)217-Gajeong-roYuseong-guDaejeon 34113Korea Korea Institute of Energy Technology(KENTECH) 50772 Ujeong-roNaju Jeonnam 58217Korea

To demonstrate flexible and tandem device applications,a low-temperature Cu_(2)ZnSnSe_(4)(CZTSe)deposition process,combined with efficient alkali doping,was ***,high-quality CZTSe films were grown at 480℃by a single co-evaporation,which is applicable to polyimide(PI)*** of the alkali-free substrate,Na and K alkali doping were systematically studied and optimized to precisely control the alkali distribution in *** bulk defect density was significantly reduced by suppression of deep acceptor states after the(NaF+KF)*** the low-temperature deposition with(NaF+KF)PDTs,the CZTSe device on glass yields the best efficiency of 8.1%with an improved Voc deficit of 646 *** developed deposition technologies have been applied to *** the first time,we report the highest efficiency of 6.92%for flexible CZTSe solar cells on ***,CZTSe devices were utilized as bottom cells to fabricate four-terminal CZTSe/perovskite tandem cells because of a low bandgap of CZTSe(~1.0 eV)so that the tandem cell yielded an efficiency of 20%.The obtained results show that CZTSe solar cells prepared by a low-temperature process with in-situ alkali doping can be utilized for flexible thin-film solar cells as well as tandem device applications.

关键词： alkali doping Earth-abundant Cu_(2)ZnSnSe_(4) flexible solar cells four-terminal tandem cells low-temperature process

Psychological predictors of bipolarity in panic disorder

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World Journal of Psychiatry 2021年第6期11卷 242-252页

作者： Da Hye Oh Doo-Heum Park seung-Ho Ryu Jee Hyun Ha Hong jun Jeon Department of Psychiatry Konkuk University Medical CenterSeoul 05030South Korea Department of Psychiatry Konkuk University School of MedicineSeoul 05029South Korea

BACKGROUND Panic disorders frequently occur with affective disorders,particularly bipolar *** with panic disorder and bipolar disorder are more likely to present with severe symptoms,such as high rates of suicidal behavior,poor symptomatic and functional recovery,and poor drug *** To investigate the psychological characteristics of panic disorder patients related to *** A total of 254 patients(136 men and 118 women,mean age=33.48±3.2 years)who were diagnosed with panic disorder were included in the *** disorder with bipolarity(BP+)was defined as a score of≥7 on the Korean version of the Mood Disorder Questionnaire(K-MDQ),and a score lower than 7 was considered as a panic disorder without bipolarity(BP-).Self-report questionnaires were analyzed to examine their association with *** tests used in the study were the Mood Disorder Questionnaire(MDQ),Panic Disorder Severity Scale,Beck Depression Inventory,State-Trait Anxiety Inventory(STAI),Temperament and Character Inventory(TCI),and Minnesota Multiphasic Personality Inventory(MMPI).Statistical analyses were performed to evaluate the correlation between bipolarity of panic disorder patients and various psychological test results indicative of psychological *** Patients with a K-MDQ score of 7 or more were considered to have a history of manic or hypomanic episodes(BP+group,n=128),while patients with K-MDQ scores below 7 were defined as those without bipolarity(BP-group,n=126).The BP+group were more likely to be unmarried(single 56.2%vs 44.4%,P=0.008)and younger(30.78±0.59 vs 37.11±3.21,P<0.001).Additionally,the BP+group had significantly higher scores on psychological assessment scales,such as the hypochondriasis,psychopathic deviate,masculinity-femininity,psychasthenia,schizophrenia,and hypomania(Ma)in MMPI,and novelty seeking,harm avoidance and self-transcendence in TCI,and STAI(state and trait)compared to the *** logistic

关键词： Panic disorder Bipolar disorder Bipolarity Anxiety Minnesota Multiphasic Personality Inventory Temperament and Character Inventory

Upgrading and upstaging of low-risk prostate cancer among Korean patients： a multicenter study

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Asian Journal of Andrology 2015年第5期17卷 811-814,I0009页

作者： Insang Hwang Donghoon Lim Young Beom Jeong seung Chol Park jun Hwa Noh Dong Deuk Kwon Taek Won Kang Department of Urology Chonnam National University Medical School Gwangju Korea Department of Urology Chosun University Medical School Gwangju Korea Department of Urology Chonbuk National University Medical School Jeonju Korea Department of Urology Wonkwang University School of Medicine Iksan Korea Department of Urology Kwangju Christian Hospital Gwangju Korea

Only 54% of prostate cancer cases in Korea are localized compared with 82% of cases in the US. Furthermore, half of Korean patients are upgraded after radical prostatectomy （41.6%-50.6%）. We investigated the risk factors for upgrading and/or upstaging of low-risk prostate cancer after radical prostatectomy. We retrospectively reviewed the medical records of 1159 patients who underwent radical prostatectomy at five hospitals in Honam Province. Preoperative data on standard clinicopathological parameters were collected. The radical prostatectomy specimens were graded and staged and we defined a ＂worsening prognosis＂ as a Gleason score ≥ 7 or upstaging to ≥ pT3. Multivariate logistic regression models were used to assess factors associated with postoperative pathological upstaging. Among the 1159 patients, 324 were classified into the clinically low-risk group, and 154 （47.5%） patients were either upgraded or upstaged. The multivariable analysis revealed that the preoperative serum prostate-specific antigen level （odds ratio [OR], 1.131; 95% confidence interval [CI], 1.007-1.271; P = 0.037）, percent positive biopsy core （OR： 1.018; 95% CI： 1.002-1.035; P = 0.032）, and small prostate volume （≤30 ml）（OR： 2.280; 95% CI： 1.351-3.848; P = 0.002） were predictive of a worsening prognosis. Overall, 47.5% of patients with low-risk disease were upstaged postoperatively. The current risk stratification criteria may be too relaxed for our study cohort.

关键词： prostate cancer prostatectomy risk factors